Article
Pediatrics
Shin-Hee Kim, Yun Jung Choi, Moon Bae Ahn, Won Kyoung Cho, Kyoung Soon Cho, Min Ho Jung, Byung-Kyu Suh
Summary: Among children and adolescents with obesity, serum sclerostin was negatively correlated with HOMA-IR. Further studies are needed to clarify the mechanisms involved to understand how sclerostin affects the glucose metabolism.
Article
Nutrition & Dietetics
Justyna Jurczewska, Joanna Ostrowska, Magdalena Chelchowska, Mariusz Panczyk, Ewa Rudnicka, Marek Kucharski, Roman Smolarczyk, Dorota Szostak-Wegierek
Summary: Abdominal obesity increases the odds of insulin resistance (IR) in women with polycystic ovary syndrome (PCOS). Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), VAT/SAT ratio, and waist-to-hip ratio (WHR) are indicators of abdominal adiposity that are associated with IR. Adhering to a recommended diet for IR and engaging in vigorous physical activity can help reduce central fat accumulation and improve the management of abdominal obesity in PCOS women.
Article
Nutrition & Dietetics
Justyna Jurczewska, Joanna Ostrowska, Magdalena Chelchowska, Mariusz Panczyk, Ewa Rudnicka, Marek Kucharski, Roman Smolarczyk, Dorota Szostak-Wegierek
Summary: Insulin resistance is a prominent feature of polycystic ovary syndrome (PCOS). This study evaluated the link between diet, physical activity, and insulin resistance in PCOS women. The findings suggest that higher levels of physical activity are associated with lower HOMA-IR and a greater chance of reaching a normal value in PCOS women. The study supports the beneficial role of physical activity in managing insulin resistance in PCOS.
Article
Multidisciplinary Sciences
Maria Izabel Siqueira de Andrade, Juliana Souza Oliveira, Vanessa Sa Leal, Poliana Coelho Cabral, Pedro Israel Cabral de Lira
Summary: This study revealed a high prevalence of insulin resistance among Brazilian adolescents, with factors such as age, geographical location, lifestyle choices, and obesity being associated with its occurrence.
Article
Nutrition & Dietetics
Minna F. Schleu, Beatriz Barreto-Duarte, Maria B. Arriaga, Mariana Araujo-Pereira, Ana Marice Ladeia, Bruno B. Andrade, Maria L. Lima
Summary: The study found that lower levels of VITD are strongly associated with increased insulin resistance in obese women. Different expression profiles of laboratory markers were observed according to 25(OH)D levels.
Article
Medicine, General & Internal
Sara Lundgren, Sara Kuitunen, Kirsi H. Pietilainen, Mikko Hurme, Mika Kahonen, Satu Mannisto, Markus Perola, Terho Lehtimaki, Olli Raitakari, Jaakko Kaprio, Miina Ollikainen
Summary: This study utilized data from the Finnish Twin Cohort and found a significant association between increased BMI and accelerated biological aging. These results suggest a potential role of BMI in the aging process.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Pedro Renato Chocair, Precil Diego Miranda de Menezes Neves, Victor Augusto Hamamoto Sato, Sara Mohrbacher, Erico Souza Oliveira, Leonardo Victor Barbosa Pereira, Alessandra Martins Bales, Fagner Pereira da Silva, John A. Duley, Americo Lourenco Cuvello-Neto
Summary: Insulin resistance and/or hyperinsulinemia are closely associated with adiposity, metabolic syndrome, and inflammatory processes. Among individuals with metabolic abnormalities and hyperinsulinemia, it is recommended to initiate intervention in patients with level 1 metabolic syndrome to reduce the occurrence of complications.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Paloma Ferrero-Hernandez, Claudio Farias-Valenzuela, Emilio Jofre-Saldia, Adilson Marques, Irina Kovalskys, Georgina Gomez, Attilio Rigotti, Lilia Yadira Cortes, Martha Yepez Garcia, Rossina G. Pareja, Marianella Herrera-Cuenca, Mauro Fisberg, Danilo R. Silva, Kabir P. Sadarangani, Gerson Ferrari
Summary: This study aims to establish cut-off points for the number of minutes of physical activity intensity and the number of daily steps that identify overweight/obesity in adolescents, adults, and older adults. The results can be used to develop specific recommendations for the prevention of overweight/obesity.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Jean-Michel Oppert, Alice Bellicha, Cecile Ciangura
Summary: Physical activity and exercise have various benefits for individuals with obesity, aiding in weight loss and reduction of body fat. Different types of training have slightly different effects on weight loss but all improve physical fitness and reduce cardiovascular risk. Tailored physical activity counseling and exercise prescriptions are crucial in achieving specific treatment goals for individual patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Tahmina Akter, Zebunnesa Zeba, Ismail Hosen, Firoj Al-Mamun, Mohammed A. Mamun
Summary: During the pandemic, some participants experienced an increase in overweight status, but following a proper diet plan can significantly decrease BMI status.
Article
Endocrinology & Metabolism
Brenda Kitilya, Robert Peck, John Changalucha, Kidola Jeremiah, Bazil B. Kavishe, Henrik Friis, Suzanne Filteau, Rikke Krogh-Madsen, Soren Brage, Daniel Faurholt-Jepsen, Mette F. Olsen, George PrayGod
Summary: This study examined the associations between physical activity, cardiorespiratory fitness, and beta-cell dysfunction, insulin resistance, and diabetes among people living with HIV and HIV-uninfected Tanzanian adults. The results showed that low physical activity was associated with beta-cell dysfunction, insulin resistance, and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Sport Sciences
Chelsea L. Kracht, Peter T. Katzmarzyk, Cathierine M. Champagne, Stephanie T. Broyles, Daniel S. Hsia, Robert L. Newton, Amanda E. Staiano
Summary: This study aimed to examine the effects of substituting sedentary time with sleep or physical activity on adiposity in a longitudinal sample of adolescents. The results showed that substituting sedentary time with vigorous-intensity physical activity was related to lower adiposity in later adolescence. Promoting a balance of sleep, sedentary time, and physical activity in all adolescents is encouraged for optimal development.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Nutrition & Dietetics
Marleen A. van Baak, Gabby Hul, Arne Astrup, Wim H. Saris
Summary: In this study, it was found that higher levels of physical activity were associated with improvements in cardiometabolic variables, although baseline physical activity did not predict more weight loss during the low-calorie diet. The analysis suggests that self-imposed higher levels of physical activity may improve cardiometabolic risk profiles during weight loss and aid in maintaining weight loss.
FRONTIERS IN NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Yan Du, Tao Xu, Zenong Yin, Sara Espinoza, Yiqiong Xie, Caleb Gentry, Qing Tian, Lan-Juan Zhao, Hui Shen, Zhe Luo, Hong-Wen Deng
Summary: This study examined the associations between physical activity, obesity, and sarcopenia in middle-aged and older adults. The results showed that the associations varied considerably across gender and age groups. Higher frequency of exercise was associated with lower likelihood of obesity, sarcopenia, and sarcopenia obesity in all groups.
Article
Rehabilitation
Stephen Leb, Christina Marciniak, Deborah Gaebler-Spira, Liqi Chen, Ariane Garrett
Summary: This study aimed to describe the relationship between activity level and cardiovascular risk measures, as well as the general activity patterns of adults with cerebral palsy. The study found that adults with GMFCS levels I or II who engaged in more activity tended to have more favorable anthropometric profiles, while those with GMFCS levels III, IV, or V did not show a similar trend.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Cardiac & Cardiovascular Systems
Dong-Hyuk Park, Seon Young Goo, Sung Hyun Hong, Ji-hee Min, Ji Yong Byeon, Mi-Kyung Lee, Hae Dong Lee, Byoung Wook Ahn, Heejin Kimm, Sun Ha Jee, Dong Hoon Lee, Yong-ho Lee, Eun Seok Kang, Justin Y. Jeon
Summary: This study aimed to investigate the association between resting heart rate (RHR) and the prevalence of undiagnosed diabetes. The results showed that participants with higher RHR had a significantly higher prevalence of undiagnosed diabetes, and this association was stronger among younger and leaner individuals. Therefore, RHR can be used as an indicator to identify and prevent undiagnosed diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Health Care Sciences & Services
Soo Hyun Kim, Kyoung-A Kim, Jiwon Baek, JiYeon Choi, Sang Hui Chu
Summary: This scoping review aimed to summarize the current science on e-health for screening and treating PTSD in traumatized refugees, examining its benefits and challenges. The findings suggest that smartphone is the most commonly used technology modality and telephonic screening of PTSD is equally effective as in-person screening. Interventions through smartphone and the internet demonstrate high feasibility and acceptability.
TELEMEDICINE AND E-HEALTH
(2023)
Article
Endocrinology & Metabolism
Dong Hoon Lee, Xiao Luo, Leandro F. M. Rezende, Hee-Kyung Joh, NaNa Keum, Eric B. Rimm, Fred K. Tabung, Xuehong Zhang, Edward L. Giovannucci
Summary: This study examined the relationship between long-term weight training and mortality in male health professionals with and without type 2 diabetes. The results showed that moderate levels of weight training were associated with lower mortality, independent of aerobic activity, among both groups. Furthermore, combining weight training with aerobic activities provided additional benefits in reducing mortality risk.
Article
Endocrinology & Metabolism
Yong-ho Lee, Doo-Man Kim, Jae Myung Yu, Kyung Mook Choi, Sin Gon Kim, Kang Seo Park, Hyun-Shik Son, Choon Hee Chung, Kyu Jeung Ahn, Soon Hee Lee, Ki-Ho Song, Su Kyoung Kwon, Hyeong Kyu Park, Kyu Chang Won, Hak Chul Jang
Summary: This study compared the effects of anagliptin 100 mg BID versus sitagliptin 100 mg QD on managing glycaemic variability and found that the anagliptin BID regimen was superior in blood glucose control after dinner, as indicated by MAGE and TIR, but was equivalent to the QD regimen in terms of HbA1c and FPG.
DIABETES OBESITY & METABOLISM
(2023)
Article
Oncology
Jiin Ryu, Eun-Young Lee, Jihee Min, Sujin Yeon, Ji-Won Lee, Sang Hui Chu, Hyangkyu Lee, Seung Il Kim, Jee Ye Kim, Seho Park, Justin Y. Jeon
Summary: This 12-month randomized controlled trial investigates the effects of tailored home-based exercise programs on short-term and long-term physiological outcomes in patients with breast cancer. The study found that exercise interventions customized to patients' treatment phase, surgery type, and physical function can improve shoulder function, body composition, and insulin resistance. These findings provide guidance for the development of effective exercise programs for patients with breast cancer post-operatively.
Article
Gastroenterology & Hepatology
Jihee Min, Ki-yong An, Hyuna Park, Wonhee Cho, Hye Jeong Jung, Sang Hui Chu, Minsoo Cho, Seung Yoon Yang, Justin Y. Jeon, Nam Kyu Kim
Summary: This study aimed to investigate the effects of postoperative exercise on the recovery of colorectal cancer patients. The results indicated that patients in the postoperative exercise group had shorter hospital stay, greater readiness for discharge, and increased muscle mass. Therefore, postoperative inpatient exercise may facilitate faster recovery and discharge after colorectal cancer surgery.
BMC GASTROENTEROLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Dong Hoon Lee, Edward L. Giovannucci
Article
Endocrinology & Metabolism
Soo Heon Kwak, Kyung Ah Han, Kyung-Soo Kim, Jae Myung Yu, EunSook Kim, Jong Chul Won, Jun Goo Kang, Choon Hee Chung, Seungjoon Oh, Sung Hee Choi, Kyu Chang Won, Sin Gon Kim, Seung Ah Cho, Bo Young Cho, Kyong Soo Park
Summary: This study evaluated the efficacy and safety of enavogliflozin 0.3 mg as a monotherapy for Korean patients with inadequately controlled type 2 diabetes through diet and exercise. The results showed that enavogliflozin 0.3 mg improved glycemic control in patients with T2DM, and also had beneficial effects on body weight, blood pressure, and lipid profile.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hyeong Kyu Park, Kyoung-Ah Kim, Kyung-Wan Min, Tae-Seo Sohn, In Kyung Jeong, Chul Woo Ahn, Nan-Hee Kim, Ie Byung Park, Ho Chan Cho, Choon Hee Chung, Sung Hee Choi, Kang Seo Park, Seoung-Oh Yang, Kwan Woo Lee
Summary: This study evaluated the effects of dapagliflozin compared with glimepiride on body composition in Korean patients with type 2 diabetes. The results showed that dapagliflozin had a greater impact on reducing total body fat mass, abdominal visceral adipose tissue, and subcutaneous adipose tissue compared to glimepiride. This 52-week study also found that dapagliflozin had better glycemic control and safety profile when added to metformin monotherapy.
DIABETES OBESITY & METABOLISM
(2023)
Article
Oncology
Qi Jin, Ni Shi, Dong Hoon Lee, Kathryn M. Rexrode, JoAnn E. Manson, Raji Balasubramanian, Xuehong Zhang, Marian L. Neuhouser, Melissa Lopez-Pentecost, Cynthia A. Thomson, Suzanna M. Zick, Ashley S. Felix, Daniel G. Stover, Sagar D. Sardesai, Ashwini Esnakula, Xiaokui Mo, Steven K. Clinton, Fred K. Tabung
Summary: This study investigated the association between dietary patterns related to insulinemia, inflammation, and overall dietary quality, and the risk of cancer among postmenopausal women. The results showed that higher overall dietary quality was associated with a lower risk of total cancer and colorectal cancer. The dietary patterns contributing to higher insulinemia and inflammation were associated with a greater risk of total and specific cancers, while higher overall dietary quality was associated with a lower risk. These findings emphasize the importance of testing these dietary patterns in clinical trials for cancer prevention among postmenopausal women.
Review
Psychiatry
Ocksim Kim, Kyoung-A Kim, Sang Hui Chu
Summary: This scoping review aimed to appraise the measurement properties of patient-reported outcome measures (PROMs) that assess PTSD among North Korean defectors. After screening the articles, nine instruments from 40 studies were included. Among these instruments, Impact of Event Scale - Revised was the most frequently used (13 studies [38.1%]).
PSYCHIATRY INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Seong Gyu Choi, Minsuk Oh, Dong-Hyuk Park, Byeongchan Lee, Yong-ho Lee, Sun Ha Jee, Justin Y. Jeon
Summary: This study compares the prediction performance of machine learning-based undiagnosed diabetes prediction models and traditional statistics-based prediction models. The results show that the machine learning-based models have higher AUC values when using features such as sex, age, and waist circumference. Similarly, when additional features including family history of diabetes, hypertension, alcohol consumption, and smoking status are included, the machine learning-based models still outperform the traditional statistics-based models. The study concludes that machine learning-based prediction models using anthropometric and lifestyle measurements may be more accurate in predicting undiagnosed diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Na Won Park, Eun Soo Lee, Kyung Bong Ha, Su Ho Jo, Hong Min Kim, Mi-Hye Kwon, Choon Hee Chung
Summary: This study evaluated the efficacy of umbelliferone in hepatic steatosis and palmitate-induced hepatocellular lipotoxicity. The results showed that umbelliferone improved insulin resistance by inhibiting lipid accumulation and regulating endoplasmic reticulum stress. These findings suggest that umbelliferone may be a potential therapeutic compound against non-alcoholic fatty liver disease.
YONSEI MEDICAL JOURNAL
(2023)
Article
Pediatrics
Ehn-Young Kim, Hye-Won Lee, Ji-Won Lee, Yu-Jin Kwon, Nak-Hoon Son
Summary: The study aimed to analyze the trends in serum uric acid (SUA) levels among Korean children and adolescents over a 5-year period, considering factors such as age, sex, obesity, and abdominal obesity. The study utilized nationally representative data from the Korea National Health and Nutritional Examination Survey conducted from 2016 to 2020. The findings showed a significant increase in SUA levels among boys with obesity or abdominal obesity, indicating the need for further research on the health outcomes associated with SUA in this population.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Health Care Sciences & Services
Hun Kang, Jiwon Baek, Sang Hui Chu, Jiyeon Choi
Summary: This study aims to identify the current understanding of digital literacy among older adults in South Korea and evaluate the measurement methods used in previous studies. The findings show that attention towards digital literacy among South Korean older adults has increased in recent years. However, due to the heterogeneity of measurement methods, the level of digital literacy among older adults in South Korea remains inconclusive. Therefore, it is necessary to develop and validate more robust measures for evaluating digital literacy among older adults.
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)
