期刊
CLINICA CHIMICA ACTA
卷 412, 期 15-16, 页码 1306-1318出版社
ELSEVIER
DOI: 10.1016/j.cca.2011.04.018
关键词
Postprandial remnant lipoproteins; Chylomicron remnants; Very low density lipoprotein (VLDL) remnants; ApoB-48; ApoB-100; Remnant-like lipoprotein particles (RIP)
资金
- NCRR NIH HHS [UL1 RR024146, UL1 RR024146-01] Funding Source: Medline
- NHLBI NIH HHS [R01 HL075675, R01 HL091333, R01 HL107256, R01 HL075675-05] Funding Source: Medline
- Grants-in-Aid for Scientific Research [23590663] Funding Source: KAKEN
Since Zilversmit first proposed postprandial lipemia as the most common risk of cardiovascular disease, chylomicrons (CM) and CM remnants have been thought to be the major lipoproteins which are increased in the postprandial hyperlipidemia. However, it has been shown over the last two decades that the major increase in the postprandial lipoproteins after food intake occurs in the very low density lipoprotein (VLDL) remnants (apoB-100 particles), not CM or CM remnants (apoB-48 particles). This finding was obtained using the following three analytical methods; isolation of remnant-like lipoprotein particles (RLP) with specific antibodies, separation and detection of lipoprotein subclasses by gel permeation HPLC and determination of apoB-48 in fractionated lipoproteins by a specific ELISA. The amount of the apoB-48 particles in the postprandial RLP is significantly less than the apoB-100 particles, and the particle sizes of apoB-48 and apoB-100 in RLP are very similar when analyzed by HPLC Moreover, CM or CM remnants having a large amount of TG were not found in the postprandial RLP. Therefore, the major portion of the TG which is increased in the postprandial state is composed of VLDL remnants, which have been recognized as a significant risk for cardiovascular disease. (C) 2011 Elsevier B.V. All rights reserved.
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