期刊
CLINICA CHIMICA ACTA
卷 412, 期 3-4, 页码 268-270出版社
ELSEVIER
DOI: 10.1016/j.cca.2010.10.015
关键词
Alzheimer's disease; LRP2; Apolipoprotein E; Single nucleotide polymorphism
资金
- National Basic Research Development Program of China [2006CB500706, 2010CB945200]
- National Natural Science Foundation of China [30700251]
- Shanghai Key Discipline Program [S30202]
- Shanghai Key Project of Basic Science Research [09DZ1950400]
- Program for Outstanding Medical Academic Leader [LJ 06003]
Background: LRP2 (also called megalin) plays a potential key role in the pathogenesis of Alzheimer's disease (AD). Recently, one genome-wide association study has revealed that the rs3755166 (G/A) polymorphism located in the LRP2 promoter is associated with development of AD in Caucasians, while there are no studies on the association LRP2 of with AD risk in Asians. Methods: To evaluate the relationship between the rs3755166 polymorphism of the LRP2 gene and AD in the ethnic Chinese Han, we conducted a case-control study (n = 361, age > 50) to determine the prevalence of one common single-nucleotide polymorphism (SNP) of LRP2 (rs3755166) in patients with AD in Chinese population of Mainland China, and clarified whether this polymorphism is a risk factor for AD. Results: The prevalence of the minor allele (A) in the rs3755166 polymorphism was significantly different in AD patients and control subjects (P < 0.05). The rs3755166 polymorphism was associated with AD in the ethnic Chinese Han (OR = 1.378, 95% Cl: 1.017-1.867, P = 0.039), and the results were not influenced by age, gender, or APOE status (P = 0.441, P = 0.94, P = 0.432, respectively). Conclusion: Our data revealed the allele (A) of the rs3755166 polymorphism within LRP2 gene may contribute to AD risk in the Chinese Han Population. (C) 2010 Elsevier B.V. All rights reserved.
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