Article
Biochemistry & Molecular Biology
Jia-Mei Luo, Tong-Tong Zhang, Yu-Ying He, Hui-Na Luo, Yu-Qi Hong, Zeng-Ming Yang
Summary: Decidualization is crucial for early pregnancy in rodents and humans. Disturbed decidualization can lead to implantation failure, spontaneous abortion, and preeclampsia. This study demonstrates that IL4I1-catalyzed metabolites of Trp enhance human decidualization through the AHR-Epiregulin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ying Liu, Xiao-Ya Ren, Ya-Guang Peng, Shao-Ke Chen, Xin-Ran Cheng, Miao Qin, Xiao-Ling Wang, Yan-Ning Song, Li-Jun Fan, Chun-Xiu Gong
Summary: The study demonstrated that hCG/hMG therapy is feasible and effective for treating male adolescents with CHH, with the initial 3 months of treatment showing the strongest effects. Results from the extended time-period also showed positive outcomes at the 1-year mark, indicating the potential of hCG/hMG regimen, although further research is needed to assess its long-term effectiveness and limitations.
CHINESE MEDICAL JOURNAL
(2021)
Article
Environmental Sciences
Arash Derakhshan, Huan Shu, Maarten A. C. Broeren, Andreas Kortenkamp, Christian H. Lindh, Barbara Demeneix, Robin P. Peeters, Carl-Gustaf Bornehag, Tim I. M. Korevaar
Summary: This study investigated the association between concentrations of endocrine disrupting chemicals (EDCs) in urine and blood during pregnancy and serum human chorionic gonadotropin (hCG) concentrations. The results showed that higher exposure to bisphenol A was associated with lower hCG concentrations, while higher triclosan exposure was associated with higher hCG concentrations. Higher exposure to certain phthalates and polychlorinated biphenyls (PCBs) was also associated with lower hCG concentrations. These findings suggest that EDC exposure may have negative effects on placental hCG production and secretion, warranting further experimental studies.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Agriculture, Dairy & Animal Science
E. M. Cabrera, M. R. Lauber, T. Valdes-Arciniega, M. S. El Azzi, J. P. N. Martins, T. R. Bilby, P. M. Fricke
Summary: The study aimed to compare the effects of GnRH and hCG treatments on pregnancies per artificial insemination in lactating dairy cows. The results showed that cows treated with GnRH had higher pregnancy rates and there were no significant differences in ovulation time and luteolysis completeness between GnRH and hCG treatments.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Danbi Lee, Yu-Gyeong Lee, Jieun Won, Seon-Hwa Hong, Jee Hyun Kim, Youn-Jung Kang
Summary: This study aimed to investigate the optimal timing of hCG administration to enhance embryo implantation rates. The results showed that hCG administration induced a significant increase in endometrial receptivity and angiogenesis-related gene expression levels within 72 hours, and promoted the stability of embryo attachment in an in vitro model.
Article
Oncology
Hirokazu Takami, Christopher S. Graffeo, Avital Perry, Caterina Giannini, Yoichi Nakazato, Nobuhito Saito, Masao Matsutani, Ryo Nishikawa, Koichi Ichimura, David J. Daniels
Summary: This study investigates the optimal cut-offs for tumor markers in CNS germ cell tumors (GCTs) to specify non-germinomatous GCTs. It concludes that an integrated diagnosis based on tumor markers and histopathology is key to precise diagnosis and treatment strategies for this rare and heterogeneous tumor. The study also raises questions about the treatment approach for marker-positive germinomas or teratomas and optimal treatment strategy for marker-negative immature teratomas.
Article
Medicine, General & Internal
Allison A. Gockley, Lawrence H. Lin, Michelle Davis, Alexander Melamed, Anthony Rizzo, Sue Yazaki Sun, Kevin Elias, Donald P. Goldstein, Ross S. Berkowitz, Neil S. Horowitz
Summary: This study found that age and race/ethnicity did not affect hCG regression rates, while obesity and hormonal contraceptive use were associated with faster hCG regression rates, although clinically insignificant. Understanding how clinical characteristics may influence hCG regression curve is important for predicting the risk of gestational trophoblastic neoplasia.
Article
Chemistry, Analytical
Xue Wang, Huanyuan Wang, Yingying Sun, Zhe Liu, Na Wang
Summary: This study presents a liquid crystal biosensor using Au nanoparticles for signal amplification to detect HCG antigen in a micro and cost-effective manner. The sensor utilizes the unique properties of LC for HCG detection, providing excellent sensitivity and low detection limits.
Article
Endocrinology & Metabolism
Yindi Liu, Fei Guo, Spyridoula Maraka, Yong Zhang, Chen Zhang, Tim I. M. Korevaar, Jianxia Fan
Summary: The study found that higher hCG concentrations in early pregnancy are associated with a lower risk of GDM, and this association may be mediated through maternal thyroid hormones, specifically free thyroxine (fT4).
Article
Immunology
Liyan Wang, Yanbiao Jiang, Haofei Shen, Xiaoling Ma, Mingxia Gao, Panpan Jin, Rui Zhang, Lihui Zhao, Xuehong Zhang
Summary: The serum beta-hCG level after 14 days of embryo transfer has a strong independent predictive value for the occurrence of early pregnancy loss in fresh IVF/ICSI cycles.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qing Cong, Ling Lin, Biao Qi, Congjian Xu, Xiaoyan Zhang
Summary: The study developed an active targeted therapeutic system that efficiently delivered chemotherapy drug MTX to choriocarcinoma cells through HCG receptor mediation, significantly improving chemotherapy efficacy.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemical Research Methods
Qinpei Deng, Lixiu He, Fangyan Xu, Qiaochun Deng, Tongze Xu, Junkai Jiang, Zhenxiang Hu, Jiaming Yang
Summary: Human chorionic gonadotropin (hCG), a glycoprotein hormone, is used for infertility treatment. The beta (0-) subunit determines its specificity, while the alpha (a-) subunit is shared by gonadotropin family. Analysis showed that the beta (0-) subunit has two variants, 01 and 02, with different glycosylation patterns at Asn 13 and Asn 30.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Hatem Mohamed Elsheikh, Shadia Abdel-Hamid Fathy, Nahed Hassan Ebeid, Khaled Mohamed Sallam, Ahmed Sami El-bayoumy, Nagy Lahzy Mehany, Germine Mohsen Hamdy
Summary: The main objective of this study was to prepare and evaluate primary reagents for the liquid phase human chorionic gonadotropin-radioimmunoassay (HCG-RIA) kit. Polyclonal antibodies were found to be specific and valid, while monoclonal antibodies were more specific. The developed in-house HCG-RIA method showed high sensitivity, specificity, precision, and accuracy, making it suitable for quantifying HCG in human sera for pregnancy monitoring and diagnosis of gestational trophoblastic diseases.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Kiwamu Noshiro, Takeshi Umazume, Rifumi Hattori, Soromon Kataoka, Takashi Yamada, Hidemichi Watari
Summary: This study found that serum ketone levels peak in the third trimester of pregnancy, but do not directly correlate with neonatal body shape. Weight loss during pregnancy may be related to morning sickness, with a higher pre-pregnancy body mass index leading to greater weight loss.
Article
Chemistry, Analytical
Adrian Koterwa, Magdalena Bojko, Jacek Ryl, Krzysztof Lukaszuk, Kornelia Kozlowska, Wiktor Sieklicki, Sylwia Rodziewicz-Motowidlo, Pawel Niedzialkowski
Summary: This work describes the modification of a gold electrode to create an electrochemical biosensor capable of detecting human chorionic gonadotropin (hCG). The biosensor was obtained by modifying the gold electrode with cysteamine and oligopeptide (PPLRINRHILTR). The effectiveness of the biosensor was confirmed in human serum, and the results indicate that it is selective for the presence of hCG hormone.
Article
Medical Laboratory Technology
Joannes F. M. Jacobs, Katherine A. Turner, Maria Stella Graziani, Jody L. Frinack, Michael W. Ettore, Jillian R. Tate, Ronald A. Booth, Christopher R. McCudden, David F. Keren, Julio C. Delgado, Galina Zemtsovskaja, Robert O. Fullinfaw, Anna Caldini, Theo de Malmanche, Katina Katakouzinos, Matthew Burke, Giovanni Palladini, Sara Altinier, Martina Zaninotto, Gabriella Righetti, Marie Therese Melki, Stephen Bell, Maria Alice Vieira Willrich
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2020)
Letter
Urology & Nephrology
Rayees Sheikh, Swapnil Hiremath, Edward G. Clark, Ayub Akbari, Christopher McCudden, Pierre Antoine Brown
KIDNEY INTERNATIONAL REPORTS
(2020)
Editorial Material
Medical Laboratory Technology
Christopher R. McCudden
CLINICAL CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Stefan Rodic, Christopher McCudden, Carl van Walraven
Summary: Several small studies have found possible associations between low serum zinc levels and worse outcomes in acutely hospitalized patients. However, current research on the association between serum zinc levels and outcomes in hospitalized patients is limited by sample sizes, patient populations, and statistical analyses. The relationship between zinc levels and outcomes in hospitalized patients remains unclear.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Medical Informatics
Jenny Alderden, Kathryn P. Drake, Andrew Wilson, Jonathan Dimas, Mollie R. Cummins, Tracey L. Yap
Summary: This study aimed to develop and compare predictive models for HAPrIs among surgical ICU patients using EHR data. Results showed the feasibility and effectiveness of using easily accessible predictor variables for accurate prediction of HAPrIs, providing potential for future research validation.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Article
Medical Laboratory Technology
Adam Suleman, D. William Cameron, Vicente Corrales-Medina, Christopher McCudden, Juthaporn Cowan
Summary: The study evaluated the performance of serum protein gap (PG) in detecting hyper- or hypogammaglobulinemia, showing that high and low PG values were not sensitive in detection, but had high negative predictive values.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Nursing
Marc-Aurel Martial, Katherine A. Sward, Janice M. Morse, Andrew R. Wilson, Cempaka Martial, Debra S. Penney, Elie Nicolas
Summary: The study examined factors influencing anemia outcomes in rural children following implementation of a prevention program, finding a 21.2% decrease in anemia prevalence with clinic visit number and age at first visit as predictors of increased hemoglobin. Once anemia improved, children were likely to remain improved.
JOURNAL OF TRANSCULTURAL NURSING
(2021)
Article
Oncology
Echo L. Warner, Anne C. Kirchhoff, Andrew Wilson, Kristin G. Cloyes, Ye Sun, Austin R. Waters, Taylor Nelson, Lee Ellington
Summary: The study explored how young adult cancer caregivers and their followers used social media for social support, finding that emotional support was the most common form, while informational and companionship support increased in the first 6 months of caregiving.
JOURNAL OF CANCER SURVIVORSHIP
(2022)
Article
Environmental Sciences
Echo L. Warner, Andrew R. Wilson, Jessica G. Rainbow, Lee Ellington, Anne C. Kirchhoff
Summary: Young adults in the United States are increasingly taking on caregiving roles, with cancer caregivers often experiencing a greater burden than others, leading to employment challenges. Female cancer caregivers, those with lower education, and those earning below USD 20,000 annually may be at greater risk for employment detriments.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Psychology, Social
Echo L. as Warner, Andrew Wilson, Lee Ellington, Ye Sun, Kristin G. Cloyes, Austin R. Waters, Taylor Nelson, Anne C. Kirchhoff
Summary: Studying the association between social media platforms and cancer content with social support in responses provides insights for intervention development. Emphasizing the suitability of different social media platforms for specific support seeking behaviors is crucial for psychosocial providers.
JOURNAL OF PSYCHOSOCIAL ONCOLOGY
(2022)
Article
Education, Scientific Disciplines
Pari Mokhtari, Kristine C. Jordan, Andrew Wilson, Brittany Sisco-Tylor, Julie M. Metos
Summary: This study developed and validated a questionnaire to assess diabetes knowledge, attitudes, beliefs, and intent to change among middle school students. Statistical analyses demonstrated the reliability and construct validity of the questionnaire. The findings suggest that the questionnaire is suitable for evaluating diabetes knowledge and behavioral intentions among middle school students.
JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR
(2023)
Article
Medical Laboratory Technology
Douglas F. Stickle, Rebecca Koob, Christopher R. McCudden
Summary: Serum potassium exhibits a positive shift relative to plasma potassium due to clotting, which means that plasma potassium results outside of the reference interval may not produce classification-concordant results in serum. In this study, simulation results indicate that serum potassium should be considered an inferior substitute marker for plasma potassium.
CLINICAL BIOCHEMISTRY
(2023)
Article
Psychology, Social
Rosaleen Duggan Bloom, Maija Reblin, Wen-Ying Sylvia Chou, Susan L. Beck, Andrew Wilson, Lee Ellington
Summary: By exploring CaringBridge, it was found that cancer caregivers mainly requested emotional support while guests predominantly offered emotional support. There was a high level of alignment between the types of support requested and offered.
JOURNAL OF PSYCHOSOCIAL ONCOLOGY
(2021)
Article
Medical Laboratory Technology
Julie L. Shaw, Christopher R. McCudden, David A. Colantonio, Ronald A. Booth, Danny C. Lin, Ivan M. Blasutig, Thomas Moran, Dana Trofimczuk, Chantal Carriere, Anas Gharra, Cheryl Portelance, Chantal Tremblay, Dianne Dupaul, Nathalie Breton, Merina Angelkovski, Chetan Jariwala, Maureen Embleton, Christine Campbell, Kristina Groulx, Karen Larmour
PRACTICAL LABORATORY MEDICINE
(2020)
Article
Endocrinology & Metabolism
Cathy J. Sun, Christopher McCudden, Diane Brisson, Julie Shaw, Daniel Gaudet, Teik C. Ooi
JOURNAL OF THE ENDOCRINE SOCIETY
(2020)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)
