Article
Biochemistry & Molecular Biology
Ilaria Coppola, Bas Brouwers, Sandra Meulemans, Bruno Ramos-Molina, John W. M. Creemers
Summary: FURIN cleaves the insulin receptor non-redundantly in beta cells, while redundantly in liver. The study demonstrated that the insulin receptor in beta cells plays a limited role in glucose homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jun Peng, Liming Yu, Linzhang Huang, Vivian A. Paschoal, Haiyan Chu, Camila O. de Souza, Joseph V. Varre, Da Young Oh, Jennifer J. Kohler, Xue Xiao, Lin Xu, William L. Holland, Philip W. Shaul, Chieko Mineo
Summary: The synthesis and sialylation of sialic acid in the liver play a critical role in regulating hepatic glucose metabolism.
MOLECULAR METABOLISM
(2023)
Article
Medicine, Research & Experimental
Catherine C. Cohen, Kelvin W. Li, Adina L. Alazraki, Carine Beysen, Carissa A. Carrier, Rebecca L. Cleeton, Mohamad Dandan, Janet Figueroa, Jack Knight-Scott, Cynthia J. Knott, Kimberly P. Newton, Edna M. Nyangau, Claude B. Sirlin, Patricia A. Ugalde-Nicalo, Jean A. Welsh, Marc K. Hellerstein, Jeffrey B. Schwimmer, Miriam B. Vos
Summary: Dietary sugar restriction in adolescents with NAFLD can reduce hepatic de novo lipogenesis (DNL) and fasting insulin levels, as well as decrease hepatic fat and ALT. These results support the hypothesis that hepatic DNL is a critical metabolic abnormality linking dietary sugar and NAFLD.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jari E. Karppinen, Hanna-Kaarina Juppi, Jukka Hintikka, Petri Wiklund, Eero A. Haapala, Matti Hyvaerinen, Tuija H. Tammelin, Pauliina Aukee, Urho M. Kujala, Jari Laukkanen, Eija K. Laakkonen
Summary: This study investigated the relationship between fat oxidation and glucose regulation during cycling in middle-aged women, and found that sex hormone profile did not explain fat oxidation capacity, and higher fat oxidation did not indicate better glucose control.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Endocrinology & Metabolism
Anela Blazevic, Anand M. Iyer, Marie-Louise F. Van Velthuysen, Johannes Hofland, Lindsey Oudijk, Wouter W. de Herder, Leo J. Hofland, Richard A. Feelders
Summary: Small-intestinal neuroendocrine tumors (SI-NETs) have a higher prevalence and worse prognosis in male patients. This study found that mesenteric metastasis and fibrosis were more common in men than women. The risk of mesenteric metastasis in women increased around menopause. The expression of estrogen receptor alpha and androgen receptor was observed in primary tumors and mesenteric metastases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Hye Kyoung Sung, Patricia L. Mitchell, Sean Gross, Andre Marette, Gary Sweeney
Summary: This study demonstrates that the use of ALY688 in skeletal muscle cells can activate adiponectin signaling pathways, leading to improved insulin sensitivity and beneficial metabolic effects.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kathryn L. Gwizdala, Lydia A. Bazzano, Robert L. Newton Jr, Owen T. Carmichael
Summary: Glycemic markers throughout life are associated with worse midlife cognition, especially in women, African Americans, and White Americans. This association may reflect broader health disparities.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Nutrition & Dietetics
Haiwen Li, Obaid Ullah Beg, Ahmed Reza Rafie, Sadia Kanwal, Alexandra Ovalle-Cisneros, Milton Omar Faison, Rafat Ali Siddiqui
Summary: The objective of this study was to evaluate the anti-oxidation and anti-diabetic properties of green and yellow papaya. The results showed that extracts from yellow papaya had higher polyphenolic content and anti-oxidation activity compared to green papaya. Additionally, the pulp extract from yellow papaya had stimulatory effects on glucose uptake, Glut-2 expression, and triglyceride reduction in liver cells. These findings suggest that different parts of papaya can be beneficial for preventing diabetes and promoting wound healing.
Review
Biochemistry & Molecular Biology
Srdan Pandurevic, Djuro Macut, Flaminia Fanelli, Uberto Pagotto, Alessandra Gambineri
Summary: Polycystic ovary syndrome (PCOS) is highly heterogeneous in terms of clinical manifestations, with genetic, molecular, and environmental factors playing a role in long-term metabolic and cardiovascular consequences. PCOS patients are more likely to experience metabolic complications earlier in comparison to the general population, with key biomarkers including obesity, low SHBG levels, hyperandrogenemia, insulin resistance, and compensatory hyperinsulinemia.
Article
Multidisciplinary Sciences
Ryosuke Shirakawa, Takayuki Nakajima, Aya Yoshimura, Yukako Kawahara, Chieko Orito, Miwako Yamane, Haruka Handa, Shingo Takada, Takaaki Furihata, Arata Fukushima, Naoki Ishimori, Masao Nakagawa, Isao Yokota, Hisataka Sabe, Satoshi Hashino, Shintaro Kinugawa, Takashi Yokota
Summary: Systemic inflammation is associated with the link between obesity and nonalcoholic fatty liver disease (NAFLD). In this study, researchers investigated changes in leukocytes' mitochondria in obese individuals and their correlation with NAFLD. The findings suggest that obese individuals have increased mitochondrial respiratory capacity in peripheral blood mononuclear cells (PBMCs), and this enhanced oxidative metabolism is associated with hepatic steatosis in obese young adults.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Bellina A. S. Mushala, Bingxian Xie, Ian J. Sipula, Michael W. Stoner, Dharendra Thapa, Janet R. Manning, Paramesha Bugga, Amber M. Vandevender, Michael J. Jurczak, Iain Scott
Summary: Loss of GPR19 impacts whole-body energy metabolism in a sex-dependent manner, promoting increased energy expenditure and decreased activity in both male and female mice. Only male GPR19 KO mice display glucose intolerance and diet-induced hepatomegaly with decreased expression of key fatty acid oxidation genes in the liver.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Mari Lahelma, Panu K. Luukkonen, Sami Qadri, Noora Ahlholm, Susanna Lallukka-Bruck, Kimmo Porthan, Anne Juuti, Henna Sammalkorpi, Anne K. Penttila, Johanna Arola, Marju Orho-Melander, Hannele Yki-Jarvinen
Summary: Detailed assessment of lifestyle factors, in addition to physical, biochemical and genetic factors, helps identify obese patients with non-alcoholic fatty liver disease (NAFLD) fibrosis more accurately. This comprehensive approach was shown to be more effective in predicting NAFLD fibrosis than evaluating lifestyle, physical, biochemical, or genetic factors alone.
Article
Biochemistry & Molecular Biology
Lena Steppe, Jasmin Buelow, Jan Tuckermann, Anita Ignatius, Melanie Haffner-Luntzer
Summary: The deletion of ER alpha gene in osteoblast progenitors and hypertrophic chondrocytes has differential effects on bone mass regulation in male and female mice. Male mice showed increased cortical bone mass and femur rigidity, while female mice exhibited trabecular bone loss and reduced cortical bone diameters. This study improves understanding of ER alpha signaling in bone cells in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Alexis M. Stranahan, De-Huang Guo, Masaki Yamamoto, Caterina M. Hernandez, Hesam Khodadadi, Babak Baban, Wenbo Zhi, Yun Lei, Xinyun Lu, Kehong Ding, Carlos M. Isales
Summary: Preferential energy storage in subcutaneous adipose tissue (SAT) provides protection against obesity-induced pathophysiology in females. Differences in adipose tissue distribution before obesity onset determine susceptibility to inflammation in males and females, independent of sex hormones.
Article
Endocrinology & Metabolism
Alexandra G. Yunker, Shan Luo, Sabrina Jones, Hilary M. Dorton, Jasmin M. Alves, Brendan Angelo, Alexis DeFendis, Trevor A. Pickering, John R. Monterosso, Kathleen A. Page
Summary: The study found that sucrose ingestion leads to a less robust increase in glucose, insulin, GLP-1, and PYY compared to glucose ingestion, but similar acyl-ghrelin suppression. Biological factors such as BMI, insulin sensitivity, and sex influence the differential hormone responses to sucrose vs glucose consumption, indicating that sucrose is less efficient at signaling postprandial satiation than glucose.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Sripathi M. Sureban, Randal May, Dongfeng Qu, Parthasarathy Chandrakesan, Nathaniel Weygant, Naushad Ali, Stan A. Lightfoot, Kai Ding, Shahid Umar, Michael J. Schlosser, Courtney W. Houchen
Article
Oncology
Naushad Ali, Parthasarathy Chandrakesan, Charles B. Nguyen, Sanam Husain, Allison F. Gillaspy, Mark Huycke, William L. Berry, Randal May, Dongfeng Qu, Nathaniel Weygant, Sripathi M. Sureban, Michael S. Bronze, Danny N. Dhanasekaran, Courtney W. Houchen
Article
Oncology
Nathaniel Weygant, Dongfeng Qu, Randal May, Ryan M. Tierney, William L. Berry, Lichao Zhao, Shweta Agarwal, Parthasarathy Chandrakesan, Harisha R. Chinthalapally, Nicholas T. Murphy, James D. Li, Sripathi M. Sureban, Michael J. Schlosser, James J. Tomasek, Courtney W. Houchen
Article
Biochemistry & Molecular Biology
Parthasarathy Chandrakesan, Jiannan Yao, Dongfeng Qu, Randal May, Nathaniel Weygant, Yang Ge, Naushad Ali, Sripathi M. Sureban, Modhi Gude, Kenneth Vega, Eddie Bannerman-Menson, Lijun Xia, Michael Bronze, Guangyu An, Courtney W. Houchen
Article
Gastroenterology & Hepatology
Dongfeng Qu, Randal May, Sripathi M. Sureban, Nathaniel Weygant, Parthasarathy Chandrakesan, Naushad Ali, Linheng Li, Terrence Barrett, Courtney W. Houchen
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2014)
Article
Oncology
Sripathi M. Sureban, Randal May, Nathaniel Weygant, Dongfeng Qu, Parthasarathy Chandrakesan, Eddie Bannerman-Menson, Naushad Ali, Panayotis Pantazis, Christoph B. Westphalen, Timothy C. Wang, Courtney W. Houchen
Article
Biochemistry & Molecular Biology
Nathaniel Weygant, Dongfeng Qu, William L. Berry, Randal May, Parthasarathy Chandrakesan, Daniel B. Owen, Sripathi M. Sureban, Naushad Ali, Ralf Janknecht, Courtney W. Houchen
Article
Biochemistry & Molecular Biology
P. Chandrakesan, B. Roy, L. U. M. R. Jakkula, I. Ahmed, P. Ramamoorthy, O. Tawfik, R. Papineni, C. Houchen, S. Anant, S. Umar
Article
Multidisciplinary Sciences
Sripathi M. Sureban, Randal May, Dongfeng Qu, Nathaniel Weygant, Parthasarathy Chandrakesan, Naushad Ali, Stan A. Lightfoot, Panayotis Pantazis, Chinthalapally V. Rao, Russell G. Postier, Courtney W. Houchen
Article
Multidisciplinary Sciences
Dongfeng Qu, Jeremy Johnson, Parthasarathy Chandrakesan, Nathaniel Weygant, Randal May, Nicole Aiello, Andrew Rhim, Lichao Zhao, Wei Zheng, Stanley Lightfoot, Shubham Pant, Jeremy Irvan, Russell Postier, James Hocker, Jay S. Hanas, Naushad Ali, Sripathi M. Sureban, Guangyu An, Michael J. Schlosser, Ben Stanger, Courtney W. Houchen
Article
Multidisciplinary Sciences
Dongfeng Qu, Nathaniel Weygant, Randal May, Parthasarathy Chandrakesan, Mohammad Madhoun, Naushad Ali, Sripathi M. Sureban, Guangyu An, Michael J. Schlosser, Courtney W. Houchen
Article
Cell & Tissue Engineering
Randal May, Dongfeng Qu, Nathaniel Weygant, Parthasarathy Chandrakesan, Naushad Ali, Stanley A. Lightfoot, Linheng Li, Sripathi M. Sureban, Courtney W. Houchen
Article
Oncology
Parthasarathy Chandrakesan, Nathaniel Weygant, Randal May, Dongfeng Qu, Harisha R. Chinthalapally, Sripathi M. Sureban, Naushad Ali, Stan A. Lightfoot, Shahid Umar, Courtney W. Houchen
Article
Oncology
Parthasarathy Chandrakesan, Janani Panneerselvam, Randal May, Nathaniel Weygant, Dongfeng Qu, William R. Berry, Kamille Pitts, Ben Z. Stanger, Chinthalapally Rao, Michael S. Bronze, Courtney W. Houchen
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Ling Ding, Yuning Yang, Qin Lu, Dongfeng Qu, Parthasarathy Chandrakesan, Hailan Feng, Hong Chen, Xuzheng Chen, Zhuhui Liao, Jian Du, Zhiyun Cao, Nathaniel Weygant
Summary: This study investigates the function and mechanism of bufalin against colorectal cancer stemness. The results demonstrate that bufalin inhibits CRC stemness by targeting the C-Kit/Slug signaling axis, leading to inhibited CRC growth and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)