Letter
Gastroenterology & Hepatology
Lucas Wauters, Paul R. Harris, Marjorie M. Walker, Carolina A. Serrano, Andrea Villagran, Gurpreet S. Rakhra, Jean E. Crabtree, Nicholas J. Talley
Summary: This article is connected to the paper by Broeders et al. To access this article, visit the provided link.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Paolo Usai-Satta, Francesco Oppia, Mariantonia Lai, Francesco Cabras
Summary: This study examines the utility of hydrogen breath testing (BT) in the diagnosis of carbohydrate malabsorption, finding that lactose BT has good sensitivity and specificity for lactose malabsorption, while dose-dependent fructose and sorbitol malabsorption do not show diagnostic advantage compared to dietary intervention.
Article
Gastroenterology & Hepatology
Ilse Julia Broekaert, Osvaldo Borrelli, Jernej Dolinsek, Javier Martin-de-Carpi, Emmanuel Mas, Erasmo Miele, Corina Pienar, Carmen Ribes-Koninckx, Rut Thomassen, Mike Thomson, Christos Tzivinikos, Marc Benninga
Summary: This study aims to provide expert guidance and recommendations on the use of breath testing in paediatric patients. The study evaluated the use of breath testing through expert opinion and systematic literature search, and provided corresponding recommendations. The results of the study indicate that breath testing is widely used in paediatric gastroenterology, primarily for assessing carbohydrate malabsorption, but also for diagnosing and monitoring other gastrointestinal conditions.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Alexander C. Ford, Evangelos Tsipotis, Yuhong Yuan, Grigorios Leontiadis, Paul Moayyedi
Summary: The study suggests that H. pylori eradication therapy can lead to both cure and improvement of symptoms in patients with functional dyspepsia, although the benefit is modest. Successful eradication of H. pylori is associated with a greater effect, but also with more adverse events.
Review
Gastroenterology & Hepatology
Francesco Di Mario, Pellegrino Crafa, Alberto Barchi, Lorella Franzoni, Marilisa Franceschi, Michele Russo, Ludovica Bricca, Lorenzo Brozzi, Kryssia Rodriguez Castro, Massimo Rugge
Summary: PgII serology has clinical value in assessing gastric inflammation and as a marker of H. pylori infection status, but its reliability is lower in distinguishing between successfully eradicated and persistently infected patients.
Review
Medicine, General & Internal
Chunmei Wang, Yue Yin, Le Wang, Xiaozhong Guo, Lu Liu, Xingshun Qi
Summary: This study found that Helicobacter pylori infection is associated with an increased risk of irritable bowel syndrome (IBS) and that H. pylori eradication treatment can improve IBS symptoms.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Boldbaatar Gantuya, Hashem B. El Serag, Batsaikhan Saruuljavkhlan, Dashdorj Azzaya, Takashi Matsumoto, Tomohisa Uchida, Khasag Oyuntsetseg, Nyamdorj Oyunbileg, Duger Davaadorj, Yoshio Yamaoka
Summary: 16S rRNA amplicon sequencing shows high sensitivity and specificity in detecting Helicobacter pylori infection, identifying additional positive cases compared to routine diagnostic methods. The quantitative number and relative abundance of H. pylori can provide insights into its dynamics in disease and interactions with other microbiota.
Article
Gastroenterology & Hepatology
Carles Pons, Modesto Varas, Javier P. Gisbert, Merce Barenys, Francesca Pajuelo, Francisco Javier Fernandez
Summary: The study confirmed minimal interference of almagate in the UBT testing for Helicobacter pylori, with 97.5% of patients still testing negative in the second UBT after stopping almagate. It can be used in the weeks prior to a UBT without affecting the results.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2021)
Review
Gastroenterology & Hepatology
Heinz F. Hammer, Mark R. Fox, Jutta Keller, Silvia Salvatore, Guido Basilisco, Johann Hammer, Loris Lopetuso, Marc Benninga, Osvaldo Borrelli, Dan Dumitrascu, Bruno Hauser, Laszlo Herszenyi, Radislav Nakov, Daniel Pohl, Nikhil Thapar, Marc Sonyi
Summary: This clinical practice guideline on H2-CH4-breath tests was developed based on consensus among experts from multiple European countries. It incorporates new insights into the role of symptom assessment in diagnosing carbohydrate intolerance and highlights confounding factors associated with the interpretation of breath tests for different indications. The guideline aims to harmonize diagnostic approaches in gastroenterology practice across Europe and identifies areas for future research on diagnostic and therapeutic approaches.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Medicine, General & Internal
Natalia Garcia-Morales, Angeles Perez-Aisa, Giulia Fiorini, Bojan Tepes, Manuel Castro-Fernandez, Alfredo Lucendo, Irina Voynovan, Luis Bujanda, Ana Garre, Luis Rodrigo, Samuel Jesus Martinez Dominguez, Maja Denkovski, Jose M. Huguet Malaves, Laimas Jonaitis, Renate Bumane, Oleg Zaytsev, Pilar Mata Romero, Jesus Barrio, Luis Fernandez-Salazar, Aiman Silkanovna Sarsenbaeva, Inmaculada Ortiz Polo, Sergey Alekseenko, Ilaria Maria Saracino, Dino Vaira, Alma Keco-Huerga, Dmitry Bordin, Antonio Gasbarrini, Frode Lerang, Theodore Rokkas, Juozas Kupcinskas, Marcis Leja, Gulustan Babayeva, Ricardo Marcos Pinto, Ante Tonkic, Sinead Smith, Perminder Phull, Gyorgy Buzas, Halis Simsek, Doron Boltin, Oleksiy Gridnyev, Marino Venerito, Vladimir Milivojevic, Nuria Tora, Anna Cano-Catala, Leticia Moreira, Olga P. Nyssen, Francis Megraud, Colm O'Morain, Javier P. Gisbert, Ignasi Puig
Summary: This study evaluates the tests used for diagnosing Helicobacter pylori infection in Europe, including initial diagnosis and confirmation of eradication. The results show a great heterogeneity in the tests used among different countries, indicating a need to further explore the reasons for the lack of adherence to clinical guidelines.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Malek Shatila, Anusha Shirwaikar Thomas
Summary: Helicobacter pylori is a prevalent organism that infects a large population and is closely associated with the risk of gastric cancer. Diagnosis can be achieved non-invasively or invasively, and treatment involves acid suppression and antibiotic therapy. Eradication of H. pylori is essential, and post-eradication follow-up is crucial. There have been recent advances in both diagnosis and treatment of H. pylori.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Fernando Javier Barreyro, Nicolas Sanchez, Maria Virginia Caronia, Karina Elizondo, Graciela Jorda, Adolfo Schneider, Pedro Dario Zapata
Summary: This study found a significant association between low-grade duodenal eosinophilia and cagA strain in Helicobacter pylori-related dyspepsia.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Daniel Schebela Mazzoleni, Felipe Mazzoleni, Luiz Edmundo Mazzoleni, Carlos Fernando de Magalhaes Francesconi, Tobias Cancian Milbradt, Diego Mendonca Uchoa, Heitor Ribeiro Birnfeld, Luiza Vitelo Andrighetto, Sacha Allebrandt da Silva Ries, Daniel Simon, Nicholas Joseph Talley
Summary: The study revealed a lower prevalence of RAS in H. pylori-positive patients. Smoking, gender, age, income, education level, and anxiety were found to be associated with RAS.
Editorial Material
Gastroenterology & Hepatology
Shunji Fujimori
Summary: H. pylori infection causes changes in intestinal flora, increases gastric acid secretion-stimulating hormones, affects the immune system, and increases the risk of colorectal adenoma and colorectal cancer.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Xiangyu Wang, Shuzhen Zhang, Eng Guan Chua, Yongsheng He, Xiaofeng Li, Aijun Liu, Haiting Chen, Michael J. Wise, Barry J. Marshall, Dayong Sun, Xuehong Li, Chin Yen Tay
Summary: The study assessed and compared the diagnostic performance of C-13- and C-14-UBT assays for H. pylori infection, and found that using new cutoff values and including an indeterminate range can improve the specificity of the tests.
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)