Article
Nutrition & Dietetics
Monica C. Serra, Alice S. Ryan
Summary: The study compared changes in bone mineral density (BMD) during weight loss and regain periods in overweight postmenopausal women who underwent a 6-month aerobic exercise intervention. Results indicated that less loss of appendicular lean mass and greater increases in VO(2)max during the weight loss phase were associated with attenuated BMD loss during weight regain.
Article
Endocrinology & Metabolism
Eugene Lucas, Okeefe Simmons, Beverly Tchang, Louis Aronne
Summary: Although bariatric surgery leads to significant long-term weight loss, weight gain after surgery affects a considerable percentage of patients. Additionally, some patients experience inadequate weight loss. The effectiveness of anti-obesity medications for post-operative weight gain has not been firmly established yet due to varying study populations and designs. Observational studies consistently show the benefits of medical weight management after bariatric surgery, particularly with liraglutide, topiramate, and phentermine/topiramate, while new anti-obesity medications are expected to be helpful for post-surgical weight optimization.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Leonard Spranger, January Weiner, Josephine Bredow, Ulrike Zeitz, Ulrike Grittner, Michael Boschmann, Sophia Dickmann, Nicole Stobaeus, Reiner Jumpertz-von Schwartzenberg, Maria Brachs, Joachim Spranger, Knut Mai
Summary: This study aims to investigate the long-term effects of weight loss and metabolism improvement on obesity, and found that the specific impact of negative energy balance or modified body composition on metabolism and weight regain is still unclear. Through a randomized controlled trial, researchers found that weight loss had effects on insulin sensitivity and lean body mass, while negative energy balance had no additional effect on insulin sensitivity. Furthermore, the adaptation of body composition and metabolism may be related to the FGFR1 signaling pathway.
CLINICAL NUTRITION
(2023)
Article
Food Science & Technology
Christopher Papandreou, Jesus Garcia-Gavilan, Lucia Camacho-Barcia, Thea Toft Hansen, Joanne A. Harrold, Anders Sjodin, Jason C. G. Halford, Monica Bullo
Summary: This study examines the relationship between changes in circulating metabolites during diet-induced weight loss and changes in adiposity, finding significant associations between lipid species and citric acid with body weight and adiposity reduction. The results also show that changes in lysophosphatidylcholines and citric acid concentrations during weight loss are linked to adiposity regain and loss during the maintenance period, highlighting the importance of adipose lipid metabolism in weight and adiposity maintenance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Petras Minderis, Andrej Fokin, Tomas Povilonis, Mindaugas Kvedaras, Aivaras Ratkevicius
Summary: Caloric restriction induces similar weight loss in aging mice regardless of the diet's macronutrient composition. After caloric restriction, an high-fat diet leads to excessive energy intake and significant gain in body fat during the refeeding phase.
Article
Endocrinology & Metabolism
Nawfal W. Istfan, Marine Lipartia, Wendy A. Anderson, Donald T. Hess, Caroline M. Apovian
Summary: This study presents a practical approach for early recognition of weight regain after bariatric surgery, including classification and treatment options. Emphasizing the importance of regular long-term follow-up for all bariatric surgery patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Catia Martins, Siren Nymo, Silvia R. Coutinho, Jens F. Rehfeld, Gary R. Hunter, Barbara A. Gower
Summary: The aim of this study was to determine the relationship between % FFML following weight loss and weight regain, as well as the association between % FFML and changes in appetite markers. The results showed that % FFML was not a significant predictor of weight regain at 1 year in individuals with obesity. However, a greater % FFML was associated with a greater increase in ghrelin secretion.
JOURNAL OF NUTRITION
(2023)
Article
Surgery
Yi-Ting Su, Yen-Hao Su, Ka-Wai Tam, Yu-Chun Yen, Weu Wang, Ming-Te Huang, Shih-Yun Wang, Fang-Yi Pai, Chih-Ying Kuo, Shih-Chiang Shen
Summary: This study investigated the predictive effects of early weight loss on long-term weight loss and regain after sleeve gastrectomy. The results showed that the percentage of total weight loss at 1 and 3 months post-surgery was significantly correlated with weight loss after 5 years, and early weight loss significantly influenced weight regain. Therefore, patients with poor early weight loss are recommended to receive early interventions to achieve long-term weight loss and prevent weight regain.
Article
Nutrition & Dietetics
Salvatore Vaccaro, Leila Itani, Francesca Scazzina, Stefano Bonilauri, Concetto Maria Cartelli, Marwan El Ghoch, Massimo Pellegrini
Summary: Structural lifestyle interventions prior to gastric bypass surgery seem to prevent long-term weight regain.
Article
Sport Sciences
Catia Martins, Barabara A. A. Gower, Gary R. R. Hunter
Summary: This study aimed to determine if percent fat-free mass loss (% FFML) after diet alone, diet plus aerobic, or diet plus resistance exercise is a predictor of weight regain in women with overweight. In premenopausal women with overweight, % FFML was found to be a significant predictor of weight regain. The results support strategies to preserve fat-free mass during weight loss.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Endocrinology & Metabolism
Rutger J. Franken, Josephine Franken, Nina R. Sluiter, Ralph de Vries, Sjoerd Euser, Victor E. A. Gerdes, Maurits de Brauw
Summary: A systematic review and meta-analysis were conducted to evaluate various revisional techniques for addressing weight regain and inadequate weight loss after Roux-en-Y gastric bypass. The results showed that endoscopic procedures resulted in short-term weight loss, while surgical revision techniques were more successful in achieving long-term weight loss, albeit with higher complication rates.
Article
Gastroenterology & Hepatology
Laurens de Vries, Claire van den Broecke, Alexander Decruyeneare, Yves Van Nieuwenhove
Summary: The study used the SIMPLE approach to evaluate the performance of bariatric procedures, showing that a significant proportion of individuals did not achieve success or experienced significant weight regain after surgery, indicating that a combined approach to reporting bariatric performance is preferred.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
Po-Jen Yang, Chi-Ling Chen, Chiung-Nien Chen, Ming-Tsan Lin, Weu Wang
Summary: The study examined the effects of early weight loss on medium-term weight regain after sleeve gastrectomy, revealing that early weight loss can predict weight regain 3 years after surgery. Early lifestyle and behavioral interventions are recommended for high-risk patients with poor weight loss outcomes.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Gastroenterology & Hepatology
Kelvin Higa
Summary: The history and evolution of bariatric/metabolic surgical procedures have only briefly introduced complications and surgical approaches for improved weight loss. Currently, the lack of standardization in our field regarding gastric pouch size, intestinal bypass lengths, and the best procedure for each individual patient is a challenge. Short and long-term outcomes can be influenced by both anatomical factors and adherence to lifestyle modifications. The indications for bariatric/metabolic surgery are expanding, and the utilization of new innovative operations has added complexity to patient care.
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2023)
Review
Endocrinology & Metabolism
Mary S. Himmelstein, Kristen A. Knepp, Sean M. Phelan
Summary: Obesity is highly stigmatized, and individuals who undergo bariatric surgery are subject not only to weight stigma, but also to stigma related to the procedure itself. Difficulty estimating weight regain after surgery arises from patients lost to follow-up, often due to the shame of weight regain. Patients report struggling to follow the necessary diet for weight maintenance. Seeking support after surgery can result in encountering stigmatizing messages about weight. Internalized weight bias, weight stigma, and stigma about surgery contribute to social isolation, disordered eating, and reduced motivation for physical activity.
FRONTIERS IN ENDOCRINOLOGY
(2022)