Article
Geriatrics & Gerontology
Amit Kiran, Neil M. Schultz, Emad Siddiqui, Lora Todorova, Bas Van der Poel, Matthias Stoelzel, Lynne Robinson
Summary: This study described the epidemiology and treatment of vasomotor symptoms (VMS) in the UK. The results showed stable prevalence and incidence rates, but variations in treatment patterns, suggesting the need for education among clinicians and women.
Article
Obstetrics & Gynecology
M. Ren, X. Ruan, L. Gu, C. Pexman-Fieth, E. Kahler, Q. Yu
Summary: The study showed that continuous combined ultra-low-dose estradiol and dydrogesterone can effectively reduce vasomotor symptoms and improve the quality of life in postmenopausal women in China.
Article
Clinical Neurology
Rebecca C. Thurston, Minjie Wu, Yue-Fang Chang, Howard J. Aizenstein, Carol A. Derby, Emma A. Barinas-Mitchell, Pauline Maki
Summary: Research shows that more severe menopausal symptoms may be associated with greater white matter hyperintensity volume, especially for symptoms occurring during sleep. This finding is important for early intervention and prevention of brain health issues related to middle-aged women.
Article
Obstetrics & Gynecology
Monica Mittal, Paradzai Chitongo, Prasanna Raj Supramaniam, Linda Cardozo, Mike Savvas, Nick Panay, Roopen Arya, Haitham Hamoda
Summary: This study compares the impact of micronized progesterone (MP) or medroxyprogesterone acetate (MPA) in combination with transdermal estradiol (t-E-2) on traditional coagulation factors and thrombin generation parameters in postmenopausal women with premature ovarian insufficiency or early menopause. The results suggest that the thrombin generation parameters remain neutral after 3 months of hormone therapy, while the traditional coagulation factors show significant changes.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Geriatrics & Gerontology
Nick Panay, Rossella E. Nappi, Petra Stute, Santiago Palacios, Tomasz Paszkowski, Risa Kagan, David F. Archer, Julie Heroux, Mitra Boolell
Summary: This study compared the risk of venous thromboembolism between women treated with oral 17 beta-estradiol/micronized progesterone (E2/P4) and those treated with oral conjugated equine estrogens/medroxyprogesterone acetate (CEE/MPA). The study found that women receiving oral E2/P4 had a significantly lower risk of venous thromboembolism compared with those receiving oral CEE/MPA.
Article
Geriatrics & Gerontology
Cynthia A. Stuenkel
Summary: VMS in older women may persist into advanced age and increase cardiovascular disease risks. Nonhormonal treatment options are available for those who elect not to use, or are advised not to use, menopausal hormone therapies.
Article
Obstetrics & Gynecology
H-F Chung, D. Zhu, A. J. Dobson, D. Kuh, E. B. Gold, S. L. Crawford, N. E. Avis, E. S. Mitchell, N. F. Woods, D. J. Anderson, G. D. Mishra
Summary: The study found that early age at menarche is a risk factor for vasomotor menopausal symptoms, particularly for frequent symptoms, and that midlife BMI can modify this risk. Overweight and obese women have a higher risk of vasomotor symptoms related to early menarche compared to those of normal weight.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bingtao Ren, Jieyun Zhou, Yingyi Hu, Ruihua Zhong, Qiaoying Lv, Shuwu Xie, Guoting Li, Bingyi Yang, Xiaojun Chen, Yan Zhu
Summary: Progestin resistance is a major obstacle to conservative therapy in patients with endometrial cancer and endometrial atypical hyperplasia. This study found that lower expression of thyroid hormone receptor beta may be associated with progesterone resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Valdemar Landgren, Josephine Savard, Cecilia Dhejne, Jussi Jokinen, Stefan Arver, Michael C. Seto, Christoffer Rahm
Summary: Guidelines for the pharmacological treatment of paraphilic disorders have been mainly based on data from forensic settings and risk levels for sexual crime. However, emerging treatment options are being evaluated, targeting individuals experiencing distress because of their sexual urges and preferences. Some studies suggest that testosterone-lowering drugs may reduce sexual activity for patients with paraphilic disorders, but the evidence is limited.
Article
Endocrinology & Metabolism
Bethany Sander, Amira Muftah, Laurie Sykes Tottenham, Julia A. Grummisch, Jennifer L. Gordon
Summary: The study found that testosterone levels increase with time since the last menstrual period during the menopause transition, with less pronounced increases in overweight women. The testosterone/estradiol ratio was positively associated with depressive symptoms, while the mean ratio was also related to sleep difficulties and vasomotor symptom bother.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Pharmacology & Pharmacy
Atsuo Tahara, Hajime Takamatsu, Akiyoshi Ohtake, Keiko Tanaka-Amino, Seiji Kaku
Summary: The study shows that fezolinetant can attenuate hot flash-like symptoms by inhibiting neuronal activity in the median preoptic nucleus of ovariectomized rats, and reduce hyperphagia and weight gain in menopausal rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Matthew William Woods, Muhammad Atif Zahoor, Jeffrey Lam, Puja Bagri, Haley Dupont, Chris P. Verschoor, Aisha Nazli, Charu Kaushic
Summary: The study found that MPA causes changes in gene expression in vaginal epithelial cells, increasing the expression of genes related to cholesterol/sterol synthesis while decreasing those related to cell division and cell-cell adhesion, which in turn reduces barrier integrity and increases susceptibility to HIV-1 infection.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Obstetrics & Gynecology
Veronica Djapardy, Nicholas Panay
Summary: Ovarian function starts to decline a few years before menopause, which is diagnosed retrospectively after 12 months of amenorrhea. Vasomotor symptoms and vulvovaginal atrophy during menopause can have a significant impact on women's physical and psychological well-being. This review examines the evidence, efficacy, and safety of various complementary or alternative treatments and non-hormonal pharmacological treatments for managing vasomotor symptoms and vulvovaginal atrophy in menopause.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Emilia Berin, Anna-Clara Spetz Holm, Mats Hammar, Lotta Lindh-Astrand, Carina Bertero
Summary: This study explores the experiences of postmenopausal women participating in resistance training intervention. It finds that symptoms act as a motivating factor to initiate training, and resistance training improves overall well-being and vasomotor symptoms. The motivation factor changes from symptom improvement to enjoyment and well-being.
Article
Medicine, General & Internal
Alison J. Huang, Steven R. Cummings, Peter Ganz, Michael Schembri, Harini Raghunathan, Eric Vittinghoff, Carolyn J. Gibson, Deborah Grady
Summary: This randomized clinical trial found that continuous use of NTG did not result in sustained improvements in hot flash frequency or severity relative to placebo and was associated with more early but not persistent headache.
JAMA INTERNAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Kati Korhonen, Leila Unkila-Kallio, Henrik Alfthan, Esa Hamalainen, Aila Tiitinen, Tomi Mikkola, Juha Tapanainen, Hanna Savolainen-Peltonen
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2020)
Article
Obstetrics & Gynecology
Christian Falconer, Daniel Altman, Georgios Poutakidis, Paivi Rahkola-Soisalo, Tomi Mikkola, Edward Morcos
Summary: The study found that for pelvic organ prolapse repair using a mesh-capturing device, the outcomes were better in a single-center approach compared to a multicenter trial. Recurrence rates and complications were higher in the multicenter study, indicating the benefits of centralizing the use of standardized procedures for this type of surgery.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Biochemistry & Molecular Biology
Maria A. Ahonen, Muhammad Yasir Asghar, Suvi J. Parviainen, Gerhard Liebisch, Marcus Hoering, Marjut Leidenius, Pamela Fischer-Posovszky, Martin Wabitsch, Tomi S. Mikkola, Kid Tornquist, Hanna Savolainen-Peltonen, P. A. Nidhina Haridas, Vesa M. Olkkonen
Summary: miR-221-3p overexpression inhibits terminal differentiation of adipocytes, while its inhibitor increases triglyceride storage. The effects of miR-221-3p may be mediated through 14-3-3 gamma, and it also impacts lipid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Obstetrics & Gynecology
Sari A. Tulokas, Paivi Rahkola-Soisalo, Mika Gissler, Tomi S. Mikkola, Maarit J. Mentula
Summary: The study found that pregnancy after mid-urethral sling (MUS) operation did not increase the risk of stress urinary incontinence (SUI) re-procedure or re-visit. Therefore, future pregnancies do not need to be considered as an absolute contraindication for MUS operation.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Obstetrics & Gynecology
Anna-Maija Itkonen Freitas, Tomi S. Mikkola, Paivi Rahkola-Soisalo, Sari Tulokas, Maarit Mentula
Summary: In a comparison study of TVT and PAHG treatments for SUI, both groups showed improvement in incontinence and health-related quality of life at 1 year, with better outcomes in the TVT group.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Natalia Hetemaki, Tomi S. Mikkola, Matti J. Tikkanen, Feng Wang, Esa Hamalainen, Ursula Turpeinen, Mikko Haanpaa, Veera Vihma, Hanna Savolainen-Peltonen
Summary: The study found that premenopausal adipose tissue demonstrates high levels of estrogenic enzyme activity and significant local estrogen concentrations, which may contribute to the typical distribution of adipose tissue in premenopausal women.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
Johanna Joensuu, Hannu Saarijarvi, Hanna Rouhe, Mika Gissler, Veli-Matti Ulander, Seppo Heinonen, Tomi Mikkola
Summary: The study showed that the time of delivery can influence the childbirth experience, with evening deliveries leading to impaired experience. Further research on the impact of labor induction and the organization of delivery services is recommended.
Article
Medicine, General & Internal
Johanna Joensuu, Hannu Saarijarvi, Hanna Rouhe, Mika Gissler, Veli-Matti Ulander, Seppo Heinonen, Paulus Torkki, Tomi Mikkola
Summary: The study aimed to examine the correlation between labor pain relief methods and childbirth experience as measured by Visual Analogue Scale (VAS). The findings revealed that the use of epidural or non-epidural pain relief methods reduced the likelihood of highly positive childbirth experience for both primiparous and multiparous women. However, the effects of epidural differed between the two groups. Additionally, the study suggests that the use of any medical pain relief decreased the odds of experiencing highly positive childbirth. Thus, the effect of pain relief on childbirth experience is strongly confounded by indication.
Article
Obstetrics & Gynecology
Johanna M. Joensuu, Hannu Saarijarvi, Hanna Rouhe, Mika Gissler, Veli-Matti Ulander, Seppo Heinonen, Paulus Torkki, Tomi S. Mikkola
Summary: This study assessed the impact of spontaneous labor and labor induction on maternal childbirth experience. The findings revealed that labor induction had a negative effect on childbirth experience in all modes of delivery, especially in cases of operative delivery. Labor induction also more than doubled the risk of caesarean section.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Urology & Nephrology
Anna-Maija Itkonen Freitas, Camilla Isaksson, Paivi Rahkola-Soisalo, Sari Tulokas, Maarit Mentula, Tomi S. Mikkola
Summary: This study compared the efficacy of polyacrylamide hydrogel (PAHG) and tension-free vaginal tape (TVT) in the treatment of primary stress urinary incontinence (SUI). The results showed that PAHG did not meet the noninferiority criteria set in the study, and TVT slings had better subjective and objective cure rates but were associated with more complications. Therefore, PAHG can be offered as a safe and durable alternative treatment for women with primary SUI.
JOURNAL OF UROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexandra Robciuc, Hanna Savolainen-Peltonen, Mikko Haanpaa, Jukka A. O. Moilanen, Tomi S. Mikkola
Summary: The sexual dimorphism in inflammatory/autoimmune diseases is mainly caused by sex hormone actions. Dry eye, a common eye disease, disproportionately affects women. The hormone levels in tears are correlated with serum levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Minttu Venetkoski, Johanna Joensuu, Mika Gissler, Olavi Ylikorkala, Tomi Sakari Mikkola, Hanna Savolainen-Peltonen
Summary: Pre-eclampsia has a significant impact on the future cardiovascular risk of Finnish women, with elevated risks for ischemic heart disease, myocardial infarction, and stroke among women with a history of pre-eclampsia.
Article
Obstetrics & Gynecology
M. Venetkoski, O. Ylikorkala, J. M. Joensuu, M. Gissler, T. S. Mikkola, H. Savolainen-Peltonen
Summary: This study compared the trends of hormone therapy (HT) use between women with and without a history of pre-eclampsia. The results showed that the use of HT increased in women with a history of pre-eclampsia during the later half of the follow-up period, possibly due to changes in international recommendations, increased awareness of pre-eclampsia-related cardiovascular risk later in life, and the aim to reduce this risk through HT.
Article
Polymer Science
Rubina Ajdary, Guillermo Reyes, Jani Kuula, Eija Raussi-Lehto, Tomi S. Mikkola, Esko Kankuri, Orlando J. Rojas
Summary: Direct ink writing is used to synthesize layer-by-layer meshes using renewable polysaccharides, which demonstrate excellent mechanical performance, wet stability, and biocompatibility, making them suitable for biomedical implants.
Article
Obstetrics & Gynecology
Sari Tulokas, Maarit Mentula, Paivi Harkki, Tea Brummer, Tea Kuittinen, Tomi Mikkola, Paivi Rahkola-Soisalo
Summary: Hysterectomy after or concomitant with mid-urethral sling (MUS) does not appear to increase the risk for stress urinary incontinence (SUI) re-operation or hospital re-visits for urinary incontinence.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)