Psychosocial work environment and lifestyle as related to lipid profiles in perimenopausal women

Objective The aim of the study was to characterize lipid profiles of perimenopausal women and to relate these to the psychosocial work environment and lifestyle using a longitudinal design. Methods A population-based sample of 107 women, aged 47-53 years, participated in a baseline study and in a follow-up 2 years later. Psychosocial work stress was measured using the Job Content Questionnaire. The women also completed a health questionnaire and participated in a psychological interview. Fasting blood samples were analyzed for concentrations of total cholesterol, high and low density lipoprotein (HDL, LDL) cholesterol and triglycerides. Results Multiple regression analyses showed that work control was a significant predictor of higher HDL cholesterol (p0.05), lower LDL cholesterol/HDL cholesterol ratio (p0.01) and lower total cholesterol/HDL cholesterol ratio (p0.01). Job strain predicted a higher LDL cholesterol/HDL cholesterol ratio (p0.01) and higher total cholesterol/HDL cholesterol ratio (p0.05). Lifestyle variables smoking, body mass index and waist/hip ratio predicted an unfavorable lipid profile, whereas alcohol consumption predicted a favorable lipid profile. Age but not menopausal status was associated with lipid levels at baseline and on follow-up. Use of hormone replacement therapy was a significant predictor of lower cholesterol levels in the multivariate analyses. Conclusions Our results demonstrated a significant association between the psychosocial work environment and women's cardiovascular health at menopause. Job strain was a significant contributor to an atherogenic lipid profile, whereas work control predicted a favorable profile. Hence, the argument is now compelling that psychosocial factors should be included in the risk profiles for cardiovascular disease in women.