Article
Radiology, Nuclear Medicine & Medical Imaging
Aida Ksouri, Pauline Copin, Fanny Bonvalet, Lilian Bozi, Dominique Cazals-Hatem, Lorenzo Garzelli, Yves Panis, Emmanuel Weiss, Yves Castier, Yoram Bouhnik, Olivier Corcos, Valerie Vilgrain, Maxime Ronot, Alexandre Nuzzo
Summary: Colonic involvement in patients with acute mesenteric ischemia is associated with increased morbidity and mortality, and should be carefully assessed during initial CT scans.
EUROPEAN RADIOLOGY
(2022)
Review
Critical Care Medicine
Annika Reintam Blaser, Stefan Acosta, Yaseen M. Arabi
Summary: The treatment of acute mesenteric ischemia includes a multidisciplinary approach, early diagnosis, and restoration of mesenteric perfusion. There are challenges in the diagnosis and management of nonocclusive mesenteric ischemia.
CURRENT OPINION IN CRITICAL CARE
(2021)
Review
Gastroenterology & Hepatology
Sinan Sadalla, Andrea Lisotti, Lorenzo Fuccio, Pietro Fusaroli
Summary: Colonoscopy poses a risk for colon ischemia due to various factors such as impaired splanchnic circulation, medications used for sedation, bowel preparation, bowel wall ischemia from insufflation, and endoscope insertion. Gastroenterologists should be aware of these risk factors to minimize risks, facilitate early diagnosis, and administer appropriate treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Liya Y. Qiao, Jonathan Madar
Summary: This study introduces a non-surgical method, colonometry, to assess colonic mechanical sensitivity in mice. The results show that colonometry can be utilized to analyze colonic hypersensitivity, where increased strength of colonic stretch-reflex contraction and decreased threshold of colonic mechanical sensation were observed. Chemogenetic intervention was effective in reducing hypersensitivity symptoms.
Review
Cell Biology
Luisa Marracino, Francesca Fortini, Esmaa Bouhamida, Francesca Camponogara, Paolo Severi, Elisa Mazzoni, Simone Patergnani, Emanuele D'Aniello, Roberta Campana, Paolo Pinton, Fernanda Martini, Mauro Tognon, Gianluca Campo, Roberto Ferrari, Francesco Vieceli Dalla Sega, Paola Rizzo
Summary: Dysregulation of the Notch pathway is implicated in cardiovascular diseases, and using microRNAs may offer a promising avenue for targeting Notch to treat common cardiovascular diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Surgery
Zhobin Moghadamyeghaneh, Henry Talus, Garth Ballantyne, Michael J. Stamos, Alessio Pigazzi
Summary: This study comparing laparoscopic and open approaches for emergent/urgent partial colectomy for colonic obstruction from colonic cancer found that laparoscopic surgery was associated with lower morbidity and shorter hospitalization length, but longer operation duration compared to open surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Cardiac & Cardiovascular Systems
Kriti Kalra, Mohamad B. Moumneh, Michael G. Nanna, Abdulla A. Damluji
Summary: With the rapid expansion of the global older adult population, there is a need to shift towards managing multiple chronic diseases, including cardiovascular illness, which may be exacerbated by other conditions. Stable ischemic heart disease (SIHD) is a leading cause of morbidity and mortality in older adults. However, the current management approach is suboptimal due to insufficient representation of older adults in clinical trials and inadequate consideration of the interaction between biological aging, concurrent geriatric syndromes, and patient preferences. Therefore, a more patient-centered approach is necessary to manage SIHD in older adults, taking into account holistic health outcomes and prevention of major adverse cardiovascular outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Atheer Awad, Christine M. Madla, Laura E. McCoubrey, Fabiana Ferraro, Francesca K. H. Gavins, Asma Buanz, Simon Gaisford, Mine Orlu, Florence Siepmann, Juergen Siepmann, Abdul W. Basit
Summary: Targeted drug delivery to the colon offers numerous benefits, including treatment of local diseases and direct access to specific therapeutic targets. New technologies incorporating multi-stimuli release mechanisms have advanced colonic drug delivery and expanded possibilities for delivering biopharmaceuticals, vaccines, nutrients, and microbiome therapeutics for local and systemic diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Surgery
Saskia Irene Willemsen, Martijn Geert Ten Berge, Randolph George Statius van Eps, Hugo Thomas Christian Veger, Hans van Overhagen, Lukas Carolus van Dijk, Hein Putter, Jan Jacob Wever
Summary: This large-scale cohort study of 9,433 patients who underwent AAA surgery over the past two years identified colonic ischemia as a major risk factor for open repair, along with several other factors contributing to colonic ischemia after AAA repair. The proposed prediction model can help in identifying high-risk patients for developing colonic ischemia.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Faisal Mehmood, Amina Khalid, Sultan Mahmood
Summary: Colonic ischemia is the most common form of gastrointestinal ischemia, often seen in the elderly population. Diagnosis and treatment can be challenging due to the debilitated state and multiple comorbidities of patients. The case presented highlights the potential for prolonged complications like chronic ischemic colitis or stricture requiring surgical intervention.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Surgery
Samuel Ersryd, Khatereh Djavani Gidlund, Anders Wanhainen, Martin Bjorck
Summary: This study evaluated the safety and feasibility of postoperative extraluminal pH measurement using colonic tonometry after open abdominal aortic aneurysm repair. Results showed that prolonged periods of pHe <7.2 indicate colonic malperfusion, while shorter durations of low pHe were well tolerated without clinical signs of colonic ischemia.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Ra Ri Cha, Hee Jin Kim, Chang Min Lee, Jae Min Lee, Sang Soo Lee, Hyun Jin Cho, Chang Yoon Ha, Hyun Jin Kim, Ok-Jae Lee
Summary: Diagnostic iatrogenic colonic perforation is more frequent in older women, mostly occurring in the rectosigmoid region, and can be immediately detected. Endoscopic repair is more suitable for diagnostic perforations and smaller perforations.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Health Care Sciences & Services
Katarzyna Smilowska, Marek Smilowski, Robert Partyka, Danuta Kokocinska, Przemyslaw Jalowiecki
Summary: The study found that serum suPAR levels in ischemic stroke patients increased over time, with higher suPAR and CRP concentrations in patients with hypertension, ischemic heart disease, and type 2 diabetes. A suPAR-3 concentration above 10.5ng/mL, NIHSS-1 score above 12 points, and CRP-3 concentration above 15.6mg/L significantly increased mortality risk in patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Clinical Neurology
Elisa Gouvea Bogossian, Lorenzo Peluso, Jacques Creteur, Fabio Silvio Taccone
Summary: Hyperventilation is a commonly used therapy for intracranial hypertension in traumatic brain injury patients, by promoting hypocapnia to reduce cerebral blood flow and volume temporarily. However, it can have serious systemic and cerebral deleterious effects, so routine use is not recommended. In specific conditions like refractory ICHT, it can be an effective life-saving rescue therapy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Nicolas Meurisse, Markoen Mertens, Steffen Fieuws, Nicholas Gilbo, Ina Jochmans, Jacques Pirenne, Diethard Monbaliu
Summary: A study on liver transplant found that a combined drug approach targeting the donor graft and graft recipient did not reduce ischemia-reperfusion injury. This suggests that a clinically effective combined drug approach may need to include an upstream strategy targeting the donor graft.
