Clinical translation of stem cell transplantation in Parkinson's disease

Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease

(2015) Penelope J. Hallett et al.   Cell Stem Cell

Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson's disease model

(2015) Julius A Steinbeck et al.   NATURE BIOTECHNOLOGY

Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease

(2014) Shane Grealish et al.   Cell Stem Cell

Remote control of induced dopaminergic neurons in parkinsonian rats

(2014) Maria Teresa Dell’Anno et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-Term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients

(2014) Penelope J. Hallett et al.   Cell Reports

Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation

(2014) Daisuke Doi et al.   Stem Cell Reports

Developing dopaminergic cell therapy for Parkinson's disease-give up or move forward?

(2013) Olle Lindvall   MOVEMENT DISORDERS

Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons

(2013) Maria Sundberg et al.   STEM CELLS

Rapid Generation of Functional Dopaminergic Neurons From Human Induced Pluripotent Stem Cells Through a Single-Step Procedure Using Cell Lineage Transcription Factors

(2013) Ilda Theka et al.   Stem Cells Translational Medicine

Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease

(2013) Zinovia Kefalopoulou et al.   JAMA Neurology

Clinical Translation of Stem Cells in Neurodegenerative Disorders

(2012) Olle Lindvall et al.   Cell Stem Cell

Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease

(2012) Roger A Barker et al.   LANCET NEUROLOGY

Serotonin Neuron Loss and Nonmotor Symptoms Continue in Parkinson's Patients Treated with Dopamine Grafts

(2012) M. Politis et al.   Science Translational Medicine

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

(2012) Agnete Kirkeby et al.   Cell Reports

Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts

(2011) Jongpil Kim et al.   Cell Stem Cell

Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease

(2011) Yong-Hee Rhee et al.   JOURNAL OF CLINICAL INVESTIGATION

Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio

(2011) Marios Politis et al.   MOVEMENT DISORDERS

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

(2010) Jia-Yi Li et al.   MOVEMENT DISORDERS

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

(2010) G. Hargus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants

(2010) M. Politis et al.   Science Translational Medicine

Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions

(2010) Andrzej Swistowski et al.   STEM CELLS

Dopamine Cell Implantation in Parkinson's Disease: Long-Term Clinical and 18F-FDOPA PET Outcomes

(2009) Y. Ma et al.   JOURNAL OF NUCLEAR MEDICINE

Deep brain stimulation in Parkinson's disease following fetal nigral transplantation

(2008) Jan Herzog et al.   MOVEMENT DISORDERS

Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

(2008) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

(2008) Ivar Mendez et al.   NATURE MEDICINE

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE