Article
Cardiac & Cardiovascular Systems
Benjamin J. R. Buckley, Stephanie L. Harrison, Elnara Fazio-Eynullayeva, Paula Underhill, Rajiv Sankaranarayanan, David J. Wright, Dick H. J. Thijssen, Gregory Y. H. Lip
Summary: Exercise-based cardiac rehabilitation was associated with lower odds of all-cause mortality, hospitalization, incident stroke, and incident atrial fibrillation at 2-year follow-up for patients with heart failure (including patients with reduced ejection fraction and preserved ejection fraction).
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Jani Rankinen, Petri Haataja, Leo-Pekka Lyytikainen, Heini Huhtala, Terho Lehtimaki, Mika Kahonen, Markku Eskola, Suvi Tuohinen, Andres Ricardo Perez-Riera, Antti Jula, Harri Rissanen, Kjell Nikus, Jussi Hernesniemi
Summary: In the presence of ECG left ventricular hypertrophy (ECG-LVH), longer QRS duration is associated with increased risk of mortality and heart failure. Even within normal limits, QRS duration in ECG-LVH carries a risk of heart failure compared to individuals without ECG-LVH.
Article
Cardiac & Cardiovascular Systems
Frederick K. Ho, Ziyi Zhou, Fanny Petermann-Rocha, Solange Para-Soto, Jirapitcha Boonpor, Paul Welsh, Jason M. R. Gill, Stuart R. Gray, Naveed Sattar, Jill P. Pell, Carlos Celis-Morales
Summary: This study aimed to investigate the relationship between physical activity and heart failure. The results showed that moderate-intensity physical activity was associated with a lower risk of heart failure, and increasing moderate-intensity physical activity may be beneficial for overall health.
Article
Medicine, General & Internal
Jason Davidge, Awais Ashfaq, Kristina Malene Odegaard, Mattias Olsson, Madlaina Costa-Scharplatz, Bjoern Agvall
Summary: This study found that among heart failure patients, 57% had abnormal ejection fractions based on echocardiography results, with 35% having reduced EF, 27% having mildly reduced EF, and 38% having preserved EF. The 1-year all-cause mortality rate was 42% for those without confirmed EF, while it was 30% for those with conclusive EF.
Letter
Cardiac & Cardiovascular Systems
Timothy W. Churchill, Shawn X. Li, Lisa Curreri, Emily K. Zern, Emily S. Lau, Elizabeth E. Liu, Robyn Farrell, Mark W. Shoenike, John Sbarbaro, Rajeev Malhotra, Matthew Nayor, Carsten Tschoepe, Rudolf A. de Boer, Gregory D. Lewis, Jennifer E. Ho
Summary: The article includes additional digital content.
Review
Biochemistry & Molecular Biology
Ralf Gaebel, Cajetan Lang, Praveen Vasudevan, Larissa Luhrs, Katherine Athayde Teixeira de Carvalho, Eltyeb Abdelwahid, Robert David
Summary: Cardiovascular diseases are a leading cause of death in industrialized nations and have a significant impact on healthcare costs. Obesity and sedentary lifestyle contribute to an increased risk of heart-related complications, and there is a lack of comprehensive understanding and evidence on the underlying mechanisms and effective interventions. Therefore, there is a need for intensified research efforts in order to prevent and effectively manage cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Emmanuel Lecoeur, Orianne Domenge, Antoine Fayol, Anne-Sophie Jannot, Jean-Sebastien Hulot
Summary: This study characterized the incidence and prognosis of heart failure in young adults using nationwide medico-administrative data from France. The findings showed an increase in the incidence of heart failure among young adults, particularly young men aged 36-50 years, with ischemic heart disease as the most common cause. Young heart failure patients also presented with high rates of traditional heart disease risk factors, indicating a poor prognosis.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Alicia Uijl, Ilonca Vaartjes, S. Denaxas, Harry Hemingway, Anoop Shah, J. Cleland, Diederick Grobbee, Arno Hoes, Folkert W. Asselbergs, Stefan Koudstaal
Summary: The study revealed an increase in beta blocker prescriptions but low and stable prescription rates of mineralocorticoid receptor-antagonists for heart failure patients in recent years. Women and elderly patients were more likely to use loop diuretics, and medication prescription rates remained largely unchanged in the 6 months following a heart failure diagnosis for most patients.
Article
Medicine, General & Internal
Rosita Zakeri, Ann D. Morgan, Varun Sundaram, Chloe Bloom, John G. F. Cleland, Jennifer K. Quint
Summary: Long-term use of loop diuretics in patients with atrial fibrillation but no known diagnosis of heart failure may indicate undiagnosed heart failure and is associated with worse outcomes. Early diagnosis of heart failure, prompt intervention, and targeted evaluation of these patients may lead to better outcomes, particularly among women with atrial fibrillation, who are at higher risk of under-recognition and delayed diagnosis of heart failure compared to men.
Article
Cardiac & Cardiovascular Systems
Daniel B. Ibsen, Emily B. Levitan, Agneta Akesson, Bruna Gigante, Alicja Wolk
Summary: The study found that long-term adherence to the DASH diet and relevant food substitutions within the diet were associated with a lower risk of heart failure.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Therese Kearns, Abbey Diaz, Lisa J. Whop, Suzanne P. Moore, John R. Condon, Ross M. Andrews, Judith M. Katzenellenbogen, Veronica Matthews, William Wang, Trisha Johnston, Catherine Taylor, Boyd Potts, Alex Kathage, Abdulla Suleman, Lucy Stanley, Louise Mitchell, Gail Garvey, Daniel Williamson
Summary: The Better Cardiac Care Data Linkage project aims to identify disparities in cardiovascular healthcare between Aboriginal and Torres Strait Islander people and other Queensland residents. This population-based retrospective cohort study will analyze patient care pathways and health outcomes using linked health and administrative data collections. The project will focus on descriptive epidemiological measures and multivariate analysis to understand differences in care and outcomes.
Article
Health Care Sciences & Services
Jimin Kim, Hakyung Kim, Sol Bi Kim, Woo Yup Kim, Seung Hun Sheen, Inbo Han, Je Beom Hong, Seil Sohn
Summary: The purpose of this nationwide longitudinal study was to investigate the relationship between Parkinson's disease (PD) and congestive heart failure (CHF) patients in Korea. The study found that PD patients had a higher incidence rate of CHF.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Amitava Banerjee, Laura Pasea, Sheng-Chia Chung, Kenan Direk, Folkert Asselbergs, Diederick E. Grobbee, Dipak Kotecha, Stefan D. Anker, Tomasz Dyszynski, Benoit Tyl, Spiros Denaxas, R. Thomas Lumbers, Harry Hemingway
Summary: This study aimed to evaluate the evidence and prevalence of risk factors (RFs) for incident heart failure (HF) and their impact on prognosis. The study found that the range of RFs for HF is wide, but only a few factors have high-quality observational evidence and effective interventions supported by randomized controlled trials (RCTs). In addition, the study found that the co-occurrence of multiple RFs is common in HF patients and having multiple RFs simultaneously leads to poor prognosis.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Satyam Sarma, Erin Howden, Justin Lawley, Mitchel Samels, Benjamin D. Levine
Summary: Patients with HFpEF have lower peak oxygen consumption and heart rate compared to senior controls, but there were no significant differences in peak heart rate response during static handgrip exercise and metaboreceptor function between the two groups. The key reflex autonomic pathways regulating exercise heart rate responsiveness are intact in HFpEF despite lower peak exercise heart rates.
Article
Cardiac & Cardiovascular Systems
Andrea K. Roalfe, Sarah L. Lay-Flurrie, Jose M. Ordonez-Mena, Clare R. Goyder, Nicholas R. Jones, F. D. Richard Hobbs, Clare J. Taylor
Summary: This study reported contemporary trends in NP testing and HF diagnosis rates in adult patients in England from 2004-18. It found that NP testing in primary care has increased over time, with most patients with HF still not having an NP test recorded prior to diagnosis.
EUROPEAN HEART JOURNAL
(2022)
Article
Surgery
Stefan Wallen, Gustaf Bruze, Johan Ottosson, Claude Marcus, Johan Sundstrom, Eva Szabo, Torsten Olbers, Maria Palmetun-Ekback, Ingmar Naslund, Martin Neovius
Summary: This study aimed to compare the use of opioids in patients with obesity who underwent bariatric surgery versus those who underwent intensive lifestyle modification. The results showed that patients who underwent bariatric surgery had a higher proportion of opioid users and a larger total opioid dose, especially in those who received additional surgery during follow-up.
Article
Cardiac & Cardiovascular Systems
Halldora Ogmundsdottir Michelsen, Peter Henriksson, John Wallert, Maria Back, Ingela Sjolin, Mona Schlyter, Emil Hagstrom, Anna Kiessling, Claes Held, Emma Hag, Lennart Nilsson, Alexandru Schiopu, M. Justin Zaman, Margret Leosdottir
Summary: This study investigated the predictors of attaining risk factor targets after myocardial infarction, using data from 7549 patients and 78 cardiac rehabilitation centers in Sweden. The study found that offering psychosocial management, having a psychologist in the rehabilitation team, extended opening hours, adequate facilities, and a medical director were the strongest organizational predictors of achieving low-density lipoprotein-cholesterol and blood pressure targets. Patient-level predictors included low baseline LDL-C, no history of hypertension, participation in exercise-based rehabilitation, and group education.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Genetics & Heredity
K. Alaine Broadaway, Xianyong Yin, Alice Williamson, Victoria A. Parsons, Emma P. Wilson, Anne H. Moxley, Swarooparani Vadlamudi, Arushi Varshney, Anne U. Jackson, Vasudha Ahuja, Stefan R. Bornstein, Laura J. Corbin, Graciela E. Delgado, Om P. Dwivedi, Lilian Fernandes Silva, Timothy M. Frayling, Harald Grallert, Stefan Gustafsson, Liisa Hakaste, Ulf Hammar, Christian Herder, Sandra Herrmann, Kurt Hojlund, David A. Hughes, Marcus E. Kleber, Cecilia M. Lindgren, Ching-Ti Liu, Jian'an Luan, Anni Malmberg, Angela P. Moissl, Andrew P. Morris, Nikolaos Perakakis, Annette Peters, John R. Petrie, Michael Roden, Peter E. H. Schwarz, Sapna Sharma, Angela Silveira, Rona J. Strawbridge, Tiinamaija Tuomi, Andrew R. Wood, Peitao Wu, Bjorn Zethelius, Damiano Baldassarre, Johan G. Eriksson, Tove Fall, Jose C. Florez, Andreas Fritsche, Bruna Gigante, Anders Hamsten, Eero Kajantie, Markku Laakso, Jari Lahti, Deborah A. Lawlor, Lars Lind, Winfried Maerz, James B. Meigs, Johan Sundstrom, Nicholas J. Timpson, Robert Wagner, Mark Walker, Nicholas J. Wareham, Hugh Watkins, Ines Barroso, Stephen O'Rahilly, Niels Grarup, Stephen CJ. Parker, Michael Boehnke, Claudia Langenberg, Eleanor Wheeler, Karen L. Mohlke
Summary: Insufficient insulin secretion and increased proinsulin levels indicate beta-cell stress and insulin resistance. A meta-analysis of European-ancestry individuals identified 36 independent signals at 30 loci associated with fasting proinsulin. These loci are involved in various mechanisms that affect insulin processing and beta-cell function. Colocalization analysis provided potential candidate genes and regulatory mechanisms for proinsulin production and glucose regulation. This study highlights the importance of genetic studies for understanding disease predisposition.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Gastroenterology & Hepatology
Tracey G. Simon, Bjorn Roelstraete, Naim Alkhouri, Hannes Hagstrom, Johan Sundstrom, Jonas F. Ludvigsson
Summary: This study found that children and young adults with biopsy-proven NAFLD had significantly higher rates of incident MACE, including ischaemic heart disease and congestive heart failure, compared to matched population controls.
Article
Endocrinology & Metabolism
Liisa Tolvanen, Anne Christenson, Helen Eke, Stephanie E. Bonn, Ylva Trolle Lagerros
Summary: This study aimed to investigate the association between previous weight loss with self-esteem and different eating behaviors in adolescents and young adults with obesity seeking specialty care. The results showed that those who had previous weight loss had higher cognitive restraint eating scores. Therefore, assessing weight loss history and eating behavior may be beneficial for individualized obesity treatment.
Article
Nutrition & Dietetics
Linnea Sjoblom, Stephanie Erika Bonn, Christina Alexandrou, Anna Dahlgren, Helen Eke, Ylva Trolle Lagerros
Summary: This study aimed to evaluate the indirect effect of a smartphone-based physical activity intervention on dietary habits in patients with type 2 diabetes. Results showed that the smartphone intervention improved fruit and vegetable intake in women, but had no effect on men.
Letter
Hematology
Qingling Su, Weimin Ye
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pia Davidsson, Susanna Eketjall, Niclas Eriksson, Anna Walentinsson, Richard C. Becker, Anders Cavallin, Anna Bogstedt, Anna Collen, Claes Held, Stefan James, Agneta Siegbahn, Ralph Stewart, Robert S. Storey, Harvey White, Lars Wallentin
Summary: This study investigated the associations between circulating VEGF ligands and/or soluble receptors and cardiovascular (CV) outcomes in patients with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS). The results showed that VEGF-D, KDR, Flt-1, and PlGF were significantly associated with CV outcomes. Furthermore, genetic variants of VEGFD were also found to be independently associated with CV outcomes.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Divan Ishak, Suleman Aktaa, Lars Lindhagen, Joakim Alfredsson, Tatendashe Bernadette Dondo, Claes Held, Tomas Jernberg, Troels Yndigegn, Chris P. Gale, Gorav Batra
Summary: This nationwide cohort study found that continued use of beta-blockers (BB) beyond one year after myocardial infarction (MI) in patients without heart failure or left ventricular systolic dysfunction (LVSD) did not improve cardiovascular outcomes. The study concluded that the effectiveness of BB treatment in this patient population remains uncertain.
Article
Cardiac & Cardiovascular Systems
Anna Norhammar, Johan Bodegard, Marc Vanderheyden, Navdeep Tangri, Avraham Karasik, Aldo Pietro Maggioni, Kari Anne Sveen, Tiago Taveira-Gomes, Manuel Botana, Lukas Hunziker, Marcus Thuresson, Amitava Banerjee, Johan Sundstrom, Andreas Bollmann
Summary: The CaReMe HF study collected individual level data from digital healthcare systems in 11 countries to estimate the prevalence, clinical outcomes, and costs of HF. The study found that 1-2% of the contemporary adult population has HF, and these individuals are at significant risk of adverse outcomes and associated costs.
Article
Health Care Sciences & Services
Stephanie E. Bonn, Christina Alexandrou, Ylva Trolle Lagerros
Summary: The DiaCert system is a mobile health solution aimed at increasing patients' engagement in self-care, specifically daily walking for type 2 diabetes patients. It utilizes a simple architecture that is easily scalable, but does require healthcare personnel to integrate another process into their work.
JMIR FORMATIVE RESEARCH
(2023)
Article
Geriatrics & Gerontology
Xiao Tan, Torbjorn Akerstedt, Ylva Trolle Lagerros, Anna Miley Akerstedt, Rino Bellocco, Hans-Olov Adami, Weimin Ye, Jin-Jing Pei, Hui-Xin Wang
Summary: Both insomnia symptoms and short sleep duration increase the risk of dementia among middle-aged to older adults.
Article
Cardiac & Cardiovascular Systems
Joel Ohm, Ralf Kuja-Halkola, Anna Warnqvist, Henrike Haebel, Per H. Skoglund, Johan Sundstroem, Kristina Hambraeus, Tomas Jernberg, Per Svensson
Summary: Low socioeconomic status is associated with worse prognosis after myocardial infarction. This study identified nonparticipation in cardiac rehabilitation, cardiometabolic risk profile, and persistent smoking as mediating factors in the relationship between low income and post-MI recurrent atherosclerotic cardiovascular disease events.
Article
Psychiatry
Eric Clapham, Johan Reutfors, Marie Linder, Lena Brandt, Johan Sundstrom, Robert Boden
Summary: The risk of cardiac adverse events following the use of clozapine is debated; however, its risk for chemically related antipsychotics olanzapine and quetiapine is unknown. A Swedish study used registers to analyze the risk of perimyocarditis and heart failure in patients receiving these antipsychotics. The study found that clozapine use was associated with a significantly increased short-term risk of perimyocarditis and an increased long-term risk of heart failure. Olanzapine and quetiapine use did not show an increased risk compared to no antipsychotic treatment.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.
