Review
Medicine, General & Internal
Frans A. van Nieuwenhoven, Blanche Schroen, Lucio Barile, Lars van Middendorp, Frits W. Prinzen, Angelo Auricchio
Summary: Cardiac resynchronization therapy (CRT) is a valuable addition to heart failure treatment options, especially for patients with electrical conduction disturbances causing regional contraction patterns (dyssynchrony). Experimental studies have shown extensive molecular and cellular remodeling in dyssynchronous hearts. Increasing evidence suggests that several miRNAs are involved in this remodeling process. Measurement of myocardium-derived miRNAs in extracellular vesicles (EVs) in peripheral blood may provide new insights into investigating and monitoring (reverse) remodeling in dyssynchronous and resynchronized hearts of patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremy Layec, Marie Decroocq, Francois Delelis, Ludovic Appert, Yves Guyomar, Clemence Riolet, Helene Dumortier, Amandine Mailliet, Christophe Tribouilloy, Sylvestre Marechaux, Aymeric Menet
Summary: This study evaluated the relationship between preprocedural echocardiographic parameters of electromechanical dyssynchrony (EMD) and outcome following cardiac resynchronization therapy (CRT) in heart failure patients. The results showed that certain echocardiographic parameters were associated with treatment response and patient prognosis. Therefore, echocardiographic assessment can help select patients who will benefit from CRT.
JACC-CARDIOVASCULAR IMAGING
(2023)
Review
Cell Biology
Eleonora Russo, Giulio Russo, Mauro Cassese, Maurizio Braccio, Massimo Carella, Paolo Compagnucci, Antonio Dello Russo, Michela Casella
Summary: Functional mitral regurgitation (FMR) is caused by alterations in the left ventricle and left atrium geometry, resulting in an imbalance between closing and tethering forces. FMR affects quality of life and increases mortality, and there is no clear treatment approach. Left ventricle dyssynchrony may contribute to the onset and worsening of FMR, and is an important target for treatment.
Article
Biophysics
Pim J. A. Oomen, Thien-Khoi N. Phung, Seth H. Weinberg, Kenneth C. Bilchick, Jeffrey W. Holmes
Summary: Cardiac resynchronization therapy (CRT) is effective for heart failure patients, but response rate is limited. Computational models can predict remodeling outcomes to help clinicians tailor personalized treatment strategies.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Francisco Leyva, Abbasin Zegard, Peysh Patel, Berthold Stegemann, Howard Marshall, Peter Ludman, Jamie Walton, Joseph de Bono, Giuseppe Boriani, Tian Qiu
Summary: The optimal timing of CRT implantation remains unknown. In this study of 64,968 patients, delays in time from first HFH to CRT implantation were associated with worse long-term clinical outcomes. Each year from the first HFH to CRT implantation was associated with a higher risk of total mortality and HFH. The best outcomes after CRT were observed in patients with no previous HFHs and in those undergoing implantation during their first HFH.
Article
Cardiac & Cardiovascular Systems
Caio V. Spaggiari, Sergio F. de Siqueira, Camila Parente de Oliveira, Cinthya I. Guiarao I. Gomes, Maria Janieire de N. N. Alves, Martino Martinelli Filho
Summary: This study aimed to evaluate the feasibility of physiological pacing rate (PPR) in cardiac resynchronization therapy (CRT) patients. The results showed that PPR improved functional capacity in mildly symptomatic CRT patients, but further confirmation is needed through controlled randomized trials.
Article
Cardiac & Cardiovascular Systems
Manuel Villegas-Martinez, Hans Henrik Odland, Lars-Egil Hammersboen, Ole Jakob Sletten, Marie Stugaard, Marit Witso, Faraz Khan, Ali Wajdan, Ole Jakob Elle, Espen W. Remme
Summary: This study suggests that pulse arrival time (PAT) can be used as a simple and non-invasive method to evaluate the acute response of cardiac resynchronization therapy (CRT) in patients with left bundle branch block (LBBB) in real time. Changes in PAT are strongly correlated with changes in pre-ejection period (PEP) and can potentially identify long-term response to CRT.
Review
Medicine, General & Internal
Willem Gerrits, Ibrahim Danad, Birgitta Velthuis, Saima Mushtaq, Maarten J. Cramer, Pim van der Harst, Frebus J. van Slochteren, Mathias Meine, Dominika Sucha, Marco Guglielmo
Summary: Research has shown that using cardiac computed tomography (CT) for patient selection and guided placement in cardiac resynchronization therapy (CRT) can improve the treatment response rate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Francisco Leyva, Abbasin Zegard, Peysh Patel, Berthold Stegemann, Howard Marshall, Peter Ludman, Joseph de Bono, Giuseppe Boriani, Tian Qiu
Summary: The delivery of cardiac resynchronization therapy (CRT) for heart failure patients has increased in the past decade. This study aimed to determine whether there have been changes in clinical outcomes after CRT from the perspective of a public healthcare system. The results showed a significant increase in CRT implantations over the years, and despite an increasing comorbidity burden, there was a decrease in mortality and heart failure hospitalizations after CRT implantation.
Article
Chemistry, Medicinal
G. Ian Gallicano, Jiayu Fu, Samiksha Mahapatra, Michael V. R. Sharma, Conor Dillon, Claire Deng, Maliha Zahid
Summary: Research has shown that miRNA106a can target genes that cause hypertrophy and heart failure, reversing the disease. By using a cardiac targeting peptide reversibly linked to miRNA106a, delivery specific to cardiomyocytes has been demonstrated.
Review
Biochemistry & Molecular Biology
Emman Asjad, Halina Dobrzynski
Summary: This article summarizes the role of miRNAs as biomarkers and their interactions with targets that affect cardiac health, and provides current therapeutic knowledge in a succinct manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Elena Galli, Vincent Galand, Virginie Le Rolle, Marion Taconne, Adrien Al Wazzan, Alfredo Hernandez, Christophe Leclercq, Erwan Donal
Summary: Cardiac resynchronisation therapy (CRT) plays an important role in the management of patients with heart failure, reduced left ventricular ejection fraction (LVEF < 35%) and widened QRS (>130 msec). Currently, the assessment of LVEF is the only imaging-derived parameter used for the selection of CRT candidates, despite the complex pathophysiology of left ventricular dyssynchrony. This review provides an overview of the evolution of cardiac imaging for the assessment of LV dyssynchrony, discusses its pitfalls and advantages, and suggests perspectives for clinical application and future research in this field.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Nawaz Z. Safdar, Stephe Kamalathasan, Ankit Gupta, Joshua Wren, Rory Bird, Dorothy Papp, Rebecca Latto, Ali Ahmed, Victoria Palin, John Gierula, Klaus K. Witte, Sam Straw
Summary: Older patients receiving CRT for the management of heart failure have similar clinical response, complications, and outcomes compared to younger patients.
Article
Cardiac & Cardiovascular Systems
Koshiro Akamine, Hidekazu Kondo, Keisuke Yonezu, Kei Hirota, Katsunori Tawara, Nozomi Kodama, Ichitaro Abe, Tomoko Fukuda, Kunio Yufu, Naohiko Takahashi
Summary: A 66-year-old male patient with heart failure and QRS widening suffering from recurrent hospitalization due to acute heart failure underwent cardiac resynchronization therapy (CRT) which significantly improved his condition, leading to no recurrent hospitalization for more than 2 years.
Article
Cell Biology
Isabel Moscoso, Maria Cebro-Marquez, Alvaro Martinez-Gomez, Charigan Abou-Jokh, Maria Amparo Martinez-Monzonis, Jose Luis Martinez-Sande, Laila Gonzalez-Melchor, Javier Garcia-Seara, Xesus Alberte Fernandez-Lopez, Sandra Morana-Fernandez, Jose R. Gonzalez-Juanatey, Moises Rodriguez-Manero, Ricardo Lage
Summary: The differences in circulating miRNA may contribute to prognostic stratification of patients undergoing cardiac resynchronization therapy, and the preimplant cardiac context and remodeling response are key factors for therapeutic success.
Editorial Material
Medicine, General & Internal
Avash Das, Arjun Gupta, Saumya Das
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2017)
Editorial Material
Biochemistry & Molecular Biology
Saumya Das
Editorial Material
Biochemistry & Molecular Biology
Saumya Das
Article
Multidisciplinary Sciences
Kirsty M. Danielson, Renee Rubio, Fieda Abderazzaq, Saumya Das, Yaoyu E. Wang
Article
Multidisciplinary Sciences
Vassilios J. Bezzerides, Aifeng Zhang, Ling Xiao, Bridget Simonson, Santosh A. Khedkar, Shiro Baba, Filomena Ottaviano, Stacey Lynch, Katherine Hessler, Alan C. Rigby, David Milan, Saumya Das, Anthony Rosenzweig
SCIENTIFIC REPORTS
(2017)
Article
Cardiac & Cardiovascular Systems
Rongrong Gao, Lijun Wang, Yihua Bei, Xiaodong Wu, Jiaqi Wang, Qiulian Zhou, Lichan Tao, Saumya Das, Xinli Li, Junjie Xiao
Summary: Through lncRNA microarray profiling, we identified a novel long noncoding RNA (lncRNA) associated with exercise-induced cardiac growth, named cardiac physiological hypertrophy-associated regulator (CPhar). Our study reveals the cardioprotective role of CPhar in the heart and expands our understanding of lncRNA function.
Article
Multidisciplinary Sciences
Francois Cherbonneau, Guoping Li, Priyanka Gokulnath, Parul Sahu, Aurore Prunevieille, Robert Kitchen, Gilles Benichou, Jerome Larghero, Ibrahim Domian, Saumya Das
Summary: Current methods for analyzing gene expression require cellular destruction, making continuous analysis difficult. However, our recently developed TRACE-seq technology allows transcriptomic analysis without cell lysis, providing accurate data on stress-responsive transcriptomic changes.
Review
Endocrinology & Metabolism
Carlos Salomon, Saumya Das, Uta Erdbrugger, Raghu Kalluri, Sai Kiang Lim, Jerrold M. Olefsky, Gregory E. Rice, Susmita Sahoo, W. Andy Tao, Pieter Vader, Qun Wang, Alissa M. Weaver
Summary: The hormone-like role of extracellular vesicles (EVs) in cell-to-cell communication has gained significant interest in the past decade. EVs, as a heterogeneous population of membrane-bound vesicles, carry endocrine signals and play a role in various biological activities. They can also serve as indicators of diseases. This article aims to highlight the importance of EV research and its potential role in the field of endocrinology.
Article
Genetics & Heredity
Gregory M. Gheewalla, Jay Luther, Saumya Das, Jeffrey B. Kreher, Eleanor R. Scimone, Ashley W. Wong, Mark E. Lindsay, Angela E. Lin
Summary: Pathogenic mutations in the SMAD4 gene can cause cancer, hereditary hemorrhagic telangiectasia, and Myhre syndrome, depending on the type of mutation. The contrasting clinical phenotypes observed are attributed to different molecular mechanisms involving SMAD4.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Cardiac & Cardiovascular Systems
G. Michael Felker, Peter Buttrick, Anthony Rosenzweig, E. Dale Abel, Larry A. Allen, Michael Bristow, Saumya Das, Adam D. DeVore, Stavros G. Drakos, James C. Fang, Jane E. Freedman, Adrian F. Hernandez, Dean Y. Li, Timothy A. McKinsey, Christopher Newton-Cheh, Joseph G. Rogers, Ravi Shah, Svati H. Shah, Josef Stehlik, Craig H. Selzman
Summary: The Heart Failure Strategically Focused Research Network aims to facilitate collaborative research in the field of heart failure and provide training opportunities for young investigators.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Yihua Bei, Tianzhao Xu, Dongchao Lv, Pujiao Yu, Jiahong Xu, Lin Che, Avash Das, John Tigges, Vassilios Toxavidis, Ionita Ghiran, Ravi Shah, Yongqin Li, Yuhui Zhang, Saumya Das, Junjie Xiao
BASIC RESEARCH IN CARDIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Glenn C. Rowe, Angeliki Asimaki, Evan L. Graham, Kimberly D. Martin, Kenneth B. Margulies, Saumya Das, Jeffery Saffitz, Zoltan Arany
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Aferdita Spahillari, Sameera Talegawkar, Adolfo Correa, J. Jeffrey Carr, James G. Terry, Joao Lima, Jane E. Freedman, Saumya Das, Robb Kociol, Sarah de Ferranti, Donya Mohebali, Stanford Mwasongwe, Katherine L. Tucker, Venkatesh L. Murthy, Ravi V. Shah
CIRCULATION-HEART FAILURE
(2017)
Article
Cell Biology
Junjie Xiao, Rongrong Gao, Yihua Bei, Qiulian Zhou, Yanli Zhou, Haifeng Zhang, Mengchao Jin, Siqi Wei, Kai Wang, Xuejuan Xu, Wenming Yao, Dongjie Xu, Fang Zhou, Jingfa Jiang, Saumya Das, Xinli Li
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Article
Cell Biology
Bogdan Mateescu, Emma J. K. Kowal, Bas W. M. van Balkom, Sabine Bartel, Suvendra N. Bhattacharyya, Edit I. Buzas, Amy H. Buck, Paola de Candia, Franklin W. N. Chow, Saumya Das, Tom A. P. Driedonks, Lola Fernandez-Messina, Franziska Haderk, Andrew F. Hill, Jennifer C. Jones, Kendall R. Van Keuren-Jensen, Charles P. Lai, Cecilia Laesser, Italia di Liegro, Taral R. Lunavat, Magdalena J. Lorenowicz, Sybren L. N. Maas, Imre Maeger, Maria Mittelbrunn, Stefan Momma, Kamalika Mukherjee, Muhammed Nawaz, D. Michiel Pegtel, Michael W. Pfaffl, Raymond M. Schiffelers, Hidetoshi Tahara, Clotilde Thery, Juan Pablo Tosar, Marca H. M. Wauben, Kenneth W. Witwer, Esther N. M. Nolte-'t Hoen
JOURNAL OF EXTRACELLULAR VESICLES
(2017)
