Article
Medicine, General & Internal
Lukasz Wolowiec, Joanna Banach, Jacek Budzynski, Anna Wolowiec, Mariusz Kozakiewicz, Maciej Bielinski, Albert Jasniak, Agata Olejarczyk, Grzegorz Grzesk
Summary: The study aimed to assess the prognostic value of plasma catestatin concentration in patients with heart failure with reduced ejection fraction (HFrEF) in predicting unplanned hospitalization and all-cause death at a 2-year follow-up. The study included 122 hospitalized Caucasian patients in NYHA classes II to IV. Patients who died during the follow-up period had higher levels of CST, NT-proBNP, troponin T, creatinine, and glucose, and lower TAPSE, hemoglobin concentration, hematocrit, and platelet count compared to survivors. Plasma catestatin concentration was positively associated with NYHA class and blood NT-proBNP concentration. Higher plasma catestatin concentration increased the risk of all-cause death by more than five times. Plasma CST concentration is a valuable prognostic parameter in predicting death from all causes and unplanned hospitalization in patients with HFrEF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Sudhir Kurl, Sae Young Jae, Timo H. Makikallio, Ari Voutilainen, Magnus J. Hagnas, Jussi Kauhanen, Jari A. Laukkanen
Summary: Exercise cardiac power is associated with the risk of heart failure, and low exercise cardiac power increases the risk of heart failure.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Angiza Shahim, Marion Hourqueig, Erwan Donal, Emmanuel Oger, Ashwin Venkateshvaran, Jean-Claude Daubert, Gianluigi Savarese, Cecilia Linde, Lars H. Lund, Camilla Hage
Summary: Patients with HFpEF have high mortality rates over a 10-year period, with the majority experiencing primary outcome events. Independent predictors of primary outcome include tricuspid regurgitation peak velocity, diabetes mellitus, and cancer, while female sex is associated with reduced risk.
Article
Multidisciplinary Sciences
Anne Grauer, Talea Cornelius, Marwah Abdalla, Nathalie Moise, Ian M. Kronish, Siqin Ye
Summary: This retrospective observational study using electronic health records data found that telemedicine visits did not significantly reduce 30-day hospital readmission rates compared to in-person visits. These findings suggest that telemedicine visits are a safe and viable alternative for post-hospitalization follow-up care.
Article
Cardiac & Cardiovascular Systems
Elisabetta Salvioni, Alice Bonomi, Damiano Magri, Marco Merlo, Beatrice Pezzuto, Mattia Chiesa, Massimo Mapelli, Nikita Baracchini, Gianfranco Sinagra, Massimo Piepoli, Piergiuseppe Agostoni
Summary: Cardiopulmonary exercise tests (CPET) are crucial for evaluating the functional capacity of chronic heart failure (HF) patients. The MECKI score, developed by a group of Italian centers skilled in HF management and CPET analysis, has been extensively validated and shown to be effective in risk stratification for HF. The MECKI score research group has grown over time and is now investigating other areas such as cardiomyopathy.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Arianne Clare Agdamag, Erik H. H. Van Iterson, W. H. Wilson Tang, J. Emanuel Finet
Summary: Heart failure is a complex syndrome with diverse presentations and severity. Current prognostic markers, such as left ventricular ejection fraction, have limitations in accurately predicting outcomes and guiding management decisions. Metabolic exercise testing, which evaluates multisystem responses and aerobic capacity during exercise, provides a more comprehensive and reliable assessment, especially in heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Pilar Lopez-Diez, Aitor Alquezar-Arbe, Javier Jacob, Pere Llorens, Lluis Llauger, Pablo Herrero, Victor Gil, Julio Nunez, Francisco Javier Martin-Sanchez, Oscar Miro
Summary: This study investigated whether the existence of heart failure units (HFU) and link nurse units (LNU) in the hospital improve short-term outcomes of acute heart failure (AHF) episodes. The results showed that the complete development of these follow-up units was not associated with 30-day mortality but was associated with less prolonged hospitalization and fewer post-discharge adverse events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Kartik S. Telukuntla, Chetan P. Huded, Mingyuan Shao, Tim Sobol, Mouin Abdallah, Kathleen Kravitz, Michael Hulseman, Benico Barzilai, Randall C. Starling, Lars G. Svensson, Steven E. Nissen, Umesh N. Khot
Summary: An EMR-based appointment order for follow-up appointment scheduling was associated with increased cardiovascular medicine follow-up, but was not associated with an observed reduction in 30-day readmission rates.
NPJ DIGITAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mohammad Mostafa Ansari Ramandi, Joost P. van Melle, Thomas M. Gorter, Elke S. Hoendermis, Dirk J. van Veldhuisen, Jan F. Nauta, Martje H. L. van der Wal, Janke Warink-Riemersma, Adriaan A. Voors, Michael G. Dickinson
Summary: This study found that more than one-third of patients with new-onset heart failure have right ventricular dysfunction (RVD), which is associated with poor prognosis. Up-titration of guideline-directed medical therapy can improve right ventricular function and is associated with improved clinical outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Critical Care Medicine
Elisabetta Salvioni, Massimo Mapelli, Alice Bonomi, Damiano Magri, Massimo Piepoli, Maria Frigerio, Stefania Paolillo, Ugo Corra, Rosa Raimondo, Rocco Lagioia, Roberto Badagliacca, Pasquale Perrone Filardi, Michele Senni, Michele Correale, Mariantonietta Cicoira, Enrico Perna, Marco Metra, Marco Guazzi, Giuseppe Limongelli, Gianfranco Sinagra, Gianfranco Parati, Gaia Cattadori, Francesco Bandera, Maurizio Bussotti, Federica Re, Carlo Vignati, Carlo Lombardi, Angela B. Scardovi, Susanna Sciomer, Andrea Passantino, Michele Emdin, Claudio Passino, Caterina Santolamazza, Davide Girola, Denise Zaffalon, Fabiana De Martino, Piergiuseppe Agostoni
Summary: In patients with HF, reporting AT based on (V˙O2AT%peak_pred) is the best way to predict prognosis, with prognostic power comparable to peak (V˙O2), especially in patients with severe HF.
Article
Cardiac & Cardiovascular Systems
Ryuichi Matsukawa, Seigo Masuda, Hirohide Matsuura, Hiroka Nakashima, Hiroshi Ikuta, Kousuke Okabe, Arihide Okahara, Shunsuke Kawai, Masaki Tokutome, Tomoyuki Tobushi, Yasushi Mukai
Summary: The study suggests that early outpatient follow-up after discharge in patients with congestive heart failure may improve long-term prognosis by reducing readmission rates and composite adverse outcomes. These positive outcomes appear to not be solely dependent on medication adjustments but on early modification of patient factors post-discharge.
Article
Cardiac & Cardiovascular Systems
Emanuele Accalai, Carlo Vignati, Elisabetta Salvioni, Beatrice Pezzuto, Mauro Contini, Christian Cadeddu, Luigi Meloni, Piergiuseppe Agostoni
Summary: In heart failure patients, oxygen uptake and cardiac output measurements during exercise are important for defining severity and prognosis. The relationship between oxygen pulse and measured stroke volume is strong during exercise, but varies at rest. Stroke volume estimation during exercise can represent stroke volume for population studies, but direct measurement may be needed for individual subjects.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Giulia Elena Mandoli, Maria Barilli, Davide Soviero, Nicolo Ghionzoli, Federico Landra, Massimo Maccherini, Sonia Bernazzali, Benedetta Maria Natali, Marta Focardi, Luna Cavigli, Flavio D'Ascenzi, Maria Concetta Pastore, Carlotta Sciaccaluga, Tonino Bombardini, Serafina Valente, Matteo Cameli
Summary: In this study, the outcomes of recipients who received marginal donor hearts selected by dipyridamole stress echocardiography were compared to those who received acceptable donor hearts. The results showed that transplanting marginal donor hearts through a non-invasive bedside technique can alleviate the shortage of organs without affecting survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Nathalie Van Aerde, Philippe Meersseman, Yves Debaveye, Alexander Wilmer, Michael P. Casaer, Jan Gunst, Joost Wauters, Pieter J. Wouters, Kaatje Goetschalckx, Rik Gosselink, Greet Van den Berghe, Greet Hermans
Summary: The study evaluated aerobic exercise capacity in 5-year ICU survivors and found that they generally had lower exercise capacity, often with muscular limitation. Severity of organ failure during ICU stay was independently associated with impairments in exercise capacity.
INTENSIVE CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Atsushi Shibata, Yasuhiro Izumiya, Yumi Yamaguchi, Ryoko Kitada, Shinichi Iwata, Shoichi Ehara, Yasukatsu Izumi, Akihisa Hanatani, Minoru Yoshiyama
Summary: The study found that elevated oxidative stress marker levels after cardiopulmonary exercise testing were associated with poor prognosis in patients with heart failure, with Delta d-ROM being an independent prognostic factor for adverse events in HF patients.
Article
Cardiac & Cardiovascular Systems
Eva M. Boorsma, Jozine M. Ter Maaten, Kevin Damman, Bart J. van Essen, Faiez Zannad, Dirk J. van Veldhuisen, Nilesh J. Samani, Kenneth Dickstein, Marco Metra, Gerasimos Filippatos, Chim C. Lang, Leong Ng, Stefan D. Anker, John G. Cleland, Pierpaolo Pellicori, Ron T. Gansevoort, Hiddo J. L. Heerspink, Adriaan A. Voors, Johanna E. Emmens
Summary: Albuminuria is common in patients with heart failure and is associated with clinical symptoms and biomarkers of congestion. It is also related to the severity and prognosis of heart failure.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Luis M. Ruilope, Alberto Ortiz, Alejandro Lucia, Blanca Miranda, Gloria Alvarez-Llamas, Maria G. Barderas, Massimo Volpe, Gema Ruiz-Hurtado, Bertram Pitt
Summary: Chronic kidney disease (CKD) is a leading cause of death that requires early detection for effective management. The current diagnostic criteria for CKD only identify advanced stages, leaving a 'blind spot' in detection where kidney injury is present but undetectable. Elevated urinary albumin-excretion rate can predict future cardiovascular events. Implementing opportunistic or systematic albuminuria screening and therapy has the potential to improve cardiorenal outcomes and mitigate the projected burden of CKD and cardiovascular diseases in the future.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Lucas Lauder, Felix Mahfoud, Michel Azizi, Deepak L. Bhatt, Sebastian Ewen, Kazuomi Kario, Gianfranco Parati, Patrick Rossignol, Markus P. Schlaich, Koon K. Teo, Raymond R. Townsend, Costas Tsioufis, Michael A. Weber, Thomas Weber, Michael Boehm
Summary: Arterial hypertension is a leading cause of death worldwide, with increasing incidence due to aging, obesity, socioeconomic and environmental changes. Lifestyle modifications and antihypertensive drugs are recommended for lowering blood pressure and reducing cardiovascular morbidity and mortality. New drugs and treatments improve cardiovascular and renal outcomes. Comorbidities often complicate management of hypertension.
EUROPEAN HEART JOURNAL
(2023)
Article
Environmental Sciences
Cristina Mennitti, Annaluisa Ranieri, Ersilia Nigro, Lorella Tripodi, Mariarita Brancaccio, Jacopo Ulisse, Luca Gentile, Fabio Fimiani, Arturo Cesaro, Giovanni D'Alicandro, Giuseppe Limongelli, Aurora Daniele, Raffaela Pero, Giulia Frisso, Paolo Calabro, Lucio Pastore, Maria Rosaria Licenziati, Olga Scudiero, Barbara Lombardo
Summary: This study evaluated the differences in biochemical parameters between obese children who engage in physical exercise and sedentary obese children. It found that physical exercise reduces the inflammatory state in obese children and identified a panel of biomarkers that can help prevent obesity-related complications.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Medicine, General & Internal
Francesca Dongiglio, Emanuele Monda, Giuseppe Palmiero, Federica Verrillo, Marta Rubino, Gaetano Diana, Annapaola Cirillo, Adelaide Fusco, Erica Vetrano, Michele Lioncino, Martina Caiazza, Giuseppe Cerciello, Laura Capodicasa, Flavia Chiosi, Vincenzo Simonelli, Maria Luisa De Rimini, Francesco Natale, Alessandro Di Santo, Elisabetta Moscarella, Paolo Calabro, Giuseppe Limongelli
Summary: Gastrointestinal involvement is common in systemic amyloidosis patients, leading to debilitating symptoms, nutrient deficiencies, and indicating disease severity. However, diagnosing gastrointestinal involvement in patients with isolated symptoms is challenging. The nutritional status in systemic amyloidosis is crucial and considered a significant prognostic factor, but defining it remains difficult due to the lack of standardized thresholds in specific populations. This review aims to provide insight into the fundamental steps of nutritional assessment using clinical and instrumental tools for improved prognostic stratification and patient management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Geza Halasz, Francesco Bandera, Massimo Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ovidiu Chioncel, Lina Benson, Maria G. Crespo-Leiro, Stefan D. Anker, Andrew J. S. Coats, Gerasimos Filippatos, Theresa McDonagh, Cornelia Margineanu, Alexandre Mebazaa, Marco Metra, Massimo F. Piepoli, Marianna Adamo, Giuseppe M. C. Rosano, Frank Ruschitzka, Gianluigi Savarese, Petar Seferovic, Maurizio Volterrani, Roberto Ferrari, Aldo P. Maggioni, Lars H. Lund
Summary: This study investigates the prevalence and associations of non-cardiac comorbidities (NCCs) with in-hospital and post-discharge outcomes in acute heart failure (AHF) patients with different ejection fraction (EF) categories. Multiple NCCs are associated with poor outcomes, and the association between individual comorbidities and post-discharge outcomes varies among different EF categories, suggesting the need for specific multidisciplinary management programs for different comorbidities in post-discharge phase.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Genetics & Heredity
Stefania Lenarduzzi, Beatrice Spedicati, Beatrice Alessandrini, Paola Tesolin, Alessia Paldino, Marta Gigli, Gianfranco Sinagra, Paolo Gasparini, Matteo Dal Ferro, Giorgia Girotto
Summary: This study focuses on the genetic characterization of hereditary cardiovascular diseases, including cardiomyopathies, channelopathies, and aortopathies and pulmonary arterial hypertension. The majority of patients analyzed in this study were affected by cardiomyopathies, and a higher detection rate was observed in familial forms compared to sporadic cases. Further clinical follow-up and reevaluation of genetic data will be necessary for patients with negative results.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Davide Stolfo, Lars H. Lund, Gianfranco Sinagra, Felix Lindberg, Ulf Dahlstrom, Giuseppe Rosano, Gianluigi Savarese
Summary: This study found that predictors of renin-angiotensin system inhibitors/angiotensin receptor neprilysin inhibitors (RASI/ARNI) and beta-blockers use in heart failure patients include hypertension, younger age, outpatient care, and specialty treatment. The use of these medications was associated with lower risk of cardiovascular mortality/hospitalization and all-cause mortality in a matched cohort. Positive control analysis confirmed these findings, and there were no associations with the negative control outcome.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Letter
Cardiac & Cardiovascular Systems
Alberto Guarnaccia, Gianfranco Sinagra, John G. F. Cleland
Article
Cardiac & Cardiovascular Systems
Nathan Green, Yang Chen, Constantinos O'Mahony, Perry M. Elliott, Roberto Barriales-Villa, Lorenzo Monserrat, Aristides Anastasakis, Elena Biagini, Juan Ramon Gimeno, Giuseppe Limongelli, Menelaos Pavlou, Rumana Z. Omar
Summary: This study provides a contemporary cost-effectiveness analysis of using implantable cardioverter defibrillators (ICDs) for primary prevention in patients with hypertrophic cardiomyopathy (HCM). The researchers found that using a 5-year sudden cardiac death (SCD) risk threshold of 6% was cheaper and had marginally better total quality adjusted life years (QALYs) compared to current practice. The main factors driving this decision are the health-related quality of life (HRQL) attributed to ICD patients and the time horizon.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Sport Sciences
Dominique Hansen, Paul Beckers, Daniel Neunhaeuserer, Birna Bjarnason-Wehrens, Massimo F. Piepoli, Bernhard Rauch, Heinz Voeller, Ugo Corra, Esteban Garcia-Porrero, Jean-Paul Schmid, Michel Lamotte, Patrick Doherty, Rona Reibis, Josef Niebauer, Paul Dendale, Constantinos H. Davos, Evangelia Kouidi, Martijn A. Spruit, Luc Vanhees, Veronique Cornelissen, Frank Edelmann, Olga Barna, Christoph Stettler, Cajsa Tonoli, Eugenio Greco, Roberto Pedretti, Ana Abreu, Marco Ambrosetti, Simona Sarzi Braga, Maurizio Bussotti, Pompilio Faggiano, Tim Takken, Carlo Vigorito, Bernhard Schwaab, Karin Coninx
Summary: This study developed a digital training and decision support system (EXPERT tool) for exercise prescription in patients with CCS and/or CHF. The tool takes into account different risk factors, comorbidities, and cardiac devices to formulate personalized exercise prescriptions. Three patient cases are presented to demonstrate the application of the EXPERT tool.
Meeting Abstract
Cardiac & Cardiovascular Systems
Christos Kapelios, Lina Benson, Maria Generosa Crespo-Leiro, Stefan D. Anker, Andrew J. S. Coats, Gerasimos S. Filippatos, Mitja J. Lainscak, Theresa McDonagh, Alexandre Mebazaa, Marco Metra, Massimo Francesco Piepoli, Giuseppe Rosano, Frank Thomas Ruschitzka, Gianluigi Savarese, Petar M. Seferovic, Maurizio Volterrani, Aldo Pietro Maggioni, Lars Lund
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Chiara Oriecuia, Daniela Tomasoni, Isabella Sala, Giovanni Battista Bonfioli, Marianna Adamo, Cristina Gussago, Carlo Mario Lombardi, Matteo Pagnesi, Gianluigi Savarese, Marco Metra, Claudia Specchia
Summary: In patients with HF, regardless of their LVEF and clinical status, the addition of SGLT2i to SOC showed a significant improvement in quality of life as early as at 3-month follow-up.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cell & Tissue Engineering
Satsuki Yamada, Jozef Bartunek, Thomas J. Povsic, Gad Cotter, Beth A. Davison, Christopher Edwards, Atta Behfar, Marco Metra, Gerasimos S. Filippatos, Marc Vanderheyden, William Wijns, Andre Terzic
Summary: Patients with heart failure often experience limitations in daily activities and poor quality of life. This study found that cell therapy can significantly improve the health-related quality of life in heart failure patients, particularly in those with pre-existing advanced left ventricular enlargement.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)