Article
Cardiac & Cardiovascular Systems
Patricia Garcia-Canadilla, Sergio Sanchez-Martinez, Pablo M. Marti-Castellote, Cameron Slorach, Wei Hui, Gemma Piella, Ainhoa M. Aguado, Mariana Nogueira, Luc Mertens, Bart H. Bijnens, Mark K. Friedberg
Summary: This study used interpretable machine-learning to analyze left ventricular remodeling, mechanics, systolic and diastolic function, as well as clinical characteristics and heart failure treatment in pediatric dilated cardiomyopathy (DCM). The results identified clinically distinct groups with different proportions of death or heart transplant (DoT). The findings suggest that interpretable machine-learning can potentially identify high-risk pediatric DCM patients and provide insights into the associated mechanisms.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Cardiac & Cardiovascular Systems
Seth J. Rotz, Thomas D. Ryan, Salim S. Hayek
Summary: Hematopoietic stem cell transplantation is a potentially curative treatment for various diseases, but it can also lead to significant cardiovascular complications that require pre-transplant evaluation.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Jared J. Herr, Ashwin Ravichandran, Farooq H. Sheikh, Anuradha Lala, Christopher V. Chien, Stephanie Hsiao, Ajay Srivastava, Dawn Pedrotty, Jennifer Nowaczyk, Shannon Tompkins, Sara Ahmed, Fei Xiang, Stephen Forest, Michael Z. Tong, Benjamin D'souza
Summary: The majority of referrals for advanced heart failure therapies came from heart failure cardiologists, with a prevalence of late referrals in high-risk patients. Patients referred by heart failure cardiologists were more likely to be offered AHF therapies. Late referrals correlated with worsened outcomes, highlighting the need for education among clinicians regarding the benefits and appropriate timing of referrals to AHF centers.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Marco Merlo, Marco Mase, Andrew Perry, Eluisa La Franca, Elena Deych, Laura Ajello, Diego Bellavia, Andrea Boscutti, Marco Gobbo, Giuseppe Romano, Davide Stolfo, John Gorcsan, Francesco Clemenza, Gianfranco Sinagra, Luigi Adamo
Summary: In patients with non-ischaemic dilated cardiomyopathy (NICM) and normalised left ventricular ejection fraction (LVEF), an impaired absolute global longitudinal strain (aGLS) at the time of LVEF recovery is common and associated with worse outcomes.
Article
Cardiac & Cardiovascular Systems
Amam C. Mbakwem, Johann Bauersachs, Charle Viljoen, Julian Hoevelmann, Peter van der Meer, Mark C. Petrie, Alexandre Mebazaa, Sorel Goland, Kamilu Karaye, Cecile Laroche, Karen Sliwa
Summary: In peripartum cardiomyopathy (PPCM) patients, ECG abnormalities are common, with sinus tachycardia predicting poor systolic function and wide QRS, left bundle branch block (LBBB), and left ventricular hypertrophy (LVH) associated with left ventricular dilatation.
Article
Medicine, General & Internal
Mon Myat Oo, Isaiah Tan Chung Zhen, Kee Seong Ng, Kok Leng Tan, Alexander T. B. Tan, Shireene Ratna Vethakkan, R. Jeyakantha A L Ratnasingam, Kok Han Chee
Summary: The study identified a high prevalence of stage B heart failure in patients with type 2 diabetes without a history of cardiovascular disease in Malaysia. Most participants were female, with a mean body mass index of 27.5 kg/m(2). A large proportion of patients had a history of hypertension and had been living with type 2 diabetes for more than 10 years. Diastolic dysfunction, increased left ventricular mass index, and increased left atrial volume index were common among the study population. Newer anti-diabetes agents were also frequently used in this group.
Review
Cardiac & Cardiovascular Systems
Luke C. Pickup, Jonathan P. Law, Ashwin Radhakrishnan, Anna M. Price, Charalampos Loutradis, Toby O. Smith, Nicola C. Edwards, Richard P. Steeds, Jonathan N. Townend, Charles J. Ferro
Summary: The study aimed to investigate if uraemic cardiomyopathy can be reversed by renal transplantation. Findings from meta-analyses of various studies suggested that there was no significant difference in left ventricular mass index, ejection fraction, or end-diastolic volume after transplantation. However, methodological weaknesses in the evidence should be taken into consideration when interpreting these results.
Article
Cardiac & Cardiovascular Systems
Pascal Amedro, Marie Vincenti, Hamouda Abassi, Nicolas Lanot, Gregoire De La Villeon, Sophie Guillaumont, Lucie Gamon, Thibault Mura, Karine Lopez-Perrin, Stephany Haouy, Anne Sirvent, Olivier Cazorla, Laurence Vergely, Alain Lacampagne, Martina Avesani, Nicolas Sirvent, Laure Saumet
Summary: In childhood cancer survivors, speckle tracking echocardiography (STE) detects altered myocardial strain despite normal left ventricular (LV) function, highlighting the importance of monitoring cardiomyopathy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Tae-Min Rhee, You-J Ung Choi, In-Chang Hwang, Yeonyee E. Yoon, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Goo-Yeong Cho
Summary: LARS can be used to categorize LV diastolic function and predict HF events in patients with hypertrophic cardiomyopathy.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Maciej Stapor, Adam Pilat, Andrzej Gackowski, Agnieszka Misiuda, Izabela Gorkiewicz-Kot, Michal Kaleta, Pawel Kleczynski, Krzysztof Zmudka, Jacek Legutko, Boguslaw Kapelak, Karol Wierzbicki
Summary: This study evaluates the feasibility of physiological pump speed optimization based on aortic valve opening (AVO) imaging during a cardiopulmonary exercise test (CPET) in LVAD patients. The results show that dynamic echo-guided pump speed adjustment based on AVO improves exercise tolerance and augments peak oxygen consumption and maximum workload.
Article
Cardiac & Cardiovascular Systems
Sanchi Malhotra, Imran Masood, Noberto Giglio, Jay D. Pruetz, Pia S. Pannaraj
Summary: Pediatric cardiologists in the U.S. have limited experience with Chagas disease, with most not testing or including it in their differential diagnosis. Most individuals believe that education on Chagas disease would be beneficial.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Rodrigo Cordovil Pinto Lobo da Costa, Ana Clara Tude Rodrigues, Marcelo Luiz Campos Vieira, Claudio Henrique Fischer, Claudia Gianini Monaco, Edgar Bezerra Lira Filho, Fernando Bacal, Adriano Caixeta, Samira Saady Morhy
Summary: Ventricular strain, three-dimensional left ventricular ejection fraction, and desynchrony index were not associated with rejection, whether cellular or humoral. However, left ventricle posterior wall thickness and left ventricle mass index showed evidence of association with graft rejection.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Barry J. Maron, Ethan J. Rowin, Shray P. Ambe, Martin S. Maron
Summary: This study found that patients with hypertrophic cardiomyopathy are now older and more likely to have outflow obstruction compared to previous years. However, the maximum left ventricular wall thickness has decreased. These observations may impact disease recognition and diagnostic criteria.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Teruhiko Imamura, Hiroshi Onoda, Keisuke Uchida, Koichiro Kinugawa
Summary: This study aims to investigate the role of ivabradine in up-titrating betablockers to improve clinical outcomes in patients with systolic dysfunction. The results will provide valuable information for gradually increasing the dose of beta-blockers in clinical practice.
INTERNATIONAL HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Agnieszka Ciarka, Filipa Cordeiro, Walter Droogne, Johan Van Cleemput, Jens-Uwe Voigt
Summary: This study aimed to investigate if echocardiographic parameters can detect and predict acute cellular rejection (ACR) or antibody-mediated rejection (AMR) in heart transplant patients. The results showed that patients with rejection had lower values of global longitudinal strain (GLS), global circumferential strain (GCS), and left ventricular ejection fraction (LVEF) compared to controls during acute rejection episode. Interestingly, patients with AMR showed a progressive decline of GLS and GCS in the months preceding acute rejection.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Pediatrics
Humera Ahmed, Joanne Lee, Daniel Bernstein, David Rosenthal, John Dykes, Donna Lee, Lynsey Barkoff, Kenneth Weinberg, Seth A. Hollander, Sharon Chen
Summary: Fontan patients have a higher risk of infection after heart transplantation compared to DCM patients, and modifications to induction therapy for Fontan patients should be considered.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Elif Seda Selamet Tierney, Latha Palaniappan, Mary Leonard, Jin Long, Jonathan Myers, Tania Davila, Mavis C. Lui, Feliks Kogan, Inger Olson, Rajesh Punn, Manisha Desai, Lauren M. Schneider, Chih-Hung Wang, John P. Cooke, Daniel Bernstein
Summary: In this manuscript, the design and rationale of a randomized controlled trial in pediatric Fontan patients are described. It aims to test the hypothesis that a live-video-supervised exercise intervention can improve cardiac and physical capacity, muscle mass, strength, and function, and endothelial function.
AMERICAN HEART JOURNAL
(2023)
Article
Surgery
Olivia M. Martinez, Sheri M. Krams, Mark A. Robien, Mary G. Lapasaran, Matthew P. Arvedson, Andrea Reitsma, Yarl Balachandran, Aleishia Harris-Arnold, Kenneth Weinberg, Scott D. Boyd, Brian Armstrong, Amber Trickey, Clare J. Twist, Dita Gratzinger, Brent Tan, Merideth Brown, Clifford Chin, Dev M. Desai, Thomas M. Fishbein, George V. Mazariegos, Akin Tekin, Robert S. Venick, Daniel Bernstein, Carlos O. Esquivel
Summary: EBV-positive PTLD in pediatric transplant recipients is associated with significant morbidity and mortality. Identifying individuals at increased risk of EBV-positive PTLD can inform clinical management and improve posttransplant outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan H. Soslow, Meng Xu, James C. Slaughter, Kimberly Crum, Jacob A. Kaslow, Kristen George-Durrett, Frank J. Raucci Jr, James D. Wilkinson, Linda H. Cripe, Kan N. Hor, Christopher F. Spurney, Larry W. Markham
Summary: This study evaluated the rate of change for cardiac magnetic resonance and blood biomarkers and identified the measures associated with all-cause mortality in Duchenne muscular dystrophy (DMD). The results showed that LV ejection fraction, indexed LV volumes, circumferential strain, late gadolinium enhancement full width half maximum, and NT-proBNP were associated with all-cause mortality in DMD and may be the best end points for use in cardiovascular therapeutic trials. The study also reported the change over time of cardiac magnetic resonance and blood biomarkers.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Riddhita Mukherjee, Laura H. Tetri, Sin-Jin Li, Giovanni Fajardo, Nicolai P. Ostberg, Kaleb B. Tsegay, Kanika Gera, Timothy T. Cornell, Daniel Bernstein, Daria Mochly-Rosen, Bereketeab Haileselassie
Summary: This study investigates the role of Drp1/p53 interaction in sepsis-induced myocardial dysfunction (SIMD). The results show that there is an increase in Drp1/p53 interaction following LPS treatment, leading to p53 localization to the mitochondria and mitochondrial dysfunction. Inhibiting the Drp1/p53 interaction can improve mitochondrial damage in SIMD.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Brian Hsueh, Ritchie Chen, YoungJu Jo, Daniel Tang, Misha Raffiee, Yoon Seok Kim, Masatoshi Inoue, Sawyer Randles, Charu Ramakrishnan, Sneha Patel, Doo Kyung Kim, Tony X. Liu, Soo Hyun Kim, Longzhi Tan, Leili Mortazavi, Arjay Cordero, Jenny Shi, Mingming Zhao, Theodore T. Ho, Ailey Crow, Ai-Chi Wang Yoo, Cephra Raja, Kathryn Evans, Daniel Bernstein, Michael Zeineh, Maged Goubran, Karl Deisseroth
Summary: Emotional states influence bodily physiology, and it is unclear whether an increased heart rate can induce anxiety responses. Using noninvasive optogenetic methods, researchers found that optically induced tachycardia enhances anxiety-like behavior, suggesting that both central and peripheral processes are involved in the development of emotional states.
Article
Cardiac & Cardiovascular Systems
Min Young Jang, Parth N. Patel, Alexandre C. Pereira, Jon A. L. Willcox, Alireza Haghighi, Angela C. Tai, Kaoru Ito, Sarah U. Morton, Joshua M. Gorham, David M. McKean, Steven R. DePalma, Daniel Bernstein, Martina Brueckner, Wendy K. Chung, Alessandro Giardini, Elizabeth Goldmuntz, Jonathan R. Kaltman, Richard Kim, Jane W. Newburger, Yufeng Shen, Deepak Srivastava, Martin Tristani-Firouzi, Bruce D. Gelb, Jr George A. Porter, Christine E. Seidman, Jonathan G. Seidman
Summary: This study aims to improve the diagnostic classification of genetic variants in patients with congenital heart disease (CHD) by assessing the impact of noncanonical splice region variants on RNA splicing. The results show that through the assessment of RNA splicing, a new loss-of-function variant within a CHD gene was identified in 78 probands, of whom 69 did not have a previously established genetic explanation for CHD.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Meeting Abstract
Biophysics
Daniel Bernstein, Alison S. Vander Roest, Sean Wu, Beth Pruitt, Mingming Zhao, Giovanni Fajardo, Kathleen Ruppel, James A. Spudich
BIOPHYSICAL JOURNAL
(2023)
Meeting Abstract
Biophysics
Prerna Giri, Alison S. Vander Roest, Soah Lee, Paul Heinrich, Alexander R. Dunn, Sean Wu, Daniel Bernstein
BIOPHYSICAL JOURNAL
(2023)
Meeting Abstract
Biophysics
Alison S. Vander Roest, James A. Spudich, Kathleen Ruppel, Michael Regnier, Daniel Bernstein
BIOPHYSICAL JOURNAL
(2023)
Meeting Abstract
Pediatrics
Tetsuya Tajima, Daniel Bernstein, Scott D. Boyd, Dita Gratzinger, Grant Lum, Kazunari Sasaki, Brent Tan, Clare J. Twist, Kenneth Weinberg, Mark A. Robien, Merideth Brown, Brian Armstrong, Dev Desai, George Mazariegos, Clifford Chin, Thomas M. Fishbein, Akin Tekin, Robert S. Venick, Olivia M. Martinez, Sheri M. Krams, Carlos O. Esquivel
PEDIATRIC TRANSPLANTATION
(2023)
Meeting Abstract
Critical Care Medicine
Laura Tetri, Riddhita Mukherjee, Sin Jin Li, Giovanni Fajardo, Nicolai Ostberg, Kaleb Tsegay, Kanika Gera, Timothy Cornell, Daniel Bernstein, Daria Mochly-Rosen, Bereketeab Haileselassie
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Surgery
T. Tajima, A. Gallo, D. Bernstein, C. Bonham, S. Boyd, D. Gratzinger, S. M. Krams, G. Lum, K. Sasaki, B. Tan, K. Weinberg, B. Armstrong, M. Brown, C. Chin, D. Desai, T. Fishbein, G. Mazariegos, M. Robien, A. Tekin, C. Twist, R. Venick, O. M. Martinez, C. O. Esquivel
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
T. Tajima, D. Bernstein, S. Boyd, D. Gratzinger, G. Lum, K. Sasaki, B. Tan, C. Twist, K. Weinberg, M. Robien, M. Brown, B. Armstrong, D. Desai, G. Mazariegos, C. Chin, T. Fishbein, A. Tekin, R. Venick, O. M. Martinez, S. M. Krams, C. O. Esquivel
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Medicine, Research & Experimental
Thomas A. Miller, Edgar J. Hernandez, J. William Gaynor, Mark W. Russell, Jane W. Newburger, Wendy Chung, Elizabeth Goldmuntz, James F. Cnota, Sinai C. Zyblewski, William T. Mahle, Victor Zak, Chitra Ravishankar, Jonathan R. Kaltman, Brian W. Mccrindle, Shanelle Clarke, Jodie K. Votava-Smith, Eric M. Graham, Mike Seed, Nancy Rudd, Daniel Bernstein, Teresa M. Lee, Mark Yandell, Martin Tristani-Firouzi
Summary: This study used Bayesian Networks to analyze the relationships between clinical, demographic, and genetic variables in children with single ventricle CHD. The results showed that damaging genetic variants and prolonged ventilator support after surgery can individually increase the probability of low MDI scores, and the combination of these variables has a synergistic effect on the probability of a low MDI score. Conversely, the absence of damaging variants and shorter post-operative ventilator support can increase the probability of a normal MDI score and a good outcome. These findings highlight the importance of considering the impact of genetic variants in the context of other clinical and demographic factors.
COMMUNICATIONS MEDICINE
(2023)