Article
Mathematical & Computational Biology
Kristen B. Hunter, Mark E. Glickman, Luis F. Campos
Summary: Medication adherence is a widespread concern in clinical care. Researchers have developed an approach to infer medication adherence rates based on longitudinally recorded health measures. This method can predict patients' adherence to medication and includes baseline health and socio-demographic data as reference. The approach has been applied and evaluated in a cohort of hypertensive patients.
STATISTICS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Constance P. Fontanet, Niteesh K. Choudhry, Thomas Isaac, Thomas D. Sequist, Chandrasekar Gopalakrishnan, Joshua J. Gagne, Cynthia A. Jackevicius, Michael A. Fischer, Daniel H. Solomon, Julie C. Lauffenburger
Summary: Pharmacy fill data may serve as an effective alternative to insurer claims data for measuring medication adherence. Although pharmacy fill data predicted better disease control slightly more than claims-based data, the difference was not significant.
HEALTH SERVICES RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Aikaterini Kassavou, Charlotte A. Court, Venus Mirzaei, James Brimicombe, Simon Edwards, Stephen Sutton
Summary: The digital intervention was found to be effective at improving medication adherence in non-adherent patients with Hypertension or Type 2 Diabetes. Positive changes in underlying mechanisms of behavior change were associated with intervention effectiveness. Subjective accounts highlighted the support of motivation and ability to adhere, with brief medication adherence risk appraisal and ongoing digitally delivered behavioral support recommended for clinical impact.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Akshaya Srikanth Bhagavathula, Syed Mahboob Shah, Elhadi Husein Aburawi
Summary: The study found a high prevalence of TRH among newly treated hypertensive patients in the UAE, with suboptimal medication adherence and blood pressure control among participants, highlighting the urgent need for greater efforts to improve adherence to antihypertensive therapy and focus on TRH and blood pressure control.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Alberta L. Warner, Lingyun Lu, Zunera Ghaznavi, Cynthia A. Jackevicius
Summary: This study evaluated the achievement of 2020 American College of Cardiology/AHA performance measures for heart failure in a contemporary cohort of patients. Results showed good adherence to some key treatment performance measures within the Veterans Affairs hospital system, but also highlighted treatment gaps and site-level differences.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Medicine, General & Internal
Patrick J. Campbell, David R. Axon, Ann M. Taylor, Karen Smith, Matthew Pickering, Heather Black, Terri Warholak, Chanadda Chinthammit
Summary: Limited evidence exists on the relationships between adherence, healthcare utilization, and economic outcomes among Medicare Supplemental beneficiaries. This study aimed to assess the relationship between adherence and utilization and cost over a 1-year period, finding that adherence was associated with lower healthcare utilization and expenditures across different disease cohorts.
Article
Psychiatry
Quanjun Liu, Haochen Wang, Anbang Liu, Cheng Jiang, Weiya Li, Huan Ma, Qingshan Geng
Summary: Depression is marginally associated with poor medication adherence in hypertensive patients, and the correlation increases with the severity of depression. Moreover, socioeconomic/demographic factors have an independent impact on medication adherence.
Article
Oncology
Pauline Duerr, Katja Schlichtig, Carolin Kelz, Birgit Deutsch, Renke Maas, Michael J. Eckart, Jochen Wilke, Harald Wagner, Kerstin Wolff, Caroline Preuss, Valeska Brueckl, Norbert Meidenbauer, Christian Staerk, Andreas Mayr, Rainer Fietkau, Peter J. Goebell, Frank Kunath, Matthias W. Beckmann, Andreas Mackensen, Markus F. Neurath, Marianne Pavel, Frank Doerje, Martin F. Fromm
Summary: Treatment with oral anticancer drugs is associated with a wide range of medication errors and side effects. Intensified clinical pharmacological/pharmaceutical care has significant positive effects on reducing medication errors, improving patient treatment perception, and decreasing severe side effects.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Peripheral Vascular Disease
Niteesh K. Choudhry, Ian M. Kronish, Wanpen Vongpatanasin, Keith C. Ferdinand, Valory N. Pavlik, Brent M. Egan, Antoinette Schoenthaler, Nancy Houston Miller, David J. Hyman
Summary: The widespread treatment of hypertension and improvements in blood pressure have led to a decline in heart disease and stroke, but there is still a gap between public health targets and actual blood pressure control rates. Medication nonadherence is a key factor contributing to this gap, and the scientific statement aims to summarize its impact and strategies for improving adherence.
Article
Public, Environmental & Occupational Health
Yingchao Feng, Shuai Guan, Yanyun Xu, Wenqin Chen, Xianhong Huang, Xiaohe Wang, Meng Zhang
Summary: In rural China, treatment adherence of patients with hypertension is challenging. This study found that patient trust in primary care physicians' benevolence was positively correlated with medication adherence, dietary management, and physical activity. However, patient trust in PCPs' ability was negatively correlated with adherence to dietary management and physical activity.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Sara Malo, Isabel Aguilar-Palacio, Cristina Feja, Maria Jesus Lallana, Javier Armesto, Maria Jose Rabanaque
Summary: This study analyzed patterns of antihypertensive drug use among new users in a Southern European population, identifying factors that influence persistence. The results showed that overall persistence with antihypertensive therapy was poor and influenced by sex, age, and type of therapy. Fixed combinations were found to be effective for initial therapy, especially for patients at higher risk of discontinuation.
Review
Public, Environmental & Occupational Health
Simao Pinho, Mariana Cruz, Filipa Ferreira, Andre Ramalho, Rute Sampaio
Summary: The study conducted a scoping review of medication adherence interventions in hypertensive patients and developed an evidence-based categorization system for interventions. Through analyzing 45 articles, detailed evaluations were provided on research design, participant characteristics, adherence strategies, as well as medication adherence and blood pressure outcomes. This work is significant in advancing future research efforts and providing valuable information to clinicians.
PREVENTIVE MEDICINE
(2021)
Article
Nursing
Rachel Wilkinson, Evan Garden, Rose Clarke Nanyonga, Allison Squires, Florence Nakaggwa, Jeremy Schwartz, David J. Heller
Summary: This study aimed to understand the factors that affect patients' medication adherence for hypertension and explore the acceptability and feasibility of adherence interventions. The results showed that patients expressed strong interest in adherence clubs and educational materials.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Article
Health Care Sciences & Services
Michal Shani, Alex Lustman, Doron Comaneshter, Yochai Schonmann
Summary: This study found that individuals aged 50-74 with diabetes or hypertension who maintained higher levels of medication adherence were associated with fewer ER visits and hospitalizations.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Lea Wagmann, Aline C. Vollmer, Lucas Lauder, Felix Mahfoud, Markus R. Meyer
Summary: The study aimed to monitor adherence to antihypertensive medication by developing a quantification procedure for drug concentrations in blood plasma. Results showed that plasma concentration interpretation is more complex than urine screening but can effectively assess adherence. Further data is needed to determine if plasma quantification is superior in assessing adherence to antihypertensive medication.
Article
Obstetrics & Gynecology
Juhua Luo, Joann E. Manson, Michael Hendryx, Aladdin H. Shadyab, Karen C. Johnson, Paul C. Dinh, Scott B. Going, Rowan Chlebowski, Marcia L. Stefanick, Karen L. Margolis
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2019)
Article
Medicine, Research & Experimental
Beverly B. Green, Melissa L. Anderson, Jerry Campbell, Andrea J. Cook, Kelly Ehrlich, Sarah Evers, Yoshio N. Hall, Clarissa Hsu, Dwayne Joseph, Predrag Klasnja, Karen L. Margolis, Jennifer B. McClure, Sean A. Munson, Mathew J. Thompson
CONTEMPORARY CLINICAL TRIALS
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Paul Muntner, Paula T. Einhorn, William C. Cushman, Paul K. Whelton, Natalie A. Bello, Paul E. Drawz, Beverly B. Green, Daniel W. Jones, Stephen P. Juraschek, Karen L. Margolis, Edgar R. Miller, Ann Marie Navar, Yechiam Ostchega, Michael K. Rakotz, Bernard Rosner, Joseph E. Schwartz, Daichi Shimbo, George S. Stergiou, Raymond R. Townsend, Jeff D. Williamson, Jackson T. Wright, Lawrence J. Appel
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Correction
Geriatrics & Gerontology
John J. McNeil, Robyn L. Woods, Mark R. Nelson, Anne M. Murray, Christopher M. Reid, Brenda Kirpach, Elsdon Storey, Raj C. Shah, Rory S. Wolfe, Andrew M. Tonkin, Anne B. Newman, Jeff D. Williamson, Jessica E. Lockery, Karen L. Margolis, Michael E. Ernst, Walter P. Abhayaratna, Nigel Stocks, Sharyn M. Fitzgerald, Ruth E. Trevaks, Suzanne G. Orchard, Lawrence J. Beilin, Geoffrey A. Donnan, Peter Gibbs, Colin I. Johnston, Richard H. Grimm
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Peripheral Vascular Disease
Elyse O. Kharbanda, Steve E. Asche, Steven P. Dehmer, Alan R. Sinaiko, Heidi L. Ekstrom, Nicole Trower, Patrick J. O'Connor
JOURNAL OF CLINICAL HYPERTENSION
(2019)
Article
Endocrinology & Metabolism
Patrick J. O'Connor, JoAnn M. Sperl-Hillen
DIABETES TECHNOLOGY & THERAPEUTICS
(2019)
Article
Medicine, Research & Experimental
Nathalie Moise, Karina W. Davidson, Ying Kuen K. Cheung, Gregory N. Clarke, Rowena J. Dolor, Joan Duer-Hefele, Joseph A. Ladapo, Karen L. Margolis, Tara St Onge, Faith Parsons, Jessica Retuerto, Kristine M. Schmit, Anusorn Thanataveerat, Ian M. Kronish
CONTEMPORARY CLINICAL TRIALS
(2019)
Article
Peripheral Vascular Disease
Karen L. Margolis, Steven P. Dehmer, JoAnn Sperl-Hillen, Patrick J. O'Connor, Stephen E. Asche, Anna R. Bergdall, Beverly B. Green, Rachel A. Nyboer, Pamala A. Pawloski, Nicole K. Trower, Michael V. Maciosek
Article
Cardiac & Cardiovascular Systems
Michael E. Ernst, Joanne Ryan, Enayet K. Chowdhury, Karen L. Margolis, Lawrence J. Beilin, Christopher M. Reid, Mark R. Nelson, Robyn L. Woods, Raj C. Shah, Suzanne G. Orchard, Rory Wolfe, Elsdon Storey, Andrew M. Tonkin, Amy Brodtmann, John J. McNeil, Anne M. Murray
Summary: This study found that high blood pressure variability in older adults, especially in men, is associated with increased risks of dementia and cognitive decline.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Rebecca C. Rossom, Stephanie A. Hooker, Patrick J. O'Connor, A. Lauren Crain, Joann M. Sperl-Hillen
Summary: This study compares the estimated 10-year and 30-year cardiovascular risk in primary care patients with and without serious mental illness (SMI). The results show that patients with SMI have significantly higher cardiovascular risk compared to those without SMI, even in young adults. The main contributing risk factors are elevated body mass index and smoking. Addressing uncontrolled major cardiovascular risk factors at an early age is crucial for individuals with SMI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Peripheral Vascular Disease
Karen L. Margolis, Anna R. Bergdall, A. Lauren Crain, Meghan M. JaKa, Jeffrey P. Anderson, Leif Solberg, Joann Sperl-Hillen, MarySue Beran, Beverly B. Green, Patricia Haugen, Christine K. Norton, Amy J. Kodet, Rashmi Sharma, Deepika Appana, Nicole K. Trower, Pamala A. Pawloski, Daniel J. Rehrauer, Maria L. Simmons, Zeke J. McKinney, Thomas E. Kottke, Jeanette Y. Ziegenfuss, Rae Ann Williams, Patrick J. O'Connor
Summary: This study compared the effects of clinic-based care and telehealth care on reducing blood pressure and found that telehealth care can be an effective and safe alternative for improving patient-centered care for hypertension.
Article
Peripheral Vascular Disease
Sultana Monira Hussain, Michael E. Ernst, Anna L. Barker, Karen L. Margolis, Christopher M. Reid, Johannes T. Neumann, Andrew M. Tonkin, Thao Le Thi Phuong, Lawrence J. Beilin, Thao Pham, Enayet K. Chowdhury, Flavia M. Cicuttini, Julia F. M. Gilmartin-Thomas, Prudence R. Carr, John J. McNeil
Summary: Long-term variability in mean arterial pressure is associated with an increased risk of falls in frail or prefrail individuals taking antihypertensive medications. Beta-blocker monotherapy is associated with a higher risk of falls compared to calcium channel blockers.
Article
Medicine, Research & Experimental
Karen L. Margolis, A. Lauren Crain, Beverly B. Green, Patrick J. O'Connor, Leif Solberg, MarySue Beran, Anna R. Bergdall, Pamala A. Pawloski, Jeanette Y. Ziegenfuss, Meghan M. JaKa, Deepika Appana, Rashmi Sharma, Amy J. Kodet, Nicole K. Trower, Daniel J. Rehrauer, Zeke McKinney, Christine K. Norton, Patricia Haugen, Jeffrey P. Anderson, Benjamin F. Crabtree, Sarah K. Norman, Joann M. Sperl-Hillen
Summary: This study compared two trials and found that Hyperlink 1 was more explanatory while Hyperlink 3 was more pragmatic. The recruitment process and participant characteristics differed between the two trials, with Hyperlink 1 enrolling older, male, and White participants, and Hyperlink 3 enrolling younger, female, and non-White participants with lower socioeconomic indicators and more comorbidities.
Article
Health Care Sciences & Services
JoAnn M. Sperl-Hillen, Jeffrey P. Anderson, Karen L. Margolis, Rebecca C. Rossom, Kristen M. Kopski, Beth M. Averbeck, Jeanine A. Rosner, Heidi L. Ekstrom, Steven P. Dehmer, Patrick J. O'Connor
Summary: This study aimed to evaluate the impact of a shared decision-making system on factors influencing revenue generation in primary care clinics. The results showed that the use of the SDM system significantly increased the proportion of encounters assigned high-complexity (level 5) CPT codes.
JMIR FORMATIVE RESEARCH
(2022)