Article
Radiology, Nuclear Medicine & Medical Imaging
Seokhun Yang, Masahiro Hoshino, Bon-Kwon Koo, Taishi Yonetsu, Jinlong Zhang, Doyeon Hwang, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Jianan Wang, Shaoliang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Kubo, Hyuk-Jae Chang, Tsunekazu Kakuta, Jagat Narula
Summary: The study found that high-risk plaque features and plaque burden at coronary CT angiography were associated with coronary pressure and flow, and could independently predict the occurrence of cardiovascular events.
Review
Cardiac & Cardiovascular Systems
Zaheer Alisiddiq, Harish Sharma, James Cotton, Lampson Fan
Summary: Coronary physiological measurements have revolutionized the treatment of coronary artery disease, allowing for more precise and tailored therapy. Pressure wire guided revascularization has proven to be effective in influencing clinical outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Hironori Hara, Scot Garg, Hideyuki Kawashima, Bjarne L. Norgaard, Marc R. Dweck, Jeroen J. Bax, Juhani Knuuti, Koen Nieman, Jonathon A. Leipsic, Saima Mushtaq, Daniele Andreini, Yoshinobu Onuma
Summary: Coronary computed tomography angiography (CTA) has undergone significant technological advancements and is now considered a high-accuracy substitute for conventional invasive coronary angiography in diagnosing and making treatment decisions for patients with suspected coronary artery disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Alec Saunders, Nick Curzen
Summary: The use of coronary physiology testing in patients with chronic coronary syndromes varies greatly and the evidence base is complex. Traditional invasive tests have been used, but now there are new non-invasive methods available that provide additional anatomical information. This review examines the evidence for and against the value of these tests in patients being investigated for chest pain that may be due to chronic coronary syndromes and for those undergoing percutaneous coronary intervention.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmoud Mohamed, Maria Bosserdt, Viktoria Wieske, Benjamin Dubourg, Hatem Alkadhi, Mario J. Garcia, Sebastian Leschka, Elke Zimmermann, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Kristian A. Ovrehus, Axel C. P. Diederichsen, Juhani Knuuti, Bjrn A. Halvorsen, Vladymir Mendoza-Rodriguez, Yung-Liang Wan, Nuno Bettencourt, Eugenio Martuscelli, Ronny R. Buechel, Hans Mickley, Kai Sun, Simone Muraglia, Philipp A. Kaufmann, Bernhard A. Herzog, Jean-Claude Tardif, Georg M. Schuetz, Michael Laule, David E. Newby, Stephan Achenbach, Matthew Budoff, Robert Haase, Federico Biavati, Aldo Vasquez Mezquita, Peter Schlattmann, Marc Dewey
Summary: Combining coronary computed tomography angiography (CCTA) with coronary artery calcium (CAC) score can significantly improve the diagnosis of coronary artery disease (CAD). The addition of CAC score is particularly beneficial when CCTA alone is inconclusive.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maurizio Lodi Rizzini, Sakura Nagumo, Diego Gallo, Jeroen Sonck, Takuya Mizukami, Fabrizio D'Ascenzo, Dimitri Buytaert, Umberto Morbiducci, Bernard De Bruyne, Claudio Chiastra, Carlos Collet
Summary: The assessment of lesion length in coronary artery disease shows differences between morphological and functional evaluations. The mismatch in lesion length between angiography, OCT, and mFFR can affect the outcomes of PCI and may influence clinical decision-making regarding revascularization strategy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dominik Laskowski, Sarah Feger, Maria Bosserdt, Elke Zimmermann, Mahmoud Mohamed, Benjamin Kendziora, Matthias Rief, Henryk Dreger, Melanie Estrella, Marc Dewey
Summary: In this study, CTA detected clinically relevant ECFs that may explain chest pain in patients without CAD, whereas ICA did not. This suggests that CTA may eliminate the need for ICA in certain patients.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meiling Li, Runjianya Ling, Lihua Yu, Wenyi Yang, Zirong Chen, Dijia Wu, Jiayin Zhang
Summary: In this study, a deep learning model was developed for automated reconstruction of chronic total occlusion (CTO) imaging. The model significantly reduced postprocessing time and demonstrated excellent correlation and agreement in the assessment of occlusion features.
Article
Radiology, Nuclear Medicine & Medical Imaging
Natasa Javorszky, Balint Homonnay, Gary Gerstenblith, David Bluemke, Peter Kiss, Mihaly Torok, David Celentano, Hong Lai, Shenghan Lai, Marton Kolossvary
Summary: This study developed an open-source deep learning model for segmenting coronary plaques on coronary CT angiography. The model showed excellent performance in quantifying plaque volumes in both the test set and an external dataset, and transfer learning further improved the accuracy of the model.
EUROPEAN RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jelmer Westra, Laust Dupont Rasmussen, Ashkan Eftekhari, Simon Winther, Salma Raghad Karim, Jane Kirk Johansen, Osama Hammid, Hanne Maare Sondergaard, June Anita Ejlersen, Lars C. Gormsen, Lone Juul Hune Mogensen, Morten Bottcher, Niels Ramsing Holm, Evald Hoj Christiansen
Summary: This study compares the diagnostic performance of non-invasive QFR and invasive FFR in evaluating intermediate coronary artery stenosis. The results show that the wire-free QFR solution has similar diagnostic accuracy to invasive FFR, suggesting that QFR can be a feasible alternative for assessing the severity of coronary artery stenosis.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Medicine, General & Internal
Thomas P. W. van den Boogert, Bimmer E. P. M. Claessen, Adrienne van Randen, Joost van Schuppen, S. Matthijs Boekholdt, Marcel A. M. Beijk, M. Karlijn Vrijmoeth, Jan Baan, M. Marije Vis, Jacobus A. Winkelman, Antoine H. G. Driessen, Jaap Stoker, R. Nils Planken, Jose P. Henriques
Summary: CTCA as an initial imaging modality is feasible to rule out CAD in patients awaiting non-coronary cardiac surgery, cardiomyopathy, heart failure, and ventricular arrhythmias, with only 17% requiring additional CAG after initial CTCA. Revascularization procedures were infrequently performed in both groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gilberto J. Aquino, Andres F. Abadia, U. Joseph Schoepf, Tilman Emrich, Basel Yacoub, Ismail Kabakus, Alexis Violette, Courtney Wiley, Andreina Moreno, Pooyan Sahbaee, Chris Schwemmer, Richard R. Bayer, Akos Varga-Szemes, Daniel Steinberg, Nicholas Amoroso, Madison Kocher, Jeffrey Waltz, Thomas J. Ward, Jeremy R. Burt
Summary: This study evaluated the predictive value of machine learning-based CT-FFR in candidates for TAVR. The results demonstrated that CT-FFR had independent predictive value for MACE and improved the predictive value of coronary CT angiography assessment.
Article
Cardiac & Cardiovascular Systems
Ganesh Gajanan, Saurabhi Samant, Chad Hovseth, Yiannis S. Chatzizisis
Summary: Coronary angiography has been the gold standard for assessing coronary artery disease (CAD), but new physiology-guided PCI methods and hemodynamic assessment modalities provide reliable and user-friendly alternatives. It is important for interventional cardiologists and cardiovascular healthcare providers to be familiar with the strengths and weaknesses of these assessment modalities.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shaowei Ma, Ke Zhou, Yue Ma, Quanmei Ma, Yang Hou
Summary: Coronary computed tomographic angiography (CTA) can facilitate invasive angiography in patients with coronary artery bypass grafting (CABG) by reducing procedure/fluoroscopy time and contrast agent consumption.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Lin, Liang Wang, Xiao-Na Zhang, Xiao Li, Jian Wang, Zhu-Jun Shen, Wei Chen, Zheng-Yu Jin, Yi-Ning Wang
Summary: This study evaluated the diagnostic performance of 1.5-T non-contrast MR coronary angiography for detecting coronary artery disease. The results showed that the combined use of whole-heart and volume-targeted imaging in MRCA can efficiently diagnose significant coronary stenosis with high sensitivity and moderate specificity.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ole Froebert, Matthias Goetberg, David Erlinge, Zubair Akhtar, Evald H. Christiansen, Chandini R. MacIntyre, Keith G. Oldroyd, Zuzana Motovska, Andrejs Erglis, Rasmus Moer, Ota Hlinomaz, Lars Jakobsen, Thomas Engstrom, Lisette O. Jensen, Christian O. Fallesen, Svend E. Jensen, Oskar Angeras, Fredrik Calais, Amra Karegren, Joerg Lauermann, Arash Mokhtari, Johan Nilsson, Jonas Persson, Per Stalby, Abu K. M. M. Islam, Afzalur Rahman, Fazila Malik, Sohel Choudhury, Timothy Collier, Stuart J. Pocock, John Pernow
Summary: Influenza vaccination early after myocardial infarction (MI) improves prognosis, and its effectiveness may vary depending on the type of MI. The beneficial effect of influenza vaccination on adverse cardiovascular events may be enhanced in patients with non-ST-segment elevation MI (NSTEMI) compared to those with ST-segment elevation MI (STEMI).
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Mark A. Hlatky, Sam Wilding, Beth Stuart, Zoe Nicholas, James Shambrook, Zina Eminton, Kim Fox, Derek Connolly, Peter O'Kane, Alex Hobson, Anoop Chauhan, Neal Uren, Gerry P. Mccann, Colin Berry, Justin Carter, Carl Roobottom, Mamas Mamas, Ronak Rajani, Ian Ford, Pamela S. Douglas, Nick Curzen
Summary: The study compares costs between CTCA with selective FFRCT and standard care pathways in the FORECAST trial, and finds no significant difference in US healthcare costs. However, certain factors such as coronary risk factors and planned invasive angiography increase costs.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Hussein Bashar, Andrija Matetic, Nick Curzen, Mamas A. Mamas
Summary: This study compared the management and outcomes of acute myocardial infarction (AMI) between rural and urban settings using nationwide data. The results showed that AMI patients in rural hospitals had a higher risk of in-hospital mortality and major adverse cardiovascular events (MACCE), but a lower utilization of invasive procedures such as coronary angiography (CA) and percutaneous coronary intervention (PCI).
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sandeep Arunothayaraj, Jens Flensted Lassen, Gerald J. Clesham, Mark S. Spence, Rene Koning, Adrian P. Banning, Mitchell Lindsay, Evald H. Christiansen, Mohaned Egred, James Cockburn, Darren Mylotte, Philippe Brunel, Miroslaw Ferenc, Thomas Hovasse, Adrian Wlodarczak, Manuel Pan, Marc Silvestri, Andrejs Erglis, Evgeny Kretov, Alaide Chieffo, Thierry Lefevre, Francesco Burzotta, Olivier Darremont, Goran Stankovic, Marie-Claude Morice, Yves Louvard, David Hildick-Smith
Summary: This study aimed to analyze the impact of technical variables on procedural outcomes and periprocedural myocardial infarction following left main bifurcation intervention. The results showed that the use of jailed wires was associated with successful rewiring of jailed vessels, and the use of jailed wires was not associated with increased risk of periprocedural myocardial infarction. Side vessel preparation in provisional cases was linked to increased side vessel dissection requiring stenting. The use of noncompliant balloons for proximal optimization technique was associated with a reduction in the need for additional side vessel intervention and periprocedural myocardial infarction.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Tim Kinnaird, Sean Gallagher, Vasim Farooq, Majd Protty, Liam Back, Peadar Devlin, Richard Anderson, Andrew Sharp, Peter Ludman, Samuel Copt, Mamas A. Mamas, Nick Curzen
Summary: Despite increasing patient and procedural complexity, in-hospital patient outcomes have improved after unprotected left main stem percutaneous intervention over time.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Mayooran Shanmuganathan, Ambra Masi, Matthew K. Burrage, Rafail A. Kotronias, Alessandra Borlotti, Roberto Scarsini, Abhirup Banerjee, Dimitrios Terentes-Printzios, Qiang Zhang, Evan Hann, Elizabeth Tunnicliffe, Andrew Lucking, Jeremy Langrish, Rajesh Kharbanda, Giovanni Luigi De Maria, Adrian P. Banning, Robin P. Choudhury, Keith M. Channon, Stefan K. Piechnik, Vanessa M. Ferreira
Summary: The acute responses in both infarcted and noninfarcted myocardium post-STEMI are independent incremental predictors of long-term major adverse cardiac events (MACE). These findings may have implications for treatment and risk stratification in STEMI.
JACC-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Medicine, General & Internal
Richard J. Jabbour, Helen Routledge, Nick Curzen
Summary: Stroke is a leading cause of death in the UK, and mechanical thrombectomy is the most effective treatment for large vessel ischaemic strokes. Unfortunately, the use of mechanical thrombectomy is low among UK patients. In this editorial, the main barriers to its use and strategies to improve its uptake are explored.
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Noman Ali, David Hildick-Smith, Jessica Parker, Christopher J. Malkin, Michael S. Cunnington, Shuslim Gurung, Jonathan Mailey, Philip A. MacCarthy, Apurva Bharucha, Stephen J. Brecker, Stephen P. Hoole, Stephen Dorman, Sagar N. Doshi, Andrew Wiper, Mamta H. Buch, Adrian P. Banning, Mark S. Spence, Daniel J. Blackman
Summary: This study evaluated the long-term valve function and incidence of severe structural valve deterioration (SVD) among patients >=10 years post-TAVI and with at least 5 years of echocardiographic follow-up. The study found that the incidence of severe SVD was 5.9% in patients with echocardiographic follow-up exceeding 10 years. The incidence of severe SVD was higher in patients with balloon-expandable valves compared to self-expanding valves.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Alice Moroni, Federico Marin, Gabriele Venturi, Roberto Scarsini, Flavio Ribichini, Giovanni Luigi De Maria, Adrian P. Banning
Summary: Percutaneous coronary intervention (PCI) is increasingly used to treat unprotected left main coronary artery (ULMCA) disease in patients who cannot undergo cardiac surgery. However, treating failed stents in ULMCA is complex and poses unique challenges. Intracoronary imaging has provided new insights into mechanisms of stent failure and treatment options have significantly improved. This study provides an overview of ULMCA stent failure and proposes a tailored algorithm for best management.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Christian Fielder Camm, Abhishek Joshi, Helen Eftekhari, Rachael O'Flynn, Rebecca Dobson, Nick Curzen, Guy Lloyd, John Pierre Greenwood, Christopher Allen
Summary: Inappropriate behaviour in UK cardiology departments is a widespread issue that negatively affects the workforce and patient care. It is influenced by the unit's cultural and practice issues, with discrimination, harassment, and bullying being common occurrences. Both bystanders and direct victims suffer from the impact of inappropriate behaviour. Therefore, improving the culture and professional behaviours within these departments is crucial for a positive and inclusive workplace environment.
Article
Cardiac & Cardiovascular Systems
Sneha S. Jain, Ditian Li, Ovidiu Dressler, Lak Kotinkaduwa, Patrick W. Serruys, A. Pieter Kappetein, Joseph F. Sabik, Marie-Claude Morice, John Puskas, David E. Kandzari, Dimitri Karmpaliotis, Nicholas J. Lembo, W. Morris Brown, Adrian P. Banning, Gregg W. Stone
Summary: This study assessed the association between periprocedural major adverse events (MAE) and subsequent mortality after percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery revascularization. The study found that nonfatal periprocedural MAE strongly predicted both early and late mortality after both PCI and CABG.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Andre Briosa e Gala, Michael Timothy Brian Pope, Milena Leo, Alexander James Sharp, Victor Tsoi, John Paisey, Nick Curzen, Timothy Rider Betts
Summary: This study aims to systematically summarize the feasibility, safety, and efficacy of 'pill-in-the-pocket' oral anticoagulation in AF patients. The results show that pill-in-the-pocket OAC can reduce bleeding complications and provide the same thromboembolic protection as continuous OAC. However, current evidence is insufficient to guide practice, and further studies are needed to improve our understanding of the relationship between AF burden and thromboembolic risk.
ARRHYTHMIA & ELECTROPHYSIOLOGY REVIEW
(2023)
Review
Cardiac & Cardiovascular Systems
Balen Abdulrahman, Richard J. Jabbour, Nick Curzen
Summary: The prevalence of AF is high in patients with coronary artery disease. Guidelines recommend combination single antiplatelet and anticoagulation therapy for 12 months after percutaneous coronary intervention, followed by anticoagulation alone. However, the evidence for anticoagulation alone in reducing stent thrombosis risk is limited, while combined therapy increases the risk of bleeding.
INTERVENTIONAL CARDIOLOGY-REVIEWS RESEARCH RESOURCES
(2023)
Article
Cardiac & Cardiovascular Systems
Hussein Bashar, Ofer Kobo, Kamlesh Khunti, Louise Y. Sun, Martin K. Rutter, Nicholas W. S. Chew, Nick Curzen, Mamas A. Mamas
Summary: In the past few decades, diabetes-related cardiovascular mortality has been declining, but the COVID-19 pandemic caused a significant increase in mortality in the first year. Younger patients and the Black population experienced the greatest increase in mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Christopher A. Rajkumar, Michael J. Foley, Fiyyaz Ahmed-Jushuf, Alexandra N. Nowbar, Florentina A. Simader, John R. Davies, Peter D. O'Kane, Peter Haworth, Helen Routledge, Tushar Kotecha, Reto Gamma, Gerald Clesham, Rupert Williams, Jehangir Din, Sukhjinder S. Nijjer, Nick Curzen, Neil Ruparelia, Manas Sinha, Jason N. Dungu, Sashiananthan Ganesananthan, Ramzi Khamis, Lal Mughal, Tim Kinnaird, Ricardo Petraco, James C. Spratt, Sayan Sen, Joban Sehmi, David J. Collier, Afzal Sohaib, Thomas R. Keeble, Graham D. Cole, James P. Howard, Darrel P. Francis, Matthew J. Shun-Shin, Rasha K. Al-Lamee
Summary: This study aimed to investigate whether PCI is more effective than a placebo procedure in relieving angina symptoms in patients with stable angina. The results showed that PCI resulted in a lower angina symptom score compared to the placebo procedure, indicating a better health status with respect to angina.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)