Review
Cardiac & Cardiovascular Systems
Bingchen Guo, Zhaoyue Li, Peiyang Tu, Hao Tang, Yingfeng Tu
Summary: Thrombosis in atherosclerosis patients can have life-threatening consequences, emphasizing the importance of early detection and treatment. Traditional imaging modalities have limitations in detecting early thrombus formation, but novel molecular and non-molecular imaging strategies have improved diagnostic accuracy. These advancements have led to reduced rates of atherothrombotic events and better management of cardiovascular health in patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
XiaoQing Cheng, Jia Liu, HongXia Li, JiaLuo Yang, ChangSheng Zhou, BeiBei Zhi, QuanHui Liu, YingLe Li, LuLu Xiao, WuSheng Zhu, GuangMing Lu
Summary: This study aimed to evaluate the contribution of plaque enhancement features to culprit plaque identification and further risk stratification. The results showed that enhanced length longer than plaque length and grade II enhancement were independently associated with culprit plaques. The combination of stenosis and plaque enhancement grade resulted in better culprit plaque identification.
INSIGHTS INTO IMAGING
(2023)
Article
Engineering, Environmental
Shaoshen Wang, Xing Zhang, Yang Liu, Ying Wang, Na Sun, Jie Yin, Jieli Bao, Gege Liao, Dongye Li, Tongda Xu, Fenglei Gao
Summary: An innovative SAmOCP nanoprobe with versatile functions has been developed for precise diagnosis of vulnerable atherosclerosis (AS) plaques at the molecular level. The SAmOCP nanoprobes actively recognize foam cells and specifically target vulnerable AS plaques in vivo. By utilizing the enhanced localized surface plasmon resonance effects, the encapsulated liquid perfluoropentane (PFP) can transform into abundant microbubbles, enabling greatly enhanced ultrasonic imaging capacity. The SAmOCP nanoprobes exhibit a triple-modality diagnostic efficacy of ultrasound/fluorescence/photothermal imaging, offering a promising solution for the diagnosis of vulnerable AS.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Lana Fani, Dianne H. K. Van Dam-Nolen, Meike Vernooij, Maryam Kavousi, Aad van der Lugt, Daniel Bos
Summary: The study suggests that innate immunity is linked to larger carotid atherosclerotic plaques, while adaptive immunity seems to be associated with smaller plaques and a lower frequency of intraplaque hemorrhage. This imbalance in innate and adaptive immunity may play a role in the vulnerability of carotid atherosclerotic plaques.
Article
Engineering, Biomedical
Ming Zhang, Zhongjian Xie, Haijiao Long, Kun Ren, Lianjie Hou, Yu Wang, Xiaodan Xu, Weixing Lei, Zhicheng Yang, Shakeel Ahmed, Han Zhang, Guojun Zhao
Summary: Early delineation of vulnerable atherosclerotic plaques is crucial for prevention and treatment of cardio-cerebral vascular accidents. However, currently available imaging technologies have limitations. Nanoparticle technology is a promising diagnostic strategy for detecting hallmarks of vulnerable plaques.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Martin Karl Schneider, James Wang, Aris Kare, Shaunak S. Adkar, Darren Salmi, Caitlin F. Bell, Tom Alsaigh, Dhananjay Wagh, John Coller, Aaron Mayer, Sarah J. Snyder, Alexander D. Borowsky, Steven R. Long, Maarten G. Lansberg, Gary K. Steinberg, Jeremy J. Heit, Nicholas J. Leeper, Katherine W. Ferrara
Summary: The study demonstrates the potential of near-infrared auto-photoacoustic (NIRAPA) imaging in detecting plaque components and differentiating stable and vulnerable plaques. The researchers also developed a methodology to combine molecular imaging with spatial transcriptomic and proteomic methods for a more comprehensive understanding of plaque characteristics.
Article
Clinical Neurology
Manabu Shirakawa, Kiyofumi Yamada, Hiroko Watase, Baocheng Chu, Yukiko Enomoto, Takao Kojima, Kazuki Wakabayashi, Jie Sun, Daniel S. Hippe, Marina S. Ferguson, Niranjan Balu, Shinichi Yoshimura, Thomas S. Hatsukami, Chun Yuan
Summary: Recent studies found that the rate of recurrent stroke decreases over time after cerebral infarction in patients with atherosclerotic carotid stenosis. This study used carotid MRI to examine temporal differences in early stage carotid plaque components after acute cerebrovascular ischemic events. The results showed that the volume of juxtaluminal loose matrix/inflammation (LM/I) decreased over time and was significantly smaller in patients with >30 days interval from symptom onset to carotid MRI. This indicates that carotid plaques undergo rapid evolution after acute cerebrovascular ischemic events.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marcin Basiak, Marcin Hachula, Michal Kosowski, Grzegorz Machnik, Mateusz Maliglowka, Maria Dziubinska-Basiak, Robert Krysiak, Boguslaw Okopien
Summary: Atherosclerosis is a multifactorial, progressive, chronic inflammatory disease. Ultrasound and magnetic resonance imaging are the most accurate predictors of atherosclerotic plaque instability (MRI). Cytokines such as osteopontin, osteoprotegerin, and metalloproteinase 9 could be used as the most recent markers to identify and track the efficacy of anti-atherosclerotic therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanyue Zhou, Jiayu Xiao, Siddarth Ganesh, Alexander Lerner, Dan Ruan, Zhaoyang Fan
Summary: An automated processing pipeline for quantitative plaque assessment based on 3D magnetic resonance vessel wall imaging (VWI) has been developed and evaluated. The VWI-APP was found to be an accurate and efficient approach for intracranial atherosclerotic plaque quantification.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yao Meng, Yuyan Zhang, Xi Chu, Yun Song, Wei Zhao, Meimei Zheng, Jun Zhang, Ju Han
Summary: This study evaluated changes in vessel wall features of intracranial atherosclerotic disease (ICAD) lesions after drug-coated balloon (DCB) treatment using vessel wall MRI (VWMRI). The results showed a significant decrease in the degree of luminal stenosis after DCB treatment, with some patients showing normal appearance of the target vessel wall on follow-up VWMRI. The incidence of hyperintense plaques and prominent wall enhancement also decreased in the stenosis group. These findings suggest that DCB treatment promotes vascular healing in ICAD lesions.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Weiyu Chen, Sergey Tumanov, Stephanie M. Y. Kong, David Cheng, Erik Michaeelsson, Andre Bongers, Carl Power, Anita Ayer, Roland Stocker
Summary: This study found that the pharmacological inhibition of myeloperoxidase (MPO) activity with AZM198 can convert pre-existing unstable atherosclerotic lesions into stable plaques in a preclinical model. This highlights the potential therapeutic potency of MPO inhibition for high-risk patients and the development of novel protective strategies against cardiovascular diseases.
Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luescher
Summary: LOX-1, a scavenger receptor that promotes atherosclerotic plaque formation, plays a critical role in the development of cardiovascular diseases. Its expression in various cell types underscores its significance in disease progression, highlighting the potential for LOX-1 as a novel therapeutic target in CVDs prevention and treatment.
EUROPEAN HEART JOURNAL
(2021)
Article
Chemistry, Analytical
Jingruo Chen, Shufen Li, Di Ma, Lilan Li, Weihua Zhuang, Mao Chen
Summary: This study developed a LD-specific fluorescence probe TBI, which could precisely target and image lipid droplets in cells and atherosclerotic tissues. TBI exhibited excellent biocompatibility and imaging performance, making it a potential tool for investigating the biological functions and pathological roles of lipid droplets.
Article
Cardiac & Cardiovascular Systems
Eric J. Meester, Boudewijn J. Krenning, Erik de Blois, Marion de Jong, Antonius F. W. van der Steen, Monique R. Bernsen, Kim van der Heiden
Summary: The study demonstrated DOTA-JR11 as a promising ligand for visualization of atherosclerotic plaque inflammation. In vivo and post-mortem scans showed plaque uptake of [In-111]In-DOTA-JR11 with high target-to-background ratios. Histological processing confirmed the presence of CD68 and SST2 expressing cells in plaques.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Pieter J. Steinkamp, Jasper Vonk, Lydian A. Huisman, Gert-Jan Meersma, Gilles F. H. Diercks, Jan-Luuk Hillebrands, Wouter B. Nagengast, Clark J. Zeebregts, Riemer H. J. A. Slart, Hendrikus H. Boersma, Gooitzen M. van Dam
Summary: This study investigated the safety and feasibility of using bevacizumab-800CW, a near-infrared tracer targeting VEGF-A, for molecular assessment of atherosclerotic carotid plaques with MSOT. Results showed that the administration of 4.5 mg bevacizumab-800CW appeared to be safe in patients, but further studies are needed to evaluate tracer safety and optimize imaging outcomes.
Article
Cardiac & Cardiovascular Systems
Mahesh K. Vidula, Justyna Rajewska-Tabor, J. Jane Cao, Yu Kang, Jason Craft, Winifred Mei, Preethi S. Chandrasekaran, Daniel E. Clark, Ana-Maria Poenar, Miroslawa Gorecka, Maan Malahfji, Eilidh Cowan, Jennifer M. Kwan, Samuel W. Reinhardt, Sarah Al-Tabatabaee, Patrick Doeblin, Adriana D. M. Villa, Ilya Karagodin, Nazia Alvi, Panagiota Christia, Nicholas Spetko, Mark Philip Cassar, Christine Park, Lakshmi Nambiar, Alper Turgut, Mahan Roosta Azad, Moritz Lambers, Timothy C. Wong, Michael Salerno, Jiwon Kim, Michael Elliott, Betty Raman, Stefan Neubauer, Connie W. Tsao, Gina LaRocca, Amit R. Patel, Amedeo Chiribiri, Sebastian Kelle, Lauren A. Baldassarre, Dipan J. Shah, Sean G. Hughes, Matthew S. Tong, Malgorzata Pyda, Orlando P. Simonetti, Sven Plein, Yuchi Han
Summary: This study investigated myocardial injury in COVID-19 patients using cardiac magnetic resonance (CMR) and found that approximately 20.9% of patients had myocardial injury, which can be classified into different patterns. The presence of chest discomfort, abnormal electrocardiogram (ECG), elevated natriuretic peptide, and troponin levels were associated with specific patterns of myocardial injury.
JACC-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Amit R. Patel, Christopher M. Kramer
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jeremy A. Slivnick, Varun Subashchandran, Nitasha Sarswat, Amit R. Patel
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremy A. Slivnick, Nazia Alvi, Cristiane C. Singulane, Seth Scheetz, Akash Goyal, Hena Patel, Nitasha Sarswat, Karima Addetia, Fabio Fernandes, Marcelo Luiz Campos Vieira, Caio Reboucas Fonseca Cafezeiro, Suenia Freitas Carvalhal, Orlando P. Simonetti, Jai Singh, Roberto M. Lang, Karolina M. Zareba, Amit R. Patel
Summary: This study aimed to determine whether a novel CMR and light-chain biomarker-based algorithm could accurately diagnose ATTR-CA. The combination of a typical LGE and Look-Locker pattern on CMR with negative light chains showed high specificity for ATTR-CA.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Hena N. Patel, Shuo Wang, Swati Rao, Amita Singh, Luis Landeras, Stephanie A. Besser, Spencer Carter, Satish Mishra, Takuro Nishimura, Dalise Y. Shatz, Roderick Tung, Hemal Nayak, Keigo Kawaji, Victor Mor-Avi, Amit R. Patel
Summary: Although late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging is frequently used for scar assessment in patients with implantable cardioverter defibrillators (ICDs), metal artefact affects image quality. Our study aimed to determine the clinical indications for CMR referral and its impact on decision-making and prognosis. We found that CMR provided new diagnoses and influenced clinical management in a significant proportion of patients with ICDs, and the presence of LGE was associated with worse outcomes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Medicine, General & Internal
Wenli Zhou, Jason Sin, Andrew T. Yan, Haonan Wang, Jing Lu, Yuehua Li, Paul Kim, Amit R. Patel, Ming-Yen Ng
Summary: Stress cardiovascular magnetic resonance (CMR) imaging is a non-invasive stress test that has higher diagnostic accuracy than other common functional imaging modalities for diagnosing significant coronary artery disease (CAD). It provides a cost-effective method for one-stop assessment of myocardial ischemia, cardiac function, and myocardial viability in clinical practice. In addition to CAD, stress CMR also has diagnostic performance and prognostic value for other common cardiovascular diseases (CVDs), especially coronary microvascular dysfunction (CMD). This review focuses on the clinical applications of stress CMR in CVDs with possible myocardial ischemia, including scanning methods, image interpretation, and clinical utility.
Editorial Material
Cardiac & Cardiovascular Systems
Purvi Parwani, Amit R. Patel
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rajshekhar A. Kore, Samir V. Jenkins, Azemat Jamshidi-Parsian, Alan J. Tackett, Robert J. Griffin, Srinivas Ayyadevara, Jawahar L. Mehta
Summary: Research has shown that mesenchymal stem cell exosomes can alleviate cardiac dysfunction in animal models of ischemia. These exosomes carry active and inactive proteins, including often-overlooked transcriptional regulators, which can influence the transcriptome and proteome of recipient cells. The study investigates the differentially modulated transcriptional factors and regulators in MSC exosome-treated ischemic mouse hearts and their potential role in modulating cardiac function. The findings provide insight into the mechanisms underlying cardiac dysfunction during ischemia and pave the way for future studies on the modulation of cardiac function by MSC exosomes.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Evan M. Masutani, Rahul S. Chandrupatla, Shuo Wang, Chiara Zocchi, Lewis D. Hahn, Michael Horowitz, Kathleen Jacobs, Seth Kligerman, Francesca Raimondi, Amit Patel, Albert Hsiao
Summary: The purpose of this study was to evaluate the feasibility of a newly developed deep learning synthetic strain (DLSS) algorithm to infer myocardial velocity and detect wall motion abnormalities in patients with ischemic heart disease. The DLSS algorithm was developed using a retrospective dataset of cardiac MRI examinations. The algorithm's performance was assessed using receiver operating characteristic curve analysis. The results showed that the DLSS algorithm had comparable performance in inferring myocardial velocity and detecting wall motion abnormalities in patients with ischemic heart disease.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jonathan A. Pan, Shuo Wang, Connor Wolff, Hena Patel, Jeremy Slivnick, Patrick Norton, Christopher M. Kramer, Amit R. Patel
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Bobby Heydari, Yin Ge, Panagiotis Antiochos, Sabeeh Islam, Kevin E. Steel, Scott E. Bingham, Shuaib Abdullah, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Amit R. Patel, Sujata Madhukar Shanbhag, Afshin Farzaneh-Far, John Heitner, Chetan Shenoy, Steven Leung, Jorge A. Gonzalez, Subha V. Raman, Victor A. Ferrari, Dipan J. Shah, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Nisha Hosadurg, Shannon May, Amit R. Patel, Christopher M. Kramer, Patricia Rodriguez Lozano
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Nisha Hosadurg, Amit R. Patel, Christopher M. Kramer, Patricia Rodriguez Lozano
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Sabeeh Islam, Bobby Heydari, Yin Ge, Panagiotis Antiochos, Kevin E. Steel, Scott E. Bingham, Shuaib Abdullah, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Amit R. Patel, Sujata Madhukar Shanbhag, Afshin Farzaneh-Far, John Heitner, Chetan Shenoy, Steve Leung, Jorge A. Gonzalez, Subha V. Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Orlando P. Simonetti, Matthias Stuber, Raymond Y. Kwong
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Saadia Qazi, Yin Ge, Krishna Patel, Panagiotis Antiochos, Sabeeh Islam, Ryan B. Longmore, Bobby Heydari, Scott E. Bingham, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Sujata Madhukar Shanbhag, Amit R. Patel, Afshin Farzaneh-Far, John Heitner, Chetan Shenoy, Steve Leung, Jorge A. Gonzalez, Dipan J. Shah, Subha V. Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)