☆ 3.8 Article

Genetics of Ischemic Stroke in Young Adults

CIRCULATION-CARDIOVASCULAR GENETICS (2014)

期刊

CIRCULATION-CARDIOVASCULAR GENETICS

卷 7, 期 3, 页码 383-392

出版社

LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1161/CIRCGENETICS.113.000390

关键词

cerebral infarction; genetics; molecular epidemiology

类别

Cardiac & Cardiovascular Systems Genetics & Heredity

资金

Department of Veterans Affairs (Career Development Award) [1IK2BX001823]
Department of Veterans Affairs (Medical Research Service)
Department of Veterans Affairs (Stroke Research Enhancement Award)
Department of Veterans Affairs (Merit Review Award)
National Institute Health [U01 HG004436, U01 NS069208, P30 DK072488]

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

3.8

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Gastroenterology & Hepatology

Novel insights into causal effects of serum lipids and lipid-modifying targets on cholelithiasis

Lanlan Chen, Wei Qiu, Xiaodong Sun, Menghan Gao, Yuexuan Zhao, Mingyue Li, Zhongqi Fan, Guoyue Lv

Summary: Serum levels of LDL-C and HDL-C are inversely associated with the risk of cholelithiasis in a linear manner. However, the relationship between serum TC and cholelithiasis risk is non-linear, with lower TC being associated with higher risk, and serum TG has an inverted "U-shaped" relationship with cholelithiasis risk. MR analyses suggest that lower TC and higher TG levels are independent causal risk factors. Drug-target MR analysis indicates that inhibition of HMGCR can reduce the risk of cholelithiasis, which is supported by colocalisation analysis.

GUT (2023)

添加到收藏夹

Article Genetics & Heredity

Integrated case-control and somatic-germline interaction analyses of soft-tissue sarcoma

Fulan Hu, Yao Yu, Jiun-Sheng Chen, Hao Hu, Paul Scheet, Chad D. Huff

Summary: The study revealed strong genome-wide signals for NF1 in multiple STS subtypes, as well as significant association signals for TP53, RB1, and MSH2. Additionally, BAG1 showed a strong genome-wide signal after NF1, suggesting it as a novel candidate high-risk gene for STS.

JOURNAL OF MEDICAL GENETICS (2021)

添加到收藏夹

Article Medicine, General & Internal

Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study

Luke C. Pilling, Deniz Turkmen, Hannah Fullalove, Janice L. Atkins, Joao Delgado, Chia-Ling Kuo, George A. Kuchel, Luigi Ferrucci, Jack Bowden, Jane A. H. Masoli, David Melzer

Summary: The study found that in UK primary care patients, individuals carrying CYP2C19 loss-of-function alleles had a higher risk of ischemic stroke and myocardial infarction when prescribed clopidogrel. Therefore, genotype-guided selection of antiplatelet medications may improve outcomes in patients with CYP2C19 genetic variants.

BMJ OPEN (2021)

添加到收藏夹

Review Medicine, General & Internal

The Evolving Landscape of the Molecular Epidemiology of Malignant Pleural Mesothelioma

Sara Lettieri, Chandra Bortolotto, Francesco Agustoni, Filippo Lococo, Andrea Lancia, Patrizia Comoli, Angelo G. Corsico, Giulia M. Stella

Summary: Malignant pleural mesothelioma is a rare and aggressive malignancy that mainly affects the pleural lining of the lungs, commonly associated with exposure to biopersistent fibers like asbestos. Patients with chronic exposure to asbestos often have a long latency period with few symptoms, leading to advanced disease and poor overall survival. While modern targeted therapies have not been successful in treating MPM, molecular high-throughput profiling is revealing new biomarkers and actionable targets for potential diagnostic and therapeutic advancements.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article Microbiology

The Molecular Genetic Epidemiology and Antimicrobial Resistance of Neisseria gonorrhoeae Strains Obtained from Clinical Isolates in Central Panama

Virginia Nunez-Samudio, Mellissa Herrera, Genarino Herrera, Gumercindo Pimentel-Peralta, Ivan Landires

Summary: This study aimed to analyze Neisseria gonorrhoeae isolates in central Panama, characterize the associated gonococcal antimicrobial resistance (AMR), and conduct molecular epidemiology and genetic typing. The isolates showed resistance to penicillin, tetracycline, and ciprofloxacin, but sensitivity to extended-spectrum cephalosporins and azithromycin. The most frequent subtype identified was ST1901, and the study represents the first genomic analysis of gonococcal isolates in Central America.

MICROORGANISMS (2023)

添加到收藏夹

Article Genetics & Heredity

Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies and Transcriptome-Wide Association Study

Ekaterina Orlova, Tom Dudding, Jonathan M. Chernus, Rasha N. Alotaibi, Simon Haworth, Richard J. Crout, Myoung Keun Lee, Nandita Mukhopadhyay, Eleanor Feingold, Steven M. Levy, Daniel W. McNeil, Betsy Foxman, Robert J. Weyant, Nicholas J. Timpson, Mary L. Marazita, John R. Shaffer

Summary: Although genetics plays a role in early childhood caries (ECC) risk, little is known about the specific genetic determinants. This study conducted genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) to identify genes associated with ECC. The results indicated suggestive evidence for the involvement of certain genetic regions and revealed four risk genes, including TAS2R14 which is associated with innate immunity and antimicrobial defense against cariogenic bacteria. These findings provide insights into the genetic architecture of ECC and highlight the importance of host-microbial interaction in caries risk.

GENES (2023)

添加到收藏夹

Article Microbiology

Diversity and Within-Host Evolution of Leishmania donovani from Visceral Leishmaniasis Patients with and without HIV Coinfection in Northern Ethiopia

Susanne U. Franssen, Yegnasew Takele, Emebet Adem, Mandy J. Sanders, Ingrid Mueller, Pascale Kropf, James A. Cotton

Summary: Visceral leishmaniasis is a growing public health problem in East Africa, particularly in Ethiopia among migrant agricultural workers. Coinfection with HIV makes VL more difficult to treat and leads to high rates of relapse. Research shows that VL and VL/HIV infections are caused by the same parasite population, and relapses are primarily due to the initial infecting parasite. Treatment results in a loss of genetic diversity in the parasite population, suggesting a need to improve antiparasitic treatment to prevent relapse in VL/HIV patients.

MBIO (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Whole-genome sequencing of carbapenem-resistant Enterobacterales isolates in southeast Louisiana reveals persistent genetic clusters spanning multiple locations

Rebecca Rose, Amy Feehan, Benjamin N. Lain, Deborah Ashcraft, David J. Nolan, Leonor Velez-Climent, Christopher Huston, Tessa LaFleur, Simon Rosenthal, Gary B. Fogel, Lucio Miele, George Pankey, Julia Garcia-Diaz, Susanna L. Lamers

Summary: This study investigated carbapenem-resistant Enterobacterales isolates in southeast Louisiana and found genetically related infections and isolates of the same species, but without genetic relatedness. The results highlight regional genomic and resistance diversity within related bacterial lineages.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2023)

添加到收藏夹

Article Critical Care Medicine

Determinants of Lung Fissure Completeness

Marieke C. van der Molen, Jorine E. Hartman, Cornelis J. Vermeulen, Maarten van den Berge, Alen Faiz, Huib A. M. Kerstjens, Jean-Paul Charbonnier, Lowie E. G. W. Vanfleteren, Dirk-Jan Slebos

Summary: Genetic factors play a significant role in determining fissure completeness, while clinical and environmental factors, including COPD severity, do not have a clinically relevant impact. Specific genetic variations were identified as associated with fissure completeness, showing higher completeness in African American subjects compared to non-Hispanic White subjects. Rs2173623, rs6504172, and rs7209556 lead to WNT5A and HOXB antisense RNA expression, which play an important role during embryogenesis.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

添加到收藏夹

Article Plant Sciences

Population genetics and phylogeography of alfalfa mosaic virus in China and a comparison with other regional epidemics based on the cp gene

Xin Wang, Chenchen Liu, Zhaoyan Tan, Jiantai Zhang, Rongqun Wang, Yuanhong Wang, Xiliang Jiang, Beilei Wu

Summary: This study conducted a large-scale long-term survey on the genetic variability of AMV populations in China, Iran, and Spain, and found significant genetic differentiation among localities. Inappropriate agronomical practices might have contributed to the rapid viral diversification within localities.

FRONTIERS IN PLANT SCIENCE (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Underlying Mechanism and Active Ingredients of Tianma Gouteng Acting on Cerebral Infarction as Determined via Network Pharmacology Analysis Combined With Experimental Validation

Xiaolei Tang, Jing Lu, Haoyuan Chen, Lu Zhai, Yuxin Zhang, Huijuan Lou, Yufeng Wang, Liwei Sun, Bailin Song

Summary: Through analyzing the chemical constituents of Tianma Gouteng (TMGT) and screening for protein targets, this study found that TMGT may inhibit neuroinflammation and protect brain cells from damage caused by cerebral infarction by modulating the HIF-1 alpha/PPAR gamma/NF-kappa B signaling pathway.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Microbiology

The Low Variability of Tc24 in Trypanosoma cruzi TcI as an Advantage for Chagas Disease Prophylaxis and Diagnosis in Mexico

Ingeborg Becker, Haydee Miranda-Ortiz, Edith A. Fernandez-Figueroa, Sokani Sanchez-Montes, Pablo Colunga-Salas, Estefania Grostieta, Javier Juarez-Gabriel, Yokomi N. Lozano-Sardaneta, Minerva Arce-Fonseca, Olivia Rodriguez-Morales, Gabriela Meneses-Ruiz, Sergio Pasten-Sanchez, Irma Lopez Martinez, Saul Gonzalez-Guzman, Vladimir Paredes-Cervantes, Otacilio C. Moreira, Paula Finamore-Araujo, Julio C. Canseco-Mendez, Uriel Coquis-Navarrete, Laura Rengifo-Correa, Constantino Gonzalez-Salazar, Myrna M. Alfaro-Cortes, Jorge A. Falcon-Lezama, Roberto Tapia-Conyer, Christopher R. Stephens

Summary: This study evaluated the genetic diversity and structure of Tc24 in Triatoma cruzi isolates from Mexico, and found that there is low genetic variability in this region. This information suggests the potential development of in silico strategies for the production of antigens to optimize the diagnosis of Chagas disease.

PATHOGENS (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

Global Epidemiology and Genetics of Hepatocellular Carcinoma

Ming Ren Toh, Evelyn Yi Ting Wong, Sunny Hei Wong, Alvin Wei Tian Ng, Lit-Hsin Loo, Pierce Kah-Hoe Chow, Joanne Ngeow

Summary: Hepatocellular carcinoma (HCC) is a leading global cancer, primarily occurring in genetically susceptible individuals with liver cirrhosis and exposure to risk factors. Temporal and geographical variations exist in HCC, with a shift from viral to nonviral causes and a higher burden in regions with a high sociodemographic index. Hepatitis viruses are the predominant causes of HCC in Asia and Africa, while genetic conditions contributing to HCC risk are less recognized outside North America and Europe. This review evaluates the epidemiology, risk factors, and genetics of HCC, including monogenic diseases, single-nucleotide polymorphisms, gut microbiome, and somatic mutations.

GASTROENTEROLOGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Integrative Genome-Based Survey of the SARS-CoV-2 Omicron XBB.1.16 Variant

Fabio Scarpa, Ilenia Azzena, Alessandra Ciccozzi, Marta Giovanetti, Chiara Locci, Marco Casu, Pier Luigi Fiori, Alessandra Borsetti, Eleonora Cella, Miriana Quaranta, Stefano Pascarella, Daria Sanna, Massimo Ciccozzi, Igor Rogozin

Summary: The XBB.1.16 variant of SARS-CoV-2 has the potential to evade immune response but its evolutionary rate is slower than dangerous lineages. Structural analysis shows no significant differences from previous lineages, indicating no exceptional danger or high expansion capability. Continuous genome-based monitoring is important for understanding its descendants and other lineages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Article Psychology, Developmental

Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

Eshim S. Jami, Anke R. Hammerschlag, Hill F. Ip, Andrea G. Allegrini, Beben Benyamin, Richard Border, Elizabeth W. Diemer, Chang Jiang, Ville Karhunen, Yi Lu, Qing Lu, Travis T. Mallard, Pashupati P. Mishra, Ilja M. Nolte, Teemu Palviainen, Roseann E. Peterson, Hannah M. Sallis, Andrey A. Shabalin, Ashley E. Tate, Elisabeth Thiering, Natalia Vilor-Tejedor, Carol Wang, Ang Zhou, Daniel E. Adkins, Silvia Alemany, Helga Ask, Qi Chen, Robin P. Corley, Erik A. Ehli, Luke M. Evans, Alexandra Havdahl, Fiona A. Hagenbeek, Christian Hakulinen, Anjali K. Henders, Jouke Jan Hottenga, Tellervo Korhonen, Abdullah Mamun, Shelby Marrington, Alexander Neumann, Kaili Rimfeld, Fernando Rivadeneira, Judy L. Silberg, Catharina E. van Beijsterveldt, Eero Vuoksimaa, Alyce M. Whipp, Xiaoran Tong, Ole A. Andreassen, Dorret Boomsma, Sandra A. Brown, S. Alexandra Burt, William Copeland, Danielle M. Dick, K. Paige Harden, Kathleen Mullan Harris, Catharina A. Hartman, Joachim Heinrich, John K. Hewitt, Christian Hopfer, Elina Hypponen, Marjo-Riitta Jarvelin, Jaakko Kaprio, Liisa Keltikangas-Jarvinen, Kelly L. Klump, Kenneth Krauter, Ralf Kuja-Halkola, Henrik Larsson, Terho Lehtimaki, Paul Lichtenstein, Sebastian Lundstrom, Hermine H. Maes, Per Magnus, Marcus R. Munafo, Jake M. Najman, Pal R. Njolstad, Albertine J. Oldehinkel, Craig E. Pennell, Robert Plomin, Ted Reichborn-Kjennerud, Chandra Reynolds, Richard J. Rose, Andrew Smolen, Harold Snieder, Michael Stallings, Marie Standl, Jordi Sunyer, Henning Tiemeier, Sally J. Wadsworth, Tamara L. Wall, Andrew J. O. Whitehouse, Gail M. Williams, Eivind Ystrom, Michel G. Nivard, Meike Bartels, Christel M. Middeldorp

Summary: The study investigates the genetic architecture of internalizing symptoms in children and adolescents, finding rater-based heterogeneity in genetic effects and genetic correlations with adult internalizing disorders and other childhood psychiatric traits. Additionally, reducing phenotypic heterogeneity in childhood samples is crucial for future GWAS success.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin

Laura M. Bozzi, Braxton D. Mitchell, Joshua P. Lewis, Kathy A. Ryan, William R. Herzog, Jeffrey R. O'Connell, Richard B. Horenstein, Alan R. Shuldiner, Laura M. Yerges-Armstrong

CURRENT VASCULAR PHARMACOLOGY (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes

Alexander Teumer, Adrienne Tin, Rossella Sorice, Mathias Gorski, Nan Cher Yeo, Audrey Y. Chu, Man Li, Yong Li, Vladan Mijatovic, Yi-An Ko, Daniel Taliun, Alessandro Luciani, Ming-Huei Chen, Qiong Yang, Meredith C. Foster, Matthias Olden, Linda T. Hiraki, Bamidele O. Tayo, Christian Fuchsberger, Aida Karina Dieffenbach, Alan R. Shuldiner, Albert V. Smith, Allison M. Zappa, Antonio Lupo, Barbara Kollerits, Belen Ponte, Benedicte Stengel, Bernhard K. Kraemer, Bernhard Paulweber, Braxton D. Mitchell, Caroline Hayward, Catherine Helmer, Christa Meisinger, Christian Gieger, Christian M. Shaffer, Christian Mueller, Claudia Langenberg, Daniel Ackermann, David Siscovick, Eric Boerwinkle, Florian Kronenberg, Georg B. Ehret, Georg Homuth, Gerard Waeber, Gerjan Navis, Giovanni Gambaro, Giovanni Malerba, Gudny Eiriksdottir, Guo Li, H. Erich Wichmann, Harald Grallert, Henri Wallaschofski, Henry Voelzke, Herrmann Brenner, Holly Kramer, I. Mateo Leach, Igor Rudan, Hans L. Hillege, Jacques S. Beckmann, Jean Charles Lambert, Jian'an Luan, Jing Hua Zhao, John Chalmers, Josef Coresh, Joshua C. Denny, Katja Butterbach, Lenore J. Launer, Luigi Ferrucci, Lyudmyla Kedenko, Margot Haun, Marie Metzger, Mark Woodward, Matthew J. Hoffman, Matthias Nauck, Melanie Waldenberger, Menno Pruijm, Murielle Bochud, Myriam Rheinberger, Niek Verweij, Nicholas J. Wareham, Nicole Endlich, Nicole Soranzo, Ozren Polasek, Pim van der Harst, Peter Paul Pramstaller, Peter Vollenweider, Philipp S. Wild, Ron T. Gansevoort, Rainer Rettig, Reiner Biffar, Robert J. Carroll, Ronit Katz, Ruth J. F. Loos, Shih-Jen Hwang, Stefan Coassin, Sven Bergmann, Sylvia E. Rosas, Sylvia Stracke, Tamara B. Harris, Tanguy Corre, Tanja Zeller, Thomas Illig, Thor Aspelund, Toshiko Tanaka, Uwe Lendeckel, Uwe Volker, Vilmundur Gudnason, Vincent Chouraki, Wolfgang Koenig, Zoltan Kutalik, Jeffrey R. O'Connell, Afshin Parsa, Iris M. Heid, Andrew D. Paterson, Ian H. de Boer, Olivier Devuyst, Jozef Lazar, Karlhans Endlich, Katalin Susztak, Johanne Tremblay, Pavel Hamet, Howard J. Jacob, Carsten A. Boeger, Caroline S. Fox, Cristian Pattaro, Anna Koettgen

DIABETES (2016)

添加到收藏夹

Article Neurosciences

Heritability of Complex White Matter Diffusion Traits Assessed in a Population Isolate

Peter Kochunov, Mao Fu, Katie Nugent, Susan N. Wright, Xiaoming Du, Florian Muellerklein, Mary Morrissey, George Eskandar, Dinesh K. Shukla, Neda Jahanshad, Paul M. Thompson, Binish Patel, Teodor T. Postolache, Kevin A. Strauss, Alan R. Shuldiner, Braxton D. Mitchell, L. Elliot Hong

HUMAN BRAIN MAPPING (2016)

添加到收藏夹

Article Clinical Neurology

Shared Genetic Contribution to Ischemic Stroke and Alzheimer's Disease

Matthew Traylor, Poneh Adib-Samii, Denise Harold, Martin Dichgans, Julie Williams, Cathryn M. Lewis, Hugh S. Markus

ANNALS OF NEUROLOGY (2016)

添加到收藏夹

Article Genetics & Heredity

Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation

Audrey Y. Chu, Xuan Deng, Virginia A. Fisher, Alexander Drong, Yang Zhang, Mary F. Feitosa, Ching-Ti Liu, Olivia Weeks, Audrey C. Choh, Qing Duan, Thomas D. Dyer, John D. Eicher, Xiuqing Guo, Nancy L. Heard-Costa, Tim Kacprowski, Jack W. Kent, Leslie A. Lange, Xinggang Liu, Kurt Lohman, Lingyi Lu, Anubha Mahajan, Jeffrey R. O'Connell, Ankita Parihar, Juan M. Peralta, Albert V. Smith, Yi Zhang, Georg Homuth, Ahmed H. Kissebah, Joel Kullberg, Rene Laqua, Lenore J. Launer, Matthias Nauck, Michael Olivier, Patricia A. Peyser, James G. Terry, Mary K. Wojczynski, Jie Yao, Lawrence F. Bielak, John Blangero, Ingrid B. Borecki, Donald W. Bowden, John Jeffrey Carr, Stefan A. Czerwinski, Jingzhong Ding, Nele Friedrich, Vilmunder Gudnason, Tamara B. Harris, Erik Ingelsson, Andrew D. Johnson, Sharon L. R. Kardia, Carl D. Langefeld, Lars Lind, Yongmei Liu, Braxton D. Mitchell, Andrew P. Morris, Thomas H. Mosley, Jerome I. Rotter, Alan R. Shuldiner, Bradford Towne, Henry Voelzke, Henri Wallaschofski, James G. Wilson, Matthew Allison, Cecilia M. Lindgren, Wolfram Goessling, L. Adrienne Cupples, Matthew L. Steinhauser, Caroline S. Fox

NATURE GENETICS (2017)

添加到收藏夹

Article Nutrition & Dietetics

A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations

Christopher R. D'Adamo, Antonietta D'Urso, Kathleen A. Ryan, Laura M. Yerges-Armstrong, Richard D. Semba, Nanette I. Steinle, Braxton D. Mitchell, Alan R. Shuldiner, Patrick F. McArdle

NUTRIENTS (2016)

添加到收藏夹

Article Genetics & Heredity

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis

Martha C. Castano-Betancourt, Dan S. Evans, Yolande F. M. Ramos, Cindy G. Boer, Sarah Metrustry, Youfang Liu, Wouter den Hollander, Jeroen van Rooij, Virginia B. Kraus, Michelle S. Yau, Braxton D. Mitchell, Kenneth Muir, Albert Hofman, Michael Doherty, Sally Doherty, Weiya Zhang, Robert Kraaij, Fernando Rivadeneira, Elizabeth Barrett-Connor, Rose A. Maciewicz, Nigel Arden, Rob G. H. H. Nelissen, Margreet Kloppenburg, Joanne M. Jordan, Michael C. Nevitt, Eline P. Slagboom, Deborah J. Hart, Floris Lafeber, Unnur Styrkarsdottir, Eleftheria Zeggini, Evangelos Evangelou, Tim D. Spector, Andre G. Uitterlinden, Nancy E. Lane, Ingrid Meulenbelt, Ana M. Valdes, Joyce B. J. van Meurs

PLOS GENETICS (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis

Pradeep Natarajan, Joshua C. Bis, Lawrence F. Bielak, Amanda J. Cox, Marcus Dorr, Mary F. Feitosa, Nora Franceschini, Xiuqing Guo, Shih-Jen Hwang, Aaron Isaacs, Min A. Jhun, Maryam Kavousi, Ruifang Li-Gao, Leo-Pekka Lyytikainen, Riccardo E. Marioni, Ulf Schminke, Nathan O. Stitziel, Hayato Tada, Jessica van Setten, Albert V. Smith, Dina Vojinovic, Lisa R. Yanek, Jie Yao, Laura M. Yerges-Armstrong, Najaf Amin, Usman Baber, Ingrid B. Borecki, J. Jeffrey Carr, Yii-Der Ida Chen, L. Adrienne Cupples, Pim A. de Jong, Harry de Koning, Bob D. de Vos, Ayse Demirkan, Valentin Fuster, Oscar H. Franco, Mark O. Goodarzi, Tamara B. Harris, Susan R. Heckbert, Gerardo Heiss, Udo Hoffmann, Albert Hofman, Ivana Isgum, J. Wouter Jukema, Mika Kahonen, Sharon L. R. Kardia, Brian G. Kral, Lenore J. Launer, Joe Massaro, Roxana Mehran, Braxton D. Mitchell, Thomas H. Mosley, Renee de Mutsert, Anne B. Newman, Khanh-dung Nguyen, Kari E. North, Jeffrey R. O'Connell, Matthijs Oudkerk, James S. Pankow, Gina M. Peloso, Wendy Post, Michael A. Province, Laura M. Raffield, Olli T. Raitakari, Dermot F. Reilly, Fernando Rivadeneira, Frits Rosendaal, Samantha Sartori, Kent D. Taylor, Alexander Teumer, Stella Trompet, Stephen T. Turner, Andre G. Uitterlinden, Dhananjay Vaidya, Aad van der Lugt, Uwe Volker, Joanna M. Wardlaw, Christina L. Wassel, Stefan Weiss, Mary K. Wojczynski, Diane M. Becker, Lewis C. Becker, Eric Boerwinkle, Donald W. Bowden, Ian J. Deary, Abbas Dehghan, Stephan B. Felix, Vilmundur Gudnason, Terho Lehtimaki, Rasika Mathias, Dennis O. Mook-Kanamori, Bruce M. Psaty, Daniel J. Rader, Jerome I. Rotter, James G. Wilson, Cornelia M. van Duijn, Henry Volzke, Sekar Kathiresan, Patricia A. Peyser, Christopher J. O'Donnell

CIRCULATION-CARDIOVASCULAR GENETICS (2016)

添加到收藏夹

Article Rheumatology

Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians

Michelle S. Yau, Laura M. Yerges-Armstrong, Youfang Liu, Cora E. Lewis, David J. Duggan, Jordan B. Renner, James Torner, David T. Felson, Charles E. McCulloch, C. Kent Kwoh, Michael C. Nevitt, Marc C. Hochberg, Braxton D. Mitchell, Joanne M. Jordan, Rebecca D. Jackson

ARTHRITIS & RHEUMATOLOGY (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Increased usual physical activity is associated with a blunting of the triglyceride response to a high-fat meal

Braxton D. Mitchell, Gurmannat Kalra, Kathleen A. Ryan, Man Zhang, Carole Sztalryd, Nanette I. Steinle, Simeon I. Taylor, Soren Snitker, Joshua P. Lewis, Michael Miller, Alan R. Shuldiner, Huichun Xu

JOURNAL OF CLINICAL LIPIDOLOGY (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients

Joshua P. Lewis, Joshua D. Backman, Jean-Luc Reny, Thomas O. Bergmeijer, Braxton D. Mitchell, Marylyn D. Ritchie, Jean-Pierre Dery, Ruth E. Pakyz, Li Gong, Kathleen Ryan, Eun-Young Kim, Daniel Aradi, Israel Fernandez-Cadenas, Ming Ta Michael Lee, Ryan M. Whaley, Joan Montaner, Gian Franco Gensini, John H. Cleator, Kiyuk Chang, Lene Holmvang, Willibald Hochholzer, Dan M. Roden, Stefan Winter, Russ B. Altman, Dimitrios Alexopoulos, Ho-Sook Kim, Meinrad Gawaz, Kevin P. Bliden, Marco Valgimigli, Rossella Marcucci, Gianluca Campo, Elke Schaeffeler, Nadia P. Dridi, Ming-Shien Wen, Jae Gook Shin, Pierre Fontana, Betti Giusti, Tobias Geisler, Michiaki Kubo, Dietmar Trenk, Jolanta M. Siller-Matula, Jurrien M. ten Berg, Paul A. Gurbel, Matthias Schwab, Teri E. Klein, Alan R. Shuldiner

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY (2020)

添加到收藏夹

Article Clinical Neurology

Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study

Simon Frerich, Rainer Malik, Marios K. Georgakis, Moritz F. Sinner, Steven J. Kittner, Braxton D. Mitchell, Martin Dichgans

Summary: This study used genetic data to assess the associations between cardiac traits and stroke risk, finding that cardiac traits have limited effects on stroke risk beyond known clinical risk factors.

STROKE (2022)

添加到收藏夹

Article Genetics & Heredity

Meta-Analysis of Transcriptome-Wide Association Studies across 13 Brain Tissues Identified Novel Clusters of Genes Associated with Nicotine Addiction

Zhenyao Ye, Chen Mo, Hongjie Ke, Qi Yan, Chixiang Chen, Peter Kochunov, L. Elliot Hong, Braxton D. Mitchell, Shuo Chen, Tianzhou Ma

Summary: This study utilized eQTL data to conduct transcriptome-wide association studies (TWAS) and identified genes associated with nicotine addiction and their regulatory mechanism in the brain. Three major gene clusters were identified, and downstream enrichment analysis revealed unique biological pathways associated with nicotine dependence.

GENES (2022)

添加到收藏夹

Article Genetics & Heredity

Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium

Huichun Xu, Kevin Nguyen, Brady J. Gaynor, Hua Ling, Wei Zhao, Patrick F. McArdle, Timothy D. O'Connor, O. Colin Stine, Kathleen A. Ryan, Megan Lynch, Jennifer A. Smith, Jessica D. Faul, Yao Hu, Jeffrey W. Haessler, Myriam Fornage, Charles Kooperberg, James A. Perry, Charles C. Hong, John W. Cole, Elizabeth Pugh, Kimberly Doheny, Sharon L. R. Kardia, David R. Weir, Steven J. Kittner, Braxton D. Mitchell

Summary: Recent genome wide association studies have identified 89 common genetic variants associated with ischemic stroke, primarily in non-coding regions. This study performed an exome array analysis and found 15 coding variants significantly associated with ischemic stroke, including common SNPs in the ABO gene. The associations were driven by African American samples and not replicated in other populations, emphasizing the need for diverse cohorts and genotyping technologies for rare variant studies.

GENES (2023)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Decoding Hypertension Through Primary Aldosteronism

Braxton D. Mitchell, Hilary B. Whitlatch

CIRCULATION (2023)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.