Article
Mathematics, Applied
Evan V. Jenkins, Dhani Dharmaprani, Madeline Schopp, Jing Xian Quah, Kathryn Tiver, Lewis Mitchell, Martyn P. Nash, Richard H. Clayton, Kenneth Pope, Anand N. Ganesan
Summary: This study investigates the influence of phase singularity (PS) population size on the formation and destruction rates of PS in atrial and ventricular fibrillation (AF/VF). Results from computational simulations, human AF and human VF indicate that the changes in PS population affect the formation and destruction rates, suggesting the presence of inhibitory interactions between PS.
Review
Biochemistry & Molecular Biology
Andrei Alexandru Mircea, Mihaela Rusu, Elisa Anamaria Liehn, Octavian Bucur
Summary: This review focuses on newly developed strategies, such as vernakalant and stereotactic ablative therapy, for the treatment of arrhythmias. These therapies are important for improving the management of atrial fibrillation and ventricular tachycardia, offering higher success rates and lower costs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jean-Baptiste Guichard, Feng Xiong, Xiao-Yan Qi, Nathalie L'Heureux, Roddy Hiram, Jiening Xiao, Patrice Naud, Jean-Claude Tardif, Antoine Da Costa, Stanley Nattel
Summary: This study assessed the specific contributions of atrial fibrillation-related atrial arrhythmia vs. associated ventricular arrhythmia to remodeling. The results showed that both atrial tachyarrhythmia and rapid ventricular response during AF produce distinct atrial remodelling, providing new insights into AF-related remodeling and ventricular rate-control considerations.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Chang-Hao Xu, Feng Xiong, Wei-Feng Jiang, Xu Liu, Tao Liu, Mu Qin
Summary: Despite significant progress in understanding atrial fibrillation, there are still challenges in its treatment. The review focuses on the rotor mechanism and compares recent clinical approaches to identifying rotors. Though initial studies have shown promising results in rotor ablation, there are some inconclusive outcomes. Hence, there is a need to improve the resolution of mapping techniques and address limitations in current research methodology.
Article
Physics, Fluids & Plasmas
Yin-Jie He, Qi-Hao Li, Kuangshi Zhou, Ruhong Jiang, Chenyang Jiang, Jun-Ting Pan, Dafang Zheng, Bo Zheng, Hong Zhang
Summary: Spiral waves in excitable systems are key motifs of self-sustained dynamical patterns, with phase singularities capturing the complexity of their dynamics. Clinical studies have shown that ablating tissue at phase singularity locations may cure atrial fibrillation. The authors propose a method to determine phase singularity locations by calculating the topological charge at each grid point in space.
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Hansuk Kim, Hana Sheitt, Stephen B. Wilton, James A. White, Julio Garcia
Summary: Patients with nonvalvular paroxysmal atrial fibrillation (PAF) demonstrated a reduced fraction of direct flow and an increase in delayed ejection compared to healthy controls.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Weiyi Yang, Di Wang, Wei Fan, Gong Zhang, Chunying Li, Tong Liu
Summary: In this study, a multi-angle dual-channel fusion network was proposed to automatically recognize AFIB and VFIB heartbeats. By extracting deep task-related and correlation features from two-lead ECGs and fusing them at the decision level, the proposed method achieved accurate classification of arrhythmias.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2023)
Review
Emergency Medicine
Brit Long, William J. Brady, Michael Gottlieb
Summary: This paper evaluates key evidence-based updates concerning atrial fibrillation (AF) with rapid ventricular rate/response (RVR) for emergency clinicians. Differentiating primary and secondary AF with RVR and evaluating hemodynamic stability are important in emergency department assessment and management. Cardioversion is indicated in unstable patients, while rate or rhythm control is recommended for stable patients. Anticoagulation is an essential part of management, and there are tools available to assist with this decision. Understanding recent literature updates on AF with RVR can aid emergency clinicians in providing care for these patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yun Gi Kim, Yun Young Choi, Kyung-Do Han, Kyongjin Min, Ha Young Choi, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: The study found that patients with new-onset AF have a higher risk of developing VT, VFL, and VF, and the incidence of various ventricular arrhythmias significantly increases. The potential risk of suffering lethal ventricular arrhythmia in individuals with AF should be taken into consideration in clinical practice.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Victor Peris-Yaguee, Tony Rubio, Funsho E. Fakuade, Niels Voigt, Stefan Luther, Rupamanjari Majumder
Summary: This paper presents the first ionically detailed mathematical model of porcine atrial electrophysiology. The model is modified based on measured data for different action potential characteristics and shows that early repolarization in pig atria is primarily driven by a calcium-mediated chloride current, which is completely inactivated at high pacing frequencies.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Caroline H. Roney, Nicholas Child, Bradley Porter, Iain Sim, John Whitaker, Richard H. Clayton, Jacob Laughner, Allan Shuros, Petr Neuzil, Steven E. Williams, Reza S. Razavi, Mark O'Neill, Christopher A. Rinaldi, Peter Taggart, Matt Wright, Jaswinder S. Gill, Steven A. Niederer
Summary: This study identified preferential activation pathways during atrial fibrillation (AF) and demonstrated that targeting patient-specific activation pathways from the pulmonary vein antra to the left atrial body using pulmonary vein isolation (PVI) can result in successful termination of AF during the procedure.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ange Maguy, Yuvaraj Mahendran, Jean-Claude Tardif, David Busseuil, Jin Li
Summary: This study explores the association between autoantibodies targeting cardiac ion channels and unexplained AF. They found a common autoantibody response against K(ir)3.4 protein in patients with AF, even before the development of clinically apparent AF. Functional studies and a mouse model of K(ir)3.4 autoimmunity support the causal relationship between K(ir)3.4 autoantibodies and AF.
Article
Cardiac & Cardiovascular Systems
Shirui Lu, Hongyun Liu, Jie Sun, Jun Zhang, Li Li, Qiaoying Tang, Yani Liu, Youbin Deng
Summary: We investigated the changes in left atrial (LA) and left ventricular (LV) in different subtypes of atrial fibrillation (AF) using two-dimensional echocardiography strain techniques. Patients with AF had dilated LA volume, decreased LA reservoir strain, lower LV ejection fraction (LVEF), and impaired global longitudinal strain (GLS). The impairments in LA function were more severe in persistent AF (PerAF) compared to paroxysmal AF (PAF) patients, regardless of LA enlargement.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Thomas Koertl, Thea Stehle, Dominic Riedl, Johanna Trausel, Sabine Rebs, Steffen Pabel, Michael Paulus, Andreas Holzamer, Nassir Marrouche, Lars S. Maier, Christian Sohns, Katrin Streckfuss-Boemeke, Samuel Sossalla
Summary: In vitro experiments using induced pluripotent stem cell-derived cardiomyocytes revealed that an atrial fibrillation burden higher than 50% led to significant functional and structural alterations, potentially impairing cardiac contractility. These findings aid in explaining the adverse effects of atrial fibrillation burden observed in previous clinical studies.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marina Lopez-Yunta, Daniel G. Leon, Jose Manuel Alfonso-Almazan, Manuel Marina-Breysse, Jorge G. Quintanilla, Javier Sanchez-Gonzalez, Carlos Galan-Arriola, Victoria Canadas-Godoy, Daniel Enriquez-Vazquez, Carlos Torres, Borja Ibanez, Julian Perez-Villacastin, Nicasio Perez-Castellano, Jose Jalife, Mariano Vazquez, Jazmin Aguado-Sierra, David Filgueiras-Rama
Article
Cardiac & Cardiovascular Systems
Jose Maria Lillo-Castellano, Juan Jose Gonzalez-Ferrer, Manuel Marina-Breysse, Jose Bautista Martinez-Ferrer, Luisa Perez-Alvarez, Javier Alzueta, Juan Gabriel Martinez, Anibal Rodriguez, Juan Carlos Rodriguez-Perez, Ignasi Anguera, Xavier Vinolas, Arcadio Garcia-Alberola, Jorge G. Quintanilla, Jose Manuel Alfonso-Almazan, Javier Garcia, Luis Borrego, Victoria Canadas-Godoy, Nicasio Perez-Castellano, Julian Perez-Villacastin, Javier Jimenez-Diaz, Jose Jalife, Davidue Filgiras-Rama
Article
Cardiac & Cardiovascular Systems
David Filgueiras-Rama, Jasmina Vasilijevic, Jose Jalife, Sami F. Noujaim, Jose M. Alfonso, Jose A. Nicolas-Avila, Celia Gutierrez, Noelia Zamarreno, Andres Hidalgo, Alejandro Bernabe, Christopher Pablo Cop, Daniela Ponce-Balbuena, Guadalupe Guerrero-Serna, Daniel Calle, Manuel Desco, Jesus Ruiz-Cabello, Amelia Nieto, Ana Falcon
Summary: The study found that human influenza A virus can infect the mouse heart and cardiac-specific conduction system, with highly pathogenic viruses causing faster replication, higher levels of inflammatory cytokines, and higher viral titres in the heart, leading to cardiac conduction abnormalities and high mortality rates.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemical Research Methods
Sung-Soo Park, Daniela Ponce-Balbuena, Rork Kuick, Guadalupe Guerrero-Serna, Justin Yoon, Dattatreya Mellacheruvu, Kevin P. Conlon, Venkatesha Basrur, Alexey I. Nesvizhskii, Jose Jalife, Jean-Francois Rual
MOLECULAR & CELLULAR PROTEOMICS
(2020)
Article
Multidisciplinary Sciences
David Tinaquero, Teresa Crespo-Garcia, Raquel G. Utrilla, Paloma Nieto-Marin, Andres Gonzalez-Guerra, Marcos Rubio-Alarcon, Anabel Camara-Checa, Maria Dago, Marcos Matamoros, Marta Perez-Hernandez, Maria Tamargo, Jorge Cebrian, Jose Jalife, Juan Tamargo, Juan Antonio Bernal, Ricardo Caballero, Eva Delpon
SCIENTIFIC REPORTS
(2020)
Review
Cardiac & Cardiovascular Systems
Giulio La Rosa, Jorge G. Quintanilla, Ricardo Salgado, Juan Jose Gonzalez-Ferrer, Victoria Canadas-Godoy, Julian Perez-Villacastin, Jose Jalife, Nicasio Perez-Castellano, David Filgueiras-Rama
Summary: Anatomical-based approaches, including pulmonary vein isolation, are commonly used in ablation treatments for atrial fibrillation patients. In addition to PVI, electrical isolation of extra PV targets has also increased. New technologies such as cryoballoon ablation have shown promising results in treating paroxysmal AF.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Paloma Nieto-Marin, David Tinaquero, Raquel G. Utrilla, Jorge Cebrian, Andres Gonzalez-Guerra, Teresa Crespo-Garcia, Anabel Camara-Checa, Marcos Rubio-Alarcon, Maria Dago, Silvia Alfayate, David Filgueiras, Rafael Peinado, Jose Luis Lopez-Sendon, Jose Jalife, Juan Tamargo, Juan Antonio Bernal, Ricardo Caballero, Eva Delpon
Summary: TBX5 variants identified in this study are associated with and modulate the electrical phenotype in patients with LQTS and BrS, highlighting their impact on cardiac conduction and action potentials.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Alvaro Macias, J. Jaime Diaz-Larrosa, Yaazan Blanco, Victor Fanjul, Cristina Gonzalez-Gomez, Pilar Gonzalo, Maria Jesus Andres-Manzano, Andre Monteiro da Rocha, Daniela Ponce-Balbuena, Andrew Allan, David Filgueiras-Rama, Jose Jalife, Vicente Andres
Summary: This study found that heart tissue from Hutchinson-Gilford progeria syndrome (HGPS) patients has structural and electrophysiological defects, including disruption of the t-tubular system, shortened sarcomeres, bradycardia, and atrio-ventricular conduction abnormalities. Chronic treatment with low-dose paclitaxel partially corrected these abnormalities.
CARDIOVASCULAR RESEARCH
(2022)
Article
Endocrinology & Metabolism
Abdelwahab Jalal Eldin, Baris Akinci, Andre Monteiro da Rocha, Rasimcan Meral, Ilgin Yildirim Simsir, Suleyman Cem Adiyaman, Ebru Ozpelit, Nicole Bhave, Ramazan Gen, Banu Yurekli, Nilufer Ozdemir Kutbay, Zeynep Siklar, Adam H. Neidert, Rita Hench, Marwan K. Tayeh, Jeffrey W. Innis, Jose Jalife, Hakan Oral, Elif A. Oral
Summary: LMNA variants are associated with a higher prevalence of cardiac events, particularly arrhythmias, in patients with familial partial lipodystrophy (FPLD). Non-codon 482 LMNA variants are more likely to be associated with cardiac events, especially atrial fibrillation or flutter. Studies on LMNA mutant hiPSC-CMs show increased spontaneous activity and shorter action potential duration.
CLINICAL ENDOCRINOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Jorge G. Quintanilla, Shlomo Shpun, Jose Jalife, David Filgueiras-Rama
Summary: Modern cardiac electrophysiology has made significant advancements in understanding the mechanisms of atrial fibrillation (AF) and the debate between randomly propagating wavelets and deterministic rotors continues. Recent research supports the feasibility of targeting and ablating AF driver regions outside of pulmonary veins. New technologies and methodologies have provided platforms for clinicians to implement novel approaches in AF ablation procedures.
CARDIOVASCULAR RESEARCH
(2021)
Correction
Cardiac & Cardiovascular Systems
Alba Alvarez-Franco, Raquel Rouco, Rafael J. Ramirez, Guadalupe Guerrero-Serna, Maria Tiana, Sara Cogliati, Kuljeet Kaur, Mohammed Saeed, Ricardo Magni, Jose Antonio Enriquez, Fatima Sanchez-Cabo, Jose Jalife, Miguel Manzanares
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Giulio La Rosa, Jorge G. Quintanilla, Ricardo Salgado, Juan Jose Gonzalez-Ferrer, Victoria Canadas-Godoy, Julian Perez-Villacastin, Nicasio Perez-Castellano, Jose Jalife, David Filgueiras-Rama
Summary: Catheter ablation is the most effective and relatively minimally invasive therapy for rhythm control in patients with AF, providing significant improvement in patients' quality of life. However, it is not exempt from potential risk of complications and pro-arrhythmia.
EUROPEAN CARDIOLOGY REVIEW
(2021)
Article
Cardiac & Cardiovascular Systems
Alba Alvarez-Franco, Raquel Rouco, Rafael J. Ramirez, Guadalupe Guerrero-Serna, Maria Tiana, Sara Cogliati, Kuljeet Kaur, Mohammed Saeed, Ricardo Magni, Jose Antonio Enriquez, Fatima Sanchez-Cabo, Jose Jalife, Miguel Manzanares
Summary: Transcriptomic and proteomic analysis of AF progression in a large animal model shows significant changes occurring at early stages, including previously undescribed increase in mitochondria, changes to the chromatin of atrial CMs, and genes related to neural function and cell proliferation.
CARDIOVASCULAR RESEARCH
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Alvaro Macias, Andres Gonzalez-Guerra, Ana Isabel Moreno Manuel, Francisco Miguel Cruz Urendez, Garcia Nieves, Lilian Karina Gutierrez-Espinosa de los Monteros, Marta Roche, Francisco Jose Bermudez Jimenez, Maria Linarejos Vera-Pedrosa, Juan A. Bernal, Jose Jalife
Review
Cardiac & Cardiovascular Systems
Mark J. Shen, Rishi Arora, Jose Jalife
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2019)