Article
Oncology
Ge Sun, Harriett Fuller, Hayley Fenton, Amanda D. Race, Amy Downing, Elizabeth A. Williams, Colin J. Rees, Louise C. Brown, Paul M. Loadman, Mark A. Hull
Summary: Urinary levels of PGE-M and 11-d-TXB2 are reduced by aspirin and EPA, and high levels of 11-d-TXB2 predict increased risk of colorectal polyps.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Food Science & Technology
Huilian Chen, Shenghao Zhang, Hui Wang, Ruikun He, Xuguang Zhang, Ruomei Qi
Summary: This study investigated the effect of water-soluble tomato extract, Fruitflow, on platelet function in participants. The results showed that Fruitflow intervention decreased platelet aggregation rate and reduced certain indicators in plasma, indicating that Fruitflow is a functional food for reducing platelet activity.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Pharmacology & Pharmacy
David G. Menter, Robert S. Bresalier
Summary: Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or prevent the progression or recurrence of cancer. Aspirin has shown potential in preventing precursor lesions and cancers, although most clinical data are inferential. The biological targets of aspirin include cyclooxygenases, with newly recognized molecular and cellular interactions suggesting additional modifiable functional targets. This review focuses on pharmacological developments and innovations in biopharmacology for a better understanding of aspirin's role in cancer chemoprevention.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shabbir Ahmed, Kiwon Seo, Yonggyun Kim
Summary: In the polytrophic ovarioles of Spodoptera exigua, the mucin-like protein Se-Mucin1 plays a crucial role in choriogenesis, with its expression levels increasing during the adult stage. RNA interference of Se-Mucin1 results in reduced fecundity and malformed egg development, while supplementation of PGE(2) rescues these impairments. These results suggest that prostaglandins mediate choriogenesis in S. exigua by activating genes associated with chorion formation, including Se-Mucin1.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rachel A. Myers, Thomas L. Ortel, Alexander Waldrop, Sandeep Dave, Geoffrey S. Ginsburg, Deepak Voora
Summary: The study demonstrates a dose-independent effect of aspirin on the platelet transcriptome, potentially acting as an inhibitor of protein synthesis, and correlated with platelet function levels.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Oncology
Linda L. Garland, Jose Guillen-Rodriguez, Chiu-Hsieh Hsu, Lisa E. Davis, Eva Szabo, Christopher R. Husted, Hanqiao Liu, Ashley LeClerc, Yuriy O. Alekseyev, Gang Liu, Julie E. Bauman, Avrum E. Spira, Jennifer Beane, Malgorzata Wojtowicz, H. -H. Sherry Chow
Summary: Aspirin and zileuton have lung cancer prevention effects, but minimal effects on nasal gene expression related to smoking, lung cancer, and COPD. However, they do have a favorable effect on the gene expression related to squamous dysplasia. Continued investigation of leukotriene inhibitors is needed to confirm these findings and identify the safest, optimally dosed agents.
Article
Hematology
Christina C. Rolling, Marcin A. Sowa, Tricia T. T. Wang, MacIntosh Cornwell, Khrystyna Myndzar, Tamar Schwartz, Hanane El Bannoudi, Jill Buyon, Tessa J. Barrett, Jeffrey S. Berger
Summary: Monocyte-platelet aggregates (MPAs) play a role in the intersection of thrombosis and inflammation, and targeting this axis could suppress thromboinflammation. The effect of platelets on monocyte activation and the impact of antiplatelet therapy (APT) on MPA and platelet-induced monocyte activation were analyzed.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Sean P. Heffron, Ada Weinstock, Bianca Scolaro, Shiyu Chen, Brian E. Sansbury, Greg Marecki, Christina C. Rolling, Hanane El Bannoudi, Tessa Barrett, James W. Canary, Matthew Spite, Jeffrey S. Berger, Edward A. Fisher
Summary: Platelet-conditioned media induces an anti-inflammatory, pro-resolving phenotype in macrophages. This effect is partially mediated by prostaglandin E2 stimulating the EP4 receptor on macrophages, leading to altered gene expression and function.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Multidisciplinary Sciences
Ali R. Keramati, Ming-Huei Chen, Benjamin A. T. Rodriguez, Lisa R. Yanek, Arunoday Bhan, Brady J. Gaynor, Kathleen Ryan, Jennifer A. Brody, Xue Zhong, Qiang Wei, Kai Kammers, Kanika Kanchan, Kruthika Iyer, Madeline H. Kowalski, Achilleas N. Pitsillides, L. Adrienne Cupples, Bingshan Li, Thorsten M. Schlaeger, Alan R. Shuldiner, Jeffrey R. O'Connell, Ingo Ruczinski, Braxton D. Mitchell, Nauder Faraday, Margaret A. Taub, Lewis C. Becker, Joshua P. Lewis, Rasika A. Mathias, Andrew D. Johnson
Summary: Platelet aggregation is associated with myocardial infarction and stroke. A whole genome sequencing study identified a locus in RGS18, suggesting an effect on haematopoeitic lineage transcription factors.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Fionnuala Mone, Juhi K. Gupta, Marie M. Phelan, Shireen Meher, Lu Yung Lian, Ben Francis, Eunice Zhang, Cecilia Mulcahy, Ana Alfirevic, Fionnuala M. Mcauliffe, Kate Navaratnam
Summary: This multi-center prospective study recruited pregnant women taking low dose aspirin to develop reference intervals for a range of laboratory based platelet function tests, identify genomic variants influencing platelet response to aspirin, and evaluate the effectiveness of biochemical testing strategies. The study found that combining 11DTXB2 with adherence testing was an accurate strategy for detecting aspirin responsiveness in pregnant women, and no significant genetic variants were associated with aspirin response in pregnancy. Further research is needed to optimize dosing and benefits for specific subgroups.
Article
Cardiac & Cardiovascular Systems
Arthur Shiyovich, Liat Sasson, Eli Lev, Alejandro Solodky, Ran Kornowski, Leor Perl
Summary: This study found a significant association between MV-CAD and HAPR, with a dose-response relationship between the number of stenotic coronary arteries and the rate of HAPR.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Review
Allergy
Cesar Picado, Joaquim Mullol, Jordi Roca-Ferrer
Summary: Aspirin-exacerbated respiratory disease (AERD) is characterized by excessive cysteinyl leukotrienes (CysLTs) production, reduced prostaglandin E2 (PGE2) synthesis and downregulated expression of the EP2 receptor. The dysregulation of the COX-2 pathway in AERD is attributed to alterations in the autocrine metabolic loop involving IL-113, IL-1 receptor type I, EP2, COX-2, membrane-bound PGE2 prostaglandin E2 synthase-1, and PGE2. Blocking IL-4 with dupilumab can normalize the expression of EP2, restore the functioning of the COX-2 pathway, and improve aspirin tolerance.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Hematology
Joanne L. Dunster, Alexander P. Bye, Neline Kriek, Tanya Sage, Joanne L. Mitchell, Carly Kempster, Joana Batista, Harriet McKinney, Patrick Thomas, Chris Jones, Kate Downes, Amanda J. Unsworth, Jonathan M. Gibbins
Summary: The PPAnalysis assay provides a detailed characterization of platelet function and identifies distinct subpopulations of donors based on their platelet reactivity metrics. It shows that platelet reactivity is not simply categorized as high or low responders, but exists in 6 subgroups with distinct platelet phenotypes within healthy cohorts. These platelet phenotypes are stable and can be used for stratification of cohorts to investigate the causes and consequences of differences in platelet function.
Article
Cardiac & Cardiovascular Systems
Zhiyong Qi, Liang Hu, Jianjun Zhang, Wenlong Yang, Xin Liu, Daile Jia, Zhifeng Yao, Lin Chang, Guanxing Pan, Haoxuan Zhong, Xinping Luo, Kang Yao, Aijun Sun, Juying Qian, Zhongren Ding, Junbo Ge
Summary: PCSK9 in plasma directly enhances platelet activation and in vivo thrombosis by binding to platelet CD36 and activating downstream signaling pathways. PCSK9 inhibitors or aspirin can abolish the enhancing effects of PCSK9.
Article
Oncology
Maeve Kiely, Ginger L. Milne, Tsion Z. Minas, Tiffany H. Dorsey, Wei Tang, Cheryl J. Smith, Francine Baker, Christopher A. Loffredo, Clayton Yates, Michael B. Cook, Stefan Ambs
Summary: The study investigated the association of urinary PGE-M levels with lethal prostate cancer in African American and European American men, finding a significant relationship between high PGE-M and all-cause mortality in African American men with prostate cancer who did not regularly use aspirin. This association disappeared among cases who reported using aspirin, suggesting a potential benefit of aspirin in reducing mortality among African American men with prostate cancer.
