Article
Neurosciences
Min Zhu, Longfei Jia, Jianping Jia
Summary: The study identified miR-96-5p as the upstream miRNA for ABCA1, and inhibition of miR-96-5p in AD models could reduce A beta(42)/A beta(40) ratios by upregulating the expression of ABCA1, indicating an important role of miR-96-5p in regulating A beta content.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Public, Environmental & Occupational Health
Liv Tybjaerg Nordestgaard, Mette Christoffersen, Shoaib Afzal, Borge Gronne Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: Genetic variants in ABCA1 associated with high HDL cholesterol concentrations are also associated with higher risk of AMD, suggesting a role for ABCA1 in AMD pathogenesis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fengqing Zhu, Guanglei Chang, Xiaoqiong Tang, Lingyun Gao, Nan Zhang
Summary: Doxorubicin (DOX) is used for cancer treatment but can cause cardiovascular toxicity. This study examined whether DOX promotes atherosclerosis by impairing cardiac function. The results showed that DOX increased miR-33 expression and reduced the protein level of ATP binding cassette transporter A1 (ABCA1). DOX also suppressed cholesterol efflux, especially under high-cholesterol conditions. Transfection of miR-33 mimics or inhibitors into cells respectively decreased or increased ABCA1 protein expression and regulated intracellular lipid accumulation. Overall, DOX upregulates miR-33 to suppress ABCA1 expression, leading to intracellular lipid deposition in macrophages, which is an early sign of atherosclerosis. This study provides new insights for the clinical observation and evaluation of DOX side effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song
Summary: The study investigated the lipid profile in hypertensive disorders of pregnancy (HDP) patients, finding significantly altered levels of plasma triglycerides, total cholesterol, LDL-C, and HDL-C compared to normotensive controls. ANP was shown to inhibit ABCA1 and ABCG1 expression at both mRNA and protein levels, leading to impaired cholesterol efflux, possibly explaining the decreased HDL-C levels in HDP patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Leonor Jacobo-Albavera, Mayra Dominguez-Perez, Diana Jhoseline Medina-Leyte, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina
Summary: ABCA1 plays a crucial role in cholesterol homeostasis, reverse cholesterol transport, lipid content in the plasma membrane, and the development of organ diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Waqas Javed, Sylvain Vallet, Marie-Pierre Clement, Aline Le Roy, Martine Moulin, Michael Hartlein, Cecile Breyton, Odile Burlet-Schiltz, Julien Marcoux, Cedric Orelle, Christine Ebel, Anne Martel, Jean-Michel Jault
Summary: This study used small angle neutron scattering and hydrogen/deuterium exchange coupled to mass spectrometry to investigate the conformational states of the BmrA transporter during its ATPase cycle. The researchers found that under specific mutation conditions, the BmrA transporter can be trapped in an ATP-bound inward-facing conformation. Comparing the transition-like state induced by vanadate with the apo state or the presence of ADP/Mg, it was observed that in the post-hydrolytic step, the distances between the two nucleotide-binding domains appeared to be more separated but remained shorter than in the widest opening state found in the related transporter MsbA.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Plant Sciences
Fiza Liaquat, Muhammad Farooq Hussain Munis, Samiah Arif, Muhammad Aamir Manzoor, Urooj Haroon, Iftikhar Hussain Shah, Muhammad Ashraf, Hyun Seok Kim, Shengquan Che, Liu Qunlu
Summary: This study investigated the differential gene expression of Schima superba under Mn metal stress through transcriptomic analysis. The differentially expressed genes were found to be involved in defense, signaling pathways, oxidative burst, transcription factors, and stress responses. The results provide insights into the metal resistance mechanisms and contribute to the understanding of heavy metal tolerance and detoxification.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yaolei Mi, Xue Cao, Xuewen Zhu, Weiqiang Chen, Xiangxiao Meng, Huihua Wan, Wei Sun, Sifan Wang, Shilin Chen
Summary: This study identified and characterized 113 ABC transporters in C. sativa, and proposed seven core transporters that may participate in cannabinoid transport. These candidate genes showed high correlation with cannabinoid biosynthetic pathway genes and content, and were highly expressed in cannabinoid biosynthesis and accumulation sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jie Gao, Yanan Liang, Jinping Li, Shuqi Wang, Meiqi Zhan, Meihui Zheng, He Li, Zhenming Yang
Summary: This study identified and characterized a SbSTAR1 gene in sweet sorghum that is implicated in aluminum tolerance, suggesting the existence of a SbSTAR1-mediated aluminum tolerance mechanism in sorghum. Overexpression of SbSTAR1 significantly enhanced the aluminum tolerance of transgenic plants through possibly regulating the hemicellulose content in root cell wall. The transcription of SbSTAR1 is induced by aluminum in a time- and dosage-dependent manner in the root, especially in the root tip.
PLANT SIGNALING & BEHAVIOR
(2021)
Review
Biochemistry & Molecular Biology
Samiksha Kukal, Debleena Guin, Chitra Rawat, Shivangi Bora, Manish Kumar Mishra, Priya Sharma, Priyanka Rani Paul, Neha Kanojia, Gurpreet Kaur Grewal, Shrikant Kukreti, Luciano Saso, Ritushree Kukreti
Summary: ABCG2 is a widely distributed protein in different cell types that plays a crucial role in maintaining cellular homeostasis and protecting tissues against xenobiotic insults, but its expression is influenced by various pathophysiological conditions. Therapeutic interventions should focus on regulating levels of ABCG2 rather than directly inhibiting its function to avoid serious side effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Solene Marie, Irene Hernandez-Lozano, Oliver Langer, Nicolas Tournier
Summary: Hepatocyte transporters play a crucial role in the hepatobiliary elimination of various substances, influenced by different pathophysiological conditions and specific drugs; Tc-99m-mebrofenin has been used for hepatobiliary scintigraphy for years, but the specific transporters controlling its liver kinetics have only recently been characterized; Pharmacokinetic modeling offers a translational method to study transporter-mediated drug interactions, providing insights into liver function as a biomarker.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Latifa Alketbi, Abeer Al-Ali, Iman M. Talaat, Qutayba Hamid, Khuloud Bajbouj
Summary: Colorectal cancer (CRC) is a common malignancy worldwide, ranked fourth in cancer-related deaths. Mutations in oncogenes, tumor suppressor genes, and DNA repair genes contribute to the development of CRC. Chemoresistance is one of the major challenges in CRC treatment, and the overexpression of ATP-binding cassette (ABC) transporters has been identified as a facilitating mechanism for chemoresistance. ABC transporters are involved in lipid transport and homeostasis, which play a crucial role in tumor development and progression. Altered expression of ABCA transporters in CRC is associated with poor prognosis and overall survival. This minireview suggests that ABCA transporters could serve as potential diagnostic and therapeutic targets in CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Silpa Narayanan, Zhuo-Xun Wu, Jing-Quan Wang, Hansu Ma, Nikita Acharekar, Jagadish Koya, Sabesan Yoganathan, Shuo Fang, Zhe-Sheng Chen, Yihang Pan
Summary: In this study, GS-9973 showed efficacy in overcoming ABCG2-mediated multidrug resistance in non-small cell lung cancer cells. The drug reversed drug resistance by blocking ABCG2 efflux activity and downregulating ABCG2 expression at the protein level, suggesting it as a potential strategy to overcome MDR in cancers.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Applied
Alba M. Garcia-Lino, Alex Gomez-Gomez, Dafne Garcia-Mateos, Alvaro de la Fuente, Ana I. Alvarez, Oscar J. Pozo, Gracia Merino
Summary: ABCG2 is involved in the secretion of several compounds in milk, with higher levels of tryptophan-related compounds in wild-type mice compared to Abcg2(-/-) mice. The milk-to-plasma ratio of these compounds was also higher in dairy cows carrying the ABCG2 Y581S polymorphism compared to noncarrier animals. In vitro transport assays confirmed these findings and validated differences in the bovine protein variants.
Article
Pharmacology & Pharmacy
Louise Breuil, Nora Ziani, Sarah Leterrier, Gaelle Hugon, Fabien Caille, Viviane Bouilleret, Charles Truillet, Maud Goislard, Myriam El Biali, Martin Bauer, Oliver Langer, Sebastien Goutal, Nicolas Tournier
Summary: This study investigated the impact of CYP inducers and inhibitors on the brain and plasma kinetics of [C-11]metoclopramide using PET imaging. The results showed that CYP induction or inhibition had negligible effects on the plasma kinetics and metabolism of [C-11]metoclopramide, but ritonavir significantly increased brain penetration.
Article
Endocrinology & Metabolism
Kylie Kavanagh, Alexander C. Bashore, Matthew A. Davis, Matthew J. Jorgensen, Christopher J. McClouth, Daniel A. Beavers, John S. Parks
Summary: This study demonstrates the efficacy of early time-restricted feeding (eTRF) in increasing high-density lipoprotein (HDL) cholesterol efflux capacity (CEC) in nonhuman primates (NHPs). eTRF induces larger-sized HDL particles, increases HDL apolipoprotein A-1 content, lowers triglyceride concentrations, and increases plasma CEC primarily to HDL particles.
Article
Chemistry, Medicinal
Mingxia Liu, Kaiyao Zhang, Qinjue Li, Haiying Pang, Zhaoping Pan, Xiaowei Huang, Lian Wang, Fengbo Wu, Gu He
Summary: In recent years, extensive research has been carried out on the molecular mechanisms and inhibitors targeting bromodomains (BRDs) and extra-terminal (BET) family proteins. Non-BET BRDs are gaining attention as a research hot spot. BRDs are abundant in histone acetyltransferase (HAT)-associated activating transcription factors, and BRD-containing HATs have been associated with cancer, inflammation, and viral replication. The development of BRD-containing HATs as chemical probes is valuable for understanding the specific biological roles of BRDs in diseases and drug discovery. Different types of BRD-containing HATs, including CBP/P300, PCAF/GCN5, and TAF1, are discussed in terms of their structures, functions, and small-molecule inhibitors. Furthermore, the progress in BRD inhibitors/chemical probes and proteolysis targeting chimeras regarding drug design, biological activity, and disease application is summarized. These findings provide insights into the development of BRD inhibitors as potential drug candidates for various diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Computer Science, Artificial Intelligence
Yuqi Fang, Mingliang Wang, Guy G. Potter, Mingxia Liu
Summary: This study proposes a novel discrepancy-based unsupervised cross-domain fMRI adaptation framework (UFA-Net) for automated identification of major depressive disorder (MDD) using resting-state functional magnetic resonance imaging (rs-fMRI) data. The UFA-Net models the spatio-temporal fMRI patterns of labeled source and unlabeled target samples and aligns features between two domains using attention-guided graph convolution module and maximum mean discrepancy constrained module. The proposed method outperforms several state-of-the-art methods and can facilitate fMRI-based analysis of MDD in clinical practice.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Oncology
Zhiwei Ji, Jade Moore, Nelmi O. Devarie-Baez, Joshua Lewis, Hanzhi Wu, Kirtikar Shukla, Elsa I. Silva Lopez, Victor Vitvitsky, Chia-Chi Chuang Key, Mercedes Porosnicu, Melissa L. Kemp, Ruma Banerjee, John S. Parks, Allen W. Tsang, Xiaobo Zhou, Cristina M. Furdui
Summary: Redox metabolism is an important regulator in cancer, affecting tumor progression, response to therapies, and patients' quality of life. However, the ability to integrate redox information across signaling and metabolic networks is currently limited, hindering the advancement of new cancer therapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhen Guo, Carla Valenzuela Ripoll, Antonino Picataggi, David R. Rawnsley, Mualla Ozcan, Julio A. Chirinos, Ezhilarasi Chendamarai, Amanda Girardi, Terrence Riehl, Hosannah Evie, Ahmed Diab, Attila Kovacs, Krzysztof Hyrc, Xiucui Ma, Aarti Asnani, Swapnil Shewale, Marielle Scherrer-Crosbie, Lauren Ashley Cowart, John S. Parks, Lei Zhao, David Gordon, Francisco Ramirez-Valle, Kenneth B. Margulies, Thomas P. Cappola, Ankit A. Desai, Lauren N. Pedersen, Carmen Bergom, Nathan O. Stitziel, Michael P. Rettig, John F. DiPersio, Stefan Hajny, Christina Christoffersen, Abhinav Diwan, Ali Javaheri
Summary: This study reveals that Apolipoprotein M (ApoM) is inversely associated with mortality in heart failure patients and is reduced by anthracyclines like doxorubicin. In the presence of Dox stress, ApoM can sustain myocardial autophagic flux through post-transcriptional regulation, attenuate Dox cardiotoxicity, and prevent lysosomal injury.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Allergy
Bilal Haider Shamsi, Haiyuan Chen, Xiong Yang, Mingxia Liu, Yonglin Liu
Summary: This study found that SNPs in GSDMB gene are associated with susceptibility to allergic rhinitis (AR), with rs4795400 showing a protective effect in overall, males, people with BMI ≤ 24, and those living in wind-blown sand area. rs2305479 is associated with reduced risk of AR in males, while rs12450091 is a risk factor for AR in people living in the loess hilly region. The findings suggest that GSDMB polymorphisms are correlated with AR susceptibility.
Article
Chemistry, Analytical
Mingxia Liu, Jing He, Canjun Ruan, Weigang Pan, Peixian Mao, Zuoli Sun, Gang Wang, Jian Yang
Summary: A convenient LC-MS/MS method was developed for simultaneous measurement of L- and D-amino acids. The method was applied to quantify serum chiral amino acids in late-life depression patients and controls, revealing potential biomarkers of late-life depression.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Neurosciences
Hao Guan, Mingxia Liu
Summary: Domain adaptation is an important technique in machine learning-based medical data analysis to reduce distribution differences between different datasets. The Domain Adaptation Toolbox for Medical data analysis (DomainATM) is an open-source software package implemented in MATLAB, offering a collection of popular data adaptation algorithms for medical image analysis. It provides researchers with the capability to perform fast feature-level and image-level adaptation, visualization, and performance evaluation of adaptation methods. Users can also develop and test their own adaptation methods through scripting, enhancing the utility and extensibility of DomainATM. The software, source code, and manual are available online.
Article
Chemistry, Physical
Chunjie Ding, Xiaoyu Zhang, Mingxia Liu, Lisheng Zhang, Shuo Yang, Yan Fang
Summary: The morphology of hollow noble metal nanoparticles is crucial for their unique properties and applications. In this study, a galvanic replacement reaction was used to synthesize hollow gold nanocubes, and ascorbic acid and CTAB were introduced to control the shape of the resulting hollow gold nanotetrakaidecahedrons. CTAB selectively adsorbed on specific facets, inhibiting their growth and allowing the {111} facet to grow fastest. Optical absorption spectra further confirmed the formation and growth mechanism. The study demonstrates the ability to fabricate hollow nanoparticles with desired shapes by adjusting experimental conditions.
Review
Gastroenterology & Hepatology
Lianrui Cao, Na Qu, Xin Wang, Lijiang Chen, Mingxia Liu
Summary: Non-alcoholic fatty liver disease, a prevalent disease worldwide, is increasingly becoming the main concern in liver diseases. The pathogenesis remains unclear, but recent studies have shown the involvement of long non-coding RNAs in various biological processes and their impact on disease through gene regulation. This review explores the role of long non-coding RNAs in lipid metabolism, glucose metabolism, liver fibrosis, and apoptosis, providing insights into their potential therapeutic targets and limitations.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Jinjian Wu, Yuqi Fang, Xin Tan, Shangyu Kang, Xiaomei Yue, Yawen Rao, Haoming Huang, Mingxia Liu, Shijun Qiu, Pew-Thian Yap
Summary: Research shows that the functional connectivity in patients with T2DM is associated with mild cognitive impairment, and rs-fMRI can be used for early diagnosis. By analyzing the rs-fMRI data of T2DM-MCI patients, T2DM-NCI patients, and normal controls, it was found that the thalamus, angular, caudate nucleus, and paracentral lobule had the greatest contribution to the classification outcome. These findings provide valuable knowledge for classification and prediction of T2DM-related cognitive impairment, aid in early clinical diagnosis, and lay the foundation for future studies.
SCIENTIFIC REPORTS
(2023)
Article
Geriatrics & Gerontology
Yue Du, Guangyu Wang, Chengcheng Wang, Yangyang Zhang, Xiaoming Xi, Limei Zhang, Mingxia Liu
Summary: In this paper, an accurate module induced Pearson correlation (AM-PC) model is proposed to estimate functional brain networks (FBNs) with a clear modular structure by incorporating sparse and low-rank constraints on the Laplacian matrix of the network. Experimental results show that the proposed method achieves better classification performance for classifying subjects with mild cognitive impairment (MCI) from healthy controls compared to previous methods.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Immunology
Rui Chen, Mingxia Liu, Quanhong Jiang, Xiangbo Meng, Junmin Wei
Summary: cGAS-STING pathway, a vital component of host innate immunity, detects infections or tissue damage by binding to microbial or self-DNA in the cytoplasm. Recent studies suggest that this pathway might play an important role in anticancer immunity, although its mechanism is still unclear. This review highlights the latest understanding of the cGAS-STING pathway in tumor development and the advances in combination therapy of STING agonists and immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Physical
Mingxia Liu, Xin Hui, Xin Xue, Yuzhen Lin, Chong-Wen Zhou
Summary: Chemical kinetic studies of hydrogen atom abstraction reactions by hydroperoxyl radical from six alkyl cyclohexanes are conducted through high-level ab initio calculations. Rate constants, branching ratios, and thermodynamic properties are obtained, and their effects on ignition delay time predictions and species concentrations are investigated. The investigated reactions promote ignition delay times and improve the prediction of cyclic olefin species formation.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Mingxia Liu, Mingyang Fan, Shu Zhu, Weiping Liu, Lili Yang, Dengteng Ge
Summary: This article reports a versatile membrane with integrated visible transparency and shape manipulation. The membrane is composed of thermo-irritated shape memory polymers and doped nonclose-packing nanoparticles (NPs). It exhibits reversible transparency change and shape deformation due to light scattering and thermal-control bidirectional actuation. The programmable reconfiguration and transparency-changing of this smart film highlight its great potential in various applications.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)