Review
Endocrinology & Metabolism
Wenqi Fan, Haipeng Pang, Zhiguo Xie, Gan Huang, Zhiguang Zhou
Summary: Diabetes mellitus is an endocrine disorder characterized by a lack of insulin. The pathogenesis of this disease remains unclear. Recent studies have shown the significant roles of circular RNAs in diabetes, suggesting their potential as biomarkers and treatment tools.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tiziana Ciarambino, Pietro Crispino, Gaetano Leto, Erika Mastrolorenzo, Ombretta Para, Mauro Giordano
Summary: Gender differences play an important role in the pathophysiology and treatment of many diseases. They are not only determined by genetic makeup but also influenced by socio-cultural habits, behaviors, and lifestyles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Ying Gao, Hu Wang, Gan Fu, Yongliang Feng, Weiwei Wu, Hailan Yang, Yawei Zhang, Suping Wang
Summary: This study found an association between high arsenic exposure and gestational diabetes mellitus (GDM). Six genes related to GDM were identified and a predictive model for GDM risk was established.
Article
Biochemistry & Molecular Biology
Guodong Ge, Jing Ren, Guili Song, Qing Li, Zongbin Cui
Summary: A zebrafish diabetes model was established by overfeeding, and the molecular basis of zebrafish diabetes induced by overfeeding was explored. The results showed that overfeeding led to increased body length, body weight, condition factor index, fasting blood glucose level, lipid droplet accumulation, and triglyceride and cholesterol levels in the liver of zebrafish. Transcriptome sequencing revealed up-regulated genes associated with fatty acid metabolism and down-regulated genes involved in glucose metabolism. These findings provide insights into the molecular basis of zebrafish diabetes induced by overfeeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kosmas Margaritis, Georgia Margioula-Siarkou, Styliani Giza, Eleni P. Kotanidou, Vasiliki Regina Tsinopoulou, Athanasios Christoforidis, Assimina Galli-Tsinopoulou
Summary: Type-1 diabetes mellitus (T1DM) is a well-defined metabolic disorder characterized by hyperglycemia, with a growing incidence in children and adolescents. Recent discoveries of molecules like micro ribonucleic acids (miRNAs) and their interactions with T1DM have provided new insights into disease diagnosis. MiRNAs play a key role in T1DM pathogenesis by interfering with pancreatic b-cell function, insulin production and secretion, and are being studied as potential biomarkers for early diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Rasoul Kowsar, Alireza Mansouri
Summary: This study used a multi-level approach to establish the relationship between diabetes, blood biochemical markers, age, and BMI. The findings identified BMI and HbA1c as the best predictors of T2D.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, Emma Vanderleeden, Melanie I. Trombly, Christina E. Baer, David M. Harlan, Dale L. Greiner, Manuel Garber, Jennifer P. Wang
Summary: This article explores the early cellular processes of autoimmune type 1 diabetes in rats, and identifies the stress response of beta- and alpha-cells as well as their association with immune cells. These findings provide insights for the development of therapeutic and prevention strategies for T1D.
Article
Urology & Nephrology
Youjin Pan, Hui Yang, Tucan Chen, Jian Jin, Luya Ruan, Liang Hu, Li Chen
Summary: This study aimed to evaluate the metabolomic characteristics of plasma extracellular vesicles (EVs) in different stages of diabetic kidney disease (DKD) and select new biomarkers for early DKD diagnosis. The results showed that uracil, LPC(O-18:1/0:0), sphingosine 1-phosphate, and 4-acetamidobutyric acid exhibited potential as suitable biomarkers for early DKD diagnosis.
Article
Medicine, Research & Experimental
Melanie R. Shapiro, Xiaoru Dong, Daniel J. Perry, James M. McNichols, Puchong Thirawatananond, Amanda L. Posgai, Leeana D. Peters, Keshav Motwani, Richard S. Musca, Andrew Muir, Patrick Concannon, Laura M. Jacobsen, Clayton E. Mathews, Clive H. Wasserfall, Michael J. Haller, Desmond A. Schatz, Mark A. Atkinson, Maigan A. Brusko, Rhonda L. Bacher, Todd M. Brusko
Summary: This study investigates the immune cell subsets in peripheral blood and their changes in individuals with type 1 diabetes (T1D). The researchers found accelerated immune aging in T1D and identified phenotypes associated with the disease. These findings provide insights for biomarker monitoring and therapeutic interventions.
Review
Biochemistry & Molecular Biology
Lowell Dilworth, Aldeam Facey, Felix Omoruyi
Summary: Adipose tissues, particularly brown and white adipose tissues, play key roles in communication and insulin sensitivity in the development and treatment of type 2 diabetes. Adipocytokines produced by adipose tissues, like leptin and adiponectin, vary in conditions such as metabolic dysfunction, diabetes, and inflammation. The regulation of satiety, energy metabolism, and insulin release by adipose tissues indicates their significance in the pathogenesis of diabetes mellitus and its complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Laura Mourino-Alvarez, Nerea Corbacho-Alonso, Tamara Sastre-Oliva, Cecilia Corros-Vicente, Jorge Solis, Teresa Tejerina, Luis R. Padial, Maria G. Barderas
Summary: Aortic stenosis (AS) and diabetes mellitus (DM) are both progressive diseases with a high prevalence of DM in AS patients, leading to more severe progression. The complexity of managing patients with common comorbidities increases the necessity for aortic valve replacement as the primary treatment option. Understanding the pathogenesis and relationship between AS and DM is crucial for designing appropriate preventive and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Subrat Kumar Bhattamisra, Hui Min Koh, Shin Yean Lim, Hira Choudhury, Manisha Pandey
Summary: Catalpol isolated from Rehmannia glutinosa shows potent antioxidant properties and has been investigated for its effects on diabetes mellitus and its complications. The molecular pathways involved include promoting IRS-1/PI3K/AKT/GLUT2 activity, suppressing PEPCK and G6Pase expression in the liver, inducing myogenesis in skeletal muscles, and exerting antioxidant effects in the pancreas and liver. Catalpol also demonstrates neuroprotective, cardioprotective, and osteoblast stimulating effects, as well as potential in preventing neurodegeneration in the retina.
Article
Endocrinology & Metabolism
Vidhu V. Thaker, Lydia Coulter Kwee, Haiying Chen, Judy Bahnson, Olga Ilkayeva, Michael J. Muehlbauer, Bruce Wolfe, Jonathan Q. Purnell, Xavier Pi-Sunyer, Christopher B. Newgard, Svati H. Shah, Blandine Laferrere
Summary: This observational study found that metabolomic changes in individuals with type 2 diabetes after weight loss are associated with improved health, particularly the association between branched-chain amino acids (BCAAs) and HbA1c change.
Article
Endocrinology & Metabolism
Runyu Du, Ling Li, Yanjun Wang
Summary: This study revealed the potential crosstalk between immune infiltration and N-6-methyladenosine (m(6)A) modification in the placentas of patients with gestational diabetes mellitus (GDM). The researchers developed a model for the diagnosis of GDM based on imbalanced immune infiltration and differentially expressed m(6)A-related genes (DMRGs). The results provide insights into novel biomarkers and therapeutic targets for GDM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Carlos A. Celis-Morales, Stefan Franzen, Katarina Eeg-Olofsson, Emma Naucler, Ann-Marie Svensson, Soffia Gudbjornsdottir, Bjorn Eliasson, Naveed Sattar
Summary: This study suggests that there is an association between type 2 diabetes and different subtypes of dementia, with the strongest association observed for vascular dementia. Additionally, poor glycemic control in patients with type 2 diabetes is associated with an increased risk of developing vascular and nonvascular dementia.
Article
Cell Biology
Claudiane Guay, Janine K. Kruit, Sophie Rome, Veronique Menoud, Niels L. Mulder, Angelika Jurdzinski, Francesca Mancarella, Guido Sebastiani, Alena Donda, Bryan J. Gonzalez, Camilla Jandus, Karim Bouzakri, Michel Pinget, Christian Boitard, Pedro Romero, Francesco Dotta, Romano Regazzi
Article
Medicine, Research & Experimental
Regan Roat, Md Munir Hossain, Jenica Christopherson, Colette Free, Claudiane Guay, Romano Regazzi, Zhiguang Guo
XENOTRANSPLANTATION
(2019)
Review
Biochemistry & Molecular Biology
Lena Eliasson, Romano Regazzi
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Mathie Tenenbaum, Valerie Plaisance, Raphael Boutry, Valerie Pawlowski, Cecile Jacovetti, Clara Sanchez-Parra, Helene Ezanno, Julien Bourry, Nicole Beeler, Gianni Pasquetti, Valery Gmyr, Stephane Dalle, Julie Kerr-Conte, Francois Pattou, Syu-ichi Hirai, Romano Regazzi, Amelie Bonnefond, Philippe Froguel, Amar Abderrahmani
Summary: The study revealed that activation of Jnk3 signaling by Dlk could be a key mechanism for adapting islet beta-cell mass during postnatal development and weight gain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Correction
Multidisciplinary Sciences
Claudiane Guay, Baroj Abdulkarim, Jennifer Y. Tan, Gilles Dubuis, Sabine Ruetti, David Ross Laybutt, Christian Widmann, Romano Regazzi, Ana Claudia Marques
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Claudiane Guay, Baroj Abdulkarim, Jennifer Y. Tan, Gilles Dubuis, Sabine Rutti, David Ross Laybutt, Christian Widmann, Romano Regazzi, Ana Claudia Marques
SCIENTIFIC REPORTS
(2020)
Article
Medicine, General & Internal
Chloe Amouyal, Julien Castel, Claudiane Guay, Amelie Lacombe, Jessica Denom, Stephanie Migrenne-Li, Christine Rouault, Florian Marquet, Eleni Georgiadou, Theodoros Stylianides, Serge Luquet, Herve Le Stunff, Raphael Scharfmann, Karine Clement, Guy A. Rutter, Olivier Taboureau, Christophe Magnan, Romano Regazzi, Fabrizio Andreelli
Review
Biochemistry & Molecular Biology
Flora Brozzi, Romano Regazzi
Summary: CircRNAs are a type of non-coding RNA with a closed circular structure that can play a role in the development of certain diseases through the adjustment of splicing processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Cristina Cosentino, Romano Regazzi
Summary: This paper summarizes the origin, function, and role of macrophages in disease, with a particular focus on the relationship between pancreatic islet resident macrophages and beta cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Cecile Jacovetti, Mustafa Bilal Bayazit, Romano Regazzi
Summary: ncRNAs play crucial roles in gene regulation, with various types having different regulatory functions. piRNAs, snoRNAs, and tRFs have potential therapeutic implications in metabolic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cecile Jacovetti, Romano Regazzi
Summary: The functional maturation of insulin-secreting beta-cells is crucial for meeting insulin needs later in life. Various cellular pathways and environmental factors affect beta-cell development and maturation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Mustafa Bilal Bayazit, Cecile Jacovetti, Cristina Cosentino, Jonathan Sobel, Kejing Wu, Flora Brozzi, Adriana Rodriguez-Trejo, Lisa Stoll, Claudiane Guay, Romano Regazzi, Kejing Wu, Flora Brozzi, Adriana Rodriguez-Trejo, Lisa Stoll, Claudiane Guay, Romano Regazzi
Summary: tRNA-derived fragments (tRFs) are a class of small non-coding RNAs that play a role in the regulation of beta cell maturation. Inhibition of specific tRFs in neonatal rat islets resulted in reduced beta cell proliferation, insulin secretion, and perturbation of mitochondrial respiration. The enriched mitochondrial localization of certain tRFs and their interaction with Musashi-1 may contribute to these regulatory effects. Furthermore, dysregulation of tRFs was observed in the islets of diabetic and diabetes-prone animals.
Article
Endocrinology & Metabolism
Shenghan Su, Qingrui Zhao, Lingfeng Dan, Yuqing Lin, Xuebei Li, Yunjin Zhang, Chunxiao Yang, Yimeng Dong, Xiaohan Li, Romano Regazzi, Changhao Sun, Xia Chu, Huimin Lu
Summary: This study demonstrates that melatonin protects against stearic acid-induced β-cell senescence by inhibiting miR-146a-5p and miR-8114 and upregulating Mafa expression. This not only provides novel targets for preventing stearic acid-induced β-cell dysfunction, but also points to melatonin as a promising drug to combat type 2 diabetes progression.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Lisa Stoll, Adriana Rodriguez-Trejo, Claudiane Guay, Flora Brozzi, Mustafa Bilal Bayazit, Sonia Gattesco, Veronique Menoud, Jonathan Sobel, Ana Claudia Marques, Morten Trillingsgaard Veno, Jonathan Lou S. Esguerra, Mohammad Barghouth, Mara Suleiman, Lorella Marselli, Jorgen Kjems, Lena Eliasson, Erik Renstroem, Karim Bouzakri, Michel Pinget, Piero Marchetti, Romano Regazzi
NATURE COMMUNICATIONS
(2020)
Article
Endocrinology & Metabolism
Julien Papin, Francesco Paolo Zummo, Nathalie Pachera, Claudiane Guay, Romano Regazzi, Alessandra K. Cardozo, Andre Herchuelz
JOURNAL OF THE ENDOCRINE SOCIETY
(2018)
