Article
Medicine, Research & Experimental
Jiabing Zhan, Kunying Jin, Nan Ding, Yufei Zhou, Guo Hu, Shuai Yuan, Rong Xie, Zheng Wen, Chen Chen, Huaping Li, Dao Wen Wang
Summary: Intensive glycemic control is insufficient for reducing the risk of heart failure in patients with diabetes mellitus. MiR-320 and CD36 mutually enhance each other's expression, forming a positive feedback loop that sustains a hyperlipidemic state in the heart.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Cardiac & Cardiovascular Systems
Jin Li, Ane M. Salvador, Guoping Li, Nedyalka Valkov, Olivia Ziegler, Ashish Yeri, Chun Yang Xiao, Bessie Meechoovet, Eric Alsop, Rodosthenis S. Rodosthenous, Piyusha Kundu, Tianxiao Huan, Daniel Levy, John Tigges, Alexander R. Pico, Ionita Ghiran, Michael G. Silverman, Xiangmin Meng, Robert Kitchen, Jiahong Xu, Kendall Van Keuren-Jensen, Ravi Shah, Junjie Xiao, Saumya Das
Summary: miR-30d can improve cardiac function and reduce fibrosis by targeting MAP4K4 and integrin alpha 5, showing a protective effect in ischemic heart failure. The communication of extracellular vesicle-contained miRNAs may provide a novel therapeutic target in heart failure treatment.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Pawel Rubis, Justyna Toton-Zuranska, Maria Kolton-Wroz, Pawel Wolkow, Ewelina Pitera, Sylwia Wisniowska-Smialek, Ewa Dziewiecka, Ann Garlitski, Piotr Podolec
Summary: This study investigated the kinetics of fibrosis-linked microRNAs and their relationship with extracellular matrix (ECM) fibrosis in dilated cardiomyopathy (DCM). The results showed that regardless of ECM fibrosis status or duration of the disease, the 12-month patterns of circulating microRNAs were similar in DCM patients. Additionally, the correlations between microRNAs measured at 3 and 12 months were lower than expected, and circulating microRNAs were not able to differentiate between DCM patients with and without fibrosis.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Weihua Bian, Wangping Chen, Thanh Nguyen, Yang Zhou, Jianyi Zhang
Summary: The study demonstrates that miR-199a-overexpressing hiPSC-CMs can increase cell proliferation in a heart infarction model, improving cardiac function and fibrosis. While the treatment may lead to lethal arrhythmia, there was no evidence of sudden death in the mouse model. Future investigations on miR-199a-overexpressing hiPSC-CMs in larger animals are supported by these results.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Brittany M. Navarre, Katie L. Clouthier, Xuhuai Ji, Anne Taylor, Chad S. Weldy, Anne M. Dubin, Sushma Reddy
Summary: Chronic ventricular pacing in children with congenital complete AV block (CCAVB) can lead to pacing-induced cardiomyopathy (PICM). This study evaluated the miR profile associated with chronic right ventricular pacing and identified potential miRs for longitudinal monitoring. The results showed differentially regulated miRs between paced children and controls, with both adaptive and maladaptive miR signaling predicted. Greater profibrotic signaling and sodium and calcium channel dysregulation were observed in patients paced for more than 10 years, particularly in a patient with sudden death. These miRs may be useful for early identification of adverse remodeling.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yanping Li, Bin Lu, Muming Yu, Jianhua Zhai, Ying Yao, Yanfen Chai
Summary: The combined detection of miR-132 and miR-223 can be used for early diagnosis and prognostic evaluation of SIC, and they are negatively correlated with CK-MB, cTnI, TNF-alpha, and IL-6.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Li Zhang, Ge Zhang, Yongzheng Lu, Jiamin Gao, Zhen Qin, Shuai Xu, Zeyu Wang, Yanyan Xu, Yu Yang, Jinying Zhang, Junnan Tang
Summary: As one of the most prevalent heritable cardiovascular diseases, dilated cardiomyopathy (DCM) induces cardiac insufficiency and dysfunction. Although genetic mutation has been identified as one of the causes of DCM, the usage of genetic biomarkers such as RNAs for DCM early diagnosis is still being overlooked. In addition, the alternation of RNAs could reflect the progression of the diseases, as an indicator for the prognosis of patients. Therefore, it is beneficial to develop genetic based diagnostic tool for DCM.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Dominic Emerson, Joanna Chikwe, Pedro Catarino, Mohamed Hassanein, Luqin Deng, Ryan S. Cantor, Amy Roach, Robert Cole, Fardad Esmailian, Jon Kobashigawa, Jaime Moriguchi, James K. Kirklin
Summary: In contemporary practice, elderly patients receiving LVADs showed improved survival, increased functional capacity, enhanced quality of life, and fewer complications compared with younger patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alessia Gallo, Valentina Agnese, Sergio Sciacca, Cesare Scardulla, Manlio Cipriani, Michele Pilato, Jae K. Oh, Salvatore Pasta, Joseph Maalouf, Pier Giulio Conaldi, Diego Bellavia
Summary: This study aimed to identify circulating miRNAs that are highly expressed in myocardial tissue and significantly associated with echocardiographic and hemodynamic measures in patients with heart failure. miR-30d was correlated with left ventricular volumes, miR-126-3p was associated with pulmonary artery pressure and pulmonary capillary wedge pressure, and miR-483-3p had an association with right ventricular end diastolic diameter and central venous pressure.
Article
Multidisciplinary Sciences
Zahra Saadatian, Yaser Mansoori, Lida Nariman-Saleh-Fam, Abdolreza Daraei, Sepideh Zununi Vahed, Shadan Navid, Ziba Nariman-Saleh-Fam
Summary: This study evaluated the alteration of miR-200c, miR-125b, miR-27b, miR-203, and miR-155 in patients with coronary artery stenosis and insignificant coronary artery stenosis compared to healthy individuals. The results showed that three of these miRNAs have the potential to differentiate between coronary artery stenosis patients and healthy individuals, suggesting they could be novel diagnostic biomarkers.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Claudia Sacchetto, Zenab Mohseni, Robin M. W. Colpaert, Libero Vitiello, Marzia De Bortoli, Indira G. C. Vonhogen, Ke Xiao, Giulia Poloni, Alessandra Lorenzon, Chiara Romualdi, Riccardo Bariani, Elisa Mazzotti, Luciano Daliento, Barbara Bauce, Domenico Corrado, Thomas Thum, Alessandra Rampazzo, Leon J. de Windt, Martina Calore
Summary: The study identified miR-185-5p as significantly upregulated in ARVC patients compared to healthy controls, with a confirmed link to ARVC pathophysiology based on receiver operating characteristic analysis.
Article
Pharmacology & Pharmacy
Xiaochen Li, Cheng Meng, Fei Han, Juhong Yang, Jingyu Wang, Yanjuan Zhu, Xiao Cui, Minxia Zuo, Jie Xu, Baocheng Chang
Summary: Vildagliptin prevents diabetic cardiomyopathy by restoring autophagy through the miR-21/SPRY1/ERK/mTOR pathway. Overexpression of miR-21 attenuates the protective effect of vild on cardiac function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xudong Zhang, Shuai Yuan, Huaping Li, Jiabing Zhan, Feng Wang, Jiahui Fan, Xiang Nie, Yan Wang, Zheng Wen, Yanghui Chen, Chen Chen, Dao Wen Wang
Summary: This study revealed that miR-320 functions differently in various cell types of the heart during the progression of heart failure, with overexpression in CMs exacerbating cardiac dysfunction, and in CFs alleviating cardiac fibrosis and hypertrophy. The effects of miR-320 were mediated through targeting different downstream signaling pathways in CMs and CFs, and could be influenced by upstream regulators such as Ago2 and cell-type-specific transcription factors.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Correction
Biochemistry & Molecular Biology
Wei Zhao, Yameng Cui, Lina Liu, Xiaoqian Qi, Jingwen Liu, Shiqing Ma, Xin Hu, Zheng Zhang, Yue Wang, Hongfa Li, Zuomin Wang, Zihao Liu, Jie Wu
Summary: After the online publication of this article, the authors identified errors in the images used for compiling Fig. 3c, 3g, and Supplementary Fig. 3g.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Martin Brundin, Dick Wagsater, Urban Alehagen, Carl-Johan Carlhall
Summary: This study compared serum levels of specific miRs and cardiac magnetic resonance imaging parameters between patients with DCM and IHD, finding that miR-29-5p levels were increased in DCM and miR-320a levels were elevated in DCM compared to healthy controls.
