Article
Hematology
Sebastian F. Mause, Elisabeth Ritzel, Annika Deck, Felix Vogt, Elisa A. Liehn
Summary: EPCs stimulate proliferation and migration of SMCs and increase their neointimal accumulation following vascular injury. Furthermore, EPCs context-dependently modify the SMC phenotype with protection from the transformative effect of cholesterol when a direct cell-cell contact is established.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Yiting Jia, Chenfeng Mao, Zihan Ma, Jiaqi Huang, Wenqiang Li, Xiaolong Ma, Siting Zhang, Meihong Li, Fang Yu, Yingying Sun, Jingzhou Chen, Juan Feng, Yuan Zhou, Qingbo Xu, Ling Zhao, Yi Fu, Wei Kong
Summary: This study reveals that Prohibitin 2 interacts with hnRNPA1 to maintain the contractile phenotype of VSMCs and counteracts metabolic reprogramming, indicating its crucial role in preventing vascular diseases.
CIRCULATION RESEARCH
(2022)
Article
Hematology
Rajinikanth Gogiraju, Sogol Gachkar, David Velmeden, Magdalena L. Bochenek, Konstantinos Zifkos, Astrid Hubert, Thomas Muenzel, Stefan Offermanns, Katrin Schaefer
Summary: Reduction of PTP1B in SMCs promotes adverse remodeling following vascular injury, including dedifferentiation, perivascular fibrosis, and collagen accumulation. This process involves a shift from SMAD2 to KLF4-regulated gene transcription driven by ERK1/2 phosphorylation.
THROMBOSIS AND HAEMOSTASIS
(2022)
Letter
Respiratory System
Fabrice Antigny, Helene Le Ribeuz, Marc Humbert, David Montani
Summary: Loss of CFTR function leads to endothelial cell dysfunction, and reduced CFTR expression in pulmonary arterial endothelial cells from patients with pulmonary arterial hypertension might contribute to the pathogenesis of PAH.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Baohui Yuan, He Liu, Xiaohua Pan, Xiaoliang Dong, Le-Feng Qu, Jia Sun, Li-Long Pan
Summary: LSD1 plays a crucial role in neointima formation, and its overexpression is associated with neointima formation. Knockdown of LSD1 significantly reduces neointima formation and inhibits platelet-derived growth factor-induced VSMC proliferation. Moreover, LSD1 overexpression exhibits opposite effects in vivo and in vitro.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G. Hsu, Vyacheslav A. Korshunov, Xiaochun Long, Peter A. Knight, Bradford C. Berk, Chen Yan
Summary: The study revealed that PDE10A contributes to SMC proliferation and intimal hyperplasia by antagonizing the CNP/NPR2/cGMP/PKG1alpha signaling pathway, suggesting that PDE10A may be a novel drug target for treating vascular occlusive disease.
CARDIOVASCULAR RESEARCH
(2022)
Article
Hematology
Fatima Daoud, Marycarmen Arevalo Martinez, Johan Holmberg, Azra Alajbegovic, Neserin Ali, Catarina Rippe, Karl Sward, Sebastian Albinsson
Summary: This study investigates the role of YAP/TAZ in vascular smooth muscle cell mechanotransduction and demonstrates their protective role against hypertensive vasculopathy. YAP/TAZ deficiency leads to decreased contractile function and attenuated transcriptional regulation in smooth muscle cells, resulting in severe vascular lesions in established hypertension.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sebastian F. Mause, Elisabeth Ritzel, Annika Deck, Felix Vogt, Elisa A. Liehn
Summary: EPCs and SMCs interact through the CXCL12-CXCR4 axis to establish an amplifying feedback loop, promoting regenerative processes and mediating SMC phenotype control to potentially maintain vascular homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jingying Liu, Xingbo Long, Hexin Li, Qiuxia Yan, Lu Wang, Ziyu Qin, Hong Zhang
Summary: This study reveals that C1QTNF4 is involved in the migration and proliferation of vascular smooth muscle cells. It inhibits abnormal neointimal formation by downregulating the FAK/PI3K/AKT pathway, thus protecting blood vessels. These findings provide new insights and potential treatments for vascular stenosis diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yichen Wu, Min Chen, Zilong Chen, Jiangcheng Shu, Luoying Zhang, Jiong Hu, Hongjun Yu, Kai Huang, Minglu Liang
Summary: Theaflavin-3,3'-digallate (TF3) in black tea has a remarkable effect in suppressing neointima formation and regulating the proliferation and migration of vascular smooth muscle cells (VSMCs). It may serve as a potential therapeutic candidate for excessive phenotypic switching of VSMCs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jochen Dutzmann, Marco Haertle, Jan-Marcus Daniel, Frederik Kloss, Robert-Jonathan Musmann, Katrin Kalies, Kai Knopp, Claudia Pilowski, Mirja Sirisko, Jan-Thorben Sieweke, Johann Bauersachs, Daniel G. Sedding, Simona Gegel
Summary: Selective inhibition of BET proteins can reduce proliferation and migration of SMCs by regulating FOXO1 transcription factor, leading to cell cycle arrest and prevention of neointima formation. Inhibition of BET epigenetic reader proteins may represent a promising therapeutic strategy to prevent adverse vascular remodeling.
CARDIOVASCULAR RESEARCH
(2021)
Article
Physiology
M. J. O'Sullivan, J. H. Jang, A. Panariti, A. Bedrat, G. Ijpma, B. Lemos, J. A. Park, A. M. Lauzon, J. G. Martin
Summary: Increased airway smooth muscle mass in asthmatic patients may contribute to disease pathology, with evidence suggesting the involvement of airway epithelium in this remodeling process. Co-culture experiments reveal that the proliferative phenotype of airway smooth muscle cells induced by epithelial cells is not driven by EGFR signaling, but may instead depend on miR210 targeting of the tumor suppressor Mnt. This study provides insights into the mechanisms underlying airway remodeling in asthma.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Hematology
Chien-Jung Lin, Bridget M. Hunkins, Robyn A. Roth, Chieh-Yu Lin, Jessica E. Wagenseil, Robert P. Mecham
Summary: This study investigates the mechanism of neointima formation due to Eln insufficiency in a mouse model, showing that cells from the secondary heart field are significant contributors to intimal hyperplasia. Two unique SMC populations were identified in the neointima of SMC-Eln knockout mice, suggesting shared mechanisms with adult vessel injury models.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Xiaohan Mei, Xiao-Bing Cui, Yiran Li, Shi-You Chen
Summary: The study discovered that circular RNA circSOD2 plays a crucial role in neointima formation following vascular injury by regulating vascular smooth muscle cell (SMC) proliferation through the miR-206/NOTCH3 pathway. circSOD2 serves as a potential therapeutic target for inhibiting the development of proliferative vascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Yuhan Chen, Yuanyuan Chen, Xueze Jiang, Mengkun Shi, Zhenwei Yang, Zhiyong Chen, Xuesheng Hua, Jie Chen, Yuepeng Wang
Summary: This study demonstrated that FGF10 derived from VAFs promoted the proliferation, migration, and neointima formation of VSMCs, while the FGF10-FGFR2 signaling pathway triggered the activation of the MAPK/PI3K-AKT pathways in VSMCs. Additionally, PDGF synergistically amplified the FGF10 signaling.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Editorial Material
Immunology
Aubryanna Hettinghouse, Guanmin Gao, Chuan-ju Liu
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Xiaofang Zhu, Xiangfen Li, Xiaoxuan Wang, Ting Chen, Fengjuan Tao, Chuanju Liu, Qisheng Tu, Guofang Shen, Jake J. Chen
Summary: Research indicates that irisin plays a crucial role in bone metabolism and in the cross-talk between bone and adipose tissue. Absence of irisin results in decreased bone density, delayed bone development and mineralization, as well as weakening of positive effects of exercise on bone strength and weight loss. Supplementation with recombinant irisin during exercise can rescue these effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Letter
Cell Biology
Wenyu Fu, Yujianan Chen, Kaidi Wang, Aubryanna Hettinghouse, Wenhuo Hu, Jing-Quan Wang, Zi-Ning Lei, Zhe-Sheng Chen, Kenneth A. Stapleford, Chuan-ju Liu
Article
Multidisciplinary Sciences
Yuanjing Ding, Jianlu Wei, Aubryanna Hettinghouse, Guangfei Li, Xin Li, Thomas A. Einhorn, Chuan-Ju Liu
Summary: This study found that PGRN expression was increased in bone fracture healing in T2DM. In vivo experiments showed that recombinant PGRN effectively promoted fracture healing and exhibited anti-inflammatory activity in the regeneration process. Exogenous PGRN may be an alternative strategy to support bone regeneration in T2DM patients.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Infectious Diseases
Lisa Sanderson, Marcelo da Silva, Gayathri N. Sekhar, Rachel C. Brown, Hollie Burrell-Saward, Mehmet Fidanboylu, Bo Liu, Lea Ann Dailey, Cecile A. Dreiss, Chris Lorenz, Mark Christie, Shanta J. Persaud, Vanessa Yardley, Simon L. Croft, Margarita Valero, Sarah A. Thomas
Summary: Sleeping sickness, caused by a parasite transferred by tsetse flies, has two stages affecting the blood and the brain, with the brain stage being fatal if untreated. The blood-brain barrier makes treating the brain stage difficult. Pluronic was not found to improve delivery of pentamidine to the brain.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Cell Biology
Inmaculada Ruz-Maldonado, Patricio Atanes, Guo Cai Huang, Bo Liu, Shanta J. Persaud
Summary: The study found that JTE 907 stimulated insulin secretion, reduced cytokine-induced apoptosis, and promoted beta-cell proliferation. This indicates that JTE 907 can act as a GPR55 agonist to maintain insulin secretion and beta-cell mass.
Article
Rheumatology
Wenyu Fu, Aubryanna Hettinghouse, Yujianan Chen, Wenhuo Hu, Xiang Ding, Meng Chen, Yuanjing Ding, Jyoti Mundra, Wenhao Song, Ronghan Liu, Young-Su Yi, Mukundan Attur, Jonathan Samuels, Eric Strauss, Philipp Leucht, Ran Schwarzkopf, Chuan-Ju Liu
Summary: This study identifies 14-3-3ε as an inducible component of the TNFR2 receptor complex in chondrocytes in response to PGRN, presenting a previously unrecognized TNFR2 pathway in the pathogenesis of osteoarthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Genetics & Heredity
Xiangli Zhao, Rossella Liberti, Jinlong Jian, Wenyu Fu, Aubryanna Hettinghouse, Ying Sun, Chuan-ju Liu
Summary: The study reveals that PGRN is a crucial mediator of autophagosome-lysosome fusion in Gaucher disease, and it interacts physically with Rab2, a molecule involved in this fusion process. A 15-kDa C-terminal fragment of PGRN is essential for binding to Rab2 and alleviating autophagic impairment caused by PGRN deficiency. These findings shed new light on autophagy mechanisms and potential therapeutic strategies for Gaucher disease.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Xiangli Zhao, Ronghan Liu, Yuehong Chen, Aubryanna Hettinghouse, Chuanju Liu
Summary: Fexofenadine, a commonly used antihistamine, has been found to be therapeutic in murine models of chemically-induced IBD, with its anti-inflammatory effects depending on cPLA2 rather than histamine H1 receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiangli Zhao, Sadaf Hasan, Benjamin Liou, Yi Lin, Ying Sun, Chuanju Liu
Summary: The study found that PGRN deficiency leads to neuron loss and activation of microglia and astrocytes in aged mice. Several characteristic neurodegenerative disease markers, including alpha-synuclein, TDP-43, Tau, and beta-amyloid, were accumulated in the brain tissue of PGRN-deficient mice. Moreover, higher aggregation of lipofuscin was observed in the brain tissue of PGRN-deficient mice, and autophagy was also defective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Bo Liu, Inmaculada Ruz-Maldonado, Klaudia Toczyska, Oladapo E. Olaniru, Mohammed Gulrez Zariwala, David Hopkins, Min Zhao, Shanta J. Persaud
Summary: This study investigated the effects of fluoxetine on beta-cell function and glucose homeostasis. The results showed that fluoxetine improved beta-cell proliferation, protected islet cells from apoptosis, and increased insulin secretion. These findings suggest that fluoxetine may be a preferential antidepressant for patients with depression and diabetes.
DIABETES OBESITY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Sourbh Suren Garg, Jeena Gupta, Debasis Sahu, Chuan-Ju Liu
Summary: Esculetin, as a potent antioxidant compound, can alleviate arthritis, diabetes, malignancies, and hepatic disorders by inhibiting pathological processes under oxidative stress conditions, reversing key factors contributing to bone and joint deterioration, and reducing liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Lida Moradi, Lukasz Witek, Vasudev Vivekanand Nayak, Angel Cabrera Pereira, Ellen Kim, Julia Good, Chuan-ju Liu
Summary: This study developed an injectable thermo-responsive hydrogel for the delivery of Atsttrin, which simultaneously inhibited inflammation and stimulated cartilage regeneration and bone formation signaling pathways, thus promoting diabetic fracture healing.
Editorial Material
Biology
Wenyu Fu, Chuan-ju Liu
Article
Biology
Yuqi Guo, Jianlu Wei, Chuanju Liu, Xin Li, Wenbo Yan
Summary: Diabetic patients are more prone to osteoporotic fractures with impaired healing. This study found that metformin can promote fracture healing and remodeling, improving the proliferation, osteogenesis, and chondrogenesis abilities of bone marrow stromal cells (BMSCs).
