Review
Medicine, Research & Experimental
Xiaoguang Wu, Yi Li, Shuchen Zhang, Xiang Zhou
Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.
Review
Biochemistry & Molecular Biology
Fatemeh Yarmohammadi, A. Wallace Hayes, Gholamreza Karimi
Summary: Cardiac diseases are on the rise due to lifestyle changes, urbanization, and aging, with oxidative stress playing a key role in cardiac injury progression. Hydrogen sulfide (H2S) has shown potential in improving various cardiac conditions through antioxidant and anti-ER stress-related activities, by regulating Nrf2 expression and its signaling pathway in myocytes.
Article
Cardiac & Cardiovascular Systems
Luyan Yao, Funan He, Quanyi Zhao, Dandan Li, Shufang Fu, Mingzhi Zhang, Xingzhong Zhang, Bingying Zhou, Li Wang
Summary: Imaging mass cytometry was used to characterize the spatial distribution and dynamics of cell phenotypes and communities in the mouse left ventricle following myocardial infarction. H3K9me3 in endothelial cells was identified as a potential therapeutic target for alleviating pathological remodeling of the heart after ischemia-reperfusion injury.
CIRCULATION RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Corrado De Marco, Thierry Charron, Guy Rousseau
Summary: Adenosine has the potential benefits in the treatment of acute myocardial infarction by inhibiting the pathophysiological processes leading to reperfusion injury. However, the heterogenous evidence regarding its effects has resulted in limited uptake in clinical practice. Therefore, studying the dose, route, timing, and site of administration of adenosine is crucial for its efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Sihan Hu, Lan Jiang, Qi Yan, Chenyang Zhou, Xiaochuan Guo, Tong Chen, Siting Ma, Yimiao Luo, Caiyu Hu, Fumin Yang, Lishan Yuan, Xiao Ma, Jinhao Zeng
Summary: Baicalin exhibits positive effects on myocardial ischemia diseases, achieved by regulating key pathological indicators and various signaling pathways. In animal models of myocardial ischemia, reperfusion injury, and myocardial infarction, baicalin can reduce myocardial infarction size, improve cardiac pathological condition, and enhance heart function indicators.
Article
Biochemistry & Molecular Biology
Csaba Horvath, Megan Young, Izabela Jarabicova, Lucia Kindernay, Kristina Ferenczyova, Tanya Ravingerova, Martin Lewis, M. Saadeh Suleiman, Adriana Adameova
Summary: RIP3 is a central point of multiple signaling pathways, but the acute myocardial ischemia/reperfusion injury is not mediated by necroptotic cell death. The study shows that RIP3 regulates reperfusion injury through oxidative stress and mitochondrial activity effects, rather than cell loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
C. Binsch, D. M. Barbosa, G. Hansen-Dille, M. Hubert, S. M. Hodge, M. Kolasa, K. Jeruschke, J. Weiss, C. Springer, S. Gorressen, J. W. Fischer, M. Lienhard, R. Herwig, S. Boerno, B. Timmermann, A. L. Cremer, H. Backes, A. Chadt, H. Al-Hasani
Summary: The study found that TBC1D4 protein plays a crucial role in cardiac metabolism and adaptation to myocardial infarction. Mice lacking TBC1D4 were unable to efficiently uptake glucose in the heart, leading to aggravated cardiac damage. This study suggests that impaired TBC1D4 signaling contributes to poor outcomes after myocardial infarction.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jamie Francisco, Dominic P. Del Re
Summary: Acute myocardial infarction (MI) is a condition that causes cardiac damage and cell loss. Restoring coronary flow is the standard treatment for MI, but reperfusion triggers inflammation and worsens heart injury. The immune response plays a crucial role in the pathogenesis and resolution of ischemia/reperfusion (I/R) injury, but our understanding is still incomplete.
Review
Pharmacology & Pharmacy
Panat Yanpiset, Chayodom Maneechote, Sirawit Sriwichaiin, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Cardiomyocyte death plays a major role in the development of myocardial infarction and myocardial ischemia/reperfusion injury. Pyroptosis, a regulated programmed cell death pathway, has been shown to be involved in these conditions. Activation of gasdermin D (GSDMD) through the canonical or non-canonical pathways is an important step in pyroptosis. Inhibition of GSDMD provides cardioprotection against myocardial infarction and myocardial ischemia/reperfusion injury.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Cell Biology
Fangze Huang, Ronghua Yang, Zezhou Xiao, Yu Xie, Xuefeng Lin, Peng Zhu, Pengyu Zhou, Jun Lu, Shaoyi Zheng
Summary: Ferroptosis, a novel form of non-apoptotic regulated cell death driven by iron and lethal lipid hydroperoxides, plays a critical role in the development of cardiovascular diseases. Recent studies have shown that ferroptosis inhibitors and other substances can alleviate myocardial injury by targeting the ferroptosis pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xuejie Han, Jie Zhang, Jian Liu, Hongxia Wang, Fenghe Du, Xiangjun Zeng, Caixia Guo
Summary: This article systematically summarizes the process and regulatory metabolisms of ferroptosis, and discusses its relationship with myocardial infarction and myocardial ischemia/reperfusion injuries. Studying the role of ferroptosis in cardiovascular diseases can provide new insights for the prevention and treatment of these conditions.
Article
Cardiac & Cardiovascular Systems
Hiran A. Prag, Dunja Aksentijevic, Andreas Dannhorn, Abigail Giles, John F. Mulvey, Olga Sauchanka, Luping Du, Georgina Bates, Johannes Reinhold, Duvaraka Kula-Alwar, Zhelong Xu, Luc Pellerin, Richard J. A. Goodwin, Michael P. Murphy, Thomas Krieg
Summary: Malonate selectively enters cardiomyocytes during reperfusion in a low pH environment caused by ischemia, protecting against cardiac ischemia/reperfusion injury.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Marie-Sophie L. Y. de Koning, B. Daan Westenbrink, Solmaz Assa, Erwin Garcia, Margery A. Connelly, Dirk J. van Veldhuisen, Robin P. F. Dullaart, Erik Lipsic, Pim van der Harst
Summary: Circulating ketone bodies are increased in patients with ST-segment elevation myocardial infarction (STEMI). Higher ketone bodies at 24 hours post-reperfusion are associated with larger myocardial infarct size and lower left ventricular ejection fraction.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Philipp Schuette, Mailin-Christin Manke, Katherina Hemmen, Patrick Muenzer, Barbara F. Schoerg, Gustavo Campos Ramos, Michaela Pogoda, Valerie Dicenta, Sabrina H. L. Hoffmann, Juergen Pinnecker, Ferdinand Kollotzek, Monika Zdanyte, Karin A. L. Mueller, Yogesh Singh, Andreas F. Mack, Bernd Pichler, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Katrin G. Heinze, Nicolas Casadei, Oliver Borst
Summary: Platelet-derived miRNAs play a critical role in myocardial inflammation and structural remodeling in response to myocardial ischemia/reperfusion (I/R). In a mouse model with a Dicer gene deletion, disrupted miRNA processing machinery in platelets led to increased myocardial inflammation, impaired angiogenesis, accelerated cardiac fibrosis, and larger infarct size. These findings highlight the importance of platelet-derived miRNA in regulating cellular processes following myocardial I/R.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
George G. Schweitzer, Sara L. Collier, Zhouji Chen, Kyle S. McCommis, Sara K. Pittman, Jun Yoshino, Scot J. Matkovich, Fong-Fu Hsu, Roman Chrast, James M. Eaton, Thurl E. Harris, Conrad C. Weihl, Brian N. Finck
Editorial Material
Cardiac & Cardiovascular Systems
Scot J. Matkovich, Ryan L. Boudreau
CIRCULATION RESEARCH
(2018)
Article
Multidisciplinary Sciences
Eric K. Johnson, Scot J. Matkovich, Jeanne M. Nerbonne
SCIENTIFIC REPORTS
(2018)
Article
Cardiac & Cardiovascular Systems
Sirisha M. Cheedipudi, Scot J. Matkovich, Cristian Coarfa, Xin Hu, Matthew J. Robertson, Mary Sweet, Matthew Taylor, Luisa Mestroni, Joseph Cleveland, James T. Willerson, Priyatansh Gurha, Ali J. Marian
CIRCULATION RESEARCH
(2019)
Review
Cardiac & Cardiovascular Systems
Scot J. Matkovich
CURRENT OPINION IN CARDIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
John T. Murphy, Haiyan Liu, Xiucui Ma, Alex Shaver, Brian M. Egan, Clara Oh, Alexander Boyko, Travis Mazer, Samuel Ang, Rohan Khopkar, Ali Javaheri, Sandeep Kumar, Xuntian Jiang, Daniel Ory, Kartik Mani, Scot J. Matkovich, Kerry Kornfeld, Abhinav Diwan
Article
Medicine, Research & Experimental
Gaelle Auguste, Leila Rouhi, Scot J. Matkovich, Cristian Coarfa, Matthew J. Robertson, Grazyna Czernuszewicz, Priyatansh Gurha, Ali J. Marian
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Cardiac & Cardiovascular Systems
Jordi Coste Pradas, Gaelle Auguste, Scot J. Matkovich, Raffaella Lombardi, Suet Nee Chen, Tyrone Garnett, Kyle Chamberlain, Jalish Mahmud Riyad, Thomas Weber, Sanjay K. Singh, Matthew J. Robertson, Cristian Coarfa, Ali J. Marian, Priyatansh Gurha
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Cardiac & Cardiovascular Systems
HyunTae Hwang, Nefthi Sandeep, Ramesh Nair, Dong-Qing Hu, Mingming Zhao, Ingrid S. Lan, Giovanni Fajardo, Scot J. Matkovich, Daniel Bernstein, Sushma Reddy
Summary: Pressure overload-induced RV failure is characterized by decreased transcription and activity of electron transport chain complexes and increased oxidative stress, which are associated with decreased energy generation. Mitochondrial fission and fusion proteins also show changes during this process.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Ali Javaheri, Geetika Bajpai, Antonino Picataggi, Smrithi Mani, Layla Foroughi, Hosannah Evie, Attila Kovacs, Carla J. Weinheimer, Krzystztof Hyrc, Qingli Xiao, Andrea Ballabio, Jin-Moo Lee, Scot J. Matkovich, Babak RazaniP, Joel D. Schilling, Kory J. Lavine, Abhinav Diwan
Article
Medicine, Research & Experimental
Cibele Rocha-Resende, Carla Weinheimer, Geetika Bajpai, Luigi Adamo, Scot J. Matkovich, Joel Schilling, Philip M. Barger, Kory J. Lavine, Douglas L. Mann
Meeting Abstract
Dermatology
M. Mathyer, I. Y. Oh, S. Matkovich, A. M. Quiggle, C. de Guzman Strong
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Brian Finck, Scot Matkovich, Jerry Colca, Kyle McCommis
Article
Medicine, Research & Experimental
Yan Huang, Conor McClenaghan, Theresa M. Harter, Kristina Hinman, Carmen M. Halabi, Scot J. Matkovich, Haixia Zhang, G. Schuyler Brown, Robert P. Mecham, Sarah K. England, Attila Kovacs, Maria S. Remedi, Colin G. Nichols
Article
Cell Biology
Conor McClenaghan, Yan Huang, Scot J. Matkovich, Attila Kovacs, Carla J. Weinheimer, Ron Perez, Thomas J. Broekelmann, Theresa M. Harter, Jin-Moo Lee, Maria S. Remedi, Colin G. Nichols