Review
Oncology
Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Adam
Summary: Hypoxia in the tumor microenvironment weakens cytotoxic T cell function and promotes recruitment of regulatory T cells, thereby reducing tumor immunogenicity. Hypoxia-inducible factors (HIFs), especially HIF1A and HIF2A, play important roles in tumor immune escape through various mechanisms. Understanding these mechanisms can lead to the development of targeted therapies for tumor treatment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Neurosciences
Jia Liu, Yakun Gu, Mengyuan Guo, Xunming Ji
Summary: The brain, as the organ with the highest oxygen demand, has poor tolerance to ischemia and hypoxia. Ischemic/hypoxic preconditioning has been studied as an effective strategy to improve tolerance and is considered significant in treating CNS diseases. It involves multiple protective mechanisms and is a research frontier in neurotherapy, with challenges in translating from basic research to clinical application.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Chemistry, Physical
Xin-Chi Jiang, Hong-Hui Wu, Tianyuan Zhang, Yun-Fei Dong, Yao-Sheng Li, Ting Huang, An-Hao Tian, Peng-Xiang Chen, Xian-Ming Lin, Ying-Zhi Huang, Chong Liu, Xiang-Nan Zhang, Zhong Chen, Yasuhiko Tabata, Jian-Qing Gao
Summary: Hypoxic preconditioning of neural stem cells (NSCs) can produce hypoxic exosomes, which can effectively treat ischemic stroke. These exosomes can target the injured brain and regulate the microenvironment to inhibit neuroinflammation and promote blood-brain barrier permeability recovery. Furthermore, they can also activate autologous NSCs and facilitate nerve regeneration. Hypoxic exosomes have therapeutic effects on both survival and behavioral outcomes in ischemic stroke mice.
Article
Nanoscience & Nanotechnology
Wen-Sheng Tzeng, Wei-Lin Teng, Pao-Hsien Huang, Tzu-Ching Lin, Feng-Lin Yen, Yow-Ling Shiue
Summary: The study demonstrated that the prepared PTS nanoparticles (PSN) showed better antihepatoma activities in HepG2 cells, especially under hypoxic conditions, and effectively improved the water solubility and drug release of PTS.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Physiology
Caitlin P. Jarrard, Mercedes J. Nagel, Sten Stray-Gundersen, Hirofumi Tanaka, Sophie Lalande
Summary: Ischemic preconditioning and intermittent hypoxia can attenuate the reduction in brachial artery endothelial function caused by ischemia-reperfusion injury in young healthy individuals.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Veterinary Sciences
Jun Ying, Qing You, Zhiguo Wang, Zhiqian Hu
Summary: This study suggests that preconditioning mesenchymal stem cells under hypoxic conditions can enhance their therapeutic effect in treating inflammatory bowel disease.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Yiwei Liu, Qipeng Luo, Zhanhao Su, Junyue Xing, Jinlin Wu, Li Xiang, Yuan Huang, Haizhou Pan, Xie Wu, Xiaoling Zhang, Jun Li, Fuxia Yan, Hao Zhang
Summary: Cyanotic congenital heart disease (CCHD) leads to maladaptation of cardiac metabolism during puberty, accompanied by impaired cardiac function. The study identified HIF-1 alpha as the key regulator of cardiac metabolic adaptation in CH animal models, with pubertal insulin resistance potentially suppressing its expression.
Article
Peripheral Vascular Disease
Dongling Luo, Wenxin Li, Changming Xie, Li Yin, Xiaoyan Su, Jie Chen, Hui Huang
Summary: The research found that capsaicin can reduce coronary artery calcification and inhibit osteogenic transdifferentiation in both in vivo and in vitro models. It does so by upregulating SIRT6, which promotes deacetylation and degradation of Hif1 alpha.
Article
Biochemistry & Molecular Biology
Kanwal Haneef, Asmat Salim, Zehra Hashim, Amber Ilyas, Basir Syed, Aftab Ahmed, Shamshad Zarina
Summary: This study investigated the mechanism by which hypoxic preconditioning enhances the survival of mesenchymal stem cells (MSCs). Proteomic analysis revealed higher expression of certain proteins in hypoxic preconditioned (HP) MSCs, which are possibly involved in cellular survival and proliferation through various cellular pathways. This research is important for understanding the processes involved in hypoxic preconditioning of MSCs and designing cell-based therapeutic strategies for tissue regeneration.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Neurosciences
Brian T. David, Jessica J. Curtin, Jennifer L. Brown, Kerri Scorpio, Veena Kandaswamy, David J. C. Coutts, Ana Vivinetto, Paola Bianchimano, Saravanan S. Karuppagounder, Mariajose Metcalfe, John W. Cave, Caitlin E. Hill
Summary: In this study, the researchers explored whether hypoxia-related preconditioning could protect transplanted Schwann cells into the injured spinal cord. The results showed that hypoxia-related preconditioning did not enhance cell survival or the recovery of sensory and motor function.
Article
Cardiac & Cardiovascular Systems
Peter Galis, Linda Bartosova, Veronika Farkasova, Adrian Szobi, Csaba Horvath, Dominika Kovacova, Adriana Adameova, Tomas Rajtik
Summary: Intermittent hypoxic preconditioning (IHP) is an effective cardioprotective intervention that has demonstrated improvement in cardiac output in a model of doxorubicin-induced cardiomyopathy. This improvement is likely due to increased expression of SERCA2a, suggesting the potential of IHP as a protective intervention in doxorubicin cardiomyopathy. However, further analysis is still required to fully understand the observed effects.
CARDIOVASCULAR TOXICOLOGY
(2023)
Review
Physiology
Sara V. Ochoa, Liliana Otero, Andres Felipe Aristizabal-Pachon, Fernando Hinostroza, Ingrid Carvacho, Yolima P. Torres
Summary: Hypoxia is characterized by reduced cellular oxygen levels, triggering cell-signaling cascades, oxidative stress, activation of pro-inflammatory molecules, and influencing various cardiovascular diseases. The BK channel plays a central role in oxygen sensing mechanisms, with modifications of its properties involved in physiological functions and response to hypoxia.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Xue Fan, Huiqing Wang, Li Zhang, Jun Tang, Yi Qu, Dezhi Mu
Summary: The neonatal brain is vulnerable to hypoxic-ischemic injury due to decreased perfusion of oxygen and glucose, which can lead to severe encephalopathy. Early therapeutic hypothermia may provide neuroprotection, but cannot reverse severe damage that has already occurred. Therefore, exploring mechanisms for treating hypoxic-ischemic brain damage, such as hypoxic/ischemic preconditioning, is crucial for protecting the neonatal brain.
REVIEWS IN THE NEUROSCIENCES
(2021)
Article
Oncology
Baoshen Wang, Chunyan Zhang, Dongmei Chu, Xiaofang Ma, Tian Yu, Xiaozhi Liu, Changqing Hu
Summary: The study confirmed that AS-IV promotes angiogenesis in hypoxic conditions by affecting the SUMO modification of HIF-1α. Rapid attenuation and delayed compensation of SUMO1 activity led to fluctuations in HIF-1α levels, while SUMO1 overexpression stabilized HIF-1α and improved blood vessel morphology.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Natalia Dionisio, Tarik Smani, Geoffrey E. Woodard, Antonio Castellano, Gines M. Salido, Juan A. Rosado
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Javier Avila-Medina, Eva Calderon-Sanchez, Patricia Gonzalez-Rodriguez, Francisco Monje-Quiroga, Juan Antonio Rosado, Antonio Castellano, Antonio Ordonez, Tarik Smani
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Clinical Neurology
Enriqueta Tristan-Clavijo, Francisco G. Scholl, Alfons Macaya, Gemma Iglesias, Ana M. Rojas, Miguel Lucas, Antonio Castellano, Amalia Martinez-Mir
MOVEMENT DISORDERS
(2016)
Article
Pharmacology & Pharmacy
Cristina Porras-Gonzalez, Antonio Ordonez, Antonio Castellano, Juan Urena
VASCULAR PHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Clara B. Garcia-Calderon, Jose Antonio Bejarano-Garcia, Isabel Tinoco-Gago, Maria Jose Castro, Paula Moreno-Gordillo, Jose Piruat, Teresa Caballero-Velazquez, Jose A. Perez-Simon, Ivan Rosado
CELL DEATH AND DIFFERENTIATION
(2018)
Article
Biochemistry & Molecular Biology
D. Falcon, R. Gonzalez-Montelongo, E. Sanchez de Rojas-de Pedro, A. Ordonez, J. Urena, A. Castellano
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2018)
Article
Clinical Neurology
Maria del Carmen Gonzalez-Montelongo, Juan Jose Egea-Guerrero, Francisco Murillo-Cabezas, Rafaela Gonzalez-Montelongo, Zaida Ruiz de Azua-Lopez, Ana Rodriguez-Rodriguez, Angel Vilches-Arenas, Antonio Castellano, Juan Urena
Article
Physiology
Alejandro Dominguez-Rodriguez, Isabel Mayoral-Gonzalez, Javier Avila-Medina, Eva S. de Rojas-de Pedro, Eva Calderon-Sanchez, Ignacio Diaz, Abdelkrim Hmadcha, Antonio Castellano, Juan A. Rosado, Jean-Pierre Benitah, Ana M. Gomez, Antonio Ordonez, Tarik Smani
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Peripheral Vascular Disease
Cristina Porras-Gonzalez, Antonio Castellano, Juan Urena
HYPERTENSION RESEARCH
(2018)
Article
Genetics & Heredity
Edgard Verdura, Carme Fons, Agatha Schluter, Montserrat Ruiz, Stephane Fourcade, Carlos Casasnovas, Antonio Castellano, Aurora Pujol
JOURNAL OF MEDICAL GENETICS
(2020)
Article
Medicine, General & Internal
V Sanchez-Lopez, L. Gao, M. Ferrer-Galvan, E. Arellano-Orden, T. Elias-Hernandez, L. Jara-Palomares, M. Asensio-Cruz, M. J. Castro-Perez, F. J. Rodriguez-Martorell, J. L. Lobo-Beristain, A. Ballaz-Quincoces, J. L. Lopez-Campos, V. Vila-Liante, R. Otero-Candelera
ANNALS OF MEDICINE
(2020)
Article
Cell Biology
Vanesa Garrido-Rodriguez, Ines Herrero-Fernandez, Maria Jose Castro, Ana Castillo, Isaac Rosado-Sanchez, Maria Isabel Galva, Raquel Ramos, Israel Olivas-Martinez, Angel Bulnes-Ramos, Julio Canizares, Manuel Leal, Yolanda Maria Pacheco
Summary: The CD4/CD8 T-cell ratio is a useful marker for evaluating immune features in older individuals, showing differences in thymic output and immune profiles that can affect health status.
Article
Immunology
Pilar Blanco Lobo, Paloma Guisado-Hernandez, Isabel Villaoslada, Beatriz de Felipe, Carmen Carreras, Hector Rodriguez, Begona Carazo-Gallego, Ana Mendez-Echevarria, Jose Manuel Lucena, Pilar Ortiz Aljaro, Maria Jose Castro, Jose Francisco Noguera-Ucles, Joshua D. Milner, Katelyn McCann, Ofer Zimmerman, Alexandra F. Freeman, Michail S. Lionakis, Steven M. Holland, Olaf Neth, Peter Olbrich
Summary: Ex vivo treatment with the JAK1/2 inhibitor ruxolitinib reduces cytokine responsiveness and normalizes STAT1 phosphorylation in DN STAT3 and STAT1 GOF patient's cells.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rocio Munoz-Hernandez, Angela Rojas, Sheila Gato, Javier Gallego, Antonio Gil-Gomez, Maria Jose Castro, Javier Ampuero, Manuel Romero-Gomez
Summary: Extracellular vesicles (EVs) are membrane-derived vesicles released by various cell types, functioning as intercellular mediators of cell-cell communication. The development and optimization of methods for EV isolation are crucial for understanding their biological functions and potential therapeutic applications. This article comprehensively reviews the role of hepatic EVs in liver diseases and discusses their potential as 'liquid biopsies' for early diagnosis, follow-up, and prognosis, as well as their use in drug delivery systems for liver disease therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Gonzalo Revilla-Gonzalez, Lourdes Maria Varela, Zaida Ruiz de Azua-Lopez, Rosario Amaya-Villar, Maria Rosa Pezzotti, Maria Jose Castro, Juan Urena, Maria del Carmen Gonzalez-Montelongo, Antonio Castellano
Summary: Aneurysmal subarachnoid hemorrhage (aSAH) is a neurovascular disease caused by blood leakage into the subarachnoid space after rupture of cerebral vessels. This study analyzed the changes in peripheral blood mononuclear cells (PBMCs) and their interaction with endothelium in aSAH patients, with a focus on adhesion and expression of adhesion molecules. The study found increased adhesion of PBMCs, particularly monocytes, in patients with aSAH, especially those who developed vasospasm. The expression of several adhesion molecules in T lymphocytes and monocytes was altered, providing insights for predicting vasospasm and improving treatment.
TRANSLATIONAL STROKE RESEARCH
(2023)