Article
Biochemistry & Molecular Biology
Rong-Mo Zhang, Kerstin Tiedemann, Muthu L. Muthu, Neha E. H. Dinesh, Svetlana Komarova, Bhama Ramkhelawon, Dieter P. Reinhardt
Summary: This study demonstrates that miR-122 in the aortic wall inhibits inflammatory responses and matrix remodeling in thoracic aortic aneurysms (TAA) associated with Marfan syndrome. Deficient fibrillin-1-cell interaction and hypoxia suppress miR-122 expression, leading to elevated pro-inflammatory cytokines and matrix metalloproteinases, as well as elastin fragmentation and aortic dilation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Environmental Sciences
Christine W. Lee, Amber L. Cathey, Deborah J. Watkins, Zaira Y. Rosario-Pabon, Carmen M. Velez-Vega, Akram N. Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: This study examined the impact of maternal phthalate exposures on inflammatory processes and found that phthalates may play a role in mediating the maternal inflammatory response, with significant sexual dimorphism observed. These findings have implications for adverse pregnancy outcomes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Sang Yeol Lee
Summary: Matrix metalloproteinases (MMPs) play crucial roles in cancer metastasis and chronic inflammatory diseases, while ginsenosides have therapeutic potentials. Ginsenosides exhibit anti-metastatic and anti-inflammatory activities by suppressing MMPs through regulation of various signaling pathways.
Review
Biochemistry & Molecular Biology
Shamila Vibhushan, Manuela Bratti, Juan Eduardo Montero-Hernandez, Alaa El Ghoneimi, Marc Benhamou, Nicolas Charles, Eric Daugas, Ulrich Blank
Summary: Chymase, an important protease found in mast cells, plays a key role in the development of kidney disease, contributing to the generation of angiotensin II, an important inflammatory mediator. While initially thought to contribute to pathogenesis, accumulating data suggest that chymase may also have beneficial effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Huan Yang, Ting Zhou, Amelia Stranz, Elise DeRoo, Bo Liu
Summary: A study using single-cell RNA sequencing on mouse AAA tissues revealed 12 distinct populations of 8 cell types. The percentages of each population and gene expression were compared between sham and AAA tissue, showing that populations within major cell types such as smooth muscle cells, fibroblasts, and macrophages may contribute differently to AAA pathogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Environmental Sciences
Carlos Ramos, Rebeca Canedo-Mondragon, Carina Becerril, Georgina Gonzalez-Avila, Ana Laura Esquivel, Ana Lilia Torres-Machorro, Martha Montano
Summary: Exposure to short-term wood smoke was found to significantly increase total cells, macrophages, neutrophils, and collagen in the respiratory system of guinea pigs, leading to overexpression of pro-inflammatory cytokines, MMPs, and TIMPs in lung tissue.
Article
Cardiac & Cardiovascular Systems
Dunpeng Cai, Chenming Sun, Gui Zhang, Xingyi Que, Ken Fujise, Neal L. Weintraub, Shi-You Chen
Summary: The study identified ADAR1 as a novel regulator of AAA development, showing its interaction with HuR to regulate the stability of MMP2 and MMP9 mRNA, leading to increased MMP levels and activities that may represent a potential new therapeutic target to hinder AAA growth and rupture.
CIRCULATION RESEARCH
(2021)
Article
Engineering, Biomedical
Misael Dalbosco, Thiago A. Carniel, Eduardo A. Fancello, Gerhard A. Holzapfel
Summary: This study investigates the relationship between the development of abdominal aortic aneurysms (AAAs) and microstructural and mechanical changes in the tissue using multiscale models. The findings suggest that the formation of AAAs disrupts the micromechanical state of the aortic tissue and triggers a growth and remodeling reaction. This leads to the formation of a thick neo-adventitia, which may act as a protective sheath for the AAA wall.
ACTA BIOMATERIALIA
(2022)
Article
Multidisciplinary Sciences
Wei-Yun Shen, Hui Li, An-Hui Zha, Ru-Yi Luo, Yan-Ling Zhang, Cong Luo, Ru-Ping Dai
Summary: Platelets have the ability to modulate immune responses and are associated with cardiac disease. Despite low platelet counts, platelets in patients with acute aortic dissection (AAD) are activated, leading to significant alterations in immune-modulating mediators. Monocytes in AAD patients have suppressed immune status, which correlates with poor outcomes following surgery. Platelets preferentially aggregate with monocytes, and the levels of monocyte-platelet aggregates (MPAs) are related to postoperative recovery. Platelets restore suppressed monocyte functions by forming aggregates and secreting matrix metalloproteinase-9 (MMP-9), potentially improving postoperative outcomes following complex cardiovascular surgery.
Article
Respiratory System
Markus Weckmann, Thomas Bahmer, Jannie Marie Sand, Sarah Rank Ronnow, Martin Pech, Cornelis Vermeulen, Alen Faiz, Diana Julie Leeming, Morten Asser Karsdal, Lars Lunding, Brian George G. Oliver, Michael Wegmann, Gudrun Ulrich-Merzenich, Uwe R. Juergens, Jannis Duhn, Yves Laumonnier, Olga Danov, Katherina Sewald, Ulrich Zissler, Marnix Jonker, Inke Koenig, Gesine Hansen, Erika von Mutius, Oliver Fuchs, Anna-Maria Dittrich, Bianca Schaub, Christine Happle, Klaus F. Rabe, Maarten van de Berge, Janette Kay Burgess, Matthias Volkmar Kopp
Summary: This study examined the degradation of COL4A3 in allergic airway inflammation and evaluated the resulting product as a biomarker for anti-IgE therapy response. The serum marker C4Ma3 was found to be increased in both adult and pediatric asthma, and was associated with a more severe, exacerbating allergic asthma phenotype.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Allergy
Martin Metz, Pavel Kolkhir, Sabine Altrichter, Frank Siebenhaar, Francesca Levi-Schaffer, Bradford A. Youngblood, Martin K. Church, Marcus Maurer
Summary: Chronic urticaria is a mast cell-dependent disease with limited therapeutic options. Current strategies focus on inhibiting IgE-mediated activation of mast cells and antagonizing the effects of released mediators. MC silencers have been developed as a new strategy to selectively block mast cell activation without causing immunosuppressive adverse effects.
Article
Biochemistry & Molecular Biology
Yu-Chung Shih, Po-Yuan Chen, Tai-Ming Ko, Po-Hsun Huang, Hsu Ma, Der-Cherng Tarng
Summary: MMP-9 knockout attenuated AV fistula stenosis by reducing perioperative vascular inflammation through decreasing neointima size, increasing lumen area, and inhibiting the expression of inflammatory genes. Experiments showed that MMP-9 knockout also reduced CD44 and RAC-alpha serine/threonine-protein kinase (Akt) and extracellular signal-regulated kinases (ERK) phosphorylation, ultimately leading to a reduction in AV fistula failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Allergy
Tahereh Derakhshan, Joshua A. Boyce, Daniel F. Dwyer
Summary: This article provides an overview of the differentiation and characteristics of mast cell (MC) progenitors, as well as the heterogeneity of MCs in health and disease. Single-cell profiling technologies offer a powerful approach to decipher complex cellular functions and interactions, and to identify candidate factors for targeted therapies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Irit Shefler, Pazit Salamon, Yoseph A. Mekori
Summary: Mast cells play a significant role in allergic responses, inflammation, and tumor progression by releasing a variety of extracellular vesicles that interact with and affect nearby cells. Understanding the role of mast cell-derived EVs in different clinical conditions can lead to the development of novel therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Ying Li, Xin Zhang, Dan He, Zhijie Ma, Ke Xue, Haiyan Li
Summary: Regulating excessive inflammation and inhibiting MMP-9 overexpression are effective strategies for improving diabetic wound healing. The ionic products of 45S5 Bioglass and chitosan nanoparticles can reduce MMP-9 expression, enhance extracellular matrix protein synthesis, and promote angiogenesis, thereby accelerating the healing process of diabetic wounds.
ACTA BIOMATERIALIA
(2022)
Article
Parasitology
P. N. Doanh, H. V. Hien, L. A. Tu, N. Nonaka, Y. Horii, Y. Nawa
JOURNAL OF HELMINTHOLOGY
(2016)
Article
Parasitology
Siritavee Pornruseetairatn, Hideto Kino, Takeshi Shimazu, Yukifumi Nawa, Toma Scholz, Jiraporn Ruangsittichai, Naowarat Tanomsing Saralamba, Urusa Thaenkham
PARASITOLOGY RESEARCH
(2016)
Review
Public, Environmental & Occupational Health
David Blair, Yukifumi Nawa, Makedonka Mitreva, Pham Ngoc Doanh
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2016)
Review
Public, Environmental & Occupational Health
Pham N. Doanh, Yukifumi Nawa
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2016)
Article
Parasitology
Y. Nawa, P. N. Doanh, U. Thaenkham
JOURNAL OF HELMINTHOLOGY
(2015)
Article
Parasitology
P. N. Doanh, U. Thaenkham, P. T. An, H. V. Hien, Y. Horii, Y. Nawa
JOURNAL OF HELMINTHOLOGY
(2015)
Article
Medicine, General & Internal
Jeong-Geun Kim, Chun-Seob Ahn, Woon-Mok Sohn, Yukifumi Nawa, Yoon Kong
JOURNAL OF KOREAN MEDICAL SCIENCE
(2018)
Article
Veterinary Sciences
Hilario Torres-Montoya, Xochilth Galaviz-Renteria, Hipolito Castillo-Ureta, Hector Lopez-Moreno, Yukifumi Nawa, Angel Bojorquez-Contreras, Sergio Sanchez-Gonzalez, Sylvia Diaz-Camacho, Rodrigo Rocha-Tirado, Jose Rendon-Maldonado
JOURNAL OF WILDLIFE DISEASES
(2014)
Article
Parasitology
Seon-Hee Kim, Young-An Bae, Jin-Sik Nam, Yichao Yang, Yukifumi Nawa, Yoon Kong
PARASITOLOGY INTERNATIONAL
(2013)
Article
Parasitology
Pham Ngoc Doanh, Zhihong Guo, Nariaki Nonaka, Yoichiro Horii, Yukifumi Nawa
PARASITOLOGY INTERNATIONAL
(2013)
Article
Infectious Diseases
Jeong-Geun Kim, Chun-Seob Ahn, Insug Kang, Jong-Wook Shin, Hae-Bong Jeong, Yukifumi Nawa, Yoon Kong
Summary: Cerebral paragonimiasis (CP) caused by Paragonimus worms can lead to serious illness. This study retrospectively evaluated 111 CP cases and found different clinical characteristics between early-stage and chronic patients. The diagnostic potential of rPwYF against serum and CSF showed high sensitivity and specificity, suggesting its usefulness in diagnosing both early and chronic cases of CP.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Thitima Nutravong, Sunpetch Angkititrakul, Nitchatorn Panomai, Netchanok Jiwakanon, Wanlaya Wongchanthong, Surang Dejsirilert, Yukifumi Nawa
SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
(2014)
Review
Parasitology
Ying Feng, Yukifumi Nawa, Kittisak Sawanyavisuth, Zhiyue Lv, Zhong-Dao Wu
KOREAN JOURNAL OF PARASITOLOGY
(2013)
Article
Parasitology
Shigehisa Habe, Pham Ngoc Doanh, Shinichiro Yahiro, Nanthasane Vannavong, Hubert Barennes, Peter Odermatt, Gilles Dreyfuss, Yoichiro Horii, Yukifumi Nawa
KOREAN JOURNAL OF PARASITOLOGY
(2013)
Article
Parasitology
Penchom Janwan, Pewpan M. Intapan, Hiroshi Yamasaki, Porntip Laummaunwai, Kittisak Sawanyawisuth, Chaisiri Wongkham, Chatchai Tayapiwatana, Amnat Kitkhuandee, Viraphong Lulitanond, Yukifumi Nawa, Wanchai Maleewong
KOREAN JOURNAL OF PARASITOLOGY
(2013)