期刊
CIRCULATION JOURNAL
卷 77, 期 9, 页码 2311-2317出版社
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-12-1548
关键词
Albuminuria; Angiopoietin-like protein 2; Chronic kidney disease; Cross-sectional study; Epidemiology
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22116010, 22240073, 22590892, 23590797, 23590798, 23500842, 24590796]
- Ministry of Health, Labour and Welfare of Japan
- Japan Society for the Promotion of Science [LS098]
- Grants-in-Aid for Scientific Research [25253048] Funding Source: KAKEN
Background: Angiopoietin-like protein 2 (Angptl2) is an adipokine that promotes inflammation and endothelial dysfunction of the vessels. The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD). Methods and Results: A total of 3,169 community-dwelling subjects aged 40 years were divided into quintiles by Angptl2 level. CKD was defined as the presence of albuminuria (urine albumin-creatinine ratio >= 30.0 mg/g) or decreased estimated glomerular filtration rate (eGFR <60 ml.min(-1).1.73 m(-2)). The odds ratio (OR) for the presence of CKD was calculated using a logistic regression model. The overall prevalence of CKD was 37.5%. The age- and sex-adjusted ORs for the presence of CKD increased with higher serum Angptl2 level. This trend remained significant after adjusting for known cardiovascular risk factors (<2.01 ng/ml: OR, 1.00 (reference); 2.01-2.48 ng/ml: OR, 1.67, 95% confidence interval [CI]: 1.24-2.24; 2.49-2.99 ng/ml: OR, 1.70, 95% Cl: 1.27-2.28; 3.00-3.65 ng/ml: OR, 1.78, 95% CI: 1.32-2.39; >= 3.66 ng/ml: OR, 1.79, 95% CI: 1.32-2.43; P-value for trend=0.001). Multivariate-adjusted ORs for the presence of albuminuria increased significantly with elevated serum Angptl2 (P-value for trend=0.004), while there was no evidence of a significant relationship between serum Angptl2 level and decreased eGFR (P-value for trend=0.08). Conclusions: Elevated serum Angptl2 is associated with the likelihood of CKD in the general population.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据