Article
Cardiac & Cardiovascular Systems
Fusako Sera, Tomohito Ohtani, Shunsuke Tamaki, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Daisaku Nakatani, Takahisa Yamada, Yoshio Yasumura, Shungo Hikoso, Keiko Yamauchi-Takihara, Yasushi Sakata
Summary: The prevalence and clinical significance of the precapillary component of pulmonary hypertension (PH) after heart failure (HF) treatment in HFpEF patients were investigated. Using different PH definitions, it was found that the occurrence of PH after HF treatment ranged from 27% to 6%. For patients with a precapillary component of PH according to the 2015 definition, poor clinical outcomes were associated with small left ventricular dimension and high early diastolic mitral inflow velocity/early diastolic mitral annular tissue velocity. Echocardiographic parameters can help risk stratification in HFpEF patients with a precapillary component of PH.
Article
Cardiac & Cardiovascular Systems
Elisa Merli, Quirino Ciampi, Maria Chiara Scali, Angela Zagatina, Pablo Martin Merlo, Rosina Arbucci, Clarissa Borguezan Daros, Jose Luis de Castro e Silva Pretto, Miguel Amor, Michael F. Salame, Hugo Mosto, Doralisa Morrone, Antonello D'Andrea, Barbara Reisenhofer, Hugo Rodriguez-Zanella, Karina Wierzbowska-Drabik, Jaroslaw D. Kasprzak, Gergely Agoston, Albert Varga, Jorge Lowenstein, Claudio Dodi, Lauro Cortigiani, Iana Simova, Martina Samardjieva, Rodolfo Citro, Jelena Celutkiene, Federica Re, Ines Monte, Suzana Gligorova, Francesco Antonini-Canterin, Mauro Pepi, Clara Carpeggiani, Patricia A. Pellikka, Eugenio Picano
Summary: Lung ultrasound can detect pulmonary congestion at rest and during exercise stress echocardiography. Stress B-lines and ejection fraction <50% are independent predictors of all-cause death.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Medicine, General & Internal
Ju-Hee Lee, Jae-Hyeong Park, In-Chang Hwang, Jin Joo Park, Jun-Bean Park
Summary: Pulmonary hypertension associated with left heart disease is the most common form of pulmonary hypertension, which has a significant impact on patients' health. The prevalence of persistent PH-LHD in patients observed on follow-up echocardiography was 21.6% and was associated with decreased left atrial function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Meidan Kuang, Yilin Chen, Yue Xing, Min Du, Huazhuo Feng, Qifeng Yang, Dongmei Wen, Xuanyi Li, Kai Yang, Ziying Lin, Ning Lai, Qian Jiang, Shiyun Liu, Dansha Zhou, Wei Hong, Xin Fu, Wenju Lu, Tengteng Zhao, Jian Wang, Yuqin Chen
Summary: Right heart failure is the leading cause of death in pulmonary hypertension (PH), and echocardiography is commonly used to assess PH risk. However, few studies have investigated the dynamic changes in the right heart during PH development. In this study, a rat model of SuHx-induced PH was evaluated using echocardiography. The results showed that right ventricular function worsened as right ventricular systolic pressure increased, and right heart hypofunction occurred earlier than pulmonary artery thickening. There was also evidence of DNA damage and cellular senescence during the early stages of PH development.
RESPIRATORY RESEARCH
(2023)
Article
Pediatrics
Kinjal Desai, Michael Di Lorenzo, Warren S. A. Zuckerman, Ezinne Emeruwa, Usha S. S. Krishnan
Summary: This is a small study on the use of sildenafil in treating left-sided heart failure. The results show that sildenafil can improve heart function, but it needs to be titrated carefully with inpatient surveillance.
Review
Biochemistry & Molecular Biology
Argen Mamazhakypov, Abdirashit Maripov, Akpay S. Sarybaev, Ralph Theo Schermuly, Akylbek Sydykov
Summary: Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure and vascular remodeling. Circulating osteopontin has been suggested as a biomarker of PH progression and right ventricular dysfunction. Preclinical studies have shown that osteopontin plays a role in PH pathogenesis by modulating various cellular processes. This article provides an overview of osteopontin regulation and its impact on pulmonary vascular remodeling, as well as the potential of targeting osteopontin for PH management.
Article
Medicine, General & Internal
Minjoo Kim, Hee Yoon, Min Yeong Kim, Ik Joon Jo, Soo Yeon Kang, Guntak Lee, Jong Eun Park, Taerim Kim, Se Uk Lee, Sung Yeon Hwang, Won Chul Cha, Tae Gun Shin
Summary: Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal disease that obstructs pulmonary vessels, causing pulmonary hypertension and right-sided heart failure. A retrospective chart review found that all patients in the case series presented with severe and rapidly progressive dyspnea, as well as signs of RV dilatation and pulmonary hypertension.
Article
Cardiac & Cardiovascular Systems
Odd Bech-Hanssen, J. Gustav Smith, Marco Astengo, Entela Bollano, Emanuele Bobbio, Christian Lars Polte, Niklas Bergh, Kristjan Karason
Summary: This study used the newly adopted definition of pulmonary hypertension (PH) and echocardiography to identify the phenotype of PH in patients with heart failure. The study also found a relationship between PH phenotype and right ventricular function.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Medicine, General & Internal
Hosan Hasan, Philippe Chouvarine, Franziska Diekmann, Nikita Diedrich, Martin Koestenberger, Georg Hansmann
Summary: This study aimed to validate the EPPVDN pediatric PH risk score and found strong correlations between CMR and echocardiographic variables with the risk score. By developing a web application, the score can be easily accessed and applied in larger pediatric PH studies.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Zenab Mohseni-Alsalhi, Maud A. M. Vesseur, Nick Wilmes, Sophie A. J. S. Laven, Daniek A. M. Meijs, Eveline M. van Luik, Esmee W. P. Vaes, Cedric J. R. Dikovec, Jan Wiesenberg, Mohamad F. Almutairi, Emma B. N. J. Janssen, Sander de Haas, Marc E. A. Spaanderman, Chahinda Ghossein-Doha
Summary: This study investigated the representation of females and the presentation of sex-stratified data in studies on the effect of antihypertensive drugs. The results showed a slight increase in female participation over the past decades, but females are still underrepresented compared to males. Additionally, the frequency of sex stratification in the studies was low.
Article
Cardiac & Cardiovascular Systems
Michele D'Alto, Biagio Liccardo, Marco Di Maio, Carmen Del Giudice, Emanuele Romeo, Paola Argiento, Francesca Renon, Andrea Vergara, Alessandro Di Vilio, Eleonora Caiazza, Eduardo Bossone, Gaetano Rea, Antonello D'Andrea, Luna Gargani, Paolo Golino, Robert Naeije
Summary: Lung ultrasound combined with echocardiography has incremental value in the differential diagnosis between PAH and PH-HFpEF.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Medicine, General & Internal
Mon Myat Oo, Isaiah Tan Chung Zhen, Kee Seong Ng, Kok Leng Tan, Alexander T. B. Tan, Shireene Ratna Vethakkan, R. Jeyakantha A L Ratnasingam, Kok Han Chee
Summary: The study identified a high prevalence of stage B heart failure in patients with type 2 diabetes without a history of cardiovascular disease in Malaysia. Most participants were female, with a mean body mass index of 27.5 kg/m(2). A large proportion of patients had a history of hypertension and had been living with type 2 diabetes for more than 10 years. Diastolic dysfunction, increased left ventricular mass index, and increased left atrial volume index were common among the study population. Newer anti-diabetes agents were also frequently used in this group.
Article
Cardiac & Cardiovascular Systems
Yasuyuki Chiba, Hiroyuki Iwano, Sanae Kaga, Mio Shinkawa, Michito Murayama, Hiroshi Ohira, Suguru Ishizaka, Miwa Sarashina, Shingo Tsujinaga, Shinobu Yokoyama, Masahiro Nakabachi, Hisao Nishino, Kazunori Okada, Kiwamu Kamiya, Toshiyuki Nagai, Toshihisa Anzai
Summary: Evaluation of left ventricular filling pressure is crucial in managing pulmonary hypertension, but the accuracy of echocardiographic parameters in cases with pulmonary vascular lesions remains uncertain. In cases of advanced pulmonary vascular lesions, conventional echocardiographic parameters may not accurately reflect left ventricular filling pressure, possibly due to the blunting effect of elevated pulmonary vascular resistance.
PULMONARY CIRCULATION
(2021)
Article
Medicine, General & Internal
Giulia Elena Mandoli, Federico Landra, Benedetta Chiantini, Carlotta Sciaccaluga, Maria Concetta Pastore, Marta Focardi, Luna Cavigli, Flavio D'Ascenzi, Sonia Bernazzali, Massimo Maccherini, Serafina Valente, Matteo Cameli, Michael Henein
Summary: This study evaluated the predictive accuracy of peak TRV for PH based on the new and old cutoff values for mPAP, and compared it with the mean RV-RA pressure gradient. The results showed that peak TRV performed better than mean RV-RA pressure gradient in predicting PH, regardless of the hemodynamic definitions, and had higher sensitivity and equal positive predictive value.
Review
Cardiac & Cardiovascular Systems
Miranda K. Culley, Stephen Y. Chan
Summary: This review discusses emerging concepts centered on endothelial senescence in pulmonary vascular disease. It proposes that endothelial senescence may serve as a unifying mechanism for pulmonary hypertension and highlights the link between aging and this disease. Additionally, it presents potential opportunities and barriers for targeting senescence in the diagnosis and treatment of pulmonary hypertension.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Jun Mukai, Hidekazu Tanaka, Hiroyuki Sano, Shun Yokota, Makiko Suto, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Kensuke Matsumoto, Kazuhiko Nakayama, Noriaki Emoto, Ken-ichi Hirata
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2020)
Correction
Multidisciplinary Sciences
Agian Jeffilano Barinda, Koji Ikeda, Dhite Bayu Nugroho, Donytra Arby Wardhana, Naoto Sasaki, Sakiko Honda, Ryota Urata, Satoaki Matoba, Ken-Ichi Hirata, Noriaki Emoto
NATURE COMMUNICATIONS
(2020)
Editorial Material
Pharmacology & Pharmacy
Bambang Widyantoro, Gusty Rizky Teguh Ryanto, Noriaki Emoto
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2020)
Editorial Material
Pharmacology & Pharmacy
Bambang Widyantoro, Noriaki Emoto
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
Nur Arfian, Yoko Suzuki, Anggoro Budi Hartopo, Nungki Anggorowati, Dwi Aris Agung Nugrahaningsih, Noriaki Emoto
Article
Multidisciplinary Sciences
Gusty R. T. Ryanto, Koji Ikeda, Kazuya Miyagawa, Ly Tu, Christophe Guignabert, Marc Humbert, Tomoyuki Fujiyama, Masashi Yanagisawa, Ken-ichi Hirata, Noriaki Emoto
Summary: The dysregulation of the activin A-bone morphogenetic protein receptor type 2 link in endothelium plays a critical role in the progression of pulmonary arterial hypertension. Inhibin-beta -A/activin-A in endothelial cells could be a potential pharmacotherapeutic target for the treatment of pulmonary arterial hypertension.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Adam Prabata, Koji Ikeda, Elda Putri Rahardini, Ken-Ichi Hirata, Noriaki Emoto
Summary: The study demonstrates that GPNMB negatively regulates macrophage inflammatory capacities and ameliorates WAT inflammation in obesity, making it a promising therapeutic target for metabolic disorders associated with obesity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Biology
Andreas Haryono, Risa Ramadhiani, Gusty Rizky Teguh Ryanto, Noriaki Emoto
Summary: In this review, the basic functions of endothelin and related molecules, including their receptors and enzymes, are described. The important role of endothelin in cardiovascular diseases is discussed, along with the clinical evidence for targeting the endothelin pathway and the future scope of endothelin-targeting treatments. The current uses of endothelin receptor antagonists and advancements in treatment options are highlighted, providing an overview of endothelin research over the years and its potential future developments.
Article
Pharmacology & Pharmacy
Ratih Paramita Suprapto, Yoko Suzuki, Tatsuya Nagano, Ken-Ichi Hirata, Noriaki Emoto
Summary: Lung adenocarcinoma, the leading cause of cancer-related deaths worldwide, was found to have increased expression of endothelin-2 (ET-2) which was associated with poor overall survival. Silencing ET-2 inhibited proliferation, migration, and invasion, and enhanced apoptosis in lung adenocarcinoma cells.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Biology
Keisuke Miwa, Yu Taniguchi, Hiroyuki Fujii, Yoichiro Matsuoka, Hiroyuki Onishi, Kenichi Yanaka, Yu Izawa, Yasunori Tsuboi, Atsushi Kono, Noriaki Emoto, Kenichi Hirata
Summary: Poor subpleural perfusion (PSP) on dual-energy computed tomography (DE-CT) is a specific imaging finding in chronic thromboembolic pulmonary hypertension (CTEPH) and suggests a different mechanism of microvasculopathy from that in pulmonary arterial hypertension (PAH).
Article
Neurosciences
Shoji Kawauchi, Taiji Mizoguchi, Sayo Horibe, Toru Tanaka, Naoto Sasaki, Koji Ikeda, Noriaki Emoto, Ken-ichi Hirata, Yoshiyuki Rikitake
Summary: This study investigated the effects of aging-related changes on the neurovascular unit (NVU). It was found that senescence in the vascular endothelial cells led to morphological alterations in astrocytes and affected the localization of the water channel AQP4 at the gliovascular interface.
Article
Cardiac & Cardiovascular Systems
Hiroyuki Fujii, Yu Taniguchi, Sachiyo Yoneda, Keisuke Miwa, Yoichiro Matsuoka, Kenichi Yanaka, Yasunori Tsuboi, Noriaki Emoto, Kenichi Hirata
Summary: In this study, data from 149 patients with chronic thromboembolic pulmonary hypertension (CTEPH) were analyzed. The results showed that the efficacy and safety of balloon pulmonary angioplasty (BPA) for CTEPH with concurrent chronic obstructive pulmonary disease (COPD) were similar to those without COPD. Oxygenation and forced expiratory volume in 1 second/forced vital capacity showed improvement in patients with COPD. Therefore, BPA should be considered as a treatment option for CTEPH patients with concurrent COPD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Gusty Rizky Teguh Ryanto, Ahmad Musthafa, Tetsuya Hara, Noriaki Emoto
Summary: Advances in technology and biomedical knowledge have improved the diagnosis and treatment of rare diseases, including pulmonary arterial hypertension (PAH). This article explores the role of activins and inhibins in PAH development and their connection to signaling pathways implicated in the pathogenesis of PAH. It also discusses the potential therapeutic benefits of activin/inhibin-targeting drugs, such as sotatercep, in improving patient outcomes. Overall, this article highlights the importance of activin/inhibin signaling as a critical mediator in PAH development and its potential as a target for future treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Sayo Horibe, Takuo Emoto, Taiji Mizoguchi, Toru Tanaka, Shoji Kawauchi, Naoto Sasaki, Tomoya Yamashita, Koji Ikeda, Noriaki Emoto, Ken-ichi Hirata, Yoshiyuki Rikitake
Summary: Alzheimer's disease is a common neurodegenerative disease associated with aging. Endothelial cell senescence has been found in the brains of Alzheimer's disease patients, but its role in the pathogenesis of the disease is unclear. The study revealed that endothelial cell senescence alters microglial morphology and function, providing a potential clue for the prevention and treatment of Alzheimer's disease.
Article
Cardiac & Cardiovascular Systems
Muhammad R. Hadwiono, Anggoro B. Hartopo, Widya Wasityastuti, Dyah W. Anggrahini, Gusty R. T. Ryanto, Noriaki Emoto, Lucia K. Dinarti
Summary: This study found that Activin A may have a role in the development and progression of pulmonary artery hypertension (PAH) caused by uncorrected congenital heart disease (CHD-PAH). Serum levels of Activin A were significantly increased in subjects with uncorrected CHD, and were even more significantly elevated in CHD-PAH patients compared to controls. Therefore, the measurement of serum Activin A shows promise in identifying uncorrected CHD patients with PAH development and progression.
PULMONARY CIRCULATION
(2023)