Article
Cardiac & Cardiovascular Systems
Leonard Mandes, Monica Rosca, Daniela Ciuperca, Andreea Calin, Carmen C. Beladan, Roxana Enache, Andreea Cuculici, Cristian Baicus, Ruxandra Jurcut, Carmen Ginghina, Bogdan A. Popescu
Summary: This study found that atrial fibrillation (AF) is associated with electrocardiographic and echocardiographic parameters (structural and functional) in patients with hypertrophic cardiomyopathy (HCM). Specifically, left atrium booster pump function and electrical dispersion were identified as independent predictors of AF in HCM patients, providing further assessment of AF risk in patients, including those considered at lower risk based on conventional assessment of left atrial size.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Mengmeng Ji, Lin He, Lang Gao, Yixia Lin, Mingxing Xie, Yuman Li
Summary: This review summarizes the recent research progress in evaluating left atrial structure and function of atrial fibrillation patients using echocardiography, as well as the role of traditional echocardiography in identifying atrial fibrillation patients at high risk of heart failure or cardiovascular death.
Review
Biochemistry & Molecular Biology
Francisco Javier Sanchez, Esther Pueyo, Emiliano Raul Diez
Summary: Postoperative atrial fibrillation (POAF) is a complication of cardiovascular surgeries that increases the risk of embolic stroke, prolonged hospital stay, and cardiovascular mortality. While many pathophysiological mechanisms are known, predicting POAF remains a hot topic. Doppler echocardiogram and strain echocardiography have shown significant predictive capacity for POAF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kanta Tanaka, Masatoshi Koga, Keon-Joo Lee, Beom Joon Kim, Tadataka Mizoguchi, Eun Lyeong Park, Juneyoung Lee, Sohei Yoshimura, Jae-Kwan Cha, Byung-Chul Lee, Junpei Koge, Hee-Joon Bae, Kazunori Toyoda
Summary: This study aimed to clarify the clinical significance of intracardiac thrombi in nonvalvular atrial fibrillation-associated stroke as identified by TEE and TTE. Results showed a positive correlation between TEE implementation rates and thrombus detection rates, with intracardiac thrombi associated with an increased risk of recurrent ischemic stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Antony Lurie, Jia Wang, Kyra J. Hinnegan, William F. McIntyre, Emilie P. Belley-Cote, Guy Amit, Jeff S. Healey, Stuart J. Connolly, Jorge A. Wong
Summary: This study found that the prevalence of left atrial thrombus in patients with atrial fibrillation or atrial flutter on guideline-directed anticoagulation was 2.73%. Patients with nonparoxysmal AF/AFL, undergoing cardioversion, or with CHA(2)DS(2)-VASc scores >= 3 had higher prevalence of left atrial thrombus.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Angela Zagatina, Maria Rivadeneira Ruiz, Quirino Ciampi, Karina Wierzbowska-Drabik, Jaroslaw Kasprzak, Elena Kalinina, Irina Begidova, Jesus Peteiro, Rosina Arbucci, Sofia Marconi, Jorge Lowenstein, Alla Boshchenko, Fiore Manganelli, Jelena Celutkiene, Doralisa Morrone, Elisa Merli, Federica Re, Clarissa Borguezan-Daros, Maciej Haberka, Ariel K. Saad, Ana Djordjevic-Dikic, Nithima Chaowalit Ratanasit, Fausto Rigo, Paolo Colonna, Jose Luis de Castro e Silva Pretto, Fabio Mori, Maria Grazia D'Alfonso, Miodrag Ostojic, Bojan Stanetic, Tamara Kovacevic Preradovic, Fabio Costantino, Andrea Barbieri, Rodolfo Citro, Annalisa Pitino, Mauro Pepi, Scipione Carerj, Patricia A. Pellikka, Eugenio Picano
Summary: In patients with chronic coronary syndromes, left atrial dilation and reservoir dysfunction are often present in paroxysmal and permanent atrial fibrillation. These abnormalities are associated with more frequent inducible ischemia and pulmonary congestion during stress.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Magnus Nakrem Lyngbakken, Peter Selmer Ronningen, Magnar Gangas Solberg, Trygve Berge, Jon Brynildsen, Erika Nerdrum Aagaard, Brede Kvisvik, Helge Rosjo, Kjetil Steine, Arnljot Tveit, Torbjorn Omland
Summary: This study found that cardiac biomarkers and echocardiographic left atrial volumetric indices are associated with the prevalence and incidence of atrial fibrillation in the general population. NT-proBNP provides incremental prognostic information.
Article
Medical Laboratory Technology
Rangrang Zhang, Weidong Jin, Minglei Han, Yonglan Hou
Summary: Atrial fibrillation (AF) is a common clinical arrhythmia associated with increased risk of death, stroke, and peripheral vascular embolism. Catheter ablation (CA) is an effective treatment, but a high recurrence rate remains a challenge. Identifying biomarkers for prediction of AF recurrence after CA is important for personalized treatment. Carbohydrate antigen 125 (CA-125) has been widely studied and may serve as a useful marker for AF.
CLINICA CHIMICA ACTA
(2023)
Article
Medicine, General & Internal
Iva Krizanovic-Grgic, Shehab Anwer, Jan Steffel, Daniel Hofer, Ardan M. Saguner, Christina M. Spengler, Alexander Breitenstein, Felix C. Tanner
Summary: This study investigated the association of 2D and 3D left atrial strain with low-voltage area in relation to the recurrence of atrial fibrillation after pulmonary vein isolation. The results showed that 3D left atrial reservoir strain and pump strain were lower in patients with recurrent AF. Furthermore, the association of 3D left atrial strain with recurrence of AF was independent of other clinical and echocardiographic parameters, making it a potential predictor for outcomes in patients undergoing PVI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Agnieszka Kaplon-Cieslicka, Monika Gawalko, Monika Budnik, Beata Uzieblo-Zyczkowska, Pawel Krzesinski, Katarzyna Starzyk, Iwona Gorczyca-Glowacka, Ludmila Danilowicz-Szymanowicz, Damian Kaufmann, Maciej Wojcik, Robert Blaszczyk, Jaroslaw Hiczkiewicz, Katarzyna Lojewska, Katarzyna Mizia-Stec, Maciej T. Wybraniec, Katarzyna Kosmalska, Marcin Fijalkowski, Anna Szymanska, Miroslaw Dluzniewski, Maciej Haberka, Michal Kucio, Blazej Michalski, Karolina Kupczynska, Anna Tomaszuk-Kazberuk, Katarzyna Wilk-Sledziewska, Renata Wachnicka-Truty, Marek Kozinski, Pawel Burchardt, Piotr Scislo, Radoslaw Piatkowski, Janusz Kochanowski, Grzegorz Opolski, Marcin Grabowski
Summary: Atrial fibrillation and flutter increase the risk of left atrial thrombus. Chronic oral anticoagulation can reduce the prevalence of left atrial thrombus. The risk of left atrial thrombus appears to be higher with vitamin K antagonists compared to non-vitamin K antagonist oral anticoagulants, and similar among different non-vitamin K antagonist oral anticoagulants.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Aditya Bhat, Henry H. L. Chen, Shaun Khanna, Gary C. H. Gan, Walter P. Abhayaratna, Maria Carmo P. Nunes, Chandini Raina MacIntyre, Timothy C. Tan
Summary: According to a study, heart failure, increased right atrial size, and impaired left atrial function are independent predictors of persistent/permanent atrial fibrillation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Yuxia Miao, Min Xu, Ling Yang, Chunxu Zhang, Huannian Liu, Xiaoliang Shao
Summary: This study found a linear and positive association between P wave duration within 72 hours after radiofrequency ablation and the risk of atrial fibrillation recurrence in patients with early persistent atrial fibrillation. This association was consistent across different subgroups and there was no significant interaction.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Veterinary Sciences
Carlo Guglielmini, Carlotta Valente, Giovanni Romito, Chiara Mazzoldi, Marco Baron Toaldo, Marlos Goncalves Sousa, Marcela Wolf, Tamyris Beluque, Oriol Domenech, Valentina Patata, Francesco Porciello, Paolo Ferrari, Domenico Caivano, Barbara Contiero, Helen Poser
Summary: The aim of this study was to identify risk factors for the development of atrial fibrillation in dogs with an echocardiographic diagnosis of dilated cardiomyopathy (DCM). The results showed that increased left atrial diameter and presence of right atrial enlargement were significant predictors of atrial fibrillation development.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Yameng Shao, Lei Chen, Changjiang Xu, Beibei Gao, Dongdong Zhang, Chuanyi Sang, Chaoqun Zhang
Summary: This study explored the relationship between left atrial epicardial adipose tissue (LA-EAT) and left atrial appendage flow velocity (LAA-FV) in patients with nonvalvular atrial fibrillation (NV-AF). The results showed that left atrial low voltage zone, LA-EAT volume, left atrial appendage shape, left atrial volume index, and type of atrial fibrillation were independent predictors of LAA-FV in NV-AF patients.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Rowlens Melduni, Vuyisile T. Nkomo, Waldemar Wysokinski, Bernard J. Gersh, Abhishek Deshmukh, Ratnasari Padang, Eddie L. Greene, Jae K. Oh, Hon-Chi Lee
Summary: Among patients with non-valvular atrial fibrillation, the presence or severity of mitral regurgitation was not associated with a decreased risk of left atrial appendage thrombus or stroke.
Article
Cardiac & Cardiovascular Systems
Jeong Hoon Yang, Tomonari Harada, Ki Hong Choi, Toshimitsu Kato, Darae Kim, Noriaki Takama, Taek Kyu Park, Masahiko Kurabayashi, Sung-A Chang, Masaru Obokata
Summary: This study demonstrated that peripheral venous pressure (PVP) could reliably estimate pulmonary artery (PA) pressures during exercise in patients with heart failure with preserved ejection fraction. Compared with the traditional method of estimating right atrial pressure (RAP), the use of PVP improved the ability to identify exercise-induced pulmonary hypertension. This finding has important implications for the diagnosis and treatment of heart failure.
CIRCULATION-HEART FAILURE
(2022)
Article
Medicine, General & Internal
Ji-won Hwang, Sang-Chol Lee, Darae Kim, Jihoon Kim, Eun Kyoung Kim, Sung-A Chang, Sung-Ji Park, Sung Mok Kim, Yeon Hyeon Choe, Joong Hyun Ahn, Seung Woo Park
Summary: The present study aimed to identify factors that may affect exercise capacity in patients with hypertrophic cardiomyopathy (HCM). The results showed that age, female sex, increased NT-proBNP level, and E/e' ratio on echocardiography were significantly associated with decreased exercise capacity. Monitoring hemodynamic changes and increased filling pressure on echocardiography is important for improved outcomes in this population.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Sung-A Chang, Sang Hyun Lee, Jung Hyun Choi, Wook-Jin Chung, Jae Young Choi, Hyung-Kwan Kim, Hae-Ok Jung, Seong-Mi Park, Won-Jang Kim, Su Young Jung, Hyuk-Jae Chang
Summary: This study aimed to investigate the real-world practice patterns and adverse event (AE) characteristics of selexipag in patients with pulmonary arterial hypertension (PAH). The results showed that AE incidence was higher during the titration phase compared to the maintenance phase, but there was no association between AE incidence and dose distribution. The most common AEs were diarrhea, headache, nausea/vomiting, and myalgia, and they were not dose-dependent in terms of frequency or severity. The recovery rates ranged from 65.0% to 76.9% with a median time of 15-70 days.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Cardiac & Cardiovascular Systems
Shin Yi Jang, Sung-Ji Park, Eun Kyoung Kim, Seung Woo Park
Summary: This study aims to determine the temporal trends of incidence, prevalence, and death of aortic stenosis (AS) in an East Asian population. The results showed that the proportion of AS patients aged 60 years and above was 80%. The age-standardized incidence rates of AS remained stable, prevalence rates increased, and death rates decreased over the course of a decade. The most common cause of death in AS patients was disease of the circulatory system. Continued efforts are needed to increase awareness of AS-related symptoms and potential complications in the elderly population.
Review
Medicine, General & Internal
Duk-Kyung Kim, Shin Yi Jang, Sung -A Chang, Taek Kyu Park
Summary: Moyamoya disease is a steno-occlusive disease of the distal cerebral arteries. A specific mutation in the RNF213 gene is associated with different manifestations in homozygous and heterozygous patients.
PRECISION AND FUTURE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Su Young Jung, Sung-A Chang, Jong-Min Song, Jae Young Choi, Hyung-Kwan Kim, Jung Hyun Choi, Jung Yeon Chin, Minseok Park, SuYoun Kim, Hyuk-Jae Chang
Summary: This study evaluated the safety and clinical outcomes of macitentan use in Korean patients with pulmonary arterial hypertension. The results showed that macitentan was well tolerated and significantly effective in improving the World Health Organization functional class. Age and disease duration were associated with treatment effectiveness and safety.
DRUGS-REAL WORLD OUTCOMES
(2023)
Article
Genetics & Heredity
Jong Eun Park, Sung-A Chang, Shin Yi Jang, Kyung Soo Lee, Duk-Kyung Kim, Chang-Seok Ki
Summary: Two novel pathogenic variants (c.2137_2138dup and c.3358-1G>A) in the EIF2AK4 gene were identified through whole-exome sequencing. Identification of possible pathogenic gene variants by whole-exome sequencing or panel sequencing is recommended as a guide to adequate treatment of patients with pulmonary hypertension.
MOLECULAR SYNDROMOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kina Jeon, Sang-Bae Yoo, Yoonhee Lee, Eun-Bin Lee, Hyung-Kwan Kim, Hyuk-Jae Chang, Sung-A Chang
Summary: This regulatory post-marketing surveillance aimed to evaluate the safety and effectiveness of ambrisentan in the Korean population. The study found that ambrisentan demonstrated tolerable safety and favorable effectiveness in Korean patients with pulmonary arterial hypertension (PAH). Age and concomitant drug use may affect the occurrence of adverse events.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Genetics & Heredity
Won Young Heo, Shin Yi Jang, Taek Kyu Park, Chang-Seok Ki, Jong-Won Kim, Duk-Kyung Kim, Ja-Hyun Jang
Summary: In this study, two patients with vEDS who were not diagnosed by conventional Sanger sequencing were reported. Targeted panel or whole-genome sequencing was performed, and cDNA sequencing was used for diagnosis. The results demonstrated that cDNA sequencing was a useful auxiliary method, especially considering the limited sensitivity of the splicing prediction tool.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Medicine, General & Internal
Shin Yi Jang, Junghyun Kim, Yi Seul Kim, Young Ae Chang, Wooin Jung, Hwang Og Kim, Kyungnam Yoo, Eun Kyoung Kim, Sung-A Chang, Sung-Ji Park, Seung Woo Park, Duk-Kyung Kim, Sung Mok Kim, June Huh, Jinyoung Song, I-Seok Kang, Soo Jin Cho, Jae K. Oh, Sang-Chol Lee, Yeon Hyeon Choe
Summary: This study evaluated the clinical characteristics of patients undergoing cardiac magnetic resonance (CMR) examinations at a tertiary referral hospital over a 10-year period. The study included 11,087 CMR examinations and found that CMR is most commonly performed in men in their 50s or 60s, and that non-stress CMR examinations are more common in pediatric patients.
PRECISION AND FUTURE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Minjung Bak, Minyeong Kim, Boram Lee, Eun Kyoung Kim, Taek Kyu Park, Jeong Hoon Yang, Duk-Kyung Kim, Sung -A Chang
Summary: This study aimed to understand the nature of rapid RV failure syndrome with a suspected diagnosis of PTTM for better clinical management. The study found that rapid RV failure syndrome showed a progressive course from symptom onset to death, and chemotherapy had limited impact on patient survival. Other treatment methods did not improve the patient's prognosis.
KOREAN CIRCULATION JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Jihoon Kim, Sung-A Chang, Yong-Jin Kim, Hyung-Kwan Kim, Sang Chol Lee
Summary: Hypertrophic cardiomyopathy (HCM) is a common inheritable cardiomyopathy with a high disease burden in Korea. Sudden cardiac death, atrial fibrillation and thromboembolic risk, dynamic left ventricular outflow tract obstruction, and heart failure progression are important issues in HCM. Implantable cardioverter-defibrillators and anticoagulation are effective strategies for preventing sudden cardiac death and reducing thrombotic risk. Symptomatic dynamic LVOT obstruction can be improved with negative inotropes and septal reduction therapy. Myocardial fibrosis plays a role in the progression of heart failure in HCM patients.
KOREAN CIRCULATION JOURNAL
(2022)
Article
Medicine, General & Internal
Shin Yi Jang, Eun Kyoung Kim, June Huh, Jinyoung Song, I-Seok Kang, Seung Woo Park, Duk-Kyung Kim, Sung-A Chang
Summary: The study found that the survival rate of IPAH patients in Korea decreases with age, and the risk of IPAH significantly increases in patients with other risk factors.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)