Article
Biochemistry & Molecular Biology
Arnold Markovics, Laszlo Csige, Erzsebet Szollosi, Hajnalka Matyi, Andrea Diana Lukacs, Nora Reka Perez, Zsofia Reka Bacso, Laszlo Stundl, Judit Remenyik, Attila Biro
Summary: Moderate wine consumption, specifically the bioactive molecules found in Hungarian aszu from the Tokaj wine region, have been shown to have antioxidant and anti-inflammatory effects on endothelial cells. This study used high-performance liquid chromatography to analyze the bioactive molecules and evaluated their impact on cytokine expression and nitric oxide synthase activity in activated endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Vijay Kondreddy, Jhansi Magisetty, Shiva Keshava, L. Vijaya Mohan Rao, Usha R. Pendurthi
Summary: The study aims to investigate the role of Gab2 in inflammatory signaling pathways and its contribution to vascular dysfunction. The results show that silencing Gab2 can significantly attenuate the expression of TF, cell adhesion molecules, and inflammatory cytokines/chemokines induced by cytokines.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cell Biology
Balaji Krishnamachary, Christine Cook, Ashok Kumar, Leslie Spikes, Prabhakar Chalise, Navneet K. Dhillon
Summary: The protein cargo in EVs can distinguish the severity of COVID-19, with enrichment of proinflammatory, procoagulation, immunoregulatory, and tissue-remodeling proteins. These proteins induce apoptosis of pulmonary microvascular endothelial cells.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Cardiac & Cardiovascular Systems
Thorsten M. Leucker, William O. Osburn, Paula Reventun, Kimberley Smith, Brian Claggett, Bridget-Anne Kirwan, Sophie de Brouwer, Marlene S. Williams, Gary Gerstenblith, David N. Hager, Michael B. Streiff, Scott D. Solomon, Charles J. Lowenstein
Summary: The P-selectin inhibitor, crizanlizumab, effectively reduced levels of P-selectin and may induce thrombolysis in COVID-19 patients. However, there were no significant differences in clinical endpoints between crizanlizumab and placebo, and crizanlizumab was well tolerated by patients.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Review
Immunology
Jiayue Ding, Baoying Song, Xiran Xie, Xaingyu Li, Zhiying Chen, Zhongao Wang, Liqun Pan, Duo Lan, Ran Meng
Summary: Cerebral venous thrombosis (CVT) is a rare cerebrovascular disease where inflammation plays a crucial role. Inflammatory factors worsen brain tissue injury and lead to poor prognosis. Peripheral blood inflammatory biomarkers, especially the neutrophil-to-lymphocyte ratio (NLR) and lymphocyte count, are correlated with CVT and predict patient outcomes. COVID-19 infection and vaccine can also induce CVT through inflammatory reactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Gloria Orlando, Barbara Molon, Antonella Viola, Mauro Alaibac, Roberta Angioni, Stefano Piaserico
Summary: Psoriasis is a chronic inflammatory skin disease associated with various comorbidities, including cardiovascular diseases. Current research focuses on the pathways linking psoriatic plaques to the cardiovascular system, as well as the potential involvement of endothelial cells in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Katherine Driscoll, Alexander D. Cruz, Jonathan T. Butcher
Summary: Calcific aortic valve disease is on the rise globally, but treatment is limited to prosthetic replacement. With a growing number of younger and more active patients, alternative therapies are needed. There is potential for biologically based diagnostics and treatments to help alleviate or delay disease progression, but a limited understanding of the disease mechanisms hinders progress towards clinical interventions.
CIRCULATION RESEARCH
(2021)
Review
Immunology
Shuren Guo, Xiaohuan Mao, Jun Liu
Summary: CTRPs family members play critical roles in the development and progression of AS by influencing inflammatory response, modulating glucose and lipid metabolism, regulating endothelial functions, and the proliferation of vascular smooth muscle cells (VSMCs).
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yukihito Higashi
Summary: Oxidative stress and chronic inflammation play a crucial role in the development of atherosclerosis, as vascular endothelial dysfunction leads to its progression and forms a vicious cycle with oxidative stress and inflammation.
Review
Biochemistry & Molecular Biology
Francesco Nappi, Adelaide Iervolino, Sanjeet Singh Avtaar Singh
Summary: SARS Coronavirus-2 is a novel positive sense single-strand RNA beta-coronavirus that infects human hosts by binding to ACE2, causing systemic illness requiring multi-organ support. This review explores the exact mechanisms by which COVID-19 affects patients, focusing on bleeding and thrombotic complications. Issues regarding thrombotic complications post vaccination with ChAdOx1 nCoV-19 have also been discussed.
Article
Chemistry, Medicinal
Annalisa Marcuzzi, Erika Rimondi, Elisabetta Melloni, Arianna Gonelli, Antonio Giacomo Grasso, Egidio Barbi, Natalia Maximova
Summary: Janus kinases (JAKs), as a family of tyrosine kinases, play important roles in immune cell regulation by transducing cytokine-mediated signals through the JAK-STAT pathway. In recent years, JAK inhibitors have shown promise in the treatment of various inflammatory conditions, including acute steroid-refractory graft-versus-host disease (SR-aGVHD). Ruxolitinib, a JAK1/2 inhibitor, has been approved by the FDA for the treatment of SR-aGVHD and has demonstrated rapid and effective response.
Article
Chemistry, Medicinal
Kenia Ubieta, Matthew James Thomas, Lutz Wollin
Summary: The study revealed that nintedanib blocks T-cell activation by inhibiting Lck-Y394 phosphorylation, reduces cluster formation as a marker of activation, and inhibits the release of various cytokines. These immunomodulatory effects further explain how nintedanib slows the progression of pulmonary fibrosis in different ILDs.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Jean-Luc Wautier, Marie-Paule Wautier
Summary: Inflammation, an old concept, is now recognized as important in infection and chronic diseases. Endothelial cells play a crucial role in regulating inflammatory processes. Advanced glycation end product receptor and inflammasome are key molecules in inflammation, and angiogenesis and thrombotic events are dysregulated during inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jinping Wang, Jinque Luo, Dante Rotili, Antonello Mai, Clemens Steegborn, Suowen Xu, Zheng Gen Jin
Summary: SIRT6 protects against lung microvascular inflammation by suppressing NF-kappa B activation, indicating its therapeutic potential for lung disorders associated with microvascular inflammation.
Article
Medicine, General & Internal
Ze Chen, Thea Laurentius, Yvonne Fait, Aline Mueller, Eva Mueckter, Leo Cornelius Bollheimer, Mahtab Nourbakhsh
Summary: Sarcopenia, characterized by muscle loss, can be diagnosed by measuring appendicular skeletal muscle index (ASMI). A study on older adults found positive correlations between ASMI and nutritional status (p = 0.001) and serum creatine kinase (CK) (p = 0.019), but negative correlations with serum CXCL12a (p = 0.023) and interleukin (IL)-7 (p = 0.024). The study identified advanced age, malnutrition, low CK levels, and high CXCL12a levels as risk factors for sarcopenia. Combining low CK and high CXCL12a levels can be used as serum markers for sarcopenia. The linear correlation between ASMI and CXCL12a levels may aid future studies on sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Katja Grabowski, Laura Herlan, Anika Witten, Fatimunnisa Qadri, Andreas Eisenreich, Diana Lindner, Martin Schaedlich, Angela Schulz, Jana Subrova, Ketaki Nitin Mhatre, Uwe Primessnig, Ralph Plehm, Sophie van Linthout, Felicitas Escher, Michael Bader, Monika Stoll, Dirk Westermann, Frank R. Heinzel, Reinhold Kreutz
Summary: Through genetic models and mouse experiments, the study identified the importance of Cpxm2 in hypertension-mediated left ventricular hypertrophy and cardiac damage, and showed that the absence of Cpxm2 can effectively reduce these injuries.
HYPERTENSION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rusan Catar, Melanie Herse-Naether, Nan Zhu, Philine Wagner, Oskar Wischnewski, Angelika Kusch, Julian Kamhieh-Milz, Andreas Eisenreich, Ursula Rauch, Bjoern Hegner, Harald Heidecke, Angela Kill, Gabriela Riemekasten, Gunnar Kleinau, Patrick Scheerer, Duska Dragun, Aurelie Philippe
Summary: Scleroderma renal crisis is a severe complication of systemic sclerosis, characterized by vascular obstruction and thrombotic microangiopathy. The study suggests that patient-derived antibodies can trigger endothelial cell proliferation and affect cellular activities through various signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jana Subrova, Karen Boehme, Allan Gillespie, Miriam Orphal, Claudia Plum, Reinhold Kreutz, Andreas Eisenreich
Summary: This study found that miRNA-29b and miRNA-497 can directly regulate the posttranscriptional expression of CPXM2 in rat cardiomyocytes by binding to the 3' UTR of CPXM2 mRNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Mario E. Goetz, Benjamin Sachse, Bernd Schaefer, Andreas Eisenreich
Summary: Alkenylbenzenes are naturally occurring substances found in various plants, including nutmeg and basil, and are commonly used as flavorings. However, many alkenylbenzenes are known to be toxic, with some being genotoxic carcinogens. There is limited toxicological data available for certain alkenylbenzenes, such as myristicin and elemicin, and existing data on their occurrence in foods is also limited. This lack of data makes it difficult to evaluate the health risks associated with these substances.
Article
Cardiac & Cardiovascular Systems
Kamila Makrutzki-Zlotek, Felicitas Escher, Zehra Karadeniz, Ganna Aleshcheva, Heiko Pietsch, Konstanze Kuechler, Heinz-Peter Schultheiss, Bettina Heidecker, Wolfgang Poller, Ulf Landmesser, Carmen Scheibenbogen, Tharusan Thevathasan, Carsten Skurk
Summary: Inflammatory dilated cardiomyopathy is characterized by cardiac inflammation, injury, and reduced cardiac function. A study found that the gain of function FOXO3A single-nucleotide polymorphism (SNP) rs12212067 may diminish cardiac inflammation and injury in pathogen-negative patients with inflammatory dilated cardiomyopathy.
Article
Cardiac & Cardiovascular Systems
Debora Brala, Tharusan Thevathasan, Simon Grahl, Steve Barrow, Michele Violano, Hendrikje Bergs, Ainoosh Golpour, Phillip Suwalski, Wolfgang Poller, Carsten Skurk, Ulf Landmesser, Bettina Heidecker
Summary: Magnetocardiography is a method for diagnosing myocardial inflammation and monitoring treatment response. It can differentiate between patients with and without cardiomyopathy, and can detect treatment response earlier than echocardiography.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Medicine, General & Internal
Wolfgang Poller, Bettina Heidecker, Enrico Ammirati, Andreas W. Kuss, Ana Tzvetkova, Wolfram C. Poller, Carsten Skurk, Arash Haghikia
Summary: In the field of clinical immunology, the outbreak of COVID-19 has driven studies on the role of inflammation in cardiovascular diseases. Advanced molecular genetic methods have been used to explore the diagnostic significance of these diseases and to identify immunological interactions at organ and system levels. Additionally, research has shown the influence of emotional stress on viral and cardiovascular disorders through brain-immune system interactions. However, there are challenges that need to be addressed before these findings can be fully applied in the clinical arena.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Martina Gast, Vanasa Nageswaran, Andreas W. W. Kuss, Ana Tzvetkova, Xiaomin Wang, Liliana H. H. Mochmann, Pegah Ramezani Rad, Stefan Weiss, Stefan Simm, Tanja Zeller, Henry Voelzke, Wolfgang Hoffmann, Uwe Voelker, Stefan B. B. Felix, Marcus Doerr, Antje Beling, Carsten Skurk, David-Manuel Leistner, Bernhard H. H. Rauch, Tetsuro Hirose, Bettina Heidecker, Karin Klingel, Shinichi Nakagawa, Wolfram C. C. Poller, Filip K. K. Swirski, Arash Haghikia, Wolfgang Poller
Summary: The NEAT1-MALAT1 gene cluster generates noncoding transcripts that remain in the nucleus, while tRNA-like transcripts derived from these precursors translocate to the cytosol. The biological functions of these cytosolic transcripts are not well studied. In this study, selective disruption of menRNA and mascRNA revealed their critical roles in innate immunity, cytokine control, angiogenesis, and cell-cell interaction systems. Defects were also observed in antiviral response, foam cell formation, and macrophage polarization, providing new insights into the functions of menRNA and mascRNA. These transcripts represent novel components of innate immunity and have unique characteristics compared to other noncoding RNAs.
Article
Cardiac & Cardiovascular Systems
Maximilian L. Mueller, Wolfgang Poller, Carsten Skurk, Denis Poddubnyy, Britta Siegmund, Thomas Schneider, Ulf Landmesser, Bettina Heidecker
Summary: This case report highlights the importance of cardiac sarcoidosis as a manifestation of systemic sarcoidosis. Complex conduction abnormalities in young patients may indicate sarcoidosis, even in the absence of more common symptoms. Timely and accurate diagnostic workup, including F-18-FDG-PET-CT as the imaging modality, is crucial for initiating specific treatment and reducing the risk of mortality associated with cardiac sarcoidosis.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)
Review
Chemistry, Applied
Andreas Eisenreich, Bernhard H. Monien, Mario E. Goetz, Thorsten Buhrke, Axel Oberemm, Katharina Schultrich, Klaus Abraham, Albert Braeuning, Bernd Schaefer
Summary: This article summarizes the current knowledge on 3-MCPD and its fatty acid esters (FE), focusing on pending issues related to exposure assessment using biomarkers and the identification of (toxic) metabolites formed after exposure to FE of 3-MCPD and their modes of action.
Editorial Material
Food Science & Technology
Andreas Eisenreich, Bernd Schaefer
Review
Plant Sciences
Mario E. Goetz, Andreas Eisenreich, Janine Frenzel, Benjamin Sachse, Bernd Schaefer
Summary: Alkenylbenzenes are natural secondary plant metabolites, some of which are proven genotoxic carcinogens. This review provides an overview of the occurrence of potentially toxic alkenylbenzenes in essential oils and extracts used for flavoring purposes in food. It focuses on well-known genotoxic alkenylbenzenes like safrole, methyleugenol, and estragole, but also considers other alkenylbenzenes commonly used for flavoring. The review emphasizes the need for quantitative occurrence data on alkenylbenzenes in plants and final plant food supplements, processed foods, and flavored beverages for more reliable exposure assessment in the future.
Review
Cell Biology
Wolfgang Poller, Susmita Sahoo, Roger Hajjar, Ulf Landmesser, Anna M. Krichevsky
Summary: While most of the human genome does not encode proteins, it is still transcriptionally active and produces a variety of noncoding RNAs with complex functions. Only a small fraction of these transcripts have been assigned specific functions. Research on the noncoding genome has revealed the complexity of the human genome and raised many unanswered questions. Recent studies suggest that noncoding RNAs could serve as novel therapeutic targets for human diseases and may be linked to brain evolution and the interaction between the brain and immune system.
Meeting Abstract
Cardiac & Cardiovascular Systems
E. Ammirati, F. Raimondi, N. Piriou, S. A. Mohiddin, M. Imazio, G. Aquaro, I. Olivotto, C. M. Van De Heyning, G. Peretto, M. Merlo, S. Klaassen, W. Poller, E. D. Adler, P. G. Camici, L. T. Cooper
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Richard Dannebaum, Phillip Suwalski, Hosseinali Asgharian, Gracie Du Zhipei, Hai Lin, January Weiner, Manuel Holtgrewe, Charlotte Thibeault, Melina Mueller, Xiaomin Wang, Zehra Karadeniz, Jacopo Saccomanno, Jan-Moritz Doehn, Ralf-Harto Huebner, Bernd Hinzmann, Anja Blueher, Sandra Siemann, Dilduz Telman, Norbert Suttorp, Martin Witzenrath, Stefan Hippenstiel, Carsten Skurk, Wolfgang Poller, Leif E. Sander, Dieter Beule, Florian Kurth, Toumy Guettouche, Ulf Landmesser, Jan Berka, Khai Luong, Florian Rubelt, Bettina Heidecker
Summary: This study analyzed the immune response of healthy individuals and patients with COVID-19, finding specific immune clone types present in severe cases and more shared clone types in healthy individuals. The findings suggest that adaptive immune receptor repertoire measures are associated with disease severity in COVID-19.
