Article
Engineering, Biomedical
Yanxin Zhang, Xin Li, Zhaowenbin Zhang, Huili Li, Dongmin Chen, Yiren Jiao, Chen Fan, Zhen Zeng, Jiang Chang, Yuhong Xu, Baowei Peng, Chen Yang, Yumei Que
Summary: This study developed a Zn2SiO4 bioceramic that can release bioactive SiO32- and Zn2+ ions simultaneously, which have synergistic effects on promoting endothelial cell angiogenesis, inhibiting cardiomyocyte apoptosis, and protecting myocardial mitochondria against reactive oxygen species-induced injury. In vivo outcomes from a murine MI model demonstrated that systemic administration or local application of the Zn2SiO4 extract or composite hydrogel promoted cardiac function and reduced cardiac fibrosis, aiding myocardial repair.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Ryan M. Burke, Ronald A. Dirkx, Pearl Quijada, Janet K. Lighthouse, Amy Mohan, Meghann O'Brien, Wojciech Wojciechowski, Collynn F. Woeller, Richard P. Phipps, Jeffrey D. Alexis, John M. Ashton, Eric M. Small
Summary: Salinomycin as an antifibrotic agent demonstrates potent anti-fibrotic activity in cardiac fibroblasts, prevents cardiac fibrosis and functional decline in mouse models of ischemic and nonischemic heart disease, and inhibits cardiac fibroblast activation by targeting p38/MAPK and Rho signaling. Moreover, salinomycin promotes cardiomyocyte survival and improves coronary vessel density, showing promise for the treatment of heart failure patients.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Philipp Schuette, Mailin-Christin Manke, Katherina Hemmen, Patrick Muenzer, Barbara F. Schoerg, Gustavo Campos Ramos, Michaela Pogoda, Valerie Dicenta, Sabrina H. L. Hoffmann, Juergen Pinnecker, Ferdinand Kollotzek, Monika Zdanyte, Karin A. L. Mueller, Yogesh Singh, Andreas F. Mack, Bernd Pichler, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Katrin G. Heinze, Nicolas Casadei, Oliver Borst
Summary: Platelet-derived miRNAs play a critical role in myocardial inflammation and structural remodeling in response to myocardial ischemia/reperfusion (I/R). In a mouse model with a Dicer gene deletion, disrupted miRNA processing machinery in platelets led to increased myocardial inflammation, impaired angiogenesis, accelerated cardiac fibrosis, and larger infarct size. These findings highlight the importance of platelet-derived miRNA in regulating cellular processes following myocardial I/R.
CIRCULATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Peng Yu, Shuai Song, Xiaokai Zhang, Shujun Cui, Gang Wei, Zihang Huang, Linqi Zeng, Ting Ni, Aijun Sun
Summary: This study revealed the regulatory mechanism of APA in post-MI HF and identified the potential therapeutic effect of the APA-regulated gene AVEN in treating HF.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Plant Sciences
Jie Yu, Xiuye Zhao, Xiuqing Yan, Wen Li, Yunqi Liu, Jiapan Wang, Jia Wang, Yilian Yang, Yan Hao, Zhen Liang, Yiping Tao, Ye Yuan, Zhimin Du
Summary: This study demonstrates that a natural anthraquinone extract called aloe-emodin (AE) can protect against acute myocardial ischemia and improve cardiac remodeling after chronic myocardial infarction (MI). AE treatment significantly improves cardiac function, reduces structural remodeling, and inhibits cardiac apoptosis and oxidative stress. Furthermore, AE activates the TGF-beta signaling pathway and regulates fibrosis-related gene expression, ultimately improving cardiac function and inhibiting cardiac fibrosis and hypertrophy.
Article
Medicine, Research & Experimental
Tianbao Ye, Zhiwen Yan, Cheng Chen, Di Wang, Aiting Wang, Taixi Li, Boshen Yang, Xianting Ding, Chengxing Shen
Summary: This study aimed to investigate the cardioprotective role of lactoferrin (Ltf) in myocardial infarction (MI) and its underlying mechanisms. Proteomic analysis revealed that Ltf was significantly upregulated in MI hearts but decreased in circulation, and its expression was positively correlated with cardiac function. Ltf administration attenuated cardiac fibrosis and remodeling, improved cardiac function, and reduced the incidence of heart failure post-MI.
Article
Chemistry, Multidisciplinary
Ju-Ro Lee, Woo-Sup Sim, Hun-Jun Park, Bong-Woo Park, Yoon Ki Joung
Summary: The modulation of inflammatory responses is important in the development of cardiac failure. In this study, apoptotic bodies-mimetic nanovesicles derived from apoptotic fibroblasts were developed as a therapeutic strategy for ischemia-reperfusion (IR)-injured hearts. These nanovesicles actively targeted the ischemic myocardium and polarized macrophages to alleviate inflammation. Injection of the nanovesicles attenuated cardiac remodeling and prevented cardiac function exacerbation in IR-injured hearts.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Ju-Ro Lee, Bong-Woo Park, Jae-Hyun Park, Songhyun Lim, Sung Pil Kwon, Ji-Won Hwang, Hyeok Kim, Hun-Jun Park, Byung-Soo Kim
Summary: This study demonstrates that local injection of senolytic drug-loaded nanoparticles can selectively kill stress-induced senescent cells in infarcted heart, reducing inflammatory cytokines and promoting normal cell survival. Further efferocytosis of apoptotic senescent cells by macrophages leads to restoration of cardiac function after myocardial ischemia-reperfusion injury. Importantly, local injection of senolytic drug does not cause systemic toxicity, unlike systemic administration, highlighting the therapeutic potential of senolysis in infarcted myocardium.
ACTA BIOMATERIALIA
(2021)
Article
Cardiac & Cardiovascular Systems
Nada Joe Melhem, Mouna Chajadine, Ingrid Gomez, Kiave-Yune Howangyin, Marion Bouvet, Camille Knosp, Yanyi Sun, Marie Rouanet, Ludivine Laurans, Olivier Cazorla, Mathilde Lemitre, Jose Vilar, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Jean-Sebastien Hulot, Jacques Callebert, Jean-Marie Launay, Jeremy Fauconnier, Jean-Sebastien Silvestre, Soraya Taleb
Summary: The study suggests that IDO could be a potential therapeutic target in acute myocardial infarction, as its deficiency limits cardiac injury and dysfunction after MI, with endothelial cell-specific deletion of IDO showing improvement in cardiac function and reduction in adverse ventricular remodeling.
Article
Chemistry, Multidisciplinary
Cagla Eren Cimenci, Nick J. R. Blackburn, Veronika Sedlakova, Justina Pupkaite, Marcelo Munoz, Benjamin H. Rotstein, David A. Spiegel, Emilio I. Alarcon, Erik J. Suuronen
Summary: The study demonstrates that fisetin-collagen hydrogel therapy can reduce the negative effects of MG post-MI by increasing glyoxalase-1 levels, decreasing MG-AGE accumulation, and reducing oxidative stress, leading to improved cardiac function. Additionally, the therapy promotes neovascularization, increases pro-healing macrophages, and decreases pro-inflammatory macrophages in the infarct area.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xuehui Zheng, Lingxin Liu, Jing Liu, Chen Zhang, Jie Zhang, Yan Qi, Lin Xie, Chunmei Zhang, Guoqing Yao, Peili Bu
Summary: The study shows that adverse remodeling after myocardial infarction (MI) is associated with heart failure and sudden cardiac death. Fibulin7 (FBLN7) is a critical profibrotic regulator of post-MI cardiac remodeling. FBLN7 binds to the epidermal growth factor receptor (EGFR) and induces autophosphorylation of EGFR, leading to fibroblast-to-myofibroblast transdifferentiation and myocardial fibrosis.
Article
Cell Biology
Lijia Zhang, Lifang Lv, Nan Zheng, Ruotong Li, Rui Yang, Tianyu Li, Yingnan Li, Yingqi Liu, Hongwei Luo, Xuelian Li, Yuhong Zhou, Hongli Shan, Bing Bai, Haihai Liang
Summary: Sox4 plays a role in promoting cardiomyocyte apoptosis during myocardial infarction by regulating Bim expression, and silencing Sox4 can attenuate cardiomyocyte apoptosis, suggesting it as a potential therapeutic target for MI.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jianqiu Pei, Lin Cai, Fang Wang, Chuansheng Xu, Shengqiang Pei, Hongwei Guo, Xiaogang Sun, Jerold Chun, Xiangfeng Cong, Weiquan Zhu, Zhe Zheng, Xi Chen
Summary: This study found that the level of lysophosphatidic acid (LPA) was increased in the peripheral blood of mice after myocardial infarction (MI), and the expression of its receptor LPA(2) was also increased in the heart. Deficiency of Lpar2 led to impaired heart function, increased scar size, and reduced vascular density. Mechanistic studies demonstrated that LPA-LPA(2) signaling promoted angiogenesis and maintained vascular homeostasis through multiple signaling pathways.
CIRCULATION RESEARCH
(2022)
Article
Immunology
Ri-Feng Gao, Xiao Li, Hai-Yan Xiang, Heng Yang, Chun-Yu Lv, Xiao-Lei Sun, Hong-Zhang Chen, Yang Gao, Jue-Sheng Yang, Wei Luo, Yi-Qing Yang, Yan-Hua Tang
Summary: Oridonin, a covalent NLRP3 inhibitor, reduces myocardial fibrosis and preserves cardiac function in a mouse MI model, indicating its potential therapeutic effect on acute MI patients. Additionally, Oridonin decreased the expression levels of inflammatory factors and reduced myocardial macrophage and neutrophil influxes in treated mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Yuejun Yao, Aoqi Li, Shuqin Wang, Yuwen Lu, Jieqi Xie, Haolan Zhang, Deteng Zhang, Jie Ding, Zhaoyi Wang, Chenxi Tu, Liyin Shen, Lenan Zhuang, Yang Zhu, Changyou Gao
Summary: Myocardial infarction (MI) is a major cause of death and disability globally. A multifunctional cardiac patch has been developed to provide mechanical support to the infarcted myocardium and improve therapeutic outcomes by mediating biological and mechanical treatments.
Article
Geriatrics & Gerontology
Xiao Chun Yang, Dong Hui Zhao, Wayne Bond Lau, Ke Qiang Liu, Jia Yu Tian, Zi Chao Cheng, Xin Liang Ma, Jing Hua Liu, Qian Fan
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2018)
Article
Multidisciplinary Sciences
Linjie Zhao, Shuang Huang, Shenglin Mei, Zhengnan Yang, Lian Xu, Nianxin Zhou, Qilian Yang, Qiuhong Shen, Wei Wang, Xiaobing Le, Wayne Bond Lau, Bonnie Lau, Xin Wang, Tao Yi, Xia Zhao, Yuquan Wei, Margaret Warner, Jan-Ake Gustafsson, Shengtao Zhou
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Medicine, Research & Experimental
Zheyi Yan, Rui Guo, Lu Gan, Wayne Bond Lau, Xiaoming Cao, Jianli Zhao, Xinliang Ma, Theodore A. Christopher, Bernard L. Lopez, Yajing Wang
Review
Biochemistry & Molecular Biology
Qilian Yang, Yuqing Yang, Nianxin Zhou, Kexin Tang, Wayne Bond Lau, Bonnie Lau, Wei Wang, Lian Xu, Zhengnan Yang, Shuang Huang, Xin Wang, Tao Yi, Xia Zhao, Yuquan Wei, Hongjing Wang, Linjie Zhao, Shengtao Zhou
Article
Cardiac & Cardiovascular Systems
Yunhui Du, Xiao Li, Haicun Yu, Li Yan, Wayne Bond Lau, Shihan Zhang, Yanwen Qin, Wen Wang, Xinliang Ma, Huirong Liu, Michael Fu
CARDIOVASCULAR DRUGS AND THERAPY
(2019)
Article
Cell Biology
Zhengbin Zhang, Liwen Zhu, Pan Feng, Yanzhen Tan, Bing Zhang, Erhe Gao, Xiaowu Wang, Chongxi Fan, Xiaoming Wang, Wei Yi, Yang Sun
CELL DEATH & DISEASE
(2019)
Article
Cell Biology
Bing Zhang, Ping Zhang, Yanzhen Tan, Pan Feng, Zhengbin Zhang, Hongliang Liang, Weixun Duan, Zhenxiao Jin, Xiaowu Wang, Jincheng Liu, Erhe Gao, Shiqiang Yu, Dinghua Yi, Yang Sun, Wei Yi
CELL DEATH & DISEASE
(2019)
Article
Medicine, Research & Experimental
Zhengbin Zhang, Yanzhen Tan, Liwen Zhu, Bing Zhang, Pan Feng, Erhe Gao, Chennian Xu, Xiaoming Wang, Wei Yi, Yang Sun
Article
Cell Biology
Bing Zhang, Yanzhen Tan, Zhengbin Zhang, Pan Feng, Wenyuan Ding, Qian Wang, Hongliang Liang, Weixun Duan, Xiaowu Wang, Shiqiang Yu, Jincheng Liu, Dinghua Yi, Yang Sun, Wei Yi
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Cell Biology
Jinyang Zhao, Xiaolong Lin, Haoxuan Sun, Donghui Zhao, Qin Ma, Wayne Bond Lau, Zichao Cheng, Fanqi Li, Jinghua Liu, Qian Fan
Summary: This study found that long non-coding RNAs play key roles as regulatory molecules in aging-related apoptosis effects. Additionally, besides promoting apoptosis, aging also inhibits myocardial apoptosis after hypoxia/reoxygenation.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cardiac & Cardiovascular Systems
Gan Lu, Demin Liu, Dina Xie, Wayne Bond Lau, Jing Liu, Theodore A. Christopher, Bernard Lopez, Lian Liu, Hang Hu, Peng Yao, Yarong He, Erhe Gao, Walter J. Koch, Jianli Zhao, Xin-Liang Ma, Yu Cao, Yajing Wang
Summary: Acute myocardial infarction causes endoplasmic reticulum stress and endocrine dysfunction in adipocytes, possibly mediated by the release of small extracellular vesicles enriched with the miR-23-27-24 cluster, to communicate with cardiomyocytes.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Zhijun Meng, Zhen Zhang, Jianli Zhao, Caihong Liu, Peng Yao, Ling Zhang, Dina Xie, Wayne Bond Lau, Jumpei Tsukuda, Theodore A. Christopher, Bernard Lopez, Di Zhu, Demin Liu, John Ry Zhang, Erhe Gao, Harry Ischiropoulos, Walter Koch, Xinliang Ma, Yajing Wang
Summary: Insulin resistance in the heart is a characteristic of diabetic cardiac injury. The molecular mechanisms underlying this resistance are not yet understood. Recent studies have shown that the diabetic heart is also resistant to other cardioprotective interventions. The role of Cav3 in diabetic impairment of cardiac protective signaling and diabetic ischemic heart failure needs further investigation.
Meeting Abstract
Cardiac & Cardiovascular Systems
Yajing Wang, Lu Gan, Dina Xie, Wayne Bond Lau, Sisi Wu, Dajun Zhao, Erhe Gao, Walter J. Koch, Xinliang Ma
Meeting Abstract
Cardiac & Cardiovascular Systems
Wenjun Yan, Lu Gan, Yunlong Xia, Yongzhen Guo, Wayne B. Lau, Erhe Gao, Theodore Christopher, Bernard Lopez, Walter Koch, Yajing Wang, Xinliang Ma, Ling Tao
Article
Biotechnology & Applied Microbiology
Linjie Zhao, Wei Wang, Shuang Huang, Zhengnan Yang, Lian Xu, Qilian Yang, Xiu Zhou, Jinjin Wang, Qiuhong Shen, Chenlu Wang, Xiaobing Le, Min Feng, Nianxin Zhou, Wayne Bond Lau, Bonnie Lau, Shaohua Yao, Tao Yi, Xin Wang, Xia Zhao, Yuquan Wei, Shengtao Zhou