Article
Cardiac & Cardiovascular Systems
Ran Wei, Cuilin Zhu, Hulin Piao, Kexiang Liu
Summary: Unicentric Castleman disease (UCD) is a rare, benign lymphoproliferative disorder characterized by highly vascularized tumors with unclear boundaries. Resection surgery presents challenges due to potential bleeding. Mixed-type UCD is rare. Here, we present a case of a 38-year-old asymptomatic patient with mixed-type UCD; the tumor measured 7.8 cm and had unclear boundaries. The tumor was successfully resected using off-pump coronary artery bypass grafting, and the patient had an uneventful recovery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mahmoud Diab, Thomas Lehmann, Wolfgang Bothe, Payam Akhyari, Stephanie Platzer, Daniel Wendt, Antje-Christin Deppe, Justus Strauch, Stefan Hagel, Albrecht Guenther, Gloria Faerber, Christoph Sponholz, Marcus Franz, Andre Scherag, Ilia Velichkov, Miriam Silaschi, Jens Fassl, Britt Hofmann, Sven Lehmann, Rene Schramm, Georg Fritz, Gabor Szabo, Thorsten Wahlers, Klaus Matschke, Artur Lichtenberg, Mathias W. Pletz, Jan F. Gummert, Friedhelm Beyersdorf, Christian Hagl, Michael A. Borger, Michael Bauer, Frank M. Brunkhorst, Torsten Doenst
Summary: This study investigated the effect of hemoadsorption during cardiac surgery for infective endocarditis (IE) on postoperative organ dysfunction and found that hemoadsorption did not reduce the occurrence of organ dysfunction. Although hemoadsorption reduced cytokine levels during surgery, it did not have an impact on clinically relevant outcome measures.
Article
Medicine, General & Internal
Panagiotis Doukas, Gabriel Hellfritsch, Daniel Wendt, Mirko Magliani, Mohammad E. Barbati, Houman Jalaie, Michael J. Jacobs, Alexander Gombert
Summary: This pilot study investigated the efficacy of cytokine adsorption in controlling early inflammation cascade in patients undergoing open thoracoabdominal aortic repair. The results suggest that intraoperative hemoadsorption may be feasible and safe, but larger trials are needed to evaluate its clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marta Macarena Rodriguez-Lima, Antonio Gonzalez-Calle, Alejandro Adsuar-Gomez, Maria Jose Sanchez-Martin, Alvaro Sepulveda Iturzaeta, Elia Sanchez-Valderrabanos, Juan Antonio Garcia-Hernandez, Maria Angeles Murillo-Pozo, Antonio Ordonez-Fernandez, Amir-Reza Hosseinpour
Summary: Mechanical ventilation during cardiopulmonary bypass in neonates improves postoperative outcome.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Yan Zhang, Bo Wang, Xiu-Juan Zhou, Li-Juan Guo, Rong-Hua Zhou
Summary: The study found that the lowest suitable DO(2)i threshold during pediatric CPB in infants undergoing cardiac surgery was 353 mL/min/m², below which there was a high probability of inducing CS-AKI and increasing postoperative morbidity.
ANNALS OF THORACIC SURGERY
(2022)
Article
Critical Care Medicine
Lee S. Nguyen, Philippe Estagnasie, Messaouda Merzoug, Alain Brusset, Jean-Dominique Law Koune, Stephane Aubert, Thierry Waldmann, Cecile Naudin, Jean-Michel Grinda, Hadrien Gibert, Pierre Squara
Summary: The study showed that continuing low tidal volume ventilation during cardiopulmonary bypass was not superior to no ventilation in reducing postoperative complications, including mortality, in cardiac surgery patients.
Review
Health Care Sciences & Services
Luan Oliveira Ferreira, Victoria Winkler Vasconcelos, Janielle de Sousa Lima, Jaime Rodrigues Vieira Neto, Giovana Escribano da Costa, Jordana de Castro Esteves, Sallatiel Cabral de Sousa, Jonathan Almeida Moura, Felipe Ruda Silva Santos, Joao Monteiro Leitao Filho, Matheus Ramos Protasio, Pollyana Sousa Araujo, Claudio Jose da Silva Lemos, Karina Dias Resende, Dielly Catrina Favacho Lopes
Summary: Patients undergoing coronary revascularization with extracorporeal circulation or cardiopulmonary bypass may develop systemic inflammatory response due to biochemical changes in the microcirculation. Inflammatory signaling pathways can be activated by surgical incision, reperfusion injury, and blood contact with non-endothelial membranes, leading to the production and activation of inflammatory cells, cytokine production, and oxidative stress. Addressing new perspectives for intraoperative treatment and management may reduce this inflammatory storm, improve prognosis, and potentially lower mortality rates in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Filiberto Serraino, Federica Jiritano, Davide Costa, Nicola Ielapi, Domenica Battaglia, Umberto Marcello Bracale, Pasquale Mastroroberto, Michele Andreucci, Raffaele Serra
Summary: This systematic review aims to explore the role of matrix metalloproteinases (MMPs) in routine cardiac operations, especially cardiopulmonary bypass (CPB). The results show that MMP levels are significantly correlated with CPB and the gelatinases MMP-2 and MMP-9 are highly released during cardiac surgery with CPB. Increased MMP levels are associated with adverse post-operative outcomes. Future large-scale prospective multicenter randomized clinical trials are needed to investigate the impact of mechanical and pharmacological strategies on the inflammatory response and postoperative outcomes in cardiac surgery and CPB.
Article
Multidisciplinary Sciences
Fatime Hawchar, Dana Tomescu, Karl Traeger, Dominik Joskowiak, Klaus Kogelmann., Jens Soukup., Singrun. Friesecke, David Jacob, Jan Gummert, Andreas Faltlhauser, Filippo Aucella, Martijn van Tellingen, Manu L. N. G. Malbrain, Ralph Bogdanski, Guenter Weiss, Andreas Herbrich, Stefan Utzolino, Axel Nierhaus, Andreas Baumann, Andreas Hartjes, Dietrich Henzler, Evgeny Grigoryev, Harald Fritz, Friedhelm Bach, Stefan Schroeder, Andreas Weyland, Udo Gottschaldt, Matthias Menzel, Olivier Zachariae, Radovan Novak, Jernej Berden, Hendrik Haake, Michael Quintel, Stephan Kloesel, Andreas Kortgen, Stephanie Stecher, Patricia Torti, Frieder Nestler, Markus Nitsch, Detlef Olboeter, Philip Muck, Michael Findeisen, Diane Bitzinger, Jens Krassler, Martin Benad, Martin Schott, Ulrike Schumacher, Zsolt Molnar, Frank Martin Brunkhorst
Summary: The aim of this study was to summarize the results of the International CytoSorb Registry. The study found that while there was no significant difference in the primary outcome of mortality, there were improvements in cardiovascular and pulmonary SOFA scores and a reduction in procalcitonin, C-reactive protein, and IL-6 levels in patients treated with blood adsorption.
Article
Cardiac & Cardiovascular Systems
Xinglong Xiong, Dongxu Chen, Shuang Cai, Li Qiu, Jing Shi
Summary: This study found that intraoperative hyperglycemia is associated with an increased risk of postoperative infections in patients undergoing cardiac surgery. The optimal blood glucose level during surgery should be maintained below 150 mg/dL to reduce infection risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Veterinary Sciences
Tomohiko Yoshida, Katsuhiro Matsuura, Ahmed S. Mandour, Yuki Aboshi, Shusaku Yamada, Hideki Yotsuida, Mizuki Hasegawa, Chieh-Jen Cheng, Youta Yaginuma, Momoko Watanabe, Shou Fukuzumi
Summary: This study retrospectively described the hemodynamic effects of protamine administration in dogs undergoing cardiac surgery. Two dogs experienced severe hypotension, while others did not show significant hemodynamic changes. Epinephrine treatment and reboot of extracorporeal circulation were effective interventions for managing the catastrophic hypotension.
VETERINARY SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Sachin D. Tadphale, Karthik Ramakrishnan, Thomas Spentzas, T. K. Susheel Kumar, Jerry Allen, Steven J. Staffa, David Zurakowski, William A. Bigelow, Srirupa Hari Gopal, Umar S. Boston, Richard A. Jonas, Christopher J. Knott-Craig
Summary: This study aimed to compare the incidence and severity of acute kidney injury after open heart surgery in neonates and infants for two different cardiopulmonary bypass strategies. The results showed that higher flow rates and higher hematocrit during cardiopulmonary bypass were associated with better preservation of renal function.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Samuel Heuts, Ellen J. S. Denessen, Jean H. T. Daemen, Wim H. M. Vroemen, Jan-Willem Sels, Patrique Segers, Otto Bekers, Arnoud W. J. van 't Hof, Jos G. Maessen, Iwan C. C. van der Horst, Alma M. A. Mingels
Summary: This meta-analysis investigated the release of high-sensitivity cardiac troponin T (hs-cTnT) after coronary artery bypass grafting (CABG). The results showed that postoperative hs-cTnT concentrations exceeded most currently defined cut-off values for myocardial infarction type 5, even in cases of perceived uncomplicated surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Immunology
Tuo Pan, Tayierjiang Tuoerxun, Xi Chen, Cheng-Jin Yang, Chen-Yu Jiang, Yi-Fan Zhu, Ze-Shi Li, Xin-Yi Jiang, Hai-Tao Zhang, He Zhang, Ya-Peng Wang, Wei Chen, Li-Chong Lu, Min Ge, Yong-Qing Cheng, Dong-Jin Wang, Qing Zhou
Summary: This study aimed to evaluate the effect of sivelestat on pulmonary protection in patients with acute lung injury (ALI) after emergent cardiovascular surgery. The results showed that sivelestat could significantly decrease the incidence of pneumonia, shorten mechanical ventilation time, and improve pulmonary function. Therefore, sivelestat may be considered to improve postoperative outcomes in ALI patients after emergent cardiovascular surgery.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Ghazal Aghagoli, Andrew Del Re, Naohiro Yano, Zhiqi Zhang, Ahmad Aboul Gheit, Ronald K. Phillips, Frank W. Sellke, Alexey Fedulov
Summary: During surgery, DNA methylation in skeletal muscle differs significantly between patients with hypertension and diabetes, with uncontrolled diabetes having a greater impact. The affected pathways involve various signaling pathways, apoptosis, and DNA damage response.
Article
Cardiac & Cardiovascular Systems
Maximilian Kreibich, Matthias Siepe, Tim Berger, Friedhelm Beyersdorf, Martin Soschynski, Christopher L. Schlett, Martin Czerny, Bartosz Rylski
Summary: This study aimed to evaluate the long-term incidence and outcome of aortic interventions for medically managed uncomplicated thoracic aortic dissections. Among the patients discharged home with uncomplicated aortic dissections, 33% of them required aortic interventions. A descending thoracic aortic diameter exceeding 45 mm was a predictive factor for aortic intervention. The risk for aortic intervention after 1 and 3 years was 27% and 36%, respectively.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Mina Farag, Christopher Buesch, Bartosz Rylski, Jochen Poeling, Daniel S. Dohle, Konstantinos Sarvanakis, Christian Hagl, Tobias Krueger, Christian Detter, Tomas Holubec, Michael A. Borger, Andreas Boening, Matthias Karck, Rawa Arif
Summary: Through a comparison study of patients with Marfan syndrome and patients without Marfan syndrome, it was found that Marfan syndrome does not have an adverse effect on 30-day outcomes after surgical repair for acute aortic Stanford type A dissection.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Michaela Kluckner, Florian Enzmann, Leonhard Gruber, Sabine Helena Wipper, Nikolaos Bonaros, Thomas Schachner
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2024)
Review
Cardiac & Cardiovascular Systems
Bartosz Rylski, Oliver Schilling, Martin Czerny
Summary: Remarkable progress has been made in aortic medicine in recent decades, leading to significant changes in the understanding and treatment of thoracic aortic dissection. This state-of-the-art review article explores the mechanisms of acute aortic dissection, the impact of its entry location and dissection extension on clinical presentation and treatment decisions, and presents the latest evidence on novel treatment methods and discussions on dissection classification. Future aspects of treating acute aortic dissection are also discussed.
EUROPEAN HEART JOURNAL
(2023)
Article
Surgery
Bartosz Rylski, Zeynep Berkarda, Friedhelm Beyersdorf, Stoyan Kondov, Martin Czerny, Jaroslaw Majcherek, Marcin Protasiewicz, Artur Milnerowicz
Summary: The success rate of closure with the suture-mediated vascular closure device Perclose ProGlide was evaluated in patients undergoing aortic or iliac artery endovascular repair using large delivery systems (>21F). The closure success rate exceeded 90% in patients using large bore sheaths. Severe femoral artery calcification is the only risk factor for conversion to open surgery.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Public, Environmental & Occupational Health
Hannah Salchner, Markus Isser, Lukas Banyai, Thomas Schachner, Franz J. Wiedermann, Wolfgang Lederer
Summary: Controlling severe extremity hemorrhage with tourniquet is life-saving. In remote areas or mass casualty incidents, improvised tourniquets may be necessary due to the lack of conventional ones.
WILDERNESS & ENVIRONMENTAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Cecilia Veraar, Arabella Fischer, Martin H. Bernardi, Isabella Worf, Mohamed Mouhieddine, Thomas Schloeglhofer, Dominik Wiedemann, Martin Dworschak, Edda Tschernko, Andrea Lassnigg, Michael Hiesmayr
Summary: Reduced oxygen consumption (VO2) has a negative impact on the survival of patients after cardiac surgery, but its efficiency as a predictive marker in patients with left ventricular assist devices (LVADs) is still unclear. In this study, we found that VO2 predicted in-hospital, 1-year, and 6-year survival with a high accuracy. LVAD patients with a VO2 below 210 mL/min had a higher mortality rate. Reduced VO2 was also an independent predictor for in-hospital and long-term mortality. The findings suggest the importance of focusing on microcirculatory perfusion and mitochondrial functioning in perioperative and intensive care medicine.
Article
Multidisciplinary Sciences
Constantin Mork, Brigita Gahl, Friedrich Eckstein, Denis A. Berdajs
Summary: This study evaluated the correlation between patient characteristics, operative variables, and the risk of bloodstream infection, as well as the association of primary bloodstream infection with adverse outcomes. The clinical records of 6500 adult patients who underwent open heart surgery between February 2008 and October 2020 were analyzed to evaluate the microbiological pattern of primary bloodstream infection and its association with adverse events such as mortality and major cardiovascular events.
Article
Biochemistry & Molecular Biology
Amila Kahrovic, Thomas Poschner, Anna Schober, Philipp Angleitner, Leila Alajbegovic, Martin Andreas, Doris Hutschala, Ruud Brands, Guenther Laufer, Dominik Wiedemann
Summary: This study aimed to investigate the relationship between changes in alkaline phosphatase (AP) levels and adverse outcomes in patients with infective endocarditis after surgery. The study found that a greater decrease in AP levels after surgery was associated with increased rates of renal replacement therapy, extracorporeal membrane oxygenation use, and higher short- and long-term mortality rates. Therefore, monitoring AP levels is important for predicting postoperative outcomes in patients with infective endocarditis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Judith Everts-Graber, Harald Bonel, Daniel Lehmann, Brigitta Gahl, HansJoerg Haeuselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
Summary: This registry-based study compared the anti-fracture effectiveness of denosumab and bisphosphonates in patients with osteoporosis. Denosumab showed significantly greater risk reduction for vertebral and any fractures compared to alendronate or ibandronate, while no difference in fracture risk reduction was found between zoledronate and denosumab.
OSTEOPOROSIS INTERNATIONAL
(2023)
Correction
Endocrinology & Metabolism
Judith Everts-Graber, Harald Bonel, Daniel Lehmann, Brigitta Gahl, HansJoerg Hauselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Silvia Mariani, Samuel Heuts, Bas C. T. van Bussel, Michele Di Mauro, Dominik Wiedemann, Diyar Saeed, Matteo Pozzi, Antonio Loforte, Udo Boeken, Robertas Samalavicius, Karl Bounader, Xiaotong Hou, Jeroen J. H. Bunge, Hergen Buscher, Leonardo Salazar, Bart Meyns, Daniel Herr, Marco L. Sacha Matteucci, Sandro Sponga, Graeme MacLaren, Claudio Russo, Francesco Formica, Pranya Sakiyalak, Antonio Fiore, Daniele Camboni, Giuseppe Maria Raffa, Rodrigo Diaz, I-wen Wang, Jae-Seung Jung, Jan Belohlavek, Vin Pellegrino, Giacomo Bianchi, Matteo Pettinari, Alessandro Barbone, Jose P. Garcia, Kiran Shekar, Glenn J. R. Whitman, Roberto Lorusso
Summary: This study investigates the characteristics and outcomes of adult patients with postcardiotomy cardiogenic shock treated with extracorporeal membrane oxygenation (ECMO). The study finds a high in-hospital mortality rate of 60.5%, but reports that two-thirds of hospital survivors have a survival rate of up to 10 years. This suggests that although ECMO has a high mortality rate in the hospital setting, the long-term survival for discharged patients is relatively good.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Maximilian Luehr, Murat Yildiz, Wei-Guo Ma, Roland Heck, Andreas Polycarpou, Arminder Jassar, Maximilian Kreibich, Daniel-Sebastian Dohle, Gabriel Weiss, Christian Hagl, Filip Rega, Thomas Schachner, Andreas Martens, Alessandro Della Corte, Hiroaki Osada, Li-Zhong Sun, Konstantinos Tsagakis, Florian Schoenhoff
Summary: This clinical study aims to determine the prevalence and potential causes of acute aortic dissection type A (AADA) in surgically treated patients <= 30 years and evaluate their postoperative outcomes. The study found that the overall prevalence of AADA in patients = 30 years was 1.8%, with connective tissue disease (CTD) being a common factor. The postoperative mortality rate was 8.6%, and the 10-year survival rate was 80%.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Health Care Sciences & Services
Gregor Widhalm, Theodor Abart, Moritz Noeske, Lisa Kumer, Katharina Ebenberger, Clemens Atteneder, Angelika Berger, Guenther Laufer, Dominik Wiedemann, Daniel Zimpfer, Heinrich Schima, Michael Wagner, Thomas Schloeglhofer
Summary: This study evaluated the user experience of non-HeartMate 3 (LVAD) heart transplant patients and laypersons using LVAD peripherals in simulated everyday and emergency scenarios. The results showed that battery exchanges and power supply changes were more complex and some participants encountered hazardous situations. The study provides suggestions for improving the design of LVAD wearables.
JOURNAL OF MEDICAL SYSTEMS
(2023)
Article
Cardiac & Cardiovascular Systems
Charlotte Mutter, Julia Benk, Tim Berger, Stoyan Kondov, Salome Chikvatia, Frank Humburger, Martin Roesslein, Felix Ulbrich, Martin Czerny, Bartosz Rylski, Maximilian Kreibich
Summary: This study analysed the risks and benefits of cerebrospinal fluid drainage (CSFD) placement in patients undergoing thoracic endovascular aortic repair. The results showed that preoperative CSFD can potentially help prevent permanent spinal cord ischaemia (SCI), but the decision to perform preoperative CSFD should be based on a comprehensive assessment of other patient factors.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)