Article
Cardiac & Cardiovascular Systems
Yupeng Liu, Wenyao Wang, Jingjing Song, Kuo Zhang, Kaihao Wang, Chunli Shao, Ping Li, Bo Xu, Min Yang, Jing Chen, Jilin Zheng, Yi-Da Tang
Summary: This study followed 10,724 patients undergoing PCI for a median of 2.4 years and found that PMI was consistently associated with increased MACE risk regardless of definition, while the SMI group had higher risks of death and MACE.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Seung-Hyun Kim, Michael Behnes, Kambis Mashayekhi, Alexander Bufe, Markus Meyer-Gessner, Ibrahim El-Battrawy, Ibrahim Akin
Summary: Studies have shown a clear association between coronary chronic total occlusion (CTO) and adverse clinical outcomes, especially in patients with acute myocardial infarction (AMI). However, the prognostic impact of CTO-percutaneous coronary intervention (PCI) during AMI remains controversial due to the higher risk of complications compared to non-occlusive coronary lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hao-Yu Wang, Bo Xu, Kefei Dou, Changdong Guan, Lei Song, Yunfei Huang, Rui Zhang, Lihua Xie, Min Zhang, Hongbing Yan, Weixian Yang, Yongjian Wu, Yuejin Yang, Shubin Qiao, Runlin Gao, Gregg W. Stone
Summary: This study found that in patients undergoing LM PCI, high levels of peak postprocedural CK-MB were independently associated with 3-year CV mortality, while elevated post-PCI cTnI did not predict mortality. The SCAI definition of PMI was significantly associated with mortality after LM PCI, while ARC-2 and UDMI definitions were not.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Medicine, General & Internal
Yao Wang, Qingbo Lv, Ya Li, Songzan Chen, Liding Zhao, Guosheng Fu, Wenbin Zhang
Summary: The Gensini score is a useful tool for evaluating the severity and complexity of coronary artery diseases. This research found a correlation between the Gensini score and periprocedural myocardial infarction (PMI), with higher scores associated with a higher incidence of PMI. The study also determined the optimal cut-off values of the Gensini score for predicting PMI.
Article
Cardiac & Cardiovascular Systems
Bahadir Simsek, Spyridon Kostantinis, Judit Karacsonyi, Khaldoon Alaswad, Oleg Krestyaninov, Dmitrii Khelimskii, Rhian Davies, Jeremy Rier, Omer Goktekin, Sevket Gorgulu, Ahmed ElGuindy, Raj H. Chandwaney, Mitul Patel, Nidal Abi Rafeh, Dimitrios Karmpaliotis, Amirali Masoumi, Jaikirshan J. Khatri, Farouc A. Jaffer, Darshan Doshi, Paul B. Poommipanit, Bavana Rangan, Yader Sandoval, James W. Choi, Basem Elbarouni, William Nicholson, Wissam A. Jaber, Stephane Rinfret, Michael Koutouzis, Ioannis Tsiafoutis, Robert W. Yeh, M. Nicholas Burke, Salman Allana, Olga C. Mastrodemos, Emmanouil S. Brilakis
Summary: This study aimed to develop risk scores for in-hospital major adverse cardiovascular events (MACE), mortality, pericardiocentesis, and acute myocardial infarction (MI) in patients undergoing CTO PCI. The risk scores were validated and showed good predictive ability.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Taku Inohara, Cameron McAlister, Rohit Samuel, Andrew Starovoytov, Tejana Grewal, Johandra Argote Parolis, G. B. John Mancini, Eve Aymong, Jacqueline Saw
Summary: Despite higher in-hospital events with revascularization in patients with SCAD, and higher revascularization with SCAD-STEMI, 1-year MACE was not different compared with UA-NSTEMI. This is reassuring, as revascularization may be required for ongoing ischemia at the time of initial presentation in STEMI-SCAD, and emphasizes the need for careful patient selection for revascularization in UA-NSTEMI.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Josephine Harrington, Stefan Anker, Javed Butler
Summary: This editorial summarizes the article 'Empagliflozin in acute myocardial infarction: the EMMY trial' by D. von Lewinski et al., which discusses the use of Empagliflozin in the treatment of myocardial infarction in diabetic patients.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Heerajnarain Bulluck, Valeria Paradies, Emanuele Barbato, Andreas Baumbach, Hans Erik Botker, Davide Capodanno, Raffaele De Caterina, Claudio Cavallini, Sean M. Davidson, Dmitriy N. Feldman, Peter Ferdinandy, Sebastiano Gili, Mariann Gyongyosi, Vijay Kunadian, Sze-Yuan Ooi, Rosalinda Madonna, Michael Marber, Roxana Mehran, Gjin Ndrepepa, Cinzia Perrino, Stefanie Schupke, Johanne Silvain, Joost P. G. Sluijter, Giuseppe Tarantini, Gabor G. Toth, Linda W. Van Laake, Clemens von Birgelen, Michel Zeitouni, Allan S. Jaffe, Kristian Thygesen, Derek J. Hausenloy
Summary: The article recommends measuring baseline and post-PCI cTn values in all CCS patients undergoing PCI and confirms the prognostic relevance of post-PCI cTn elevation >5x 99th percentile URL for defining type 4a MI. In the absence of related complications, the same cTn cut-off threshold can be used to define major periprocedural myocardial injury, which are strong predictors of all-cause mortality post-PCI and can be used as quality metrics in clinical trials. Further research is needed to evaluate treatment strategies for reducing the risk of major periprocedural myocardial injury, type 4a MI, and MACE in CCS patients undergoing PCI.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Yasushi Ueki, Tatsuhiko Otsuka, Sarah Bar, Kostantinos C. Koskinas, Dik Heg, Jonas Haener, George C. M. Siontis, Fabien Praz, Lukas Hunziker, Jonas Lanz, Stefan Stortecky, Thomas Pilgrim, Sylvain Losdat, Stephan Windecker, Lorenz Raeber
Summary: This study evaluated the frequency and impact of periprocedural myocardial infarction (MI) using different MI definitions in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI). The results showed that periprocedural MI defined by the ARC-2 and SCAI criteria was less frequent compared to the third and fourth UDMI, and was more prognostic for cardiac death at 1 year.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Lynne W. Stevenson, Andrew P. DeFilippis
Summary: The evolution of the fight-or-flight response system is to help humans deal with acute physiological threats, which are now less common than chronic cardiovascular stress. The study shows that pharmacologic inhibition of RAAS improves chronic heart failure and the natriuretic peptide system provides a counterbalance to RAAS. Neprilysin, a key neutral endopeptidase, degrades a variety of peptides including natriuretic peptides and angiotensin II.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Yasushi Ueki, Koichiro Kuwahara
Summary: Percutaneous coronary intervention (PCI) combined with guideline-directed medical therapy can reduce the risks of spontaneous myocardial infarction (MI), urgent revascularization, and angina, but it also increases the risks of periprocedural myocardial injury and MI. The definitions of periprocedural MI vary, resulting in differences in frequency and clinical significance. Accurate diagnosis of clinically-relevant periprocedural MI is crucial for patient management. In clinical trials, only clinically relevant definitions should be used to avoid obscuring meaningful outcomes. This review aims to summarize the mechanisms, predictors, frequency, and prognostic impact of periprocedural MI in patients undergoing PCI and provide the current perspective on this issue.
JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeppe K. Petersen, Abdulrahman N. Shams-Eldin, Emil L. Fosbol, Rasmus Rorth, Rikke Sorensen, Reza Jabbari, Thomas Engstrom, Lene Holmvang, Frants Pedersen, Amna Alhakak, Johanna Kroll, Christian Torp-Pedersen, Lars Kober, Jawad H. Butt
Summary: Employment status prior to acute myocardial infarction is associated with long-term risk of mortality and recurrent MI. Patients who were not part of the workforce had a higher risk of death and new heart attacks following discharge compared to those who were part of the workforce.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Antonio Landi, Claudio Montalto, Gabriele Crimi, Stefano De Servi
Summary: The prognostic relevance of periprocedural myocardial infarction (PMI) in patients with chronic coronary syndrome undergoing percutaneous coronary intervention (PCI) is still debated, with uncertainties surrounding the type and thresholds of biomarkers elevation, ancillary criteria of ischemia, and prognostic implications. Accurate definition and assessment of PMI are crucial for clinical practice and trials.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Mario Gaudino, Antonino Di Franco, Cristiano Spadaccio, Mohamed Rahouma, N. Bryce Robinson, Michelle Demetres, Stephen Fremes, Torsten Doenst
Summary: This study investigates the association between spontaneous myocardial infarction (SMI) reduction and survival benefit in coronary artery bypass (CABG) compared with percutaneous interventions (PCI). The results show that CABG is associated with a lower incidence of SMI and higher survival rate compared to PCI.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Endocrinology & Metabolism
Volker H. Schmitt, Lukas Hobohm, Thomas Munzel, Philip Wenzel, Tommaso Gori, Karsten Keller
Summary: This study found that diabetic patients have a higher in-hospital mortality rate and a higher recurrent MI rate during acute myocardial infarction (MI) compared to non-diabetic patients. Diabetic patients also had lower rates of coronary artery angiography and interventional revascularization compared to non-diabetic patients.
DIABETES & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
S. P. Sharma, A. Hirsch, M. G. M. Hunink, M. J. M. Cramer, F. A. A. Mohamed Hoesein, C. A. Geluk, G. Kramer, J. W. C. Gratama, R. L. Braam, P. M. van der Zee, W. Yassi, S. L. Wolters, C. Guerlek, G. Pundziute, R. Vliegenthart, R. P. J. Budde
Summary: This study aims to evaluate the impact of adding FFRct analysis in the diagnostic pathway of patients with coronary stenosis on CCTA on the rate of unnecessary invasive coronary angiography, cost-effectiveness, quality of life and clinical outcome.
NETHERLANDS HEART JOURNAL
(2023)
Article
Physiology
Jarno J. Steenhorst, Alexander Hirsch, Linda E. M. van den Berg, Lieke S. Kamphuis, Daphne Merkus, Eric Boersma, Willem A. Helbing
Summary: By comparing the heart rate or workload determined during upright cycling exercise with the heart rate and workload during supine push-pull exercise at similar exercise intensities, submaximal exercise intensities can be translated to supine push-pull exercise in healthy subjects.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Article
Peripheral Vascular Disease
Victor J. M. Zeijen, Lida Feyz, Isabella Kardys, Marcel L. Geleijnse, Nicolas M. Van Mieghem, Felix Zijlstra, Melvin Lafeber, Rob J. van der Geest, Alexander Hirsch, Joost Daemen
Summary: This study investigates the association between noninvasive vascular stiffness indices and renal sympathetic denervation (RDN)-mediated blood pressure (BP) reduction. The results showed that higher baseline arterial stiffness indices were associated with a smaller reduction in systolic BP following RDN. This finding can be helpful in improving the identification of patients who will respond well to RDN therapy.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Thijmen W. Hokken, Joris F. Ooms, Isabella Kardys, Alexander Hirsch, Annick C. Weustink, Sanne Schipper, Peter Heil, Joost Daemen, Ricardo P. J. Budde, Nicolas M. Van Mieghem
Summary: The aim of this study was to validate the consistency between the semiautomated calcium quantification scoring tool in 3mensio Structural Heart and the conventional manual calcium quantification tool. The results showed a high correlation between the two.
STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM
(2023)
Article
Obstetrics & Gynecology
Meddy N. Bongers-Karmaoui, Clarissa J. Wiertsema, Annemarie G. M. G. J. Mulders, Wim A. Helbing, Alexander Hirsch, Arno A. W. Roest, Vincent W. V. Jaddoe, Romy Gaillard
Summary: This study aimed to examine the association between gestational hypertensive disorders and gestational blood pressure with subclinical changes in cardiac structure and function of offspring. The results showed that offspring exposed to pre-eclampsia had lower right ventricular ejection fraction. Higher maternal diastolic blood pressure in early and late pregnancy was associated with lower left and right ventricular end-diastolic volumes. There were no consistent associations with other cardiac outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Josephine Harrington, Anthony P. Carnicelli, Kaiyuan Hua, Lars Wallentin, Manesh R. Patel, Stefan H. Hohnloser, Robert P. Giugliano, Keith A. A. Fox, Ziad Hijazi, Renato D. Lopes, Sean D. Pokorney, Hwanhee Hong, Christopher B. Granger
Summary: Through meta-analysis of multiple research databases, it was found that standard-dose DOACs are safer and more effective than warfarin in patients with kidney dysfunction. While lower-dose DOACs do not significantly lower the incidence of bleeding or intracranial hemorrhage compared to standard-dose DOACs, they are associated with a higher incidence of stroke and systemic embolism as well as death. Therefore, these findings support the use of standard-dose DOACs over warfarin in patients with kidney dysfunction.
Review
Radiology, Nuclear Medicine & Medical Imaging
Judith van der Bie, Marcel van Straten, Ronald Booij, Daniel Bos, Marcel L. Dijkshoorn, Alexander Hirsch, Simran P. Sharma, Edwin H. G. Oei, Ricardo P. J. Budde
Summary: Photon-counting computed tomography (PCCT) is a new technology that offers higher spatial resolution, energy resolved imaging, and spectral post-processing compared to conventional CT techniques. This results in improved contrast-to-noise ratio, reduction in artifacts and potential dose, as well as elimination of electronic noise. The shift from pre-clinical studies to clinical research has been observed since the introduction of clinical PCCT in 2021. This review article focuses on the initial clinical results of PCCT, including the current PCCT systems, applications, and challenges.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rajesh K. Kharbanda, Alexander D. Perkins, James Kennedy, Adrian Banning, Andreas Baumbach, Daniel J. Blackman, Matthew Dodd, Richard Evans, David Hildick-Smith, Zahra Jamal, Peter Ludman, Stephen Palmer, Rodney Stables, Tim Clayton
Summary: The BHF PROTECT-TAVI trial aims to provide definitive evidence on the clinical efficacy and cost-effectiveness of using routine cerebral embolic protection (CEP) with the SENTINEL device to reduce stroke in patients undergoing transcatheter aortic valve implantation (TAVI). The trial has enrolled 3,068 patients out of the total target of 7,730, and the primary outcome is the incidence of stroke at 72 hours post-TAVI.
Editorial Material
Cardiac & Cardiovascular Systems
Florian A. Wenzl, Keith A. A. Fox, Thomas F. Luescher
EUROPEAN HEART JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
H. S. A. Tingen, A. Tubben, J. Bijzet, M. P. van den Berg, P. van der Meer, E. J. Houwerzijl, F. L. H. Muntinghe, P. A. van der Zwaag, A. W. J. M. Glaudemans, M. I. F. J. Oerlemans, C. Knackstedt, M. Michels, A. Hirsch, B. P. C. Hazenberg, R. H. J. A. Slart, H. L. A. Nienhuis
Summary: This study found that changes in cardiac tracer uptake on bone scintigraphy may serve as an early marker of treatment-specific response or disease progression in patients with hereditary transthyretin (ATTRv) amyloidosis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Juliette C. van Hattum, Joelle J. N. Daems, Sjoerd M. Verwijs, Leonoor Wismans, Maarten A. van Diepen, Maarten Groenink, S. Matthijs Boekholdt, R. Nils Planken, Adrienne van Randen, Alexander Hirsch, Maarten H. Moen, Yigal M. Pinto, Arthur A. M. Wilde, Harald T. Jorstad
Summary: This study suggests that resuming elite-level sports after SARS-CoV-2 infection is generally safe and does not lead to detrimental cardiac effects or increases in clinical events.
Article
Cardiac & Cardiovascular Systems
Stephan A. C. Schoonvelde, Claudine W. B. Ruijmbeek, Alexander Hirsch, Marjon A. van Slegtenhorst, Marja W. Wessels, Jan H. von der Thusen, Annette F. Baas, Sophie L. V. M. Stroeks, Job A. J. Verdonschot, Paul A. van der Zwaag, Judith M. A. Verhagen, Michelle Michels
Summary: This study evaluated the phenotype of FLNC variant carriers and determined that the FLNC variant c.6864_6867dup, p.(Val2290Argfs*23) is a founder variant originating from the south of the Netherlands. Carriers are susceptible to developing heart failure and ventricular arrhythmias. The cardiac phenotype is characterized by ringlike late gadolinium enhancement, even in individuals without significantly reduced left ventricular function.
Article
Cardiac & Cardiovascular Systems
Divaka Perera, Matthew Ryan, Holly P. Morgan, John P. Greenwood, Mark C. Petrie, Matthew Dodd, Roshan Weerackody, Peter D. O'Kane, Pier Giorgio Masci, Muhummad Sohaib Nazir, Alexandros Papachristidis, Navtej Chahal, Rajdeep Khattar, Saad M. Ezad, Stam Kapetanakis, Lana J. Dixon, Kalpa De Silva, Adam K. McDiarmid, Michael S. Marber, Theresa McDonagh, Gerry P. McCann, Tim C. Clayton, Roxy Senior, Amedeo Chiribiri
Summary: The study aimed to determine the effect of the extent of viable and nonviable myocardium on the effectiveness of PCI, prognosis, and improvement in left ventricular function in patients with ischemic left ventricular dysfunction.
Article
Medicine, General & Internal
Vikram Sharma, Huili Zheng, Luciano Candilio, Jennifer M. Nicholas, Tim Clayton, Derek M. Yellon, Heerajnarain Bulluck, Derek J. Hausenloy
Summary: Baseline and post-operative elevations in high-sensitivity troponin T are independently associated with 1-year all-cause mortality in cardiac surgery patients. An elevation in hs-TnT ≥50 x URL at 24 hours post-surgery is the optimal threshold to define prognostically significant peri-operative myocardial injury.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Judith van der Bie, Simran P. Sharma, Marcel van Straten, Daniel Bosa, Alexander Hirsch, Marcel L. Dijkshoorn, Rik Adrichem, Nicolas M. D. A. van Mieghem, Ricardo P. J. Budde
Summary: Photon-counting detector CT (PCD CT) has gained increasing attention in cardiothoracic imaging due to its high spatial resolution and spectral imaging capability. It has the potential to address the limitations of current CT technology and provide improved image quality and detailed anatomical information for patients before and after TAVR.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2023)
