Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yongqi Zhang, Jia Man, Jiali Wang, Jianing Liu, Xinzhong Song, Xiaohan Yu, Jianyong Li, Ruijian Li, Yinghua Qiu, Jianfeng Li, Yuguo Chen
Summary: This study developed heparinized surfaces on PVC substrates using plasma treatment technology and chemical grafting method. The heparinized surfaces not only reduced thrombosis but also decreased side effects of anticoagulants. Sodium alginate and carboxymethyl chitosan interlayers significantly increased the graft density of heparin, improving its anticoagulant effects and hemocompatibility. The CCS/low-molecular-weight heparin surface showed the best anticoagulant properties. The heparinized surfaces prepared in this study have great potential in anticoagulant treatment for medical devices.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Hematology
Catherine Anne Lovatt, A. Mark Crowther
Summary: Heparin-induced thrombocytopenia in pregnancy is rare, with varied therapeutic options and durations. This case report discusses a 41-year-old female with HIT during pregnancy and the subsequent clinical management strategies.
THROMBOSIS RESEARCH
(2021)
Article
Medicine, General & Internal
Katarzyna Kosinska-Kaczynska, Ewa Malicka, Iwona Szymusik, Norbert Dera, Michal Pruc, Stepan Feduniw, Zubaid Rafique, Lukasz Szarpak
Summary: COVID-19 infection in pregnant women is associated with an increased risk of adverse pregnancy outcomes, including preeclampsia. This meta-analysis found that pregnant women with COVID-19 have higher sFlt-1/PlGF ratios compared to those without COVID-19. Severe COVID-19 and SARS-CoV-2 infection in hypertensive pregnant women were also associated with significantly higher sFlt-1/PlGF ratios.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Yongqi Zhang, Jia Man, Jianing Liu, Jianyong Li, Xinzhong Song, Jiali Wang, Jianfeng Li, Yuguo Chen
Summary: In this study, a mussel-inspired composite coating consisting of polydopamine, lysine, and modified heparin was constructed to reduce thrombosis and enhance the anticoagulant capability of medical devices. The results showed that the composite coating significantly inhibited platelet adhesion and activation, prolonged activated partial thromboplastin time, and exhibited excellent hemocompatibility and anticoagulant properties. This research demonstrates great potential for anticoagulant treatment in medical devices.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Lei Liu, Rencheng Wang, Ran Xu, Yuening Chu, Weirong Gu
Summary: Preeclampsia is a severe complication of pregnancy, and soluble endoglin and sFlt-1 play important roles in its pathogenesis. Procyanidin B2 can reduce the secretion of soluble endoglin and sFlt-1, alleviating endothelial dysfunction and impaired angiogenesis.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Rheumatology
Rugina Neuman, Hieronymus T. W. Smeele, A. H. Jan Danser, Radboud J. E. M. Dolhain, Willy Visser
Summary: This study shows that the sFlt-1/PlGF ratio is not altered due to disease activity in pregnant women with RA, and a cut-off of <= 38 can be used to exclude preeclampsia. Additionally, the use of SSZ does not affect the levels of sFlt-1 or PlGF in this population.
Article
Medicine, General & Internal
Ewan C. Goligher, Charlotte A. Bradbury, Bryan J. McVerry, Patrick R. Lawler, Jeffrey S. Berger, Michelle N. Gong, Marc Carrier, Harmony R. Reynolds, Anand Kumar, Alexis F. Turgeon, Lucy Z. Kornblith, Susan R. Kahn, John C. Marshall, Keri S. Kim, Brett L. Houston, Lennie P. G. Derde, Mary Cushman, Tobias Tritschler, Derek C. Angus, Lucas C. Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E. Farkouh, Maria M. Brooks, Roger J. Lewis, Lindsay R. Berry, Elizabeth Lorenzi, Anthony C. Gordon, Scott M. Berry, Colin J. McArthur, Matthew D. Neal, Judith S. Hochman, Steven A. Webb, Ryan Zarychanski, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H. Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A. Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C. Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W. Costantini, Sophie de Brouwer, Michelle A. Detry, Abhijit Duggal, Vladimir Dzavik, Mark B. Effron, Heather F. Eng, Jorge Escobedo, Lise J. Estcourt, Brendan M. Everett, Dean A. Fergusson, Mark Fitzgerald, Robert A. Fowler, Joshua D. Froess, Zhuxuan Fu, Jean P. Galanaud, Benjamin T. Galen, Sheetal Gandotra, Timothy D. Girard, Andrew L. Goodman, Herman Goossens, Cameron Green, Yonatan Y. Greenstein, Peter L. Gross, Rashan Haniffa, Sheila M. Hegde, Carolyn M. Hendrickson, Alisa M. Higgins, Alexander A. Hindenburg, Aluko A. Hope, James M. Horowitz, Christopher M. Horvat, David T. Huang, Kristin Hudock, Beverley J. Hunt, Mansoor Husain, Robert C. Hyzy, Jeffrey R. Jacobson, Devachandran Jayakumar, Norma M. Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J. King, Aaron E. Kornblith, Matthew E. Kutcher, Michael A. Laffan, Francois Lamontagne, Gregoire Le Gal, Christine M. Leeper, Eric S. Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A. Lother, Nicole Marten, Andrea Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F. McAuley, Emily G. McDonald, Anna McGlothlin, Shay P. McGuinness, Saskia Middeldorp, Stephanie K. Montgomery, Paul R. Mouncey, Srinivas Murthy, Girish B. Nair, Rahul Nair, Alistair D. Nichol, Jose C. Nicolau, Brenda Nunez-Garcia, John J. Park, Pauline K. Park, Rachael L. Parke, Jane C. Parker, Sam Parnia, Jonathan D. Paul, Mauricio Pompilio, John G. Quigley, Robert S. Rosenson, Natalia S. Rost, Kathryn Rowan, Fernanda O. Santos, Marlene Santos, Mayler O. Santos, Lewis Satterwhite, Christina T. Saunders, Jake Schreiber, Roger E. G. Schutgens, Christopher W. Seymour, Deborah M. Siegal, Delcio G. Silva, Aneesh B. Singhal, Arthur S. Slutsky, Dayna Solvason, Anne M. Turner, Wilma Van Bentum-Puijk, Frank L. van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R. Jay Widmer, Jennifer G. Wilson, Eugene Yuriditsky, Yongqi Zhong
Summary: In critically ill patients with Covid-19, initial therapeutic-dose anticoagulation did not result in improved survival rates or fewer days requiring cardiovascular or respiratory organ support compared to usual-care pharmacologic thromboprophylaxis.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Jan Soltes, Michal Skribuckij, Hynek Riha, Michal Lips, Pavel Michalek, Martin Balik, Michal Porizka
Summary: The use of ECMO is rapidly increasing and has become the preferred mode of organ support for patients with refractory respiratory or circulatory failure. However, ECMO significantly alters the coagulation system of patients, and there is a lack of evidence in the field of anticoagulation management for ECMO therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Patrick R. Lawler, Ewan C. Golighe, Jeffrey S. Berge, Matthew D. Neal, Bryan J. McVerry, Jose C. Nicolau, Michelle N. Gong, Marc Carrier, Robert S. Rosenson, Harmony R. Reynolds, Alexis F. Turgeon, Jorge Escobedo, David T. Huang, Charlotte A. Bradbury, Brett L. Houston, Lucy Z. Kornblith, Anand Kumar, Susan R. n Kah, Mary Cushman, Zoe McQuilten, Arthur S. Slutsky, Keri S. Kim, Anthony C. Gordon, Bridget-Anne Kirwan, Maria M. Brooks, Alisa M. Higgins, Roger J. Lewis, Elizabeth Lorenzi, Scott M. Berry, Lindsay R. Berry, Derek C. Angus, Colin J. McArthur, Steven A. Webb, Michael E. Farkouh, Judith S. Hochman, Ryan Zarychanski, Aaron W. Aday, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H. Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A. Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C. Cheng, Tamta Chkhikvadzw, Benjamin Coiffard, Todd W. Costantini, Sophie de Brouwer, Lennie P. G. Derde, Michelle A. Detry, Abhijit Duggal, Vladimir Dzavik, Mark B. Effron, Lise J. Estcourt, Brendan M. Everett, Dean A. Fergusson, Mark Fitzgerald, Robert A. Fowler, Jean P. Galanaud, Benjamin T. Galen, Sheetal Gandotra, Sebastian Garcia-Madrona, Timothy D. Girard, Lucas C. Godoy, Andrew L. Goodman, Herman Goossens, Cameron Green, Yonatan Y. Greenstein, Peter L. Gross, Naomi M. Hamburg, Rashan Haniffa, George Hanna, Nicholas Hanna, Sheila M. Hegde, Carolyn M. Hendrickson, R. Duncan Hite, Alexander A. Hindenburg, Aluko A. Hope, James M. Horowitz, Christopher M. Horvat, Kristin Hudock, Beverley J. Hunt, Mansoor Husain, Robert C. Hyzy, Vivek N. Iyer, Jeffrey R. Jacobson, Devachandran Jayakumar, Norma M. Keller, Akram Khan, Yuri Kim, Andrei L. Kindzelski, Andrew J. Kin, M. Margaret Knudson, Aaron E. Kornblith, Vidya Krishnan, Matthew E. Kutcher, Michael A. Laffan, Francois Lamontagne, Gregoire Le Gal, Christine M. Leeper, Eric S. Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Jose L. Lopez-Sendon Moreno, Sylvain A. Lother, Saurabh Malhotra, Miguel Marcos, Andrea Saud Marinez, John C. Marshall, Nicole Marten, Michael A. Matthay, Daniel F. McAuley, Emily G. McDonald, Anna McGlothlin, Shay P. McGuinness, Saskia Middeldorp, Stephanie K. Montgomery, Steven C. Moore, Raquel Morillo Guerreor, Paul R. Mouncey, Srinivas Murthy, Girish B. Nair, Rahul Nair, Alistair D. Nichol, Brenda Nunez-Garcia, Ambarish Pandey, Pauline K. Park, Rachael L. Parke, Jane C. Parker, Sam Parnia, Jonathan D. Paul, Yessica S. Perez Gonzalez, Mauricio Pompilio, Matthew E. Prekker, John G. Quigley, Natalia S. Rost, Kathryn Rowan, Fernanda O. Santos, Marlene Santos, Mayler Olombrada Santos, Lewis Satterwhite, Christina T. Saunders, Roger E. G. Schutgens, Christopher W. Seymour, Deborah M. Siegal, Delcio G. Silva, Manu Shankar-Hari, John P. Sheehan, Aneesh B. Singhal, Dayna Solvaso, Simon J. Stanworth, Tobias Tritschler, Anne M. Turner, Wilma Van Bentum-Puijk, Frank L. van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, Bryan J. Wells, R. Jay Widmer, Jennifer G. Wilson, Eugene Yuriditsky, Fernando G. Zampieri
Summary: This study showed that therapeutic-dose anticoagulation with heparin in non-critically ill patients with Covid-19 increased the likelihood of survival to hospital discharge and reduced the need for cardiovascular or respiratory organ support compared to usual-care thromboprophylaxis.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Anish Keepanasseril, Ajith Ananthakrishna Pillai, Jyoti Baghel, Swaraj Nandini Pande, Nivedita Mondal, Hemachandren Munuswamy, Pankaj Kundra, Rohan D'Souza
Summary: In a study comparing different anticoagulation regimens in women with mechanical heart valves, it was found that there were no significant differences in cardiac complications and pregnancy outcomes between the two groups. However, caution should be taken to avoid warfarin doses exceeding 5 mg per day in early pregnancy and ensure therapeutic levels of heparin during the first and third trimesters and peripartum period.
Review
Medicine, Research & Experimental
Alexandros Velegrakis, Elisavet Kouvidi, Persefoni Fragkiadaki, Stavros Sifakis
Summary: Preeclampsia (PE) is a serious complication of pregnancy with a high incidence rate and causes significant maternal and fetal health risks. Studies have shown that differences in maternal serum levels of angiogenic factors can be used as biomarkers to predict the development of PE. Specifically, the sFlt-1/PlGF ratio has been identified as the optimal predictive tool. However, further research is needed to enhance its clinical applicability and provide universal guidelines for consistent management of PE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Szymon Kozlowski, Anna Stelmaszczyk-Emmel, Iwona Szymusik, Aleksandra Saletra-Bielinska, Robert Brawura-Biskupski-Samaha, Pawel Pietruski, Agnieszka Osinska, Katarzyna Kosinska-Kaczynska
Summary: In this study, it was found that the concentration of sFlt-1 is higher in dichorionic twin pregnancies compared to monochorionic pregnancies. PlGF and sEng levels did not significantly differ between mono- and dichorionic gestation. Additionally, the concentrations of PlGF, sFlt-1 and sEng increased significantly during gestation and were much higher in the third trimester compared to the first trimester.
Article
Biochemistry & Molecular Biology
Isabelle Hernandez, Audrey Chissey, Jean Guibourdenche, Roger Atasoy, Xavier Coumoul, Thierry Fournier, Jean-Louis Beaudeux, Amal Zerrad-Saadi
Summary: The study demonstrates the involvement of NADPH oxidase in the secretion of sFlt-1 and PlGF in first trimester chorionic villi, and indicates the participation of p38 MAPK pathway in sFlt-1 production and Nox activation. Additionally, the research highlights the major role of placental NADPH oxidase in mediating the signal transduction cascade of sFlt-1 production, as well as the involvement of p38 activation in first trimester placental Nox activity.
Article
Medicine, General & Internal
Leandro Nobrega, Leila Katz, Luis Lippo, Melania Maria Amorim
Summary: This study aimed to examine the association between sFlt-1 and hs-CRP with maternal and perinatal outcomes in patients with severe features of preeclampsia. Results showed that sFlt-1 and hs-CRP may serve as reasonable predictors of adverse maternal outcomes, but they do not correlate with each other and differ in perinatal morbidity patterns. These findings support the hypothesis that different pathogenic pathways may lead to varied outcomes in preeclampsia.
Article
Biochemistry & Molecular Biology
Rahagir Salekeen, Asif Ahmed, Md Emdadul Islam, Md Morsaline Billah, Hafizur Rahman, Kazi Mohammed Didarul Islam
Summary: This study explores the potential of therapeutic plant peptides for combating cellular senescence by targeting key proteins in the ageing network. Using computational methods, the researchers identified 25 phytopeptides with potential anti-ageing properties, and found that one specific peptide, Cycloleonuripeptide B, exhibited strong binding affinity with key proteins. This computational study lays the groundwork for future laboratory and clinical research into repurposing therapeutic phytopeptides for cellular senescence and related pathophysiology.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Rahagir Salekeen, Sadia Noor Mou, Md Emdadul Islam, Asif Ahmed, Md Morsaline Billah, S. M. Mahbubur Rahman, Kazi Mohammed Didarul Islam
Summary: This study is the first to use cheminformatic approaches to investigate the molecular linkage between the bioactive compounds of the mangrove plant Heritiera fomes and the arachidonic acid metabolic network. The findings suggest that H. fomes may serve as a functional reservoir of safe and potent natural anti-inflammatory compounds, and highlight two specific compounds as potential inhibitors of multiple catalytic checkpoints in the inflammatory network. This research provides a primary guideline for future testing of the anti-inflammatory potential of H. fomes as a source of drug-like molecules.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Pharmacology & Pharmacy
Allyah Abbas-Hanif, Homira Rezai, Syed Faraz Ahmed, Asif Ahmed
Summary: Emerging data suggest that pregnant women with COVID-19 face higher risks of severe outcomes compared to non-pregnant women of similar age. Clinical studies have shown that COVID-19 may predispose pregnant women to conditions like pre-eclampsia, with mRNA vaccines offering a novel approach to vaccination in this population.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Toxicology
Fahim Rejanur Tasin, Asif Ahmed, Debasish Halder, Chanchal Mandal
Summary: Epigenetic modifications by toxic heavy metals, such as lead, have been extensively studied in the field of genomic research. Lead exposure during pregnancy can cause abnormal fetal development through changes in DNA methylation, histone modifications, and microRNA expression. These modifications have been associated with a wide range of health issues, including impaired growth, obesity, autism, diabetes, cardiovascular diseases, cancer risks, and Alzheimer's disease.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mandeep Kaur Marwah, Hala Shokr, Lissette Sanchez-Aranguren, Raj Kumar Singh Badhan, Keqing Wang, Shakil Ahmad
Summary: The purpose of this study was to investigate the feasibility of transdermal delivery of ADT-OH and to explore the potential of aqueous gels loaded with penetration enhancers or liposomes. The findings suggest that ADT-OH may be a promising approach in the treatment of impaired vascular function.
PHARMACEUTICAL RESEARCH
(2022)
Article
Infectious Diseases
M. Marwah, H. Shokr, A. Demitry, K. Wang, S. Ahmad, S. Marwah, F. Wandroo
Summary: The impact of COVID-19 infection on pregnancy outcomes is investigated, focusing on the association between hematological parameters and virus-related pregnancy and neonatal outcomes. Pregnant COVID-19-positive patients exhibit higher white blood cell and neutrophil counts as well as altered ratios, compared to non-pregnant COVID-19-positive patients. A simple metric, the COVID-19-Induced Immunity Response (CIIR), is identified as a predictor of neonatal distress.
Article
Chemistry, Multidisciplinary
M. K. Marwah, S. Shehzad, H. Shokr, J. Sacharczuk, K. Wang, S. Ahmad, L. Sanchez-Aranguren
Summary: Hydrogen sulphide (H2S), a gaseous signalling molecule, has cardioprotective qualities. However, its therapeutic application is limited. Controlled-release nanoparticles (NPs) encapsulating sodium thiosulphate (STS) can address these issues. The NPs are internalised into cells and maintain the pro-angiogenic potential of H2S.
JOURNAL OF EXPERIMENTAL NANOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Manal A. Babaker, Fadwa A. Aljoud, Faris Alkhilaiwi, Abdulrahman Algarni, Asif Ahmed, Mohammad Imran Khan, Islam M. Saadeldin, Faisal A. Alzahrani
Summary: Colorectal cancer is a prevalent and deadly form of cancer. Current chemotherapy treatments are not selective, causing harm to healthy cells. Milk-derived extracellular vesicles offer potential as a natural alternative with the ability to suppress tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hala Shokr, Mandeep Kaur Marwah, Hisam Siddiqi, Farooq Wandroo, Lissette Sanchez-Aranguren, Shakil Ahmad, Keqing Wang, Sukhjinder Marwah
Summary: Investigated lactate dehydrogenase/Albumin to-urea (LAU) ratio as a potential predictor for COVID-19-induced fatal clinical complications in hospitalized patients. The results showed that LAU ratio was positively correlated with infection prognostic parameters and patients with a high LAU ratio are at increased risk of mortality due to COVID-19 infection. Early assessment of this parameter, intensive intervention and close monitoring could improve the prognosis of patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Gian Diaz-Rodriguez, Alexis Braverman, Gloria G. Elam, Doreen Norris-Stojak, Kathleen Harmon, Julie Hartwig, Tiana Dunlap, Heather Nixon, Phornphat Rasamimari, Irina A. Buhimschi, Catalin S. Buhimschi
Summary: Objective timely response to obstetrical emergencies is crucial, with a recommended decision-to-incision (DTI) time of not more than 30 minutes. A study was conducted to analyze the efficiency of an institutional-specific CD acuity classification system in reflecting actual DTI time, Apgar scores, and newborn acid-base status. The findings suggest that the need for neonatal resuscitation is associated with the acuity of the procedure rather than the actual DTI time.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Peripheral Vascular Disease
William E. Ackerman, Catalin S. Buhimschi, Thomas L. Brown, Guomao Zhao, Taryn L. Summerfield, Irina A. Buhimschi
Summary: By applying transcriptomics with weighted gene correlation network analysis, this study provides evidence for a molecular subphenotype consistent with a glycolytic metabolic shift in placental specimens of early-onset preeclampsia (EOPE) with or without fetal growth restriction (FGR). The identified gene group is enriched for hypoxia-response and metabolic pathways, and the expression ratios of specific genes could be used as surrogate indices for identifying this subgroup.
Editorial Material
Cardiac & Cardiovascular Systems
William E. Ackerman, Irina A. Buhimschi, Catalin S. Buhimschi
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Proceedings Paper
Materials Science, Multidisciplinary
Md Nasir Uddin, Ling-zhi Li, Asif Ahmed, Khalil Yahya Mohammed Almajhali
Summary: This paper predicts the influence of PVA fiber on the compressive and tensile strength of Engineered Composite Cement (ECC) using Artificial Neural Networks (ANNs). Sensitivity analysis is conducted to study the impact of each parameter. The results demonstrate that employing an ANNs model is an effective strategy.
MATERIALS TODAY-PROCEEDINGS
(2022)
Letter
Medical Laboratory Technology
Irina A. Buhimschi, Laura J. Frye, Beverly Winikoff, Elizabeth G. Raymond
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)