Review
Cardiac & Cardiovascular Systems
Sunit-Preet Chaudhry, Adam D. DeVore, Himabindu Vidula, Michael Nassif, Karol Mudy, Edo Y. Birati, Timothy Gong, Pavan Atluri, Duc Pham, Benjamin Sun, Aditya Bansal, Samer S. Najjar
Summary: This review provides an overview of durable LVADs, discussing patient selection and the basic principles of LVAD care. It also covers common complications associated with LVAD therapy. The goal is to help general cardiologists recognize potential LVAD candidates and understand the principles of managing LVAD patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Manish Motwani
Summary: This paper introduces the rapid development of artificial intelligence in nuclear cardiology in the past decade and its application in the workflow of cardiology. By explaining terminology and summarizing relevant implementations, challenges, and future expectations, it provides a primer for nuclear cardiologists.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Christian Hamilton-Craig, Martin Ugander, John P. Greenwood, Rebecca Kozor
Summary: Stress cardiovascular magnetic resonance (CMR) is an emerging non-invasive imaging technique that provides information on various aspects of the heart and has shown high diagnostic and prognostic utility in the assessment of known or suspected ischaemic heart disease (IHD). It is cost-effective and has the potential to guide coronary revascularisation decisions. However, its usage varies worldwide and it is still an underutilised technology. New developments, such as rapid acquisition protocols, automated quantification, and artificial intelligence-aided analysis, are making stress CMR more accessible and standardised globally.
Review
Cardiac & Cardiovascular Systems
Antoine Bondue, Caroline Carpentier, Florence Roufosse
Summary: Eosinophil-mediated endomyocardial damage is a well-known complication in patients with hypereosinophilic syndromes. Management and survival have improved, but some patients still develop severe cardiomyopathy. Treatment of HES should be managed by clinicians with expertise, while cardiologists play a key role in managing associated cardiopathy.
Article
Clinical Neurology
Noor E. Taams, Maria J. Knol, Rens Hanewinckel, Judith Drenthen, Hieab H. H. Adams, Pieter A. van Doorn, Mohammad Arfan Ikram
Summary: This study found genetic associations between diabetes, BMI, vitamin B12 levels, alcohol intake, and chronic axonal polyneuropathy, providing evidence for causal relationships between these well-known clinical risk factors and polyneuropathy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Laura Nunez-Gonzalez, Noa Carrera, Miguel A. Garcia-Gonzalez
Summary: Gitelman and Bartter syndromes are rare inherited diseases that result in electrolyte imbalances, especially in the nephron. Both syndromes share many similar clinical symptoms and the main treatment involves electrolyte supplementation and dietary changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Dimitri Laurent, Coulter Small, Brandon Lucke-Wold, William S. Dodd, Nohra Chalouhi, Yin C. Hu, Koji Hosaka, Kartik Motwani, Melanie Martinez, Adam Polifka, Matthew Koch, Katharina M. Busl, Carolina B. Maciel, Brian Hoh
Summary: This article reviews the complex genetics of intracranial aneurysms and critically discusses the published findings. It explores promising pre-clinical models and future avenues for research, while considering limitations in current studies. This review is of great importance in understanding the genetic underpinnings of aneurysm pathophysiology and as a primer for further investigation.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
John A. Bittl
Summary: Interventional cardiologists play a crucial role in treating malfunctioning hemodialysis accesses for patients with end-stage kidney disease, collaborating with interventional nephrologists to ensure that urgent or emergent procedures can be performed outside of scheduled outpatient sessions to prevent disruptions in hemodialysis treatments.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Review
Medicine, General & Internal
Shalini Dasari, Ankita Choudhary, Bhushan Madke
Summary: Psoriasis is an inflammatory condition that affects the skin and involves various genetic and environmental factors. The Interleukin IL23/IL17 axis and immune-related cells play important roles in its pathogenesis. Biological therapies targeting TNF alpha, IL17, and IL23 have shown effectiveness. The article provides a summary of topical and systemic treatments for psoriasis, including emerging options like sphingosine 1-phosphate receptor 1 modulators and Rho-associated kinase 2 inhibitors.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Gastroenterology & Hepatology
Pichamol Jirapinyo, Christopher C. Thompson
Summary: As the obesity pandemic worsens, gastroenterologists will encounter more obese patients. They can play an important role in managing obesity by understanding the relationship between obesity and gastrointestinal conditions, as well as the interaction between obesity pathophysiology and gut hormones. Additionally, knowledge of post-surgical anatomy and medical/endoscopic management of bariatric surgical complications is essential due to the increasing number of patients undergoing bariatric surgery.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Matthew J. Belanger, Erik M. Kelly, Usman A. Tahir, Mark D. Benson
Summary: Genetic testing for cardiovascular disease has greatly impacted the diagnosis and evaluation of monogenic causes of the disease. There has been increasing interest in using genetic information for risk assessment of more common diseases, such as atherosclerotic cardiovascular disease (ASCVD). Polygenic risk scores (PRS) have been developed to assess the risk of coronary artery disease and have shown a strong association in population studies. However, the added value of PRS to existing clinical risk prediction models remains a topic of debate.
CARDIOLOGY IN REVIEW
(2022)
Review
Clinical Neurology
Lucas P. Carlstrom, Ahmed Eltanahy, Avital Perry, Alejandro A. Rabinstein, Benjamin D. Elder, Jonathan M. Morris, Fredric B. Meyer, Christopher S. Graffeo, Iben Lundgaard, Terry C. Burns
Summary: The complex and dynamic system of fluid flow through the perivascular and interstitial spaces of the central nervous system (CNS) has implications for various neurological diseases. The glymphatic system, supported by astrocytes, plays a crucial role in directing extracellular fluid and removing waste products in order to optimize neurological function. Dysfunction in this system has been linked to CNS aging, neurodegenerative diseases, CNS injuries, and normal pressure hydrocephalus. Understanding the pathophysiology of glymphatics could lead to new therapeutic approaches.
Article
Multidisciplinary Sciences
Arthur W. H. Li, Katerina Zabrady, Lewis J. Bainbridge, Matej Zabrady, Sehr Naseem-Khan, Madison B. Berger, Peter Kolesar, G. Andres Cisneros, Aidan J. Doherty
Summary: This study reveals the molecular mechanism of how primases initiate primer synthesis, which is conserved in replicative primases and CRISPR-associated primase-polymerases. The study also shows that the catalytic domain of primases is sufficient for primer formation.
Review
Surgery
Jordan Hamilton, Nicole Milenkovski, Katherine Martin, Emma Tully, Calvin Peng, Ian Hayes
Summary: The widespread adoption of the acute surgical unit (ASU) model in Australia has led to an increased involvement of general surgeons in managing patients with acute abdominal pain (AAP), some of whom are diagnosed with non-specific abdominal pain (NSAP). This article reviews uncommon conditions that present as AAP and could be misdiagnosed as NSAP, highlighting demographic features, clinical findings, key investigations, and initial treatment priorities for ASU clinicians.
ANZ JOURNAL OF SURGERY
(2023)
Article
Agriculture, Multidisciplinary
Mehtap Yildiz, Carlos Arbizu
Summary: This study used 21 iPBS markers to analyze the genetic diversity and population structure of Daucus, and found the presence of four clusters. The Daucus species with 2n = 18 chromosomes separated from other species. Different clusters showed different levels of genetic diversity, with clusters 3 and 4 showing the lowest and highest diversity, respectively.
TURKISH JOURNAL OF AGRICULTURE AND FORESTRY
(2022)