Pak1 as a Novel Therapeutic Target for Antihypertrophic Treatment in the Heart

Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload

(2011) Wei Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeted Deletion of the Extracellular Signal-Regulated Protein Kinase 5 Attenuates Hypertrophic Response and Promotes Pressure Overload–Induced Apoptosis in the Heart

(2010) Tomomi E. Kimura et al.   CIRCULATION RESEARCH

Pak protein kinases and their role in cancer

(2009) Bettina Dummler et al.   CANCER AND METASTASIS REVIEWS

Cardiac-Specific Deletion of Mkk4 Reveals Its Role in Pathological Hypertrophic Remodeling but Not in Physiological Cardiac Growth

(2009) Wei Liu et al.   CIRCULATION RESEARCH

Cardiac hypertrophy: Targeting Raf/MEK/ERK1/2-signaling

(2009) Kristina Lorenz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cdc42 is an antihypertrophic molecular switch in the mouse heart

(2009) Marjorie Maillet et al.   JOURNAL OF CLINICAL INVESTIGATION

FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling

(2009) E. Eroume A Egom et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Scaffolding function of PAK in the PDK1–Akt pathway

(2008) Maiko Higuchi et al.   NATURE CELL BIOLOGY

Cardiac Plasticity

(2008) Joseph A. Hill et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes

(2007) Kai Mao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY