Review
Cell Biology
Tanawat Attachaipanich, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This review summarizes the current available evidence regarding the potential benefits of SGLT-2 inhibitors against cardiac arrhythmias, ranging from basic research to clinical reports. It comprehensively examines the effects of SGLT-2 inhibitors on cardiac action potential, cellular ion currents, calcium ion homeostasis, and cardiac mitochondrial function, as well as the association with arrhythmias such as atrial fibrillation and ventricular arrhythmias.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Monica Gallego, Julian Zayas-Arrabal, Amaia Alquiza, Beatriz Apellaniz, Oscar Casis
Summary: Diabetes is a chronic metabolic disease with hyperglycemia, and cardiovascular disease is a major complication leading to mortality in diabetic patients. Diabetic cardiomyopathy causes abnormal heart function and electrical remodeling, including prolonged QT interval, increasing the risk of life-threatening ventricular arrhythmias. New antidiabetic drugs must undergo thorough cardiovascular evaluation to reduce the risk of arrhythmia and sudden death in diabetic patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Food Science & Technology
Qianyu Qu, Penggang He, Yuqi Zhang, Shujuan Yang, Peibin Zeng
Summary: Probiotics have shown beneficial effects in the treatment of type 2 diabetes, especially in animal models. However, the translation of these findings to humans is limited by the differences between experimental animal models and humans.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Biology
Carol Ann Remme
Summary: The influx of sodium ions through voltage-gated sodium channels is crucial for proper electrical conduction in the heart. Dysfunction of sodium channels can lead to life-threatening arrhythmias in acquired conditions and inherited disorders. Recent research has revealed the complex nature of sodium channel distribution and function, as well as its impact on cardiac structural integrity. Moreover, sodium channels and their role in various extracardiac tissues are being increasingly recognized. This review provides an overview of these novel insights and their contribution to our understanding of sodium channelopathies and dysfunction.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Loryn J. Bohne, Hailey J. Jansen, Tristan W. Dorey, Irene M. Daniel, K. Lockhart Jamieson, Darrell D. Belke, Megan D. Mcrae, Robert A. Rose
Summary: This study demonstrates that GLP-1 and its analogues can reduce the incidence of atrial fibrillation and prevent atrial remodeling in patients with type 2 diabetes.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Maya Dia, Alexandre Paccalet, Bruno Pillot, Christelle Leon, Michel Ovize, Claire Crola Da Silva, Thomas Bochaton, Melanie Paillard
Summary: In light of discrepancies between animal and human studies, researchers are comparing the impact of diabetes on cell death after cardiac ischemia-reperfusion. Experiments on T2D patients and T2D mouse models suggest that anti-diabetic medications may have a potential protective effect on the heart and should be included in pre-clinical studies of cardioprotective approaches.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Physiology
Andras Varro, Jakub Tomek, Norbert Nagy, Laszlo Virag, Elisa Passini, Blanca Rodriguez, Istvan Baczko
Summary: Cardiac arrhythmias often stem from changes in the electro-physiological properties of cardiac cells and their ionic mechanisms. Understanding the pathophysiology of human cellular electrophysiology can aid in developing novel antiarrhythmic strategies.
PHYSIOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Marcela Salazar-Garcia, Juan Carlos Corona
Summary: Diabetes mellitus is a chronic metabolic disease characterized by insulin deficiency and affects various metabolic pathways. Animal models are useful for studying cellular and molecular mechanisms of diabetes and developing new therapies. Natural compounds with potential anti-diabetic effects are of interest, and rodent models are widely used in research on metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Romina Higa, Maria Laura Leonardi, Alicia Jawerbaum
Summary: Maternal diabetes increases the risk of cardiovascular diseases in offspring from fetal stage to adult life, with metabolic, pro-oxidant, and proinflammatory alterations in the fetal heart being the initial steps in adverse fetal programming of cardiovascular disease. Studies discuss potential mechanisms including epigenetic changes, cardiac metabolism alterations, effects of pro-oxidant and proinflammatory environment, extracellular matrix remodeling, and signaling pathways, as well as potential actions to prevent cardiovascular impairments in offspring of mothers with diabetes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Mateusz Mieczkowski, Beata Mrozikiewicz-Rakowska, Tomasz Siwko, Magdalena Bujalska-Zadrozny, Anna de Corde-Skurska, Renata Wolinska, Emilia Gasinska, Tomasz Grzela, Piotr Foltynski, Michal Kowara, Zofia Mieczkowska, Leszek Czupryniak
Summary: The study investigated the effect of insulin and metformin on wound healing in rats with streptozotocin-induced diabetes. Insulin treatment was found to be more effective in accelerating the wound healing process compared to metformin and control groups, with lower levels of inflammatory infiltration and higher Ki-67 density in insulin-treated animals.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Gonzalo Ferreira, Axel Santander, Romina Cardozo, Luisina Chavarria, Lucia Dominguez, Nicolas Mujica, Milagros Benitez, Santiago Sastre, Luis Sobrevia, Garth L. Nicolson
Summary: Inwardly rectifying potassium (Kir) channels are important for maintaining membrane potential and potassium homeostasis. These channels have various subtypes and can be regulated by molecules found in nutrients, such as phosphoinositols, polyamines, and Mg2+. Changes in Kir channels can affect metabolism and the ability to absorb nutrients and electrolytes. The study of nutrigenomics of ion channels is crucial for understanding how diet and nutrients can impact ion channel function, expression, and lead to pathological conditions that affect diet and electrolyte intake.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Endocrinology & Metabolism
Soroku Yagihashi
Summary: Diabetes mellitus is still a growing problem globally, especially in developing countries, causing significant economic and social burdens and affecting the quality of life for individuals with the disease. Despite recent improvements in life expectancy, further research is needed to understand the complexities and mechanisms of diabetes in order to develop effective treatments. Animal models, particularly those with spontaneous onset, play a crucial role in diabetes research and translating findings to human applications.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Clinical Neurology
Ming S. Soh, Richard D. Bagnall, Christopher Semsarian, Ingrid E. Scheffer, Samuel F. Berkovic, Christopher A. Reid
Summary: Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature death in epilepsy. This study found that SCN5A arrhythmogenic variants may confer increased risk of sudden death in individuals with epilepsy.
Review
Plant Sciences
Ruhai Chen, Keqin Ma, Siyu Li, Xin Zhou, Huaguo Chen
Summary: This study aimed to evaluate the efficacy of Opuntia polysaccharide (OPS) on diabetes mellitus (DM) through a systematic review and meta-analysis of animal models. The results showed that OPS significantly improved hyperglycemia, polydipsia, polyphagia, low body weight, and dyslipidemia in DM animals. The possible protective mechanisms of OPS on DM animals include immune regulation, repair of damaged pancreatic beta cells, and inhibition of oxidative stress and cell apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Kamyar Khoshnevisan, Hadi Baharifar, Farzad Torabi, Mahsa Sadeghi Afjeh, Hassan Maleki, Elham Honarvarfard, Hassan Mohammadi, Sayed Mahmoud Sajjadi-Jazi, Sadegh Mahmoudi-Kohan, Farnoush Faridbod, Bagher Larijani, Farshid Saadat, Reza Faridi Majidi, Mohammad Reza Khorramizadeh
Summary: A new approach for using 5-HT levels as a novel biomarker for diabetes mellitus was considered in this study, utilizing a simple nanocomposite and HPLC method. The sensor showed high selectivity, excellent reproducibility, notable anti-interference ability, and long-term stability. The significant reduction in 5-HT levels in diabetic zebrafish compared to the control group suggests that 5-HT can be applied for early diagnosis of diabetes mellitus.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Oncology
Mari Ueno, Takayuki Shiomi, Satsuki Mochizuki, Miyuki Chijiiwa, Masayuki Shimoda, Yae Kanai, Fumio Kataoka, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki, Yasunori Okada
Article
Hematology
Isabel Cunningham, Diane Hamele-Bena, Yan Guo, Takayuki Shiomi, Audrey C. Papp, Bandana Chakravarti, Jianqi Yang, Yu Shyr, Rory A. Fisher
AMERICAN JOURNAL OF HEMATOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Leroy C. Joseph, Michael Reyes, Kundanika R. Lakkadi, Blake H. Gowen, Gyorgy Hasko, Konstantinos Drosatos, John P. Morrow
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Kyeonghn Kim, Junjie Yu, Jin Ku Kang, John P. Morrow, Utpal B. Pajvani
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Christopher S. Grubb, Lea Melki, Daniel Y. Wang, James Peacock, Jose Dizon, Vivek Iyer, Carmine Sorbera, Angelo Biviano, David A. Rubin, John P. Morrow, Deepak Saluja, Andrew Tieu, Pierre Nauleau, Rachel Weber, Salma Chaudhary, Irfan Khurram, Marc Waase, Hasan Garan, Elisa E. Konofagou, Elaine Y. Wan
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Blake H. Gowen, Michael V. Reyes, Leroy C. Joseph, John P. Morrow
Review
Oncology
Dariimaa Ganbat, Bat-Erdene Jugder, Lkhamaa Ganbat, Miki Tomoeda, Erdenetsogt Dungubat, Yoshihisa Takahashi, Ichiro Mori, Takayuki Shiomi, Yasuhiko Tomita
Summary: Systematic review and meta-analysis showed that VitK treatment significantly improved clinical outcomes, including progression-free survival, overall survival, and overall response in cancer patients, with no significant difference in adverse events compared to the placebo group. VitK also demonstrated good clinical response in myelodysplastic syndrome and advanced solid tumors.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Cardiac & Cardiovascular Systems
Hirad Yarmohammadi, John P. Morrow, Jose Dizon, Angelo Biviano, Frederick Ehlert, Deepak Saluja, Marc Waase, Pierre Elias, Timothy J. Poterucha, Jeremy Berman, Alexander Kushnir, Mark P. Abrams, Geoffrey A. Rubin, Stephanie Jou, Jessica Hennessey, Nir Uriel, Elaine Y. Wan, Hasan Garan
Summary: The presence of atrial arrhythmia (AA) in COVID-19 patients is associated with significantly higher mortality rates, with predictors including older age, male gender, azithromycin use, and higher D-dimer levels.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Anna Ostropolets, Pierre A. Elias, Michael Reyes, Elain Y. Wan, Utpal B. Pajvani, George Hripcsak, John P. Morrow
Summary: This study investigated the risk of atrial and ventricular arrhythmias in diabetic patients taking different oral diabetes medications. Metformin was found to be associated with reduced risk of atrial fibrillation and ventricular arrhythmias compared with other medications such as sulfonylureas.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Editorial Material
Medicine, Research & Experimental
Leroy C. Joseph, John P. Morrow
Summary: The study found that ADH1 in paracardial fat can regulate mitochondrial content, affecting exercise performance, and may offer new clues for improving recovery time.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Gerber Adam, Takayuki Shiomi, Goldklang Monica, Sonett Jarrod, Anguiano Vincent, Mercer Becky, Zelonina Tina, D'Armiento Jeanine
Summary: COPD is a major cause of disability and death globally, with approximately 14 million sufferers in the United States alone. A potentially novel therapeutic agent targeting cigarette smoke-induced mechanisms was identified through high throughput screening, suggesting further investigation into SSRIs as a novel therapeutic for COPD may be warranted.
Article
Multidisciplinary Sciences
Uchenna Unachukwu, Takayuki Shiomi, Monica Goldklang, Kiran Chada, Jeanine D'Armiento
Summary: The study found that the pathogenesis of tuberous sclerosis originates from neural crest cell populations, which play a crucial role in renal tumors in Tsc2(+/-) mice. Targeting neural crest antigenic determinants may offer a potential alternative therapeutic approach for TS pathogenesis.
Article
Multidisciplinary Sciences
Leroy C. Joseph, Jianting Shi, Quynh N. Nguyen, Victoria Pensiero, Chris Goulbourne, Robert C. Bauer, Hanrui Zhang, John P. Morrow
Summary: This study examines the response of the heart to a high-fat diet at the metabolomic and transcriptomic levels, revealing significant sex differences in cardiac metabolites and gene expression.
Article
Oncology
Uchenna Unachukwu, Jarrod Sonett, Denzel Woode, Takayuki Shiomi, Kiran Chada, Jeanine M. D'Armiento
MOLECULAR CANCER THERAPEUTICS
(2023)
Meeting Abstract
Critical Care Medicine
U. J. Unachukwu, T. Shiomi, J. Sonnet, D. Woode, K. Chada, J. D'Armiento
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)