Article
Cardiac & Cardiovascular Systems
Anand Rohatgi, Marit Westerterp, Arnold von Eckardstein, Alan Remaley, Kerry-Anne Rye
Summary: Low high-density lipoprotein cholesterol (HDL-C) is associated with adverse lifestyle choices, cardiovascular diseases, inflammatory disorders, and other conditions. Therapeutic strategies targeting HDL-C levels have not been successful, and future focus should be on optimizing HDL function for better outcomes.
Review
Geriatrics & Gerontology
Yongzheng Lu, Xiaolin Cui, Li Zhang, Xu Wang, Yanyan Xu, Zhen Qin, Gangqiong Liu, Qiguang Wang, Kang Tian, Khoon S. Lim, Chris J. Charles, Jinying Zhang, Junnan Tang
Summary: Dyslipidemia increases the risk of atherosclerosis, and lipoproteins play a significant role in its development. Understanding lipoprotein function can help predict risk and provide novel treatment approaches for atherosclerosis.
Review
Cell Biology
Manuela Casula, Ornella Colpani, Sining Xie, Alberico L. Catapano, Andrea Baragetti
Summary: Recent studies on the role of high-density lipoprotein cholesterol (HDL-C) in cardiovascular disease have found a complex U-shaped relationship between HDL levels and cardiovascular mortality risk. Additionally, genetic studies, Mendelian randomization approaches, and clinical trials have challenged the traditional notion of a causal link between HDL-C levels and cardiovascular protection.
Review
Cardiac & Cardiovascular Systems
MacRae F. Linton, Patricia G. Yancey, Huan Tao, Sean S. Davies
Summary: Epidemiologic studies have shown that HDL-C levels are inversely related to ASCVD, suggesting that HDL-C is a major risk factor for ASCVD. However, clinical trials have questioned the role of HDL-C in mediating ASCVD risk. Progress in understanding the composition of HDL particles has revealed that HDL-C levels do not necessarily reflect HDL function. HDL has been found to have antiatherogenic functions, such as reverse cholesterol transport and suppression of inflammation, but its oxidative modifications can lead to dysfunction and inflammation.
CIRCULATION RESEARCH
(2023)
Article
Hematology
Jing Liu, Baiba K. Gillard, Dedipya Yelamanchili, Antonio M. Gotto, Corina Rosales, Henry J. Pownall
Summary: Mice lacking the HDL receptor Scarb1 exhibit increased bioavailability of FC in HDL, leading to elevated FC content in multiple tissue sites associated with female infertility, impaired cell maturation, cardiac dysfunction, and atherosclerosis. Sex-dependent differences in tissue-lipid composition and plasma FC clearance rates were also observed. Higher HDL-FC bioavailability may serve as a potential biomarker mechanistically linked to various pathologies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Clinical Neurology
Takao Hoshino, Kentaro Ishizuka, Sono Toi, Takafumi Mizuno, Ayako Nishimura, Shuntaro Takahashi, Sho Wako, Kazuo Kitagawa
Summary: This study found a close association between atherogenic dyslipidemia (AD) and residual vascular risk in stroke patients. Patients with AD were more likely to have intracranial artery stenosis and had a higher risk of major adverse cardiovascular events and ischemic stroke within 1 year. AD was predictive of major adverse cardiovascular events regardless of baseline low-density lipoprotein cholesterol (LDL-C) levels.
Article
Cardiac & Cardiovascular Systems
Maximiliano Martin, Laura Gaete, Walter Tetzlaff, Florencia Ferraro, Ezequiel Lozano Chiappe, Eliana E. Botta, Viviana Osta, Maria S. Saez, Maria V. Lorenzon Gonzalez, Patricia Palenque, Gabriela Ballerini, Patricia Sorroche, Laura Boero, Liliana Triffone, Fernando Brites
Summary: This study revealed significant abnormalities in inflammatory markers, carbohydrate metabolism, lipid profile, and HDL functionality in obese children and adolescents, which are associated with vascular-specific inflammation and impaired HDL atheroprotective capacity.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Cardiac & Cardiovascular Systems
Ayiguli Abudukeremu, Canxia Huang, Hongwei Li, Runlu Sun, Xiao Liu, Xiaoying Wu, Xiangkun Xie, Jingjing Huang, Jie Zhang, Jinlan Bao, Yuling Zhang
Summary: HDL/apoA-1 replacement therapies do not significantly decrease arterial atheroma volume in humans with acute coronary syndrome, but they are associated with decreased lesion area in mice experiments. Further studies are needed to understand the differences in efficacy between humans and animals.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Chemistry, Medicinal
Saba Soltani, Motahareh Boozari, Arrigo F. G. Cicero, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: HDL plays a crucial role in cardiovascular diseases, while phytochemicals have the potential to enhance cholesterol efflux. Current research mostly focuses on preclinical studies, indicating a need for more clinical research to develop novel clinical applications.
PHYTOTHERAPY RESEARCH
(2021)
Article
Environmental Sciences
Eleni Papadopoulou, Alina Nicolescu, Line S. Haug, Trine Hus, Calin Deleanu, Hubert Dirven, Birgitte Lindeman
Summary: This study explores the association between serum PFAS concentrations and lipoprotein subclasses. After adjusting for confounders, the adjusted models found positive associations between several PFASs and cholesterol concentrations in large to medium sized HDL and medium sized LDL particles. Significant associations were observed between certain PFASs and cholesterol in large to medium LDL particle sizes among women. The study also found that most PFASs tended to be associated with a reduction in VLDL particle number and VLDL triglyceride.
ENVIRONMENTAL POLLUTION
(2022)
Article
Hematology
Ayea El-Ghazali, Sneha Deodhar, Suzanne Saldanha, Brooke Smyth, Mark Izbrand, Anamika Gangwar, Mandana Pahlavani, Anand Rohatgi
Summary: Cholesterol efflux capacity (CEC) is a clinically relevant cardiovascular biomarker inversely associated with atherosclerotic cardiovascular disease events. Extreme high and low CEC are persistent and robust phenotypes, showing significant differences in CEC patterns across the size distribution of molecules. Further studies are needed to determine specific molecular species linked to CEC in a size-specific manner.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Weila Dong, Karen H. Y. Wong, Youbin Liu, Michal Levy-Sakin, Wei-Chien Hung, Mo Li, Boyang Li, Sheng Chih Jin, Jungmin Choi, Francesc Lopez-Giraldez, Dedeepya Vaka, Annie Poon, Catherine Chu, Richard Lao, Melek Balamir, Irina Movsesyan, Mary J. Malloy, Hongyu Zhao, Pui-Yan Kwok, John P. Kane, Richard P. Lifton, Clive R. Pullinger
Summary: Low levels of HDL-C are associated with increased risk of arteriosclerotic coronary heart disease, and this study found damaging rare variants in the ABCA1 and LDLR genes to be particularly high in individuals with low HDL-C. Numerous damaging variants were also identified in other HDL candidate genes, suggesting a potential new area of interest in HDL genomics.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Hematology
Vishal Kothari, Jingjing Tang, Yi He, Farah Kramer, Jenny E. Kanter, Karin E. Bornfeldt
Summary: The study reveals a crucial role for ADAM17 in regulating the anti-inflammatory and proinflammatory effects of HDL in macrophages, as cholesterol enrichment in ADAM17-deficient macrophages can prevent inflammatory responses induced by HDL. This highlights the importance of ADAM17 in maintaining cholesterol efflux in macrophages and modulating their immune functions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Juan Pedro-Botet, Elisenda Climent, David Benaiges
Summary: CVD in HeFH is driven by LDL cholesterol concentrations, but other classical risk factors also contribute to the high cardiovascular risk. Alterations in the phenotype and functionality of HDL particles in HeFH patients are also associated with the presence and severity of CVD.
Review
Biochemistry & Molecular Biology
Knut Tore Lappegard, Christian Abendstein Kjellmo, Anders Hovland
Summary: HDL is a diverse group of plasma molecules with varying lipid content and protein composition. Understanding the function of specific HDL subgroups and their clinical relevance is of increasing interest in relation to coronary heart disease risk. Pharmacologically manipulating beneficial and harmful HDL subgroups may potentially reduce CHD risk in the future.
Article
Cardiac & Cardiovascular Systems
Antonio J. Vallejo-Vaz, Sarah Bray, Guillermo Villa, Julia Brandts, Gaia Kiru, Jennifer Murphy, Maciej Banach, Stefano De Servi, Dan Gaita, Ioanna Gouni-Berthold, G. Kees Hovingh, Jacek J. Jozwiak, J. Wouter Jukema, Robert Gabor Kiss, Serge Kownator, Helle K. Iversen, Vincent Maher, Luis Masana, Alexander Parkhomenko, Andre Peeters, Piers Clifford, Katarina Raslova, Peter Siostrzonek, Stefano Romeo, Dimitrios Tousoulis, Charalambos Vlachopoulos, Michal Vrablik, Alberico L. Catapano, Neil R. Poulter, Kausik K. Ray
Summary: In patients with atherosclerotic cardiovascular disease (ASCVD), achieving European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) LDL-C goals may result in an additional 2% absolute risk reduction (ARR) over 10 years compared to the American College of Cardiology/American Heart Association (ACC/AHA) approach.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Clinical Neurology
Leon A. Rinkel, Chiel F. P. Beemsterboer, Nina-Suzanne Groeneveld, Nick H. J. Lobe, S. Matthijs Boekholdt, Berto J. Bouma, Fenna F. Muller, Ludo F. M. Beenen, Henk A. Marquering, Charles B. L. M. Majoie, Yvo B. W. E. M. Roos, Adrienne van Randen, R. Nils Planken, Jonathan M. Coutinho
Summary: Cardiac CT can detect cardiac thrombi in patients with acute ischemic stroke, and these patients have more severe symptoms and the thrombi are usually located in the left atrial appendage, which significantly affects the functional outcome.
EUROPEAN STROKE JOURNAL
(2023)
Article
Clinical Neurology
Mark K. Bakker, Jos P. Kanning, Gad Abraham, Amy E. Martinsen, Bendik S. Winsvold, John-Anker Zwart, Romain Bourcier, Tomonobu Sawada, Masaru Koido, Yoichiro Kamatani, Sandrine Morel, Philippe Amouyel, Stephanie Debette, Philippe Bijlenga, Takiy Berrandou, Santhi K. Ganesh, Nabila Bouatia-Naji, Gregory Jones, Matthew Bown, Gabriel J. E. HUNT All In Stroke, Jan H. CADISP Grp, Ynte M. Int Consortium Blood Pressure, Int Headache Genetics Consortium, ISGC, Intracranial Aneurysm Working Grp, Gabriel J. E. Rinkel, Jan Veldink, Ynte Ruigrok
Summary: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to have potential for genetic risk prediction. However, a genetic risk score incorporating these factors only showed limited predictive value for IA presence and ASAH incidence, suggesting that it may not be suitable for daily clinical use.
Article
Endocrinology & Metabolism
Antoine Weihs, Layal Chaker, Tiphaine C. Martin, Kim V. E. Braun, Purdey J. Campbell, Simon R. Cox, Myriam Fornage, Christian Gieger, Hans J. Grabe, Harald Grallert, Sarah E. Harris, Brigitte Kuehnel, Riccardo E. Marioni, Nicholas G. Martin, Daniel L. McCartney, Allan F. McRae, Christa Meisinger, Joyce B. J. van Meurs, Jana Nano, Matthias Nauck, Annette Peters, Holger Prokisch, Michael Roden, Elizabeth Selvin, Marian Beekman, Diana van Heemst, Eline P. Slagboom, Brenton R. Swenson, Adrienne Tin, Pei-Chien Tsai, Andre Uitterlinden, W. Edward Visser, Henry Voelzke, Melanie Waldenberger, John P. Walsh, Anna Koettgen, Scott G. Wilson, Robin P. Peeters, Jordana T. Bell, Marco Medici, Alexander Teumer
Summary: Novel associations between thyroid hormones and DNA methylation were discovered, advancing our understanding of thyroid hormone action particularly related to KLF9. This study demonstrates the utility of integrating EWAS with other -omics data for unraveling thyroid hormone signaling in humans.
Article
Nutrition & Dietetics
Alexandra P. M. de Koning-Backus, Jessica Kiefte-de C. Jong, Jeroen G. J. van Rooij, Andre G. G. Uitterlinden, Trudy A. Voortman, Magda Meester-Smoor, Caroline C. W. Klaver
Summary: Age-related macular degeneration (AMD) has a strong genetic basis, which can be reduced by environmental factors such as smoking and a healthy diet. However, many ophthalmologists do not inform patients about these beneficial lifestyle changes due to lack of trust and measurement methods. To address this, the AMD-Life study aims to investigate if personalized risk-profiling and coaching can motivate patients to change their lifestyle. The study also aims to identify biomarkers that reflect lifestyle changes beneficial for AMD.
Article
Cardiac & Cardiovascular Systems
Frank Meijerink, Marja Holierook, Susanne Eberl, Danielle Robbers-Visser, S. Matthijs Boekholdt, Marcel A. M. Beijk, Karel T. Koch, Robbert J. de Winter, Berto J. Bouma, Jan Baan
Summary: This study aimed to determine whether low-dose dobutamine stress echocardiography (DSE) during transcatheter edge-to-edge mitral valve repair (TMVR) can predict residual mitral regurgitation (MR) at discharge. The results showed that an increase of MR during DSE can predict the presence of >moderate MR at discharge.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Nutrition & Dietetics
Carolina Ochoa-Rosales, Niels van der Schaft, Kim V. E. Braun, Frederick K. Ho, Fanny Petermann-Rocha, Fariba Ahmadizar, Maryam Kavousi, Jill P. Pell, M. Arfan Ikram, Carlos A. Celis-Morales, Trudy Voortman
Summary: This study explored the association between coffee consumption and the risk of type 2 diabetes. It found that increasing coffee intake by one cup per day was associated with a 4% decrease in the risk of developing diabetes. Furthermore, coffee intake was also associated with reduced insulin resistance, lower levels of the inflammatory marker CRP, and elevated adiponectin and IL-13 concentrations. CRP partially mediated the inverse association between coffee intake and diabetes incidence.
CLINICAL NUTRITION
(2023)
Letter
Cardiac & Cardiovascular Systems
Martijn J. Tilly, Natasja M. S. de Groot, Maryam Kavousi
Article
Cardiac & Cardiovascular Systems
Martijn H. van der Ree, Edith M. T. Dieleman, Jorrit Visser, R. Nils Planken, S. Matthijs Boekholdt, Rianne H. A. de Bruin-Bon, Coen R. N. Rasch, Wiert F. Hoeksema, Rianne M. A. J. de Jong, Michiel J. B. Kemme, Jippe C. Balt, Arthur A. M. Wilde, Brian Balgobind, Pieter G. Postema
Summary: This study aims to evaluate the efficacy and safety of Stereotactic Arrhythmia Radiotherapy (STAR). It found that STAR can reduce the number of treated ventricular tachycardia episodes by more than 50% in 67% of patients with therapy-refractory VT. No decrease in cardiac and pulmonary function or treatment-related serious adverse events were observed during follow-up.
Article
Endocrinology & Metabolism
Kan Wang, Fariba Ahmadizar, Sven Geurts, Banafsheh Arshi, Jan A. Kors, Dimitris Rizopoulos, Eric J. G. Sijbrands, M. Arfan Ikram, Maryam Kavousi
Summary: This study examined the association between the longitudinal evolution of heart rate variability (HRV) and the development of type 2 diabetes (T2D). The results showed that an increase in heart rate and a decrease in HRV were independently associated with the incidence of T2D, especially among younger individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Psychology, Biological
Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, Ahmad Vaez, Natalie van Zuydam, Barbara D. Bitarello, Eugene J. Gardner, Evelina T. Akimova, Ajuna Azad, Sven Bergmann, Lawrence F. Bielak, Dorret Boomsma, Kristina Bosak, Marco Brumat, Julie E. Buring, David Cesarini, Daniel Chasman, Jorge E. Chavarro, Massimiliano Cocca, Maria Pina Concas, George Davey Smith, Gail Davies, Ian J. Deary, Tonu Esko, Jessica D. Faul, Oscar Franco, Andrea Ganna, Audrey J. Gaskins, Andrea Gelemanovic, Eco J. C. de Geus, Christian Gieger, Giorgia Girotto, Bamini Gopinath, Hans Joergen Grabe, Erica P. Gunderson, Caroline Hayward, Chunyan He, Diana van Heemst, W. David Hill, Eva R. Hoffmann, Georg Homuth, Jouke Jan Hottenga, Hongyang Huang, Elina Hyppoenen, M. Arfan Ikram, Rick Jansen, Magnus Johannesson, Zoha Kamali, Sharon L. R. Kardia, Maryam Kavousi, Annette Kifley, Tuomo Kiiskinen, Peter Kraft, Brigitte Kuehnel, Claudia Langenberg, Gerald Liew, Penelope A. Lind, Jian'an Luan, Reedik Magi, Patrik K. E. Magnusson, Anubha Mahajan, Nicholas G. Martin, Hamdi Mbarek, Mark McCarthy, George McMahon, Sarah E. Medland, Thomas Meitinger, Andres Metspalu, Evelin Mihailov, Lili Milani, Stacey A. Missmer, Paul Mitchell, Stine Mollegaard, Dennis O. Mook-Kanamori, Anna Morgan, Peter van der Most, Renee de Mutsert, Matthias Nauck, Ilja M. Nolte, Raymond Noordam, Brenda W. J. H. Penninx, Annette Peters, Patricia A. Peyser, Ozren Polasek, Chris Power, Ajka Pribisalic, Paul Redmond, Janet W. Rich-Edwards, Paul M. Ridker, Cornelius A. Rietveld, Susan M. Ring, Lynda M. Rose, Rico Rueedi, Vallari Shukla, Jennifer A. Smith, Stasa Stankovic, Kari Stefansson, Doris Stoeckl, Konstantin Strauch, Morris A. Swertz, Alexander Teumer, Gudmar Thorleifsson, Unnur Thorsteinsdottir, A. Roy Thurik, Nicholas J. Timpson, Constance Turman, Andre G. Uitterlinden, Melanie Waldenberger, Nicholas J. Wareham, David R. Weir, Gonneke Willemsen, Jing Hau Zhao, Wei Zhao, Yajie Zhao, Harold Snieder, Marcel den Hoed, Ken K. Ong, Melinda C. Mills, John R. B. Perry
Summary: Identifying genetic determinants of reproductive success can reveal the mechanisms underlying fertility and identify genes that are currently under natural selection. A genome-wide association study on individuals of European ancestry identified 43 genomic loci associated with the number of children ever born or childlessness. These loci are involved in various aspects of reproductive biology, such as puberty timing, age at first birth, sex hormone regulation, endometriosis, and age at menopause. Additionally, missense variants in ARHGAP27 were found to be associated with higher number of children ever born but shorter reproductive lifespan, suggesting a trade-off at this locus. Other genes, including PIK3IP1, ZFP82, and LRP4, were also implicated by coding variants, and a new role for the melanocortin 1 receptor (MC1R) in reproductive biology was suggested. Furthermore, integration with data from historical selection scans revealed an allele in the FADS1/2 gene locus that has been undergoing selection for thousands of years. These findings highlight the diverse biological mechanisms contributing to reproductive success.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Urology & Nephrology
Sanne J. van der Veen, Mohamed el Sayed, Carla E. M. Hollak, Marion M. Brands, C. Khya S. Snelder, S. Matthijs Boekholdt, Liffert Vogt, Susan M. I. Goorden, Andre B. P. van Kuilenburg, Mirjam Langeveld
Summary: Fabry disease is a heterogeneous X-linked lysosomal storage disease with varying manifestations in the kidneys, heart, and brain even among patients of the same sex and classification. The study investigates the association between plasma lysoGb3 levels and disease manifestations in untreated patients with Fabry disease, and finds that higher levels of lysoGb3 are associated with disease progression in various organs.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Genetics & Heredity
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Haojie Lu, Chani J. Hodonsky, Lennart P. L. Landsmeer, Adam W. Turner, Minjung Kho, Natalie R. Hasbani, Paul S. de Vries, Donald W. Bowden, Sandesh Chopade, Joris Deelen, Ernest Diez Benavente, Xiuqing Guo, Edith Hofer, Shih-Jen Hwang, Sharon M. Lutz, Leo-Pekka Lyytikaeinen, Lotte Slenders, Albert V. Smith, Maggie A. Stanislawski, Jessica van Setten, Quenna Wong, Lisa R. Yanek, Diane M. Becker, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Austin T. Hilliard, Sharon L. R. Kardia, Jason C. Kovacic, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Shaista Malik, Firdaus A. A. Mohamed Hoesein, Michal Mokry, Reinhold Schmidt, Jennifer A. Smith, Kent D. Taylor, James G. Terry, Jeroen van der Grond, Joyce van Meurs, Rozemarijn Vliegenthart, Jianzhao Xu, Kendra A. Young, Nuno R. Zilhao, Robert Zweiker, Themistocles L. Assimes, Lewis C. Becker, Daniel Bos, J. Jeffrey Carr, L. Adrienne Cupples, Dominique P. v. de Kleijn, Menno de Winther, Hester M. den Ruijter, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon D. Hingorani, John E. Hokanson, M. Arfan Ikram, Ivana Isgum, David R. Jacobs, Mika Kaehoenen, Leslie A. Lange, Terho Lehtimaeki, Gerard Pasterkamp, Olli T. Raitakari, Helena Schmidt, P. Eline Slagboom, Andre G. Uitterlinden, Meike W. Vernooij, Joshua C. Bis, Nora Franceschini, Bruce M. Psaty, Wendy S. Post, Jerome I. Rotter, Johan L. M. Bjoerkegren, Christopher J. O'Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller
Summary: This study conducted a large-scale analysis and identified eleven new risk loci for coronary artery calcification (CAC), a measure of subclinical atherosclerosis. These new loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. The findings contribute to a better understanding of the genetic architecture of CAC and provide potential targets for therapeutic interventions.
Article
Cardiac & Cardiovascular Systems
Jussi Schultz, Inge J. van den Hoogen, Jurrien H. Kuneman, Michiel A. de Graaf, Vasileios Kamperidis, Alexander Broersen, J. Wouter Jukema, Antonis Sakellarios, Sotirios Nikopoulos, Konstantina Tsarapatsani, Katerina Naka, Lampros Michalis, Dimitrios Fotiadis, Teemu Maaniitty, Antti Saraste, Jeroen J. Bax, Juhani Knuuti
Summary: This study evaluated CCTA-based ESS values in coronary arteries without atherosclerosis and identified factors affecting ESS values. The findings showed that ESS was highest in the left anterior descending artery and lower in men compared to women, even after adjusting for lumen diameter. ESS values were also highest in small segments and had a correlation with the distance from the ostium.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Review
Geriatrics & Gerontology
Michelle H. Zonneveld, Denise Abbel, Saskia le Cessie, J. Wouter Jukema, Raymond Noordam, Stella Trompet
Summary: This systematic review examined the association between cardiac troponin, cognitive function, and dementia. The findings suggest that elevated troponin is associated with cognitive impairment, increased risk of dementia, and higher prevalence of dementia hospitalization, specifically due to vascular dementia.