期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 153, 期 -, 页码 279-283出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2015.04.006
关键词
Hydroxyapatite nanocrystals; Nucleotide adsorption; Nanomaterials; Platinum complex; Antitumor drug; Antiviral drug
资金
- University of Salento, Italy
- MIUR, Ministero dell'Istruzione, dell'Universita e della Ricerca [PON 254/Ric, PONa3_00334]
- Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici (CIRCMSB), Bari (Italy)
- RINAME Project, Rete integrata per la nano medicina (funds for selected research topics) [RBAP114AMK]
The experiments here reported evidence on the importance of the residual charge of a nucleotide derivative, for the adsorption on nHAP (hydroxyapatite nanocrystals), in water solution. We found that the simple presence of phosphates on the nucleotide derivative does not guarantee adsorption on nHAP. On the other hand, we demonstrated that a cationic or neutral charge on a nucleotide derivative produces a strongly reduced chemical adsorption (chemisorption) whereas, in the presence of a net negative charge, relevant adsorption on nHAP is observed. The number of phosphates can only modulate the adsorption efficiency of a molecule provided that this latter bears an overall negative charge. The neutral zwitterionic nucleotide Pt(II) complexes, bearing negatively charged phosphates, are unable to give stable chemisorption. Previous considerations are important to model the binding ability of phosphate bearing nucleotide derivatives or molecules on hydroxyapatite. The findings reported in the present paper could be relevant in bone tissue targeting or nHAP mediated drug delivery. (C) 2015 Elsevier Inc. All rights reserved.
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