Article
Chemistry, Multidisciplinary
Fang Yuan, Cuiling Zhang, Xianzhu Luo, Xiaokun Shen, Yuezhong Xian
Summary: ATP stimulus-responsive tetrahedral DNA-gated fluorescent covalent organic frameworks (COFs) were developed for estradiol (E2) delivery and controllable release. The fluorescent COFs with an efficient E2 loading showed great potential against myocardial ischemia and reperfusion injury.
CHEMICAL COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Zenghui Liang, Huafang Chen, Xuehao Gong, Binbin Shi, Lili Lin, Fangyi Tao, Qilong Wu, Mingling Fang, Hui Li, Cuitao Lu, Helin Xu, Yingzheng Zhao, Bin Chen
Summary: This study investigated the potential of using nitric oxide-loaded microbubbles and ultrasound to treat thromboembolism. The results showed that this treatment significantly reduced thrombus area, increased recanalization rates and blood flow velocities. The treatment also activated endothelial nitric oxide synthase and mitigated oxidative stress and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stephanie M. Mutchler, Mahpara Hasan, Donald E. Kohan, Thomas R. Kleyman, Roderick J. Tan
Summary: Our study demonstrates that deletion of the gamma subunit of ENaC, while allowing for greater activation of eNOS, is not sufficient to prevent IRI. This suggests that the protective effects of alpha subunit deletion may be due, in part, to other mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Surawee Chuaiphichai, Sandy M. Chu, Ricardo Carnicer, Matthew Kelly, Jenifer K. Bendall, Jillian N. Simon, Gillian Douglas, Mark J. Crabtree, Barbara Casadei, Keith M. Channon
Summary: This study reveals a critical role for endothelial cell Gch1/BH4 biosynthesis in coronary vascular function and cardiac function. Loss of cardiac endothelial cell BH4 leads to coronary vascular dysfunction, reduced functional recovery, and increased myocardial infarct size following ischemia/reperfusion injury. Targeting endothelial cell Gch1 and BH4 biosynthesis may provide a novel therapeutic target for the prevention and treatment of cardiac dysfunction, ischemia injury, and heart failure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Younes Yassaghi, Sajad Jeddi, Nasibeh Yousefzadeh, Khosrow Kashfi, Asghar Ghasemi
Summary: Long-term nitrate intervention increased the resistance to myocardial ischemia-reperfusion injury (MIRI) in female rats, which was associated with increased heart endothelial nitric oxide synthase (eNOS) expression and circulating progesterone before ischemia and blunting ischemia-induced increased inducible nitric oxide synthase (iNOS) and decreased eNOS after MIRI.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cell Biology
Kenichiro Suno, Yasushige Shingu, Satoru Wakasa
Summary: This study evaluated the effects of trehalose preconditioning on cardiac and coronary endothelial function after ischemia-reperfusion injury. It was found that trehalose preconditioning improved heart function, reduced edema, oxidative stress, and apoptosis, and increased eNOS dimerization ratio, indicating its protective effects on cardiac and coronary endothelial function. These effects were mediated through the eNOS signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Surgery
Emre Gazyakan, Christoph Hirche, Matthias A. Reichenberger, Olena Urbach, Guenter Germann, Holger Engel
Summary: In this study, modulation of NO bioavailability through exogenous application of NOSs and L-arginine significantly attenuated ischemia-reperfusion-induced alterations in a type 2 diabetic skin flap rat model, with the best results achieved with the combination of eNOS and L-arginine. Higher enzyme dosage seemed to be less effective in improving flap vitality rates.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Yiru Guo, Qianhong Li, Yu-Ting Xuan, Wen-Jian Wu, Wei Tan, Jan Slezak, Xiaoping Zhu, Alex Tomlin, Roberto Bolli
Summary: This study demonstrates that short-term, mild exercise induces delayed cardioprotective effects against myocardial infarction, dependent on the activation of eNOS, eNOS-derived NO generation, and subsequent PKC epsilon activation during preconditioning. Furthermore, the protection 24 hours after exercise is mediated by iNOS activity.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hyang-Mi Lee, Ji Woong Choi, Min Sik Choi
Summary: Ischemia-reperfusion injury (IRI) is a damage process induced in hypoxic tissue when oxygen is supplied after ischemia. Restoration of reduced nitric oxide (NO) levels may alleviate reperfusion injury in ischemic organs, with the protective mechanism due to anti-inflammatory and antioxidant effects of NO, as well as regulation of cell signaling pathways. S-nitrosylation (SNO) mediates the detrimental or protective effect of NO depending on the nitrosylated target protein, which also plays a role in the IRI process.
Article
Cardiac & Cardiovascular Systems
Doria Boulghobra, Mathilde Dubois, Beatrice Alpha-Bazin, Florence Coste, Maxime Olmos, Sandrine Gayrard, Isabelle Bornard, Gregory Meyer, Jean-Charles Gaillard, Jean Armengaud, Cyril Reboul
Summary: Exercise training increases the activation of eNOS and its localization in mitochondria, leading to enhanced nitric oxide production, which may represent a key mechanism of exercise-induced cardioprotection.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yijie Wang, Fenfang Hong, Shulong Yang
Summary: Brain ischemia and reperfusion (I/R) is a severe manifestation of ischemic stroke. Accumulating evidence suggests that nitric oxide (NO) plays a crucial role in the pathological processes of brain I/R, including neuronal cell death and blood-brain barrier disruption. This review focuses on the role of endogenous NO in brain I/R and discusses therapeutic approaches associated with NO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Walter Petermichl, Kathrin Eglmeier, Henriette Hesse, Michael Gruber, Bernhard Graf, Andre Bredthauer, Andreas Redel
Summary: The study showed that high-fat diet-induced atherosclerosis can reduce the effectiveness of heart preconditioning in mice, but it has additional cardioprotective effects in LDLR-/- mice.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Zelin Chen, Xu Tan, Taotao Jin, Yu Wang, Linyong Dai, Gufang Shen, Can Zhang, Langfan Qu, Lei Long, Chongxing Shen, Xiaohui Cao, Jianwu Wang, Huijuan Li, Xiaofeng Yue, Chunmeng Shi
Summary: This study presents the potential of near infrared dye IR-780 for monitoring and protecting ischemic myocardium from injury. IR-780 selectively enters cardiomyocytes in at-risk heart tissues and can preconditon or administer timely to protect against cell death, myocardial remodeling, and heart failure induced by ischemia and oxidative stress. The dye binds to F0F1-ATP synthase in cardiomyocytes, decreases mitochondrial membrane potential, and slows down mitochondrial energy metabolism, leading to a quiescent mitochondria state and inhibition of mitochondrial permeability transition pore. Moderating mitochondrial function depression could be a targeted approach for developing cardioprotective reagents.
Article
Biochemistry & Molecular Biology
Miriam M. Cortese-Krott, Tatsiana Suvorava, Francesca Leo, Sophia K. Heuser, Anthea LoBue, Junjie Li, Stefanie Becher, Rebekka Schneckmann, Tanu Srivrastava, Ralf Erkens, Georg Wolff, Joachim P. Schmitt, Maria Grandoch, Jon O. Lundberg, John Pernow, Brant E. Isakson, Eddie Weitzberg, Malte Kelm
Summary: This study reveals that red blood cell endothelial nitric oxide synthase (RBC eNOS) plays a role in limiting infarct size in acute myocardial infarction (AMI) and regulates coronary blood flow and cardiac function. These findings suggest that RBC eNOS signaling may represent a novel target for interventions in ischemia/reperfusion after myocardial infarction.
Review
Biochemistry & Molecular Biology
Jirapong Vongsfak, Wasana Pratchayasakul, Nattayaporn Apaijai, Tanat Vaniyapong, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Cerebral ischemia and reperfusion injury can lead to poor oxygen supply, brain infarction, and an imbalance in mitochondrial dynamics, which plays a crucial role in cell survival and infarct area size regulation. Understanding and regulating mitochondrial dynamics may help prevent or treat cerebral injury.
Article
Cardiac & Cardiovascular Systems
Jan Gehlen, Anja Stundl, Radoslaw Debiec, Federica Fontana, Markus Krane, Dinara Sharipova, Christopher P. Nelson, Baravan Al-Kassou, Ann Sophie Giel, Jan Malte Sinning, Christopher M. H. Bruenger, Carolin F. Zelck, Laura L. Koebbe, Peter S. Braund, Thomas R. Webb, Simon Hetherington, Stephan Ensminger, Buntaro Fujita, Salah A. Mohamed, Malakh Shrestha, Heike Krueger, Matthias Siepe, Fabian Alexander Kari, Peter Nordbeck, Larissa Buravezky, Malte Kelm, Verena Veulemans, Matti Adam, Stephan Baldus, Karl Ludwig Laugwitz, Yannick Haas, Matthias Karck, Uwe Mehlhorn, Lars Oliver Conzelmann, Ingo Breitenbach, Corinna Lebherz, Paul Urbanski, Won Keun Kim, Joscha Kandels, David Ellinghaus, Ulrike Nowak-Goettl, Per Hoffmann, Felix Wirth, Stefanie Doppler, Harald Lahm, Martina Dressen, Moritz von Scheidt, Katharina Knoll, Thorsten Kessler, Christian Hengstenberg, Heribert Schunkert, Georg Nickenig, Markus M. Noethen, Aidan P. Bolger, Salim Abdelilah-Seyfried, Nilesh J. Samani, Jeanette Erdmann, Teresa Trenkwalder, Johannes Schumacher
Summary: This study provides deeper insights into the genetic risk architecture of bicuspid aortic valve (BAV) disease, including both single-marker and polygenic levels. The study identified a new risk locus and confirmed previously reported risk loci. Additionally, the study revealed that the transcriptome profile in endothelial cells plays a major role in the pathology of BAV.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Vivian Vij, Kerstin Piayda, Dominik Nelles, Steffen Gloekler, Roberto Galea, Monika Fuerholz, Bernhard Meier, Marco Valgimigli, Gilles O'Hara, Dabit Arzamendi, Victor Agudelo, Lluis Asmarats, Xavier Freixa, Eduardo Flores-Umanzor, Ole De Backer, Lars Sondergaard, Luis Nombela-Franco, Angela McInerney, Kasper Korsholm, Jens Erik Nielsen-Kudsk, Shazia Afzal, Tobias Zeus, Felix Operhalski, Boris Schmidt, Gilles Montalescot, Paul Guedeney, Xavier Iriart, Noelie Miton, Jacqueline Saw, Thomas Gilhofer, Laurent Fauchier, Egzon Veliqi, Felix Meincke, Nils Petri, Peter Nordbeck, Dmitrii Ognerubov, Evgeny Merkulov, Ignacio Cruz-Gonzalez, Rocio Gonzalez-Ferreiro, Deepak L. Bhatt, Alessandra Laricchia, Antonio Mangieri, Heyder Omran, Jan Wilko Schrickel, Josep Rodes-Cabau, Horst Sievert, Georg Nickenig, Alexander Sedaghat
Summary: This study investigated the risk factors for device-related thrombus (DRT) after left atrial appendage closure (LAAC). The results found that age, prior stroke/TIA, and spontaneous echocardiographic contrast (SEC) were associated with DRT, and implantation depth was a predictive factor. The occurrence of stroke/TIA was higher in patients with DRT.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Genetics & Heredity
Laura Wagenhaeuser, Vanessa Rickert, Claudia Sommer, Christoph Wanner, Peter Nordbeck, Simone Rost, Nurcan Ueceyler
Summary: This study investigated the relationship between X-chromosomal inactivation patterns and symptom severity in women with Fabry disease. The results indicate that XCI patterns do not reliably reflect the clinical phenotype of FD women, but blood often shows skewing of XCI patterns.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Reinoud E. Knops, Shari Pepplinkhuizen, Peter Paul H. M. Delnoy, Lucas V. A. Boersma, Juergen Kuschyk, Mikhael F. El-Chami, Hendrik Bonnemeier, Elijah R. Behr, Tom F. Brouwer, Stefan Kaab, Suneet Mittal, Anne Floor B. E. Quast, Willeke van der Stuijt, Lonneke Smeding, Jolien A. de Veld, Jan G. P. Tijssen, Nick R. Bijsterveld, Sergio Richter, Marc A. Brouwer, Joris R. de Groot, Kirsten M. Kooiman, Pier D. Lambiase, Petr Neuzil, Kevin Vernooy, Marco Alings, Timothy R. Betts, Frank A. L. E. Bracke, Martin C. Burke, Jonas S. S. G. de Jong, David J. Wright, Ward P. J. Jansen, Zachary Whinnett, Peter Nordbeck, Michael Knaut, Berit T. Philbert, Jurren M. van Opstal, Alexandru B. Chicos, Cornelis P. Allaart, Alida E. Borger van der Burg, Jose M. Dizon, Marc A. Miller, Dmitry Nemirovsky, Ralf Surber, Gaurav A. Upadhyay, Raul Weiss, Anouk de Weger, Arthur A. M. Wilde, Louise R. A. Olde Nordkamp
Summary: The subcutaneous implantable cardioverter-defibrillator (S-ICD) group had fewer complications and required less invasive interventions compared to the transvenous ICD (TV-ICD) group. Lead-related complications and systemic infections were more prevalent in the TV-ICD group.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Birgit Assmus, Christiane E. Angermann, Basil Alkhlout, Folkert W. Asselbergs, Steffen Schnupp, Jasper J. Brugts, Peter Nordbeck, Qian Zhou, Marie-Elena Brett, Greg Ginn, Philip B. Adamson, Michael Bohm, Stephan Rosenkranz
Summary: This study investigated the safety and effectiveness of PAP-guided remote patient management in heart failure patients. The results showed that the patients benefited during the post-implant follow-up, regardless of the presence or subtype of pulmonary hypertension at baseline.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Joachim Proff, Bela Merkely, Roland Papp, Corinna Lenz, Peter Nordbeck, Christian Butter, Juergen Meyhoefer, Michael Doering, Dean MacCarter, Katharina Ingel, Bernd Wolfarth, Thomas Thouet, Ulf Landmesser, Mattias Roser
Summary: This study aimed to identify criteria for selecting CRT patients who are likely to benefit from Closed Loop Stimulation (CLS) in cardiac resynchronization therapy. After analyzing the results of the responders and non-responders, the researchers recommend using CLS in heart failure patients with improved left ventricular ejection fraction (LVEF).
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Maximilian Gram, P. Albertova, V Schirmer, M. Blaimer, M. Gamer, M. J. Herrmann, P. Nordbeck, P. M. Jakob
Summary: Spin-lock based functional magnetic resonance imaging (fMRI) has the potential to directly detect neuronal activity and advance basic research in neuroscience. This study investigated the Rotary EXcitation (REX) effect through simulations, phantom, and in vivo experiments, discovering an empirical law for predicting optimal spin-lock pulse durations. The study also established experimental conditions for robust detection of ultra-weak magnetic field oscillations with compensation for static field inhomogeneities. Additionally, a novel concept for emulating brain activity using the MRI gradient system was presented, allowing validation of REX sequences under controlled conditions. Transmission of Rotary EXcitation (tREX) successfully detected magnetic field oscillations in the lower nano-Tesla range in brain tissue, opening up possibilities for biomagnetic field quantification.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Jonas Muentze, Kolja Lau, Markus Cybulla, Eva Brand, Tereza Cairns, Lora Lorenz, Nurcan Ueceyler, Claudia Sommer, Christoph Wanner, Peter Nordbeck
Summary: This study investigated therapy adherence and patient-reported outcomes in Fabry disease patients receiving migalastat treatment. The results showed that almost all patients demonstrated high therapy adherence, and there was improvement in pain and physical limitations during the treatment.
MOLECULAR GENETICS AND METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Benedikt Schrage, Jonas Sundermeyer, Stefan Blankenberg, Pascal Colson, Dennis Eckner, Matthias Eden, Ingo Eitel, Derk Frank, Norbert Frey, Tobias Graf, Paulus Kirchhof, Danny Kupka, Ulf Landmesser, Axel Linke, Nicolas Majunke, Norman Mangner, Octavian Maniuc, Johannes Mierke, Sven Moebius-Winkler, David A. Morrow, Marc Mourad, Peter Nordbeck, Martin Orban, Federico Pappalardo, Sandeep M. Patel, Matthias Pauschinger, Vittorio Pazzanese, Darko Radakovic, P. Christian Schulze, Clemens Scherer, Robert H. G. Schwinger, Carsten Skurk, Holger Thiele, Anubodh Varshney, Lukas Wechsler, Dirk Westermann
Summary: This study evaluates the association between timing of active left ventricular (LV) unloading and implantation of VA-ECMO with outcomes in patients with cardiogenic shock (CS). The results show that early active LV unloading is associated with a lower risk of 30-day mortality and a higher likelihood of successful weaning from ventilation, without increasing complications.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Dan Liu, Kai Hu, Lena Schregelmann, Clara Hammel, Bjorn Daniel Lengenfelder, Georg Ertl, Stefan Frantz, Peter Nordbeck
Summary: This study investigated the prognostic value of dynamic changes in left ventricular ejection fraction (EF) for cardiovascular outcomes in heart failure patients with reduced EF. The study found that improvement in EF is independently associated with longer survival and lower cardiovascular mortality and hospitalization rate in HFrEF patients. Elevated baseline NT-proBNP is identified as the strongest prognostic factor associated with increased cardiovascular events risk in HFrEF patients, regardless of EF improvement, age, sex, duration of HF, and other clinical risk factors.
Article
Cardiac & Cardiovascular Systems
Vivian Vij, Ignacio Cruz-Gonzalez, Roberto Galea, Kerstin Piayda, Dominik Nelles, Lara Vogt, Steffen Gloekler, Monika Furholz, Bernhard Meier, Lorenz Raber, Gilles O'Hara, Dabit Arzamendi, Victor Agudelo, Lluis Asmarats, Xavier Freixa, Eduardo Flores-Umanzor, Ole De Backer, Lars Sondergaard, Luis Nombela-Franco, Angela McInerney, Pablo Salinas, Kasper Korsholm, Jens Erik Nielsen-Kudsk, Shazia Afzal, Tobias Zeus, Felix Operhalski, Boris Schmidt, Gilles Montalescot, Paul Guedeney, Xavier Iriart, Noelie Miton, Jacqueline Saw, Thomas Gilhofer, Laurent Fauchier, Egzon Veliqi, Felix Meincke, Nils Petri, Peter Nordbeck, Rocio Gonzalez-Ferreiro, Deepak L. Bhatt, Alessandra Laricchia, Antonio Mangieri, Heyder Omran, Jan Wilko Schrickel, Josep Rodes-Cabau, Georg Nickenig, Horst Sievert, Alexander Sedaghat
Summary: This study analyzed 176 patients with device-related thrombus (DRT) after left atrial appendage closure (LAAC) and found that 14.2% experienced ischemic stroke or systemic embolism (SE). Of these events, 45.8% occurred within one month before or after DRT diagnosis. Patients with symptomatic DRT had lower left ventricular ejection fractions and higher rates of non-paroxysmal atrial fibrillation.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Benedikt Schrage, Jonas Sundermeyer, Benedikt Norbert Beer, Letizia Bertoldi, Alexander Bernhardt, Stefan Blankenberg, Jeroen Dauw, Zouhir Dindane, Dennis Eckner, Ingo Eitel, Tobias Graf, Patrick Horn, Paulus Kirchhof, Stefan Kluge, Axel Linke, Ulf Landmesser, Peter Luedike, Enzo Luesebrink, Norman Mangner, Octavian Maniuc, Sven Moebius Winkler, Peter Nordbeck, Martin Orban, Federico Pappalardo, Matthias Pauschinger, Michal Pazdernik, Alastair Proudfoot, Matthew Kelham, Tienush Rassaf, Hermann Reichenspurner, Clemens Scherer, Paul Christian Schulze, Robert H. G. Schwinger, Carsten Skurk, Marek Sramko, Guido Tavazzi, Holger Thiele, Luca Villanova, Nuccia Morici, Antonia Wechsler, Ralf Westenfeld, Ephraim Winzer, Dirk Westermann
Summary: This study aimed to evaluate the use of mechanical circulatory support (MCS) for the treatment of non-ischaemic cardiogenic shock (CS). The results showed that the use of MCS was associated with a lower 30-day mortality rate in patients with non-ischaemic CS. However, MCS treatment was also associated with more complications.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Agneta Virbickiene, Tomas Lapinskas, Christoph D. Garlichs, Stephan Mattecka, Radu Tanacli, Wolfgang Ries, Jan Torzewski, Franz Heigl, Christian Pfluecke, Harald Darius, Hueseyin Ince, Peter Nordbeck, Christian Butter, Andreas Schuster, Steffen Mitzner, Olivija Dobiliene, Ahmed Sheriff, Sebastian Kelle
Summary: This study investigated the ability of morphological features of infarcted myocardium to detect acute left ventricular dysfunction and predict left ventricular functional recovery after three months in patients with acute ST-segment elevation myocardial infarction (STEMI). The results showed that the CMR tissue characteristics of myocardial injury are correlated with the magnitude of left ventricular dysfunction during the acute stage of STEMI, and the area-at-risk predicts improvement in left ventricular ejection fraction and global longitudinal strain, while the myocardial salvage index is a sensitive marker of left ventricular global circumferential strain recovery at three months follow-up after STEMI.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Henrike Andresen, Nikolaos Pagonas, Marius Eisert, Daniel Patschan, Peter Nordbeck, Ivo Buschmann, Benjamin Sasko, Oliver Ritter
Summary: This study investigated the outcome of septuagenarians and octogenarians after ICD generator exchange. The results showed that the mortality rate was higher in septuagenarians and octogenarians after ICD generator exchange, while the mortality related to arrhythmia was relatively low.
Meeting Abstract
Cardiac & Cardiovascular Systems
Dan Liu, Kai Hu, Kolja Lau, Jonas Muntze, Octavian Maniuc, Peter Nordbeck
