Article
Cardiac & Cardiovascular Systems
Binh Y. Nguyen, Fangchao Zhou, Pablo Binder, Wei Liu, Susanne S. Hille, Xiaojing Luo, Min Zi, Hongyuan Zhang, Antony Adamson, Fozia Z. Ahmed, Sam Butterworth, Elizabeth J. Cartwright, Oliver J. Mueller, Kaomei Guan, Elizabeth M. Fitzgerald, Xin Wang
Summary: This study demonstrates that prolylcarboxylpeptidase has a protective effect on the heart by controlling myocardial angiotensin II levels, which can alleviate angiotensin II-induced hypertrophic remodeling and fibrosis. Furthermore, the combination of prolylcarboxylpeptidase overexpression and the antihypertensive drug losartan provides more effective protection against angiotensin II-induced cardiac dysfunction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Sukka Santosh Reddy, Heena Agarwal, Anant Jaiswal, Kumaravelu Jagavelu, Madhu Dikshit, Manoj Kumar Barthwal
Summary: The study found that macrophage p47phox plays a role in hypertensive cardiac remodeling, with its deficiency potentially leading to worsened cardiac dysfunction, hypertrophy, and increased interstitial fibrosis. Further experiments revealed elevated expression of M2 macrophage markers in KO mice, suggesting a restrictive role of p47phox in anti-inflammatory signaling during cardiac remodeling.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Xiaopei Cui, Guopin Pan, Ye Chen, Xiaosun Guo, Tengfei Liu, Jing Zhang, Xiaofan Yang, Mei Cheng, Haiqing Gao, Fan Jiang
Summary: Pathological vascular remodeling plays a critical role in various vascular diseases, and activation of p53 may help counteract vascular remodeling and reduce inflammation. Currently, targeting the p53 pathway through pharmacological interventions could be a novel strategy to prevent the development of vascular remodeling.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Drew Theobald, Anand R. Nair, Srinivas Sriramula, Joseph Francis
Summary: Toll-like receptor 4 (TLR4) plays a crucial role in the innate immune response and cardiovascular diseases. This study found that cardiomyocyte-specific deletion of TLR4 provides protection against hypertension, cardiac hypertrophy, and remodeling. The results showed that in mice with cardiomyocyte-specific TLR4 knockdown, angiotensin II-induced hypertension and cardiac hypertrophy were attenuated, myocardial fibrosis was reduced, and cardiac function was improved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yuantong Tian, Jun Luo, Qian Xu, Yueyang Liu, Ruiping Cai, Ming-Sheng Zhou
Summary: The study found that the use of LEC significantly reduced Ang II-induced cardiac hypertrophy and fibrosis, as well as cardiac macrophage infiltration, improved endothelium-dependent relaxation, and slightly reduced systolic blood pressure. In addition, LEC also decreased the expression of inflammatory and fibrotic factors in the heart, preventing the phosphorylation of ERK1/2 and c-Jun-N-terminal kinase induced by Ang II.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Chemistry, Multidisciplinary
Ajit Magadum, Neha Singh, Ann Anu Kurian, Mohammad Tofael Kabir Sharkar, Nishat Sultana, Elena Chepurko, Keerat Kaur, Magdalena M. Zak, Yoav Hadas, Djamel Lebeche, Susmita Sahoo, Roger Hajjar, Lior Zangi
Summary: Heart failure remains a major issue globally, with cardiac hypertrophy and fibrosis being key factors. The regulator Pip4k2c, associated with mTORC1, plays a role in these processes. Studies show that deleting Pip4k2c does not affect embryonic cardiac development, but leads to increased rates of CH, CF, and sudden death in adult mice. Upregulating Pip4k2c improves heart function, reverses CH and CF, and enhances survival through inhibiting TGF beta 1 via specific pathways. Loss-and-gain-of-function studies identify Pip4k2c as a potential therapeutic target for CF, CH, and HF, utilizing modRNA as an effective gene therapy approach.
Article
Multidisciplinary Sciences
Ruoqing Cai, Caitlin M. Tressler, Menglin Cheng, Kanchan Sonkar, Zheqiong Tan, Santosh Kumar Paidi, Vinay Ayyappan, Ishan Barman, Kristine Glunde
Summary: The study investigates the remodeling of the extracellular matrix (ECM) in the premetastatic niche and its association with lung metastasis. The findings suggest that primary breast tumors can prime the lungs for metastasis by altering ECM structure and enzymatic activities, facilitating the formation of a suitable microenvironment for cancer cell dissemination.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Tao Li, Bin Liu, Xiu-Ju Luo, Jun Peng
Summary: This study demonstrates that VPO1 promotes right ventricular remodeling in pulmonary arterial hypertension (PAH) by catalyzing hypochlorous acid (HOCl) production and activating the ERK signaling pathway. VPO1 may serve as a potential therapeutic target for PAH.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Cardiac & Cardiovascular Systems
Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser
Summary: The study suggests that metabolic syndrome in obese pregnant women may lead to pathological cardiac remodeling, increasing the risk of chronic heart disorders.
Review
Physiology
Ke-Xue Li, Zi-Chao Wang, Jeremiah Ong'Achwa Machuki, Meng-Zhen Li, Yu-Jie Wu, Ming-Kai Niu, Kang-Ying Yu, Qing-Bo Lu, Hai-Jian Sun
Summary: Hypertension is a leading cause of cardiovascular morbidity and mortality, and curcumin, a phytochemical derived from turmeric, shows promise in treating hypertension-induced vascular remodeling.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jia-Hui Hong, Hai-Gang Zhang
Summary: To compensate for increased workload, the heart undergoes structural changes and remodeling, which can ultimately lead to heart failure if it becomes pathological and uncontrolled. While many signaling pathways involved in cardiac remodeling have been studied, the complete mechanism is still not fully understood, which hinders effective treatment and drug development. Transcription factors, as gene regulators, play a critical role in cardiac remodeling by controlling various cellular activities. This review summarizes the regulation of fetal gene reprogramming, energy metabolism, apoptosis, autophagy in cardiomyocytes, and myofibroblast activation in cardiac fibroblasts by transcription factors, with a focus on their potential roles in the development and prognosis of cardiac remodeling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mareomi Hamada, Akiyoshi Ogimoto, Takashi Otani, Kiyotaka Ohshima, Tamami Kono, Yuta Watanabe, Tatsuro Tasaka, Shuntaro Ikeda
Summary: The study found that the progression of LVH in hypertension did not lead to abnormal LV systolic function, but afterload mismatch was observed in patients with LVHF. Exhaustion of preload reserve led to afterload mismatch in group III.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Volha A. Golubeva, Lisa E. Dorn, Christopher J. Gilbert, Charles P. Rabolli, Anindhya Sundar Das, Vishmi S. Wanasinghe, Roland Veress, Dmitry Terentyev, Federica Accornero
Summary: This study reveals that the loss of m(6)A binding protein YTHDF2 leads to cardiac dysfunction and controls the stability of m(6)A-modified MYZAP messenger RNA, thus playing a novel role in maintaining cardiac homeostasis.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Biology
Maria Laggner, Felicitas Oberndorfer, Bahar Golabi, Jonas Bauer, Andreas Zuckermann, Philipp Hacker, Irene Lang, Nika Skoro-Sajer, Christian Gerges, Shahrokh Taghavi, Peter Jaksch, Michael Mildner, Hendrik Jan Ankersmit, Bernhard Moser
Summary: This study investigated the gene expression profiles of hypertrophic and regenerated right hearts of two subtypes of pulmonary hypertension (PH) patients. The findings revealed unique gene alteration signatures in different PH subtypes, as well as the identification of a profibrotic factor, early growth response 1 (EGR1), in both subtypes. These findings may contribute to the identification of therapeutic candidates for PH patients who are not eligible for surgical treatment.
Article
Cardiac & Cardiovascular Systems
Elena Grakova, Sergey N. Shilov, Kristina Kopeva, Ekaterina N. Berezikova, Anna A. Popova, Maria N. Neupokoeva, Elena T. Ratushnyak, Alexander T. Teplyakov
Summary: In women without previous cardiovascular diseases, matrix metalloproteinases (MMP)-2 and 9 and the gene polymorphisms of MMP-2 (rs243865) and MMP-9 (rs3918242) are associated with adverse course of anthracycline-induced cardiotoxicity (AIC) during 24 months.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wesam Bassiouni, John M. Seubert, Richard Schulz
Summary: This study investigated the effect of staurosporine on MMP-2 activity and its role in AIF cleavage. The results showed that although staurosporine rapidly increased MMP-2 activity, the release of AIF may be independent of the proteolytic activities of MMP-2 or calpain.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Laura Gallego-Alberto, Rosa Romero-Moreno, Maria Marquez-Gonzalez, Richard Schulz, Isabel Cabrera, Javier Olazaran-Rodriguez, Andres Losada
Summary: Compassion plays a crucial role in understanding the psychological well-being of dementia caregivers. The Caregiving Compassion Scale (CCS) is a valid and reliable tool for assessing caregivers' compassion, which is significantly associated with their emotional health.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Zabed Mahmud, Svetlana Tikunova, Natalya Belevych, Corey Wagg, Pavel Zhabyeyev, Philip B. Liu, David V. Rasicci, Richard Schulz, Christopher M. Yengo, Gavin Y. Oudit, Gary D. Lopaschuk
Article
Public, Environmental & Occupational Health
Norma L. Bautista-Lopez, Richard Schulz
Summary: Infection with Trypanosoma cruzi parasite can cause Chagas cardiomyopathy, the leading cause of heart failure in certain parts of America. However, there is currently no widely accepted biomarker to track the disease's progression. Research suggests that matrix metalloproteinases (MMPs) may play a role in Chagas cardiomyopathy, leading to a growing interest in using MMP blood levels as diagnostic and prognostic indicators. The lack of consensus on the best method for evaluating MMPs has resulted in incongruent and poorly comparable data in Chagas patients.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Zabed Mahmud, Svetlana Tikunova, Natalya Belevych Belevych, Cory Wagg, Pavel Zhabyeyev, Philip Liu, David Rasicci, Richard Schulz, Christopher Yengo, Gavin Oudit, Gary Lopaschuk, Peter Reiser, Jonathan Davis, Peter Hwang
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Gerontology
Esther M. Friedman, Scott R. Beach, Richard Schulz
Summary: Identifying the factors associated with out-of-pocket (OOP) health care spending is crucial for the financial security of older adults. This paper examines the relationship between caregiving arrangements and OOP spending using data from the Health and Retirement Study. While there is no overall relationship between family caregiving and OOP health care costs, having a family caregiver is associated with higher spending on prescription medications for those with Medicare HMO insurance.
JOURNAL OF APPLIED GERONTOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
DiyaaElDin Ashour, Sabine Rebs, Panagiota Arampatzi, Antoine-Emmanuel Saliba, Jan Dudek, Richard Schulz, Ulrich Hofmann, Stefan Frantz, Clement Cochain, Katrin Streckfuss-Boemeke, Gustavo Campos Ramos
Summary: This study found that T cells in the heart and its draining lymph nodes undergo clonal expansion and exhibit an up-regulated pro-inflammatory transcription signature, including increased interferon-gamma (IFN-gamma) production, with aging. Similarly, myocardial cell populations also show increased IFN-gamma responsiveness with age, along with inflammatory and metabolic shifts typically seen in heart failure.
CARDIOVASCULAR RESEARCH
(2023)
Article
Geriatrics & Gerontology
Hansol Kim, Scott R. Beach, Esther M. Friedman, Heidi Donovan, Richard Schulz
Summary: This study aimed to evaluate the risk factors for poor mental and physical health among adult caregivers in the US. It found that intensive caregiving had adverse effects on both men and women, while being employed was beneficial for both genders. For women, not working, having children, and high-intensity caregiving were most detrimental to mental health. Among men, not working with children in the household posed the highest risk for adverse mental health effects.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Wesam Bassiouni, Robert Valencia, Zabed Mahmud, John M. Seubert, Richard Schulz
Summary: During myocardial ischemia and reperfusion (IR) injury, oxidative stress activates MMP-2, leading to the degradation of mitochondrial Mfn-2, impairing mitochondrial function and enhancing inflammation.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Meeting Abstract
Biophysics
Kevin Y. Mak, M. Rafid Feisal, Zabed Mahmud, Philip B. Liu, Laiji Li, Shu Y. Luo, Olivier Julien, Richard Schulz, Barbara J. Ballermann, Peter M. Hwang
BIOPHYSICAL JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Bridgette Hartley, Wesam Bassiouni, Richard Schulz, Olivier Julien
Summary: Ischemic heart disease is a major cause of global human mortality, and one form of it is ischemia-reperfusion injury. This review focuses on the biological roles, intracellular localization, proteolytic targets, and inhibitors of diverse proteases in cardiomyocytes after ischemia-reperfusion injury. Understanding the activation and involvement of these proteases in ischemic heart disease is crucial for developing new therapeutic strategies.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Meeting Abstract
Geriatrics & Gerontology
Scott Beach, Sara Czaja, Richard Schulz, David Loewenstein, Peter Lichtenberg
INNOVATION IN AGING
(2022)
Article
Geriatrics & Gerontology
David W. Hancock, Sara Czaja, Richard Schulz
Summary: This study examines the relationship between distress among informal caregivers and potentially harmful behaviors. The findings suggest that caregiver preparedness is negatively correlated with distress, which in turn reduces the risk of harmful behaviors. This highlights the importance of caregiver intervention research.
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Simon Doll, Richard Schulz, Lukas Schneider, Viviane Benzin, Markus Enzweiler, Hendrik P. A. Lensch
Summary: This paper presents an object-centric 3D object detection framework based on the key idea of DETR. It operates on a limited number of 3D object queries and utilizes a decoder-only transformer architecture trained on set-based loss. The proposed method, SpatialDETR, incorporates attention-based classification and bounding box estimation, as well as a novel geometric positional encoding for fusing multi-view information. Extensive experiments demonstrate the potential of global attention and achieve state-of-the-art performance.
COMPUTER VISION, ECCV 2022, PT XXXIX
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Wesam Bassiouni, John M. Seubert, Richard Schulz