期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 45, 页码 13323-13326出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201507894
关键词
crystal structure; metallo-base pairs; RNA; silver; X-ray analysis
资金
- Strategic Research Foundation from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [S1201015]
- [24245037]
- Grants-in-Aid for Scientific Research [15K13734, 14J03684] Funding Source: KAKEN
Metallo-base pairs have been extensively studied for applications in nucleic acid-based nanodevices and genetic code expansion. Metallo-base pairs composed of natural nucleobases are attractive because nanodevices containing natural metallo-base pairs can be easily prepared from commercially available sources. Previously, we have reported a crystal structure of a DNA duplex containing (THgT)-T-II base pairs. Herein, we have determined a high-resolution crystal structure of the second natural metallo-base pair between pyrimidine bases (CAgC)-C-I formed in an RNA duplex. One Ag-I occupies the center between two cytosines and forms a (CAgC)-C-I base pair through N3Ag(I)N3 linear coordination. The (CAgC)-C-I base pair formation does not disturb the standard A-form conformation of RNA. Since the (CAgC)-C-I base pair is structurally similar to the canonical Watson-Crick base pairs, it can be a useful building block for structure-based design and fabrication of nucleic acid-based nanodevices.
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