Article
Cardiac & Cardiovascular Systems
Suzanne Boursalie, Ciorsti Macintyre, John L. Sapp, Chris Gray, Amir Abdelwahab, Martin Gardner, David Lee, Kara Matheson, Ratika Parkash
Summary: Significant sex disparities exist in the utilization of primary prevention ICDs between men and women in a contemporary Canadian population.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Antonio Rapacciuolo, Saverio Iacopino, Antonio D'Onofrio, Antonio Curnis, Ennio C. Pisano, Mauro Biffi, Paolo Della Bella, Antonio Dello Russo, Fabrizio Caravati, Gabriele Zanotto, Valeria Calvi, Giovanni Rovaris, Gaetano Senatore, Daniele Nicolis, Matteo Santamaria, Massimo Giammaria, Giampiero Maglia, Antonio Duca, Giuseppe Ammirati, Salvo Andrea Romano, Marcello Piacenti, Eduardo Celentano, Giovanni Bisignani, Paola Vaccaro, Gennaro Miracapillo, Matteo Bertini, Gerardo Nigro, Daniele Giacopelli, Alessio Gargaro, Caterina Bisceglia
Summary: Although mortality rates were similar across different patient groups, patients with permanent AF and suboptimal CRT had a higher risk of appropriate shocks compared to those with sinus rhythm or AF patients with optimal CRT.
Article
Cardiac & Cardiovascular Systems
Antonio Rapacciuolo, Saverio Iacopino, Antonio D'Onofrio, Antonio Curnis, Ennio C. Pisano, Mauro Biffi, Paolo Della Bella, Antonio Dello Russo, Fabrizio Caravati, Gabriele Zanotto, Valeria Calvi, Giovanni Rovaris, Gaetano Senatore, Daniele Nicolis, Matteo Santamaria, Massimo Giammaria, Giampiero Maglia, Antonio Duca, Giuseppe Ammirati, Salvo Andrea Romano, Marcello Piacenti, Eduardo Celentano, Giovanni Bisignani, Paola Vaccaro, Gennaro Miracapillo, Matteo Bertini, Gerardo Nigro, Daniele Giacopelli, Alessio Gargaro, Caterina Bisceglia
Summary: In heart failure patients with permanent atrial fibrillation, mortality rates were similar between those receiving cardiac resynchronization therapy and those with sinus rhythm. However, patients with suboptimal CRT (<98%) had a higher risk of appropriate defibrillation shocks compared to sinus rhythm patients or AF patients with >=98% CRT.
Article
Multidisciplinary Sciences
Tomonori Takeda, Atsuhiro Tsubaki, Yoshifumi Ikeda, Ritsushi Kato, Kazuki Hotta, Tatsuro Inoue, Sho Kojima, Risa Kanai, Yoshitaka Terazaki, Ryusei Uchida, Shigeru Makita
Summary: This study found that preoperative frailty is associated with higher readmission rates among patients with cardiac implantable electrical devices (CIED). The frailty group had significantly higher readmission rates compared to the non-frailty group. The modified frailty index (mFI) can be used to predict readmission among CIED patients.
Article
Chemistry, Analytical
Dominic A. M. J. Theuns, Sumant P. Radhoe, Jasper J. Brugts
Summary: Management of heart failure remains challenging despite advances in medical and pharmacological treatments. Strategies to reduce hospitalizations and readmission rates are urgently needed. Remote monitoring of high-risk patients, including those with cardiac implantable electronic devices, has shown promise in clinical practice for early identification of worsening heart failure.
Article
Cardiac & Cardiovascular Systems
Maiwand Farouq, Cecilia Rorsman, Sofia Marinko, David Mortsell, Uzma Chaudhry, Lingwei Wang, Pyotr G. Platonov, Rasmus Borgquist
Summary: This study aimed to compare the mortality rates and mode of death in patients with nonischemic cardiomyopathy who were treated with either primary preventive CRT-D or CRT-P. The results showed that CRT-D was associated with higher 5-year survival, especially in patients aged <60 years.
Article
Cardiac & Cardiovascular Systems
Alwin Zweerink, Daniel J. Friedman, Igor Klem, Peter M. van de Ven, Caitlin Vink, P. Stefan Biesbroek, Steen M. Hansen, Raymond J. Kim, Albert C. van Rossum, Brett D. Atwater, Cornelis P. Allaart, Robin Nijveldt
Summary: The strain assessment of the septum (SLICE-ESSsep) provides a prognostic measure for clinical outcome after CRT, with positive SLICE-ESSsep patients having lower risk. Class II patients with a positive SLICE-ESSsep have similar clinical outcomes to those with a class I indication for CRT.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Antonio D'Onofrio, Francesco Solimene, Leonardo Calo, Valeria Calvi, Miguel Viscusi, Donato Melissano, Vitantonio Russo, Antonio Rapacciuolo, Andrea Campana, Fabrizio Caravati, Paolo Bonfanti, Gabriele Zanotto, Edoardo Gronda, Antonello Vado, Vittorio Calzolari, Giovanni Luca Botto, Massimo Zecchin, Luca Bontempi, Daniele Giacopelli, Alessio Gargaro, Luigi Padeletti
Summary: An algorithm was developed and validated to predict heart failure hospitalizations using remote monitoring data from implanted defibrillators. The study found that two-thirds of first post-implant heart failure hospitalizations could be predicted timely with a low false alert rate.
Article
Cardiac & Cardiovascular Systems
Jan Stassen, Xavier Galloo, Kensuke Hirasawa, Nina Ajmone Marsan, Pieter van der Bijl, Victoria Delgado, Jeroen J. Bax
Summary: The study showed that cardiac resynchronization therapy (CRT) can improve significant tricuspid regurgitation (TR) in a substantial proportion of patients with heart failure (HF), leading to better long-term outcomes.
Article
Cardiac & Cardiovascular Systems
Francisco Leyva, Abbasin Zegard, Peysh Patel, Berthold Stegemann, Howard Marshall, Peter Ludman, Jamie Walton, Joseph de Bono, Giuseppe Boriani, Tian Qiu
Summary: The optimal timing of CRT implantation remains unknown. In this study of 64,968 patients, delays in time from first HFH to CRT implantation were associated with worse long-term clinical outcomes. Each year from the first HFH to CRT implantation was associated with a higher risk of total mortality and HFH. The best outcomes after CRT were observed in patients with no previous HFHs and in those undergoing implantation during their first HFH.
Article
Cardiac & Cardiovascular Systems
Ewa Jedrzejczyk-Patej, Michal Mazurek, Agnieszka Kotalczyk, Wiktoria Kowalska, Aleksandra Konieczny-Kozielska, Jonasz Kozielski, Tomasz Podolecki, Mariola Szulik, Adam Sokal, Oskar Kowalski, Zbigniew Kalarus, Beata Sredniawa, Radoslaw Lenarczyk
Summary: The study compared long-term mortality and predictors in patients with de novo cardiac resynchronization therapy defibrillators (CRT-D) versus those who upgraded from an implantable cardioverter-defibrillator (ICD) to CRT-D. It found that mortality was significantly higher in patients who upgraded from ICD to CRT-D compared to those who had de novo CRT-D implantations, with nearly 45% mortality within 4.5 years. A new CRT scale (Creatinine; Remodelling; Threshold for NYHA) was proposed to aid in predicting survival following CRT upgrade.
Article
Cardiac & Cardiovascular Systems
Maarten Pauwelyn, Sebastian Ingelaere, Ruben Hoffmann, Johan Vijgen, Georges H. Mairesse, Ivan Blankoff, Yves Vandekerckhove, Jean-Benoit le Polain de Waroux, Bert Vandenberk, Rik Willems
Summary: The experience and outcome of patients over 80 years old implanted with an ICD in Belgium were described. The study found that 11% of patients died within the first year after ICD implantation. Age, oncological history, secondary prevention, and a lower left ventricular ejection fraction (LVEF) were associated with increased one-year mortality. Age, low LVEF, atrial fibrillation, centre volume, and oncological history were indicative of higher overall mortality.
JOURNAL OF GERIATRIC CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hilary C. Bowman, Kevin M. Shannon, Reshma Biniwale, Jeremy P. Moore
Summary: In adult congenital heart disease (ACHD) patients, overall dysfunction and reintervention rates of cardiac implantable electronic devices (CIEDs) are similar between transvenous (TV) and epicardial (EPI) approaches, but lead dysfunction is more severe in EPI devices.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Caio V. Spaggiari, Sergio F. de Siqueira, Camila Parente de Oliveira, Cinthya I. Guiarao I. Gomes, Maria Janieire de N. N. Alves, Martino Martinelli Filho
Summary: This study aimed to evaluate the feasibility of physiological pacing rate (PPR) in cardiac resynchronization therapy (CRT) patients. The results showed that PPR improved functional capacity in mildly symptomatic CRT patients, but further confirmation is needed through controlled randomized trials.
Article
Cardiac & Cardiovascular Systems
Massimiliano Marini, Lodovica Videsott, Chiara Francesca Dalle Fratte, Andrea Francesconi, Eleonora Bonvicini, Silvia Quintarelli, Marta Martin, Fabrizio Guarracini, Alessio Coser, Pier Paolo Benetollo, Roberto Bonmassari, Giuseppe Boriani
Summary: This retrospective study assessed the clinical and economic outcomes of remote monitoring (RM) vs. standard monitoring (SM) in patients with cardiac implantable electronic devices (CIED). The study found that RM can reduce mortality rate and cardiovascular-related hospitalizations, and it can also result in cost savings for both payers and hospitals.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Pardeep S. Jhund, Scott D. Solomon, Kieran F. Docherty, Hiddo J. L. Heerspink, Inder S. Anand, Michael Bohm, Vijay Chopra, Rudolf A. de Boer, Akshay S. Desai, Junbo Ge, Masafumi Kitakaze, Bela Merkley, Eileen O'Meara, Morten Shou, Sergey Tereshchenko, Subodh Verma, Pham Nguyen Vinh, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, Olof Bengtsson, Anna Maria Langkilde, Mikaela Sjostrand, John J. McMurray
Summary: The study found that dapagliflozin had consistent safety and efficacy in patients with heart failure and reduced ejection fraction regardless of kidney function status, and it could slow down the decline in eGFR. This effect was observed in patients with and without diabetes.
Article
Cardiac & Cardiovascular Systems
David D. Berg, Kieran F. Docherty, Naveed Sattar, Petr Jarolim, Paul Welsh, Pardeep S. Jhund, Inder S. Anand, Vijay Chopra, Rudolf A. de Boer, Mikhail N. Kosiborod, Jose C. Nicolau, Eileen O'Meara, Morten Schou, Ann Hammarstedt, Anna-Maria Langkilde, Daniel Lindholm, Mikaela Sjostrand, John J. V. McMurray, Marc S. Sabatine, David A. Morrow
Summary: Baseline high-sensitivity cardiac troponin T levels and increase in hsTnT over 1 year are associated with worse clinical outcomes. Dapagliflozin consistently reduces the primary endpoint risk, regardless of baseline hsTnT levels.
Review
Cardiac & Cardiovascular Systems
Alexander G. Hajduczok, Samer N. Muallem, Matthew S. Nudy, Ami L. DeWaters, John P. Boehmer
Summary: In HF patients, remote monitoring using implantable devices did not reduce mortality or CV and HF hospitalizations. Studies suggest that right ventricular/pulmonary pressure monitoring may lower hospitalization rates in HF patients.
HEART FAILURE REVIEWS
(2022)
Review
Cardiac & Cardiovascular Systems
Alexander G. Hajduczok, Samer N. Muallem, Matthew S. Nudy, Ami L. DeWaters, John P. Boehmer
Summary: The study found that remote monitoring using implantable devices did not significantly reduce mortality, cardiovascular events, or heart failure hospitalizations compared to standard care, but monitoring right ventricular/pulmonary pressure may reduce HF hospitalizations.
HEART FAILURE REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Ramesh Wariar, Gezheng Wen, Caroline Jacobsen, Stephen Ruble, John P. Boehmer
Summary: This study found that claims data can be used for the development of heart failure diagnosis with acceptable accuracy. The diagnostic performance of claims data was equivalent to that of study data, and there was good agreement between claims diagnostic codes and study event adjudication.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
John G. F. Cleland, Michael R. Bristow, Nicholas Freemantle, Brian Olshansky, Daniel Gras, Leslie Saxon, Luigi Tavazzi, John Boehmer, Stefano Ghio, Arthur M. Feldman, Jean-Claude Daubert, David de Mets
Summary: Cardiac resynchronization therapy-pacemaker has varying effects on patients with heart failure, depending on different patient characteristics, such as body surface area and use of beta-blockers. However, QRS duration and morphology cannot independently predict treatment outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Adrian F. Hernandez, Nancy M. Albert, Larry A. Allen, Rezwan Ahmed, Viktoria Averina, John P. Boehmer, Martin R. Cowie, Christopher Chien, Marie Galvao, Liviu Klein, Brian Kwan, Carolyn S. P. Lam, Stephen B. Ruble, Craig M. Stolen, Kenneth Stein
Summary: The clinical integration and safety of the HeartLogic multisensor index and alerts in heart failure (HF) care were evaluated. The study found that alert cases prompted augmentation of HF medications and were associated with faster recovery of the HeartLogic Index. Although there were a few serious adverse events related to alert-prompted medication change, the overall implementation of HeartLogic alert management was deemed safe in HF care. The levels of NTproBNP significantly decreased during the treatment process.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Kenneth C. Bilchick, Yongfei Wang, Jeptha P. Curtis, Ramin Shadman, Todd F. Dardas, Inder Anand, Lars H. Lund, Ulf Dahlstrom, Ulrik Sartipy, Wayne C. Levy
Summary: The study evaluated the impact of predicted annual mortality, left ventricular ejection fraction, and the probability of arrhythmic death on post-generator change survival in patients with implantable cardioverter-defibrillators.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
James P. Curtain, Carly Adamson, Toru Kondo, Jawad Butt, Akshay S. Desai, Faiez Zannad, Jean L. Rouleau, Luis E. Rohde, Lars Kober, Inder S. Anand, Dirk J. van Veldhuisen, Michael R. Zile, Martin P. Lefkowitz, Scott D. Solomon, Milton Packer, Mark C. Petrie, Pardeep S. Jhund, John J. McMurray
Summary: This study examined the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) in patients with heart failure and their relationship with mortality. The results showed that VT/VF events were uncommon but strongly associated with mortality in heart failure patients. These events seem to be markers of disease severity rather than risk of sudden death.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Toru Kondo, Karola S. Jering, Pardeep S. Jhund, Inder S. Anand, Akshay S. Desai, Carolyn S. P. Lam, Aldo P. Maggioni, Felipe A. Martinez, Milton Packer, Mark C. Petrie, Marc A. Pfeffer, Margaret M. Redfield, Jean L. Rouleau, Dirk J. van Veldhuisen, Faiez Zannad, Michael R. Zile, Scott D. Solomon, John J. V. McMurray
Summary: This study validated a simple risk model for predicting stroke risk in heart failure patients with preserved ejection fraction but without atrial fibrillation. The results showed that the risk for stroke increased with increasing risk score, suggesting the use of anticoagulation therapy in high-risk patients.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Toru Kondo, Pooja Dewan, Inder S. Anand, Akshay S. Desai, Milton Packer, Michael R. Zile, Marc A. Pfeffer, Scott D. Solomon, William T. Abraham, Sanjiv J. Shah, Carolyn S. P. Lam, Pardeep S. Jhund, John J. V. Mcmurray
Summary: By analyzing LVEF data in HF patients, we found that there is a threshold between 40% and 50% LVEF, below which the pattern of patient characteristics changes, and event rates begin to increase. This provides support for the current prognosis-based definition of HF with mildly reduced ejection fraction based on upper LVEF thresholds.
Article
Cardiac & Cardiovascular Systems
Mingming Yang, Toru Kondo, Jawad H. Butt, William T. Abraham, Inder S. Anand, Akshay S. Desai, Lars Kober, Milton Packer, Marc A. Pfeffer, Jean L. Rouleau, Marc S. Sabatine, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Pardeep S. Jhund, John J. McMurray
Summary: Patients with heart failure who have a history of stroke are at a high risk of subsequent cardiovascular events, regardless of ejection fraction. This study investigated the prevalence of stroke history in patients with heart failure and found that they had more vascular comorbidity and worse heart failure compared to those without stroke history. Targeting underutilization of guideline-recommended treatments might improve outcomes in this high-risk population.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jana P. Lovell, Kevin Bermea, Jinsheng Yu, Sylvie Rousseau, Charles D. Cohen, Aashik Bhalodia, Marcelle Dina Zita, Richard D. Head, Roger S. Blumenthal, Rami Alharethi, Julie Damp, John Boehmer, Jeffrey Alexis, Dennis M. Mcnamara, Garima Sharma, Luigi Adamo
Summary: This study used serum proteomic analysis to characterize the pathophysiology of peripartum cardiomyopathy (PPCM). It found that PPCM is a distinct disease entity that is characterized by dysregulation of inflammation-related pathways and cholesterol metabolism-related anti-inflammatory pathways.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
John Boehmer, Andrew J. Sauer, Roy Gardner, Craig M. Stolen, Brian Kwan, Ramesh Wariar, Stephen Ruble
Summary: The PREEMPT-HF study aims to explore the association between the HeartLogic multisensor index and HF readmissions. Through medical records evaluation at 6 months and a final in-clinic visit at 12 months, data on all-cause hospitalizations and HF outpatient visits are collected. The results of this study can help refine the clinical use of HeartLogic and improve patient outcomes.
Article
Cardiac & Cardiovascular Systems
Alessandro Capucci, Jorge A. Wong, Michael R. Gold, John Boehmer, Rezwan Ahmed, Brian Kwan, Pramodsingh H. Thakur, Yi Zhang, Paul W. Jones, Jeffrey S. Healey
Summary: This study aims to investigate the temporal association between changes in physiologic heart failure sensors, atrial fibrillation progression, and clinical heart failure in patients with cardiac resynchronization therapy implantable defibrillators. The results showed that device-measured heart failure indicators worsened before the onset of atrial fibrillation, while clinical heart failure deterioration only became apparent after atrial fibrillation occurred.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)