Review
Peripheral Vascular Disease
Giuseppe Mancia, Sverre E. Kjeldsen, Reinhold Kreutz, Atul Pathak, Guido Grassi, Murray Esler
Summary: Several hypertension guidelines have downgraded beta-blockers as first-choice drugs for hypertension treatment, but this may not be justified by available evidence. Beta-blockers effectively lower blood pressure and have solid documentation in preventing cardiovascular complications. Suspected inconveniences of beta-blockers may have been overemphasized, while patients with certain conditions can benefit from beta-blocker therapy. Beta-blockers are pathophysiologically appropriate for hypertension treatment due to the activation of the sympathetic nervous system. They also have favorable effects on various clinical conditions that coexist with hypertension. However, selecting beta-blockers with documented effects is important in guidelines.
Article
Pharmacology & Pharmacy
Palang Chotsiri, Joel Tarning, Richard M. Hoglund, James A. Watson, Nicholas J. White
Summary: This study characterizes the pharmacokinetics and electrocardiographic effects of chloroquine and azithromycin, and finds that chloroquine prolongs the cardiac intervals while azithromycin has minimal additional effect. There is no drug-drug interaction between chloroquine and azithromycin.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Physiology
Xinle Zou, Xiaoan Wu, Kevin J. Sampson, Henry M. Colecraft, H. Peter Larsson, Robert S. Kass
Summary: This study investigates the potential of compounds ML277 and R-L3 as treatment options for LQT1 and LQT5 mutant channels. The results show that ML277 and R-L3 can enhance mutant channel currents and slow down current deactivation, suggesting their potential utility in specific LQTS therapeutics.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pediatrics
Shuo Wang, Runmei Zou, Hong Cai, Cheng Wang
Summary: This study aimed to investigate the predictive value of heart rate and blood pressure on the prognosis of postural tachycardia syndrome (POTS) in children. The results showed that multiple indicators of heart rate and blood pressure were associated with the prognosis of POTS in children. The predictive value of the four combined indicators was better than that of the single indicators.
FRONTIERS IN PEDIATRICS
(2022)
Article
Peripheral Vascular Disease
Thomas Weber, Athanase D. Protogerou, Mohsen Agharazii, Antonis Argyris, Sola Aoun Bahous, Jose R. Banegas, Ronald K. Binder, Jacques Blacher, Andrea Araujo Brandao, Juan J. Cruz, Kathrin Danninger, Cristina Giannatasio, Auxiliadora Graciani, Bernhard Hametner, Piotr Jankowski, Yan Li, Alessandro Maloberti, Christopher C. Mayer, Barry J. McDonnell, Carmel M. McEniery, Marco Antonio Mota Gomes, Annelise Machado Gomes, Maria Lorenza Muiesan, Janos Nemcsik, Anna Paini, Enrique Rodilla, Aletta E. Schutte, Petros P. Sfikakis, Dimitrios Terentes-Printzios, Alexandre Vallee, Charalambos Vlachopoulos, Lisa Ware, Ian Wilkinson, Robert Zweiker, James E. Sharman, Siegfried Wassertheurer
Summary: Central systolic blood pressure (cSBP) is more closely associated with hypertension-mediated organ damage and prognosis than brachial systolic blood pressure. This study investigated the 24-hour profiles of brachial and central SBP in untreated adults, providing reference values and analyzing daytime-nighttime variability. The findings have potential implications for refining hypertension diagnosis and management.
Article
Multidisciplinary Sciences
Andy Schumann, Karl-Juergen Baer
Summary: This study provides a database of high-resolution biological signals to describe the effect of healthy aging on cardiovascular regulation, demonstrating the decline of heart rate variability with increasing age.
Article
Peripheral Vascular Disease
Han-Kyul Kim, Rie Ishizawa, Ayumi Fukazawa, Zhongyun Wang, Ursa Bezan Petric, Ming Chang Hu, Scott A. Smith, Masaki Mizuno, Wanpen Vongpatanasin
Summary: This study found that SGLT2i can reduce blood pressure in hypertensive patients and attenuate renal sympathetic nerve activity and skeletal muscle reflex activity. Additionally, the study found that SGLT2i has no impact on glycemic control. These findings have important clinical implications for preventing hypertension and hypertensive heart disease in young prehypertensive individuals.
Article
Medicine, General & Internal
Piotr Sobieraj, Maciej Sinski, Jacek Lewandowski
Summary: The study found that elevated resting heart rate remains an important independent cardiovascular risk factor that is unrelated to the reduction of systolic blood pressure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Christine Sailer, Hannah Edelmann, Cullen Buchanan, Pedro Giro, Matthew Babcock, Christine Swanson, Melanie Spotts, Margaret Schulte, Ashley Pratt-Cordova, Greg Coe, Mark Beindorff, Robert L. Page, Amrut Ambardekar, Jay D. Pal, Wendy Kohrt, Eugene Wolfel, Justin S. Lawley, Takashi Tarumi, William K. Cornwell
Summary: CF-LVAD implantation in patients with advanced heart failure results in modest improvements in autonomic tone, but persistent reductions in cardiac baroreceptor sensitivity. Exercise-induced increases in blood pressure are blunted post-LVAD implantation.
CIRCULATION-HEART FAILURE
(2021)
Article
Peripheral Vascular Disease
Massimo Nardone, Catherine F. Notarius, Mark B. Badrov, Philip J. Millar, John S. Floras
Summary: This study compared the transduction of sympathetic firing into blood pressure in treated patients with heart failure with reduced ejection fraction (HFrEF) and healthy controls. The results showed that treated HFrEF patients had lower sympathetic-BP transduction, even when muscle sympathetic nerve activity (MSNA) was not elevated, and this transduction diminished further with disease progression.
Article
Cardiac & Cardiovascular Systems
Maengjo Kim, Dan Ye, C. S. John Kim, Wei Zhou, David J. Tester, John R. Giudicessi, Michael J. Ackerman
Summary: This study using iPSC-CM provides further evidence that the common variant p.D85N-KCNE1 in combination with environmental factors such as QT prolonging drugs and female sex leads to arrhythmia.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Gyu Chul Oh, Seokyung An, Hae-Young Lee, Hyun-Jai Cho, Eun-Seok Jeon, Sang Eun Lee, Jae-Joong Kim, Seok-Min Kang, Kyung-Kuk Hwang, Myeong-Chan Cho, Shung Chull Chae, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Sue K. Park, Sang Hong Baek
Summary: In patients hospitalized for heart failure with reduced ejection fraction (HFrEF), changes in blood pressure and heart rate were assessed, and a modified reverse shock index (mRSI) was found to be a significant predictor of early outcomes. The mRSI could be used as a tool to assess patient status and guide physicians in treating patients with HFrEF.
Article
Peripheral Vascular Disease
Abby H. Chopoorian, Amr Wahba, Jorge Celedonio, Victor Nwazue, Emily C. Smith, Emily M. Garland, Sachin Paranjape, Luis E. Okamoto, Bonnie K. Black, Italo Biaggioni, Satish R. Raj, Alfredo Gamboa
Summary: The study found that patients with PoTS have significantly reduced flow-mediated dilation compared with healthy controls, suggesting that PoTS is characterized by endothelial dysfunction in conduit arteries.
Article
Peripheral Vascular Disease
Philippe Gosse, Antoine Cremer, Ajay J. Kirtane, Melvin D. Lobo, Manish Saxena, Joost Daemen, Yale Wang, Johannes Stegbauer, Michael A. Weber, Josephine Abraham, Kazuomi Kario, Sripal Bangalore, Lisa Claude, Yuyin Liu, Michel Azizi
Summary: The study found that baseline nighttime systolic blood pressure and its variability can predict the blood pressure response to renal denervation in patients with hypertension, which is helpful in identifying potential responders.
Article
Endocrinology & Metabolism
Delia Almeida Gonzalez, Maria del Cristo Rodriguez-Perez, Manuel Fuentes Ferrer, Francisco Javier Cuevas Fernandez, Itahisa Mercelino Rodriguez, Antonio Cebrera de Leon
Summary: This study aimed to evaluate the cardiovascular protective role of irisin in the general population. A cross-sectional analysis was conducted on a large sample, and the results showed that irisin was associated with factors such as heart rate, blood pressure, body mass index, and lifestyle. These findings suggest that irisin plays a protective role in maintaining cardiometabolic health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
