Article
Peripheral Vascular Disease
Daniela Carnevale, Lorenzo Carnevale, Sara Perrotta, Fabio Pallante, Agnese Migliaccio, Daniele Iodice, Marialuisa Perrotta, Giuseppe Lembo
Summary: Chronic exposure to high blood pressure leads to vascular remodeling, dysfunction, and inflammation through the interaction between vascular and immune cells. Establishing a reliable experimental model of the vascular-immune interface is crucial for developing effective therapies.
Review
Immunology
Zhiyuan Zhang, Nan Zhang, Jing Yu, Wenting Xu, Jiameng Gao, Xin Lv, Zongmei Wen
Summary: This article summarizes the functional expression of podoplanin in the immune system, its contribution to inflammatory diseases, and discusses its potential as a therapeutic target.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Peripheral Vascular Disease
Damiano Rizzoni, Carolina De Ciuceis, Piotr Szczepaniak, Pierre Paradis, Ernesto L. Schiffrin, Tomasz J. Guzik
Summary: Low-grade inflammation and oxidative stress are crucial in the development of hypertension and related organ damage. Innate immune cells and adaptive immunity play a role in vascular inflammation, while effector T lymphocytes may promote hypertension and microvascular remodeling. Immune mechanisms contribute to oxidative stress and target organ damage in hypertension.
Article
Medicine, Research & Experimental
Mingan Li, Lin Zhou, Xiaohui Sun, Yunqi Yang, Ce Zhang, Tian Wang, Fenghua Fu
Summary: Dopamine is a crucial neurotransmitter that not only plays a role in maintaining physiological function and neurological diseases, but also acts as an immunomodulatory mediator. Immune cells express dopamine receptors, synthesize and secrete dopamine to regulate immune function. dopamine receptors agonists or antagonists can improve immune system dysfunction through various signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Robert L. Medcalf, Charithani B. Keragala
Summary: The fibrinolytic system, led by the protease plasmin, plays a crucial role in removing fibrin deposits and blood clots, as well as modulating immune cell behavior and pathogen defense mechanisms. Phylogenetic studies suggest that plasmin may have originated as an immune-modifying protease before evolving to its fibrin-removing capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Magdalena Grazul, Pawel Kwiatkowski, Kacper Hartman, Anna Kilanowicz, Monika Sienkiewicz
Summary: Efficient functionality of the immune system is crucial in fighting against infectious diseases and modern common diseases connected with inflammation. Essential oils possess valuable properties such as antimicrobial, antioxidant, anti-inflammatory, and immunostimulating effects. Some constituents of essential oils can stimulate the proliferation of immune cells, and the interaction between essential oil components and recommended drugs should be explored for medical use.
Review
Biochemistry & Molecular Biology
Jessica Aijia Liu, Jing Yu, Chi Wai Cheung
Summary: Pain can be induced by tissue injuries, diseases, and infections. The interactions between the peripheral nervous system (PNS) and immune system play crucial roles in pain sensitization processes. Immune cells release mediators that activate nociceptors and promote sensitization, while also contributing to PNS repair and pain resolution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Luana Tripodi, Chiara Villa, Davide Molinaro, Yvan Torrente, Andrea Farini
Summary: The interaction between the immune system and skeletal muscle plays a crucial role in inflammatory muscle diseases and dystrophic conditions, affecting muscle regeneration and pathogenesis.
Review
Medicine, General & Internal
Susanna Campo, Antonio Lacquaniti, Domenico Trombetta, Antonella Smeriglio, Paolo Monardo
Summary: This review focuses on the pathways related to immune system dysfunction and inflammation in hemodialysis patients. Thrombogenicity and oxidative stress are considered important characteristics of biocompatibility in hemodialysis. Immune dysfunction and inflammation are closely linked with uremic toxins in hemodialysis patients, affecting clinical outcomes and mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Guzel Rafikova, Svetlana Piatnitskaia, Elena Shapovalova, Svyatoslav Chugunov, Victor Kireev, Daria Ialiukhova, Azat Bilyalov, Valentin Pavlov, Julia Kzhyshkowska
Summary: The immuno-compatibility of ceramic implants, which depends on the interaction with immune cells, is still insufficiently understood and requires intensive experimental research. This review summarizes the state of the art in ceramic implants, including their mechanical properties, chemical modifications, surface structures, and shapes. The gaps in knowledge are identified, and the possibilities for further research using advanced quantitative technologies are outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Junliang Jiang, Miaoxian Yang, Mi Tian, Zhong Chen, Lei Xiao, Ye Gong
Summary: Major depressive disorder (MDD) is a prevalent psychiatric disorder, and the COVID-19 pandemic has worsened its prevalence. Oxytocin, an endogenous neuropeptide, has emerged as a potential therapeutic option due to its anxiolytic and antidepressant properties. This review examines the interactions between oxytocin, the immune system, and depressive disorder, and speculates on the potential roles of oxytocin and the central immune system in treating emotional disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Gara Arteaga-Henriquez, Jorge Lugo-Marin, Laura Gisbert, Imanol Setien-Ramos, Monica Martinez-Gallo, Ricardo Pujol-Borrell, Josep Antoni Ramos-Quiroga
Summary: Individuals with Autism spectrum disorder (ASD) exhibit differences in immune cell levels and inflammation markers compared to typically developing (TD) controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Elena Charpentier, Sandie Menard, Catherine Marques, Antoine Berry, Xavier Iriart
Summary: This review examines the host's immune response in Pneumocystis pneumonia, discussing the differences in immune reactions and pathophysiology between immunocompetent and immunodeficient hosts.
Article
Immunology
Yurou Wang, Minmin Zeng, Lin Xia, Chinasa Valerie Olovo, Zhaoliang Su, Ying Zhang
Summary: The bacterial type VI secretion system (T6SS) is used by bacteria to infect the host, but bacteria have developed strategies to evade the host immune system. T6SS and its secreted effector proteins play an important role in the interaction between bacteria and host immune system, and can be used to develop vaccines. This review mainly discusses the impact of T6SS effector proteins on inflammation, autophagy, and apoptosis in the host immune system, as well as T6SS-based vaccines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Katalin Lumniczky, Nathalie Impens, Gemma Armengol, Serge Candeias, Alexandros G. Georgakilas, Sabine Hornhardt, Olga A. Martin, Franz Roedel, Doerthe Schaue
Summary: Ionizing radiation interacts with the immune system in complex ways, potentially altering immune fitness and accelerating immune senescence at low doses. However, low dose radiation therapy has beneficial effects in certain diseases, providing relief from pain and inflammation.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Immunology
Andrea D. Gloor, Gerald J. Berry, Jorg J. Goronzy, Cornelia M. Weyand
Summary: Giant cell arteritis and Takayasu arteritis are autoimmune and autoinflammatory vasculitides that are associated with age and show differences in pathogenesis and immunopathology.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Medicine, General & Internal
Rohit R. Jadhav, Bin Hu, Zhongde Ye, Khushboo Sheth, Xuanying Li, William J. Greenleaf, Cornelia M. Weyand, Joerg J. Goronzy
Summary: This study identified disease-associated epigenetic marks in CD4 T cells of RA patients, revealing differences in chromatin structure and the significance of reduced accessibility of super-enhancers.
Article
Biochemical Research Methods
Amy F. Chen, Benjamin Parks, Arwa S. Kathiria, Benjamin Ober-Reynolds, Jorg J. Goronzy, William J. Greenleaf
Summary: NEAT-seq is a tri-omics tool that allows profiling nuclear protein abundance, chromatin accessibility, and the transcriptome in single cells, enabling investigation of regulatory mechanisms. This technique helps to validate the regulatory activity of TFs and internally validate the impact of SNPs on gene regulation using NEAT-seq data.
Review
Immunology
Ke Jin, Simon Parreau, Kenneth J. Warrington, Matthew J. Koster, Gerald J. Berry, Joerg J. Goronzy, Cornelia M. Weyand
Summary: Vasculitides, a group of diseases causing vascular damage, result in loss of immune privilege and uncontrolled inflammation. Deficiencies in immunosuppressive regulatory T cells (Treg) play a crucial role, with different vasculitides being affected by distinct mechanisms. Exploring the mechanisms behind insufficient immunosuppression and vascular inflammation holds promise for novel therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Cornelia M. Weyand, Joerg J. Goronzy
Summary: Giant cell arteritis is an autoimmune disease that affects medium and large arteries, causing inflammation, obstruction, and aneurysm formation. The disease progresses through various steps, involving both innate and adaptive immune responses, leading to the infiltration of immune cells into the arterial wall and the development of tissue-damaging macrophages. Understanding these immune mechanisms provides opportunities for prevention and management of this devastating disease.
CIRCULATION RESEARCH
(2023)
Review
Immunology
Cornelia M. Weyand, Bowen Wu, Tao Huang, Zhaolan Hu, Jorg J. Goronzy
Summary: Mitochondria play crucial roles in cell metabolism, cell death pathways, cytoplasmic signaling networks, cellular stress responses, and nuclear gene expression. They are particularly important for immune cells, as they are involved in immune responses, autoimmunity, and tissue inflammation. Dysfunction in mitochondria has been linked to the development and progression of rheumatoid arthritis, affecting T cells during different stages of the disease.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Immunology
Qingxiang Liu, Yanyan Zheng, Jorg J. Goronzy, Cornelia M. Weyand
Summary: Immune aging is a complex process that makes the host more susceptible to cancer, infection, and insufficient tissue repair. T cells, under extreme proliferative pressure, undergo genetic and epigenetic changes, lack mitochondrial fitness, and fail to maintain proteostasis, leading to a shift from host protection to host injury. Understanding T cell aging contributes to the knowledge of autoimmune conditions and provides opportunities for immunomodulatory therapy by restoring the intactness of aging T cells.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Immunology
Huimin Zhang, Rohit R. Jadhav, Wenqiang Cao, Isabel N. Goronzy, Tuantuan V. Zhao, Jun Jin, Shozo Ohtsuki, Zhaolan Hu, Jose Morales, William J. Greenleaf, Cornelia M. Weyand, Jorg J. Goronzy
Summary: Immune aging is a combination of cellular defects and low-inflammatory state. TCR activation in older adults accelerates remodeling of the epigenome and induces transcription factor networks favoring effector cell differentiation. Reduced HELIOS expression directs T cell fate decisions toward inflammatory effector cells that infiltrate tissue in older adults.
Article
Cell Biology
Luis I. Prieto, Ines Sturmlechner, Jorg J. Goronzy, Darren J. Baker
Summary: Harnessing the immunogenic potential of senescent cells can enhance antitumor immunity in certain contexts.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Wenqiang Cao, Ines Sturmlechner, Huimin Zhang, Jun Jin, Bin Hu, Rohit R. Jadhav, Fengqin Fang, Cornelia M. Weyand, Jorg J. Goronzy
Summary: Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, indicating the presence of mechanisms that preferentially protect naive CD4+ T cells during aging. The study reveals that TRIB2 is more abundant in naive CD4+ T cells and suppresses AKT activation to prevent quiescence exit. Loss of TRIB2 leads to increased AKT activity, accelerated proliferation, and differentiation in response to IL-7. Transcription of TRIB2 is controlled by lineage-determining transcription factors ThPOK and RUNX3. Deletion of Zbtb7b (encoding ThPOK) and Cbfb (obligatory RUNT cofactor) attenuates the difference in lymphopenia-induced proliferation between naive CD4+ and CD8+ cells. In older adults, decreased expression of ThPOK and TRIB2 in naive CD4+ T cells causes loss of naivety. These findings highlight the importance of TRIB2 in regulating T cell homeostasis and provide insights into the differential resilience of CD8+ T cells to age-related changes.
Article
Cell Biology
Shozo Ohtsuki, Chenyao Wang, Ryu Watanabe, Hui Zhang, Mitsuhiro Akiyama, Melanie C. Bois, Joseph J. Maleszewski, Kenneth J. Warrington, Gerald J. Berry, Jorg J. Goronzy, Cornelia M. Weyand
Summary: Loss of function of inhibitory immune checkpoints can lead to autoimmune disease, such as giant cell arteritis (GCA). In this study, a defective CD155-CD96 immune checkpoint was found in GCA patients, resulting in the retention of CD155 in the endoplasmic reticulum (ER) of macrophages. Antigen-presenting cells with low CD155 expression induced the expansion of tissue invasive CD4+CD96+ T cells that released interleukin-9 (IL-9). The dysregulated immune response caused vessel wall destruction, which could be suppressed by anti-IL-9 antibodies in a GCA mouse model.
CELL REPORTS MEDICINE
(2023)
Review
Immunology
Yanyan Zheng, Qingxiang Liu, Jorg J. Goronzy, Cornelia M. Weyand
Summary: Evidence suggests that immune aging is one of the mechanisms leading to autoimmunity. Older adults have compromised immune responses but accumulate aged T cells, B cells, and myeloid cells. These changes can contribute to the development of autoimmune diseases through chronic inflammation and tissue damage. Dysfunctional mitochondria and lysosomes play a role in driving pathogenic T cells and macrophages in diseases like rheumatoid arthritis and giant cell arteritis. Recognizing immune aging as a risk factor for autoimmunity can lead to new immunomodulatory therapies targeting malfunctioning mitochondria and lysosomes.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Jun Jin, Yunmei Mu, Huimin Zhang, Ines Sturmlechner, Chenyao Wang, Rohit R. Jadhav, Qiong Xia, Cornelia M. Weyand, Jorg J. Goronzy
Summary: In older adults, T cells contribute to chronic inflammation by releasing mtDNA due to increased expression of CISH. CISH targets an essential component of V-ATPase for degradation, impairing lysosomal function and leading to amphisomal release. Silencing CISH in older adults' T cells restores lysosomal activity and reduces inflammatory response.
Article
Endocrinology & Metabolism
Zhaolan Hu, Tuantuan Zhao, Tao Huang, Shozo Ohtsuki, Ke Jin, Isabel N. Goronzy, Bowen Wu, Matthew P. Abdel, Jacob W. Bettencourt, Gerald J. Berry, Jorg J. Goronzy, Cornelia M. Weyand
Summary: Hu and Zhao et al. have discovered a mechanism by which tissue macrophages in autoimmune diseases adapt to nutrient stress. This mechanism involves the cytokine CCL18 and the transcription factor RFX5, which regulate metabolic adaptation and antigen-presenting function in tissue inflammation.
Review
Geriatrics & Gerontology
Tuantuan V. Zhao, Yuki Sato, Jorg J. Goronzy, Cornelia M. Weyand
Summary: Aging of the immune system leads to a decline in host protection against cancer and infection. T cell aging is associated with the accumulation of aging-related phenotypes, some of which contribute to tissue inflammation in autoimmune diseases. Recent studies have shown that T cell aging is a risk factor for autoimmune diseases and is directly linked to the breakdown of T cell tolerance and tissue inflammation.
FRONTIERS IN AGING
(2022)