Article
Radiology, Nuclear Medicine & Medical Imaging
Gilles Soulat, Michael B. Scott, Ashitha Pathrose, Kelly Jarvis, Haben Berhane, Bradley Allen, Ryan Avery, Alejandro Roldan Alsate, Cynthia K. Rigsby, Michael Markl
Summary: This study investigated the relationships between hemodynamic parameters and longitudinal changes in aortic dimensions in patients with bicuspid aortic valve (BAV) and repaired coarctation using four-dimensional (4D) flow magnetic resonance imaging (MRI). The results showed that peak velocity was associated with the progression of narrowing in the repaired coarctation.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2022)
Review
Medicine, General & Internal
Arturo Evangelista Masip, Laura Galian-Gay, Andrea Guala, Angela Lopez-Sainz, Gisela Teixido-Tura, Aroa Ruiz Munoz, Filipa Valente, Laura Gutierrez, Ruben Fernandez-Galera, Guillem Casas, Alejandro Panaro, Alba Marigliano, Marina Huguet, Teresa Gonzalez-Alujas, Jose Rodriguez-Palomares
Summary: Multimodality imaging is crucial for the diagnosis, follow-up, and surgical management of patients with bicuspid aortic valve (BAV). Transthoracic echocardiography is the first line imaging for BAV diagnosis, while computed tomography and magnetic resonance can improve the accuracy of aorta size measurement and evaluate aortic functional properties and blood flow patterns.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Elena Giulia Milano, Sandra Neumann, Froso Sophocleous, Giulia Pontecorboli, Stephanie L. Curtis, Radwa Bedair, Massimo Caputo, Giovanni Battista Luciani, Chiara Bucciarelli-Ducci, Giovanni Biglino
Summary: This study investigated the ventriculo-arterial coupling changes in bicuspid aortic valve (BAV) patients with concomitant aortic coarctation (COA) using cardiovascular magnetic resonance imaging and wave intensity analysis. Results showed that COA affects VA coupling in BAV patients, with those who have repaired COA exhibiting higher wave speed velocity even after successful surgical correction.
FRONTIERS IN PEDIATRICS
(2022)
Article
Engineering, Biomedical
Monica Emendi, Francesco Sturla, Ram P. Ghosh, Matteo Bianchi, Filippo Piatti, Francesca R. Pluchinotta, Daniel Giese, Massimo Lombardi, Alberto Redaelli, Danny Bluestein
Summary: This study successfully reproduced the hemodynamics of congenital bicuspid aortic valve using a fully coupled fluid-structure interaction model and MRI data, providing new insights into the risk of BAV patients and revealing information not directly attainable from MRI.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Guala, Arturo Evangelista, Gisela Teixido-Tura, Lucia La Mura, Lydia Dux-Santoy, Aroa Ruiz-Munoz, Filipa Valente, Laura Galian-Gay, Laura Gutierrez, Teresa Gonzalez-Alujas, Ilaria Dentamaro, Kevin M. Johnson, Oliver Wieben, Augusto Sao Aviles, Ignacio Ferreira-Gonzalez, Jose F. Rodriguez-Palomares
Summary: The study found that the length of aortic valve fusion is related to aortic dilation and flow abnormalities in BAV patients, potentially providing a pathophysiological link to aortic dilation.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Malgorzata Polacin, Julia Geiger, Barbara Burkhardt, Fraser M. Callaghan, Emanuela Valsangiacomo, Christian Kellenberger
Summary: When estimating the severity of aortic regurgitation using 4D flow, the best reproducibility and agreement with 2DPC measurements can be expected at the level of the pulmonary arteries. Measurements at the aortic valve or below the aortic valve may underestimate aortic regurgitation.
BMC MEDICAL IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yucong Zheng, Kai Yang, Xiuyu Chen, Rui Li, Guohai Su, Gang Yin, Kai Wang, Minjie Lu, Shihua Zhao
Summary: Myocardial fibrosis (MF) is more common in aortic insufficiency (AI) patients with bicuspid aortic valve (BAV) than with tricuspid aortic valve (TAV), and it is a predictor of clinical adverse events. Late gadolinium enhancement (LGE) was found to be an independent predictor of clinical adverse outcome in AI+BAV patients with MF during a median follow-up of 4.7 years.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Cardiac & Cardiovascular Systems
Chiara Trenti, Paul W. M. Fedak, James A. White, Julio Garcia, Petter Dyverfeldt
Summary: This study investigated wall shear stress (WSS) during the whole cardiac cycle in patients with bicuspid aortic valve (BAV) and aortic regurgitation. The results showed that BAV patients with aortic regurgitation had elevated oscillatory shear index (OSI) in the ascending aorta compared with other BAV patients without valve disease. This suggests that OSI could serve as a specific haemodynamic marker for BAV patients at higher risk of aortic complications.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Marek J. Jasinski, Karol Miszalski-Jamka, Kinga Kosiorowska, Radoslaw Gocol, Izabella Wenzel-Jasinska, Grzegorz Bielicki, Mikolaj Berezowski, Marceli Lukaszewski, Andrzej Kansy, Marek A. Deja
Summary: This study evaluated the efficacy of external annuloplasty and subcommissural annuloplasty for repairing BAV, finding that EA was associated with lower transvalvular gradients and larger aortic valve area compared to SCA.
BMC CARDIOVASCULAR DISORDERS
(2021)
Review
Cardiac & Cardiovascular Systems
Ali Fatehi Hassanabad, Melissa A. King, Elena Di Martino, Paul W. M. Fedak, Julio Garcia
Summary: This article presents the latest research on the biomechanics of bicuspid aortic valve (BAV), including definitions and classifications, mechanisms driving valve disease, and the impact of abnormal flow patterns on aortic dilatation. The role of cardiac magnetic resonance imaging in assessing and managing patients with BAV and bicuspid aortopathy is also discussed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Correction
Cardiac & Cardiovascular Systems
Marek J. Jasinski, Karol Miszalski-Jamka, Kinga Kosiorowska, Radoslaw Gocol, Izabella Wenzel-Jasinska, Grzegorz Bielicki, Mikolaj Berezowski, Marceli Lukaszewski, Andrzej Kansy, Marek A. Deja
Summary: A correction to this paper is available through the original article.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Michelle S. Lim, Rachael Cordina, Irina Kotchetkova, David S. Celermajer
Summary: In adults with repaired CoA, patients with CoA-BAV are more likely to require cardiovascular reintervention compared to those with CoA alone. Patients with CoA-BAV have a higher prevalence of 'CoA-site' and 'AV/AscAo' complications.
Article
Cardiac & Cardiovascular Systems
Alejandro Perez-Casares, Audrey Dionne, Kimberlee Gauvreau, Ashwin Prakash
Summary: Aortic stiffness in BAV patients declines at a significantly steeper rate compared to CTD patients, particularly in the ascending aorta. However, the distensibility of the descending aorta declines at a similar rate in both groups, providing new insights into the differing pathogenesis of aortopathy in BAV and CTD patients.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Review
Cardiac & Cardiovascular Systems
Jiaxing Jason Qin, Peyman Obeidy, Mustafa Gok, Alireza Gholipour, Stuart M. M. Grieve
Summary: The current intervention guidelines for BAV-associated AAo dilatation are not accurate predictors of clinical outcomes. This review examines the relationship between WSS and aortopathy in the BAV population, aiming to identify better biomarkers for risk stratification. The review includes 26 studies that demonstrate the elevated WSS magnitude and circumferential WSS in BAV patients, highlighting the potential of WSS as a valid biomarker for BAV aortopathy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)