Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters

Discovery and Application of Doubly Quaternized Cinchona-Alkaloid-Based Phase-Transfer Catalysts

(2014) Bangping Xiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Efficient “On Water” Catalyst-Free Nucleophilic Addition Reactions Using Difluoroenoxysilanes: Dramatic Fluorine Effects

(2014) Jin-Sheng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Tamura Cycloadditions

(2014) Francesco Manoni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Highly enantioselective Michael addition of 3-arylthio- and 3-alkylthiooxindoles to nitroolefins catalyzed by a simple cinchona alkaloid derived phosphoramide

(2014) Wei-Ming Gao et al.   CHEMICAL COMMUNICATIONS

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Mukaiyama-Michael Reactions withtrans-2,5-Diarylpyrrolidine Catalysts: Enantioselectivity Arises from Attractive Noncovalent Interactions, Not from Steric Hindrance

(2014) Eeva K. Kemppainen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Formal [3+3] Cycloaddition of an Azomethine Ylide with 3-Indolylmethanol: Enantioselective Construction of a Six-Membered Piperidine Framework

(2014) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic Enantioselective Strecker Reaction of Imines Containing a Thiazole Moiety by Using a Cinchona-Based Squaramide Catalyst

(2014) Hai-Xiao He et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3′-Disubstituted Oxindoles and Their Derivatives

(2014) Chongyang Wu et al.   ORGANIC LETTERS

QSAR analysis of the catalytic asymmetric ethylation of ketone using physical steric parameters of chiral ligand substituents

(2014) Huayin Huang et al.   TETRAHEDRON

Recent advances in asymmetric fluorination and fluoroalkylation reactions via organocatalysis

(2014) Jin-Hong Lin et al.   TETRAHEDRON LETTERS

Organocatalytic [4+2] addition reactions via tetraenamine intermediate

(2014) Julian Stiller et al.   Chemical Science

Highly stereoselective construction of adjacent tetrasubstituted carbon stereogenic centres via an organocatalytic Mukaiyama-aldol reaction of monofluorinated silyl enol ethers to isatins

(2014) Yun-Lin Liu et al.   Organic Chemistry Frontiers

Recent Advances in Catalytic Asymmetric Friedel-Crafts Reactions with Prochiral Trifluoromethylated Compounds

(2013) hanrong He et al.   ACTA CHIMICA SINICA

Highly Enantioselective Construction of 3-Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl α-Fluorinatedgem-Diols toN-Benzyl Isatins

(2013) Ibrayim Saidalimu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Tandem Approach to Spirocyclic Oxindoles Featuring Adjacent Spiro-Stereocenters

(2013) Yun-Lin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly diastereo- and enantioselective [3+2] annulation of isatin-derived Morita–Baylis–Hillman carbonates with trifluoropyruvate catalyzed by tertiary amines

(2013) Neng-Jun Zhong et al.   CHEMICAL COMMUNICATIONS

Highly Stereoselective Olefin Cyclopropanation of Diazooxindoles Catalyzed by a C2-Symmetric Spiroketal Bisphosphine/Au(I) Complex

(2013) Zhong-Yan Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Copper(I)-Catalyzed Azide–Alkyne Cycloaddition to Quaternary Oxindoles

(2013) Feng Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversifying complexity

(2013) Indrajeet Sharma et al.   Nature Chemistry

Organocatalytic enantioselective Strecker reaction of cyclic trifluoromethyl-ketoimines

(2013) Hexin Xie et al.   TETRAHEDRON LETTERS

Enantioselective Strecker-type reaction between azomethine imines and trimethylsilyl cyanide catalyzed by a cinchona alkaloid-derived thiourea bearing multiple hydrogen-bonding donors

(2013) Nai-Kai Li et al.   RSC Advances

Catalytic Asymmetric Construction of Stereogenic Carbon Centers that Feature agem-Difluoroalkyl Group

(2013) Yun-Lin Liu et al.   Asian Journal of Organic Chemistry

Highly Enantioselective Organocatalytic Asymmetric Mukaiyama-aldol Reaction of Difluoroenoxysilanes withβ,γ-Unsaturatedα-Ketoesters

(2012) Yunlin Liu et al.   ACTA CHIMICA SINICA

Organocatalytic, Highly Enantioselective Vinylogous Mukaiyama-Michael Reaction of Acyclic Dienol Silyl Ethers

(2012) Vaishali Gupta et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of 3-Fluoro-3-aryl Oxindoles: Direct Enantioselective α Arylation of Amides

(2012) Linglin Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083

(2012) Fa-Guang Zhang et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

(2012) Yun-Lin Liu et al.   CHEMICAL COMMUNICATIONS

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

(2012) Renato Dalpozzo et al.   CHEMICAL SOCIETY REVIEWS

Asymmetric Michael Addition of N-Boc-Protected Oxindoles to Nitroalkenes Catalyzed by a Chiral Secondary Amine

(2012) Chuan Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric catalytic Mannich-type reaction of hydrazones with difluoroenoxysilanes using imidazoline-anchored phosphine ligand–zinc(ii) complexes

(2012) Zhiliang Yuan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

ChiralN,N′-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions

(2011) XiaoHua Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly Enantioselective Catalytic Synthesis of Functionalized Chiral Diazoacetoacetates

(2011) Xinfang Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles

(2011) Ke Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Core-Structure-Oriented Asymmetric Organocatalytic Substitution of 3-Hydroxyoxindoles: Application in the Enantioselective Total Synthesis of (+)-Folicanthine

(2011) Chang Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindoles having Two Contiguous Quaternary Centers

(2011) Fangrui Zhong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hexafluorobenzene: a powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

(2011) Alessandra Lattanzi et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles

(2011) Yun-Lin Liu et al.   CHEMICAL COMMUNICATIONS

The Vinylogous Aldol and Related Addition Reactions: Ten Years of Progress†

(2011) Giovanni Casiraghi et al.   CHEMICAL REVIEWS

Enantioselective Organocatalytic Synthesis of Fluorinated Molecules

(2011) Guillem Valero et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral 1,2,3-Triazoliums as New Cationic Organic Catalysts with Anion-Recognition Ability: Application to Asymmetric Alkylation of Oxindoles

(2011) Kohsuke Ohmatsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Highly Functionalized Chiral 3,3′-Disubstituted Oxindoles via an Organocatalytic Enantioselective Michael Addition of Nitroalkanes to Indolylidenecyanoacetates

(2011) Lu Liu et al.   ORGANIC LETTERS

Chiral Counteranion Synergistic Organocatalysis under High Temperature: Efficient Construction of Optically Pure Spiro[cyclohexanone-oxindole] Backbone

(2011) Yu-Bao Lan et al.   ORGANIC LETTERS

A Hg(ClO4)2·3H2O Catalyzed Sakurai–Hosomi Allylation of Isatins and Isatin Ketoimines Using Allyltrimethylsilane

(2011) Zhong-Yan Cao et al.   ORGANIC LETTERS

Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of β-Amino-α,α-difluoro Carbonyl Compounds

(2011) Wataru Kashikura et al.   ORGANIC LETTERS

Noncovalent Organocatalysis: A Powerful Tool for the Nucleophilic Epoxidation of α-Ylideneoxindoles

(2011) Chiara Palumbo et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Strecker Reaction of Di- and Trifluoromethyl Ketoimines. Remarkable Fluorine Effect

(2011) Yun-Lin Liu et al.   ORGANIC LETTERS

Cinchona alkaloid-based phosphoramide catalyzed highly enantioselective Michael addition of unprotected 3-substituted oxindoles to nitroolefins

(2011) Miao Ding et al.   Chemical Science

Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action

(2011) Ke Shen et al.   Chemical Science

Organocatalyzed Conjugate Addition of Carbonyl Compounds to Nitrodienes/Nitroenynes and Synthetic Applications

(2010) Sébastien Belot et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Enantioselective Strecker Synthesis of α-Quaternary α-Trifluoromethyl Amino Acids

(2010) Dieter Enders et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly Enantioselective Catalytic Benzoyloxylation of 3-Aryloxindoles Using Chiral VAPOL Calcium Phosphate

(2010) Zuhui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Phosphinyl Phosphoramide-A Chiral Brønsted Acid Motif for the Direct Asymmetric N,O-Acetalization of Aldehydes

(2010) Sreekumar Vellalath et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving the Atom Efficiency of the Wittig Reaction by a “Waste as Catalyst/Co-catalyst” Strategy

(2010) Jun-Jie Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cinchona Alkaloid/TiIV-Catalyzed Enantioselective Enamine-Trifluoropyruvate Condensation-Cyclization Reaction and Its Application to Drug-like Heterocycles

(2010) Shinichi Ogawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral Thiophosphoramidate-Catalyzed Asymmetric Michael Addition of Ketones to Nitro Olefins

(2010) Aidang Lu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recent Progress in the Chemically Catalyzed Enantioselective Synthesis of Cyanohydrins

(2010) Wentao Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Vinylogous Aldol Reaction of Silyloxy Furans with a Chiral Organic Salt

(2010) Ravi P. Singh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Asymmetric Synthesis of Substituted 3-Hydroxy-2-oxindoles via Morita−Baylis−Hillman Reaction

(2010) Yun-Lin Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A facile method for the synthesis of oxindole based quaternary α-aminonitriles via the Strecker reaction

(2010) Yun-Lin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly Enantioselective Construction of Spiro[4H-pyran-3,3′-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine

(2010) Wen-Bing Chen et al.   ORGANIC LETTERS

Selective difluoromethylation and monofluoromethylation reactions

(2009) Jinbo Hu et al.   CHEMICAL COMMUNICATIONS

Asymmetric organocatalysis of the addition of acetone to 2-nitrostyrene using N-diphenylphosphinyl-1,2-diphenylethane-1,2-diamine (PODPEN)

(2009) David J. Morris et al.   TETRAHEDRON LETTERS

Recent advances in enantioselective trifluoromethylation reactions

(2009) Norio Shibata et al.   TETRAHEDRON-ASYMMETRY

Lewis Base Catalysis in Organic Synthesis

(2008) Scott E. Denmark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Progress in Lewis Base Activation and Control of Stereoselectivity in the Additions of Trimethylsilyl Nucleophiles

(2008) Jacek Gawronski et al.   CHEMICAL REVIEWS

Discovery of Bifunctional Thiourea/Secondary-Amine Organocatalysts for the Highly Stereoselective Nitro-Mannich Reaction of α-Substituted Nitroacetates

(2008) Bo Han et al.   CHEMISTRY-A EUROPEAN JOURNAL

Natural products as inspiration for the development of asymmetric catalysis

(2008) Justin T. Mohr et al.   NATURE

Catalytic Asymmetric Fluorination Comes of Age

(2007) Vincent A. Brunet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION