☆ 4.8 Article

Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

期刊

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

卷 54, 期 19, 页码 5628-5631

出版社

WILEY-V C H VERLAG GMBH

DOI: 10.1002/anie.201500301

关键词

antigens; azides; bioorthogonal chemistry; cell recognition; Staudinger reduction

类别

Chemistry, Multidisciplinary

资金

Netherlands Organization for Scientific Research
Veni grant from the Netherlands Organization for Scientific Research [700.59.402]
ERC [639005]
intramural NIAID funding
European Research Council (ERC) [639005] Funding Source: European Research Council (ERC)

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Protocol

Reagent

摘要

The activation of CD8(+) T-cells requires the uptake of exogenous polypeptide antigens and proteolytic processing of these antigens to octamer or nonamer peptides, which are loaded on MHC-I complexes and presented to the T-cell. By using an azide as a bioorthogonal protecting group rather than as a ligation handle, masked antigens were generated-antigens that are not recognized by their cognate T-cell unless they are deprotected on the cell using a Staudinger reduction.

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